HIV capsid is a tractable target for small molecule therapeutic intervention von Blair, Wade S, Pickford, Chris, Irving, Stephen L, Brown, David G, Anderson, Marie, Bazin, Richard, Cao, Joan, Ciaramella, Giuseppe, Isaacson, Jason, Jackson, Lynn, Hunt, Rachael, Kjerrstrom, Anne, Nieman, James A, Patick, Amy K, Perros, Manos, Scott, Andrew D, Whitby, Kevin, Wu, Hua, Butler, Scott L

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HIV envelope antibodies and TLR7 agonist partially prevent viral rebound in chronically SHIV-infected monkeys von Moldt, Brian, Chandrashekar, Abishek, Borducchi, Erica N, Nkolola, Joseph P, Stephenson, Heather, Nagel, Mark, Hung, Magdeleine, Goldsmith, Joshua, Pace, Craig S, Carr, Brian, Thomsen, Nathan D, Blair, Wade S, Geleziunas, Romas, Barouch, Dan H

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A restricted role for TYK2 catalytic activity in human cytokine responses revealed by novel TYK2-selective inhibitors von Sohn, Sue J, Barrett, Kathy, Van Abbema, Anne, Chang, Christine, Kohli, Pawan Bir, Kanda, Hidenobu, Smith, Janice, Lai, Yingjie, Zhou, Aihe, Zhang, Birong, Yang, Wenqian, Williams, Karen, Macleod, Calum, Hurley, Christopher A, Kulagowski, Janusz J, Lewin-Koh, Nicholas, Dengler, Hart S, Johnson, Adam R, Ghilardi, Nico, Zak, Mark, Liang, Jun, Blair, Wade S, Magnuson, Steven, Wu, Lawren C

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Lead identification of novel and selective TYK2 inhibitors von Liang, Jun, Tsui, Vickie, Van Abbema, Anne, Bao, Liang, Barrett, Kathy, Beresini, Maureen, Berezhkovskiy, Leo, Blair, Wade S., Chang, Christine, Driscoll, James, Eigenbrot, Charles, Ghilardi, Nico, Gibbons, Paul, Halladay, Jason, Johnson, Adam, Kohli, Pawan Bir, Lai, Yingjie, Liimatta, Marya, Mantik, Priscilla, Menghrajani, Kapil, Murray, Jeremy, Sambrone, Amy, Xiao, Yisong, Shia, Steven, Shin, Young, Smith, Jan, Sohn, Sue, Stanley, Mark, Ultsch, Mark, Zhang, Birong, Wu, Lawren C., Magnuson, Steven

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A broadly neutralizing human monoclonal antibody directed against a novel conserved epitope on the influenza virus H3 hemagglutinin globular head von Benjamin, Ebony, Wang, Weijia, McAuliffe, Josephine M, Palmer-Hill, Frances J, Kallewaard, Nicole L, Chen, Zhongying, Suzich, JoAnn A, Blair, Wade S, Jin, Hong, Zhu, Qing

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Discovery of Potent and Selective Pyrazolopyrimidine Janus Kinase 2 Inhibitors von Hanan, Emily J, van Abbema, Anne, Barrett, Kathy, Blair, Wade S, Blaney, Jeff, Chang, Christine, Eigenbrot, Charles, Flynn, Sean, Gibbons, Paul, Hurley, Christopher A, Kenny, Jane R, Kulagowski, Janusz, Lee, Leslie, Magnuson, Steven R, Morris, Claire, Murray, Jeremy, Pastor, Richard M, Rawson, Tom, Siu, Michael, Ultsch, Mark, Zhou, Aihe, Sampath, Deepak, Lyssikatos, Joseph P

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New Small-Molecule Inhibitor Class Targeting Human Immunodeficiency Virus Type 1 Virion Maturation von BLAIR, Wade S, CAO, Joan, PICKFORD, Chris, HUA WU, BUTLER, Scott L, FOK-SEANG, Juin, GRIFFIN, Paul, ISAACSON, Jason, LYNN JACKSON, R, MURRAY, Edward, PATRICK, Amy K, QINGHAI PENG, PERROS, Manos

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Inhibitors of HIV-1 attachment. Part 4: A study of the effect of piperazine substitution patterns on antiviral potency in the context of indole-based derivatives von Wang, Tao, Kadow, John F., Zhang, Zhongxing, Yin, Zhiwei, Gao, Qi, Wu, Dedong, Parker, Dawn DiGiugno, Yang, Zheng, Zadjura, Lisa, Robinson, Brett A., Gong, Yi-Fei, Blair, Wade S., Shi, Pei-Yong, Yamanaka, Gregory, Lin, Pin-Fang, Meanwell, Nicholas A.

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Inhibitors of HIV-1 attachment. Part 2: An initial survey of indole substitution patterns von MEANWELL, Nicholas A, WALLACE, Owen B, YEUNG, Kap-Sun, ZHILEI QIU, WRIGHT, J. J. Kim, ZHENG YANG, ZADJURA, Lisa, TWEEDIE, Donald L, YEOLA, Suresh, FANG ZHAO, RANADIVE, Sunanda, ROBINSON, Brett A, HAIQUAN FANG, GONG, Yi-Fei, WANG, Hwei-Gene Heidi, BLAIR, Wade S, SHI, Pei-Yong, COLONNO, Richard J, LIN, Pin-Fang, WANG, Henry, DESHPANDE, Milind, TAO WANG, ZHIWEI YIN, ZHONGXING ZHANG, PEARCE, Bradley C, JAMES, Jennifer

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Inhibitors of HIV-1 attachment. Part 3: A preliminary survey of the effect of structural variation of the benzamide moiety on antiviral activity von Meanwell, Nicholas A., Wallace, Owen B., Wang, Henry, Deshpande, Milind, Pearce, Bradley C., Trehan, Ashok, Yeung, Kap-Sun, Qiu, Zhilei, Wright, J.J. Kim, Robinson, Brett A., Gong, Yi-Fei, Wang, Hwei-Gene Heidi, Blair, Wade S., Shi, Pei-Yong, Lin, Pin-fang

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BMS-232632, a Highly Potent Human Immunodeficiency Virus Protease Inhibitor That Can Be Used in Combination with Other Available Antiretroviral Agents von ROBINSON, B. S, RICCARDI, K. A, LIN, P.-F, GONG, Y.-F, QI GUO, STOCK, D. A, BLAIR, W. S, TERRY, B. J, DEMINIE, C. A, DJANG, F, COLONNO, R. J

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High-Throughput Human Immunodeficiency Virus Type 1 (HIV-1) Full Replication Assay That Includes HIV-1 Vif as an Antiviral Target von CAO, Joan, ISAACSON, Jason, PATICK, Amy K, BLAIR, Wade S

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A survey of core replacements in indole-based HIV-1 attachment inhibitors von Wang, Tao, Wallace, Owen B., Zhang, Zhongxing, Fang, Haiquan, Yang, Zhong, Robinson, Brett A., Spicer, Timothy P., Gong, Yi-Fei, Blair, Wade S., Shi, Pei-Yong, Lin, Pin-Fang, Deshpande, Milind, Meanwell, Nicholas A., Kadow, John F.

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Compensatory substitutions in the HIV-1 capsid reduce the fitness cost associated with resistance to a capsid-targeting small-molecule inhibitor von Shi, Jiong, Zhou, Jing, Halambage, Upul D, Shah, Vaibhav B, Burse, Mallori J, Wu, Hua, Blair, Wade S, Butler, Scott L, Aiken, Christopher

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Identification and Characterization of UK-201844, a Novel Inhibitor That Interferes with Human Immunodeficiency Virus Type 1 gp160 Processing von BLAIR, Wade S, CAO, Joan, MALFAIT, Anne-Marie, TORTORELLA, Micky, PATICK, Amy K, JACKSON, Lynn, JIMENEZ, Judith, PENG, Qinghai, HUA WU, ISAACSON, Jason, BUTLER, Scott L, CHU, Alex, GRAHAM, Joanne

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Identification of an imidazopyridine scaffold to generate potent and selective TYK2 inhibitors that demonstrate activity in an in vivo psoriasis model von Liang, Jun, Van Abbema, Anne, Balazs, Mercedesz, Barrett, Kathy, Berezhkovsky, Leo, Blair, Wade S., Chang, Christine, Delarosa, Donnie, DeVoss, Jason, Driscoll, Jim, Eigenbrot, Charles, Goodacre, Simon, Ghilardi, Nico, MacLeod, Calum, Johnson, Adam, Bir Kohli, Pawan, Lai, Yingjie, Lin, Zhonghua, Mantik, Priscilla, Menghrajani, Kapil, Nguyen, Hieu, Peng, Ivan, Sambrone, Amy, Shia, Steven, Smith, Jan, Sohn, Sue, Tsui, Vickie, Ultsch, Mark, Williams, Karen, Wu, Lawren C., Yang, Wenqian, Zhang, Birong, Magnuson, Steven

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A novel HIV-1 antiviral high throughput screening approach for the discovery of HIV-1 inhibitors von Blair, Wade S., Isaacson, Jason, Li, Xinqiang, Cao, Joan, Peng, Qinghai, Kong, George F.Z., Patick, Amy K.

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HIV-1 entry – an expanding portal for drug discovery von Blair, Wade S, Lin, Pin-Fang, Meanwell, Nicholas A, Wallace, Owen B

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Identification of C‑2 Hydroxyethyl Imidazopyrrolopyridines as Potent JAK1 Inhibitors with Favorable Physicochemical Properties and High Selectivity over JAK2 von Zak, Mark, Hurley, Christopher A, Ward, Stuart I, Bergeron, Philippe, Barrett, Kathy, Balazs, Mercedesz, Blair, Wade S, Bull, Richard, Chakravarty, Paroma, Chang, Christine, Crackett, Peter, Deshmukh, Gauri, DeVoss, Jason, Dragovich, Peter S, Eigenbrot, Charles, Ellwood, Charles, Gaines, Simon, Ghilardi, Nico, Gibbons, Paul, Gradl, Stefan, Gribling, Peter, Hamman, Chris, Harstad, Eric, Hewitt, Peter, Johnson, Adam, Johnson, Tony, Kenny, Jane R, Koehler, Michael F. T, Bir Kohli, Pawan, Labadie, Sharada, Lee, Wyne P, Liao, Jiangpeng, Liimatta, Marya, Mendonca, Rohan, Narukulla, Raman, Pulk, Rebecca, Reeve, Austin, Savage, Scott, Shia, Steven, Steffek, Micah, Ubhayakar, Savita, van Abbema, Anne, Aliagas, Ignacio, Avitabile-Woo, Barbara, Xiao, Yisong, Yang, Jing, Kulagowski, Janusz J

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2-Amino-[1,2,4]triazolo[1,5-a]pyridines as JAK2 inhibitors von Siu, Michael, Pastor, Richard, Liu, Wendy, Barrett, Kathy, Berry, Megan, Blair, Wade S., Chang, Christine, Chen, Jacob Z., Eigenbrot, Charles, Ghilardi, Nico, Gibbons, Paul, He, Haiying, Hurley, Christopher A., Kenny, Jane R., Cyrus Khojasteh, S., Le, Hoa, Lee, Leslie, Lyssikatos, Joseph P., Magnuson, Steve, Pulk, Rebecca, Tsui, Vickie, Ultsch, Mark, Xiao, Yisong, Zhu, Bing-yan, Sampath, Deepak

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