Blocking LINGO-1 as a Therapy to Promote CNS Repair: From Concept to the Clinic von Mi, Sha, Blake Pepinsky, R., Cadavid, Diego

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Structural and kinetic basis for the selectivity of aducanumab for aggregated forms of amyloid-β von Arndt, Joseph W., Qian, Fang, Smith, Benjamin A., Quan, Chao, Kilambi, Krishna Praneeth, Bush, Martin W., Walz, Thomas, Pepinsky, R. Blake, Bussière, Thierry, Hamann, Stefan, Cameron, Thomas O., Weinreb, Paul H.

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Development of an aggregate-selective, human-derived α-synuclein antibody BIIB054 that ameliorates disease phenotypes in Parkinson's disease models von Weihofen, Andreas, Liu, YuTing, Arndt, Joseph W., Huy, Christian, Quan, Chao, Smith, Benjamin A., Baeriswyl, Jean-Luc, Cavegn, Nicole, Senn, Luzia, Su, Lihe, Marsh, Galina, Auluck, Pavan K., Montrasio, Fabio, Nitsch, Roger M., Hirst, Warren D., Cedarbaum, Jesse M., Pepinsky, R. Blake, Grimm, Jan, Weinreb, Paul H.

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LINGO-1 negatively regulates myelination by oligodendrocytes von Mi, Sha, Miller, Robert H, Lee, Xinhua, Scott, Martin L, Shulag-Morskaya, Svetlane, Shao, Zhaohui, Chang, Jufang, Thill, Greg, Levesque, Melissa, Zhang, Mingdi, Hession, Cathy, Sah, Dinah, Trapp, Bruce, He, Zhigang, Jung, Vincent, McCoy, John M, Pepinsky, R Blake

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LINGO-1 is a component of the Nogo-66 receptor/p75 signaling complex von Mi, Sha, Lee, Xinhua, Shao, Zhaohui, Thill, Greg, Ji, Benxiu, Relton, Jane, Levesque, Melissa, Allaire, Norm, Perrin, Steve, Sands, Bryan, Crowell, Thomas, Cate, Richard L, McCoy, John M, Pepinsky, R Blake

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LINGO-1 antagonist promotes functional recovery and axonal sprouting after spinal cord injury von Ji, Benxiu, Li, Mingwei, Wu, Wu-Tian, Yick, Leung-Wah, Lee, Xinhua, Shao, Zhaohui, Wang, Joy, So, Kwok-Fai, McCoy, John M., Blake Pepinsky, R., Mi, Sha, Relton, Jane K.

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Death receptor 6 negatively regulates oligodendrocyte survival, maturation and myelination von Mi, Sha, Lee, Xinhua, Hu, Yinghui, Ji, Benxiu, Shao, Zhaohui, Yang, Weixing, Huang, Guanrong, Walus, Lee, Rhodes, Kenneth, Gong, Bang Jian, Miller, Robert H, Pepinsky, R Blake

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TAJ/TROY, an Orphan TNF Receptor Family Member, Binds Nogo-66 Receptor 1 and Regulates Axonal Regeneration von Shao, Zhaohui, Browning, Jeffrey L., Lee, Xinhua, Scott, Martin L., Shulga-Morskaya, Sveltlana, Allaire, Norm, Thill, Greg, Levesque, Melissa, Sah, Dinah, McCoy, John M., Murray, Beth, Jung, Vincent, Pepinsky, R. Blake, Mi, Sha

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NGF Regulates the Expression of Axonal LINGO-1 to Inhibit Oligodendrocyte Differentiation and Myelination von Lee, Xinhua, Yang, Zhongshu, Shao, Zhaohui, Rosenberg, Sheila S, Levesque, Melissa, Pepinsky, R. Blake, Qiu, Mengsheng, Miller, Robert H, Chan, Jonah R, Mi, Sha

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Constitutive negative regulation in the processing of the anti-Müllerian hormone receptor II von Hirschhorn, Tal, di Clemente, Nathalie, Amsalem, Ayelet R, Pepinsky, R Blake, Picard, Jean-Yves, Smorodinsky, Nechama I, Cate, Richard L, Ehrlich, Marcelo

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Improving the solubility of anti‐LINGO‐1 monoclonal antibody Li33 by isotype switching and targeted mutagenesis von Pepinsky, R. Blake, Silvian, Laura, Berkowitz, Steven A., Farrington, Graham, Lugovskoy, Alexey, Walus, Lee, Eldredge, John, Capili, Allan, Mi, Sha, Graff, Christilyn, Garber, Ellen

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Functional activity of anti-LINGO-1 antibody opicinumab requires target engagement at a secondary binding site von Hanf, Karl J M, Arndt, Joseph W, Liu, YuTing, Gong, Bang Jian, Rushe, Mia, Sopko, Richelle, Massol, Ramiro, Smith, Benjamin, Gao, Yan, Dalkilic-Liddle, Isin, Lee, Xinhua, Mojta, Shanell, Shao, Zhaohui, Mi, Sha, Pepinsky, R Blake

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The morphogen Sonic hedgehog is an indirect angiogenic agent upregulating two families of angiogenic growth factors von Pola, Roberto, Ling, Leona E., Silver, Marcy, Corbley, Michael J., Kearney, Marianne, Blake Pepinsky, R., Shapiro, Renee, Taylor, Frederick R., Baker, Darren P., Asahara, Takayuki, Isner, Jeffrey M.

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Blocking LINGO-1 Function Promotes Retinal Ganglion Cell Survival Following Ocular Hypertension and Optic Nerve Transection von Fu, Qing-Ling, Hu, Bing, Wu, Wutian, Pepinsky, R. Blake, Mi, Sha, So, Kwok-Fai

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Efficient on-column conversion of IgG₁ trisulfide linkages to native disulfides in tandem with Protein A affinity chromatography von Aono, Hiromasa, Wen, Dingy, Zang, Li, Houde, Damian, Pepinsky, R. Blake, Evans, David R.H

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Development and validation of immunoassays to quantify the half-antibody exchange of an IgG4 antibody, natalizumab (Tysabri ®) with endogenous IgG4 von Shapiro, Renée I., Plavina, Tatiana, Schlain, Brian R., Pepinsky, R. Blake, Garber, Ellen A., Jarpe, Matthew, Hochman, Paula S., Wehner, Nancy G., Bard, Frederique, Motter, Ruth, Yednock, Ted A., Taylor, Frederick R.

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Antibody humanization by redesign of complementarity-determining region residues proximate to the acceptor framework von Hanf, Karl J.M., Arndt, Joseph W., Chen, Ling Ling, Jarpe, Matthew, Boriack-Sjodin, P. Ann, Li, You, van Vlijmen, Herman W.T., Pepinsky, R. Blake, Simon, Kenneth J., Lugovskoy, Alexey

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Production of a PEGylated Fab′ of the anti-LINGO-1 Li33 Antibody and Assessment of Its Biochemical and Functional Properties in Vitro and in a Rat Model of Remyelination von Pepinsky, R. Blake, Walus, Lee, Shao, Zhaohui, Ji, Benxiu, Gu, Sheng, Sun, Yaping, Wen, Dingyi, Lee, Xinhua, Wang, Qin, Garber, Ellen, Mi, Sha

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The anti-Müllerian hormone prodomain is displaced from the hormone/prodomain complex upon bivalent binding to the hormone receptor von Cate, Richard L., di Clemente, Nathalie, Racine, Chrystèle, Groome, Nigel P., Pepinsky, R. Blake, Whitty, Adrian

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IGF-1:Tetanus toxin fragment C fusion protein improves delivery of IGF-1 to spinal cord but fails to prolong survival of ALS mice von Chian, Ru-Ju, Li, Jianhong, Ay, Ilknur, Celia, Samuel A, Kashi, Brenda B, Tamrazian, Eric, Matthews, Jonathan C, Bronson, Roderick T, Rossomando, Anthony, Pepinsky, R. Blake, Fishman, Paul S, Brown, Robert H, Francis, Jonathan W

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