Choose and Use Your Chemical Probe Wisely to Explore Cancer Biology von Blagg, Julian, Workman, Paul

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Scaffold Diversity of Exemplified Medicinal Chemistry Space von Langdon, Sarah R, Brown, Nathan, Blagg, Julian

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Chemical biology approaches to target validation in cancer von Blagg, Julian, Workman, Paul

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Structure-Based Optimization of Potent, Selective, and Orally Bioavailable CDK8 Inhibitors Discovered by High-Throughput Screening von Czodrowski, Paul, Mallinger, Aurélie, Wienke, Dirk, Esdar, Christina, Pöschke, Oliver, Busch, Michael, Rohdich, Felix, Eccles, Suzanne A, Ortiz-Ruiz, Maria-Jesus, Schneider, Richard, Raynaud, Florence I, Clarke, Paul A, Musil, Djordje, Schwarz, Daniel, Dale, Trevor, Urbahns, Klaus, Blagg, Julian, Schiemann, Kai

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Discovery of Potent, Selective, and Orally Bioavailable Small-Molecule Modulators of the Mediator Complex-Associated Kinases CDK8 and CDK19 von Mallinger, Aurélie, Schiemann, Kai, Rink, Christian, Stieber, Frank, Calderini, Michel, Crumpler, Simon, Stubbs, Mark, Adeniji-Popoola, Olajumoke, Poeschke, Oliver, Busch, Michael, Czodrowski, Paul, Musil, Djordje, Schwarz, Daniel, Ortiz-Ruiz, Maria-Jesus, Schneider, Richard, Thai, Ching, Valenti, Melanie, de Haven Brandon, Alexis, Burke, Rosemary, Workman, Paul, Dale, Trevor, Wienke, Dirk, Clarke, Paul A, Esdar, Christina, Raynaud, Florence I, Eccles, Suzanne A, Rohdich, Felix, Blagg, Julian

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Catalytic inhibition of KDM1A in Ewing sarcoma is insufficient as a therapeutic strategy von Romo‐Morales, Antonio, Aladowicz, Ewa, Blagg, Julian, Gatz, Susanne A., Shipley, Janet M.

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High Proliferation Rate and a Compromised Spindle Assembly Checkpoint Confers Sensitivity to the MPS1 Inhibitor BOS172722 in Triple-Negative Breast Cancers von Anderhub, Simon J, Mak, Grace Wing-Yan, Gurden, Mark D, Faisal, Amir, Drosopoulos, Konstantinos, Walsh, Katie, Woodward, Hannah L, Innocenti, Paolo, Westwood, Isaac M, Naud, Sébastien, Hayes, Angela, Theofani, Efthymia, Filosto, Simone, Saville, Harry, Burke, Rosemary, van Montfort, Rob L M, Raynaud, Florence I, Blagg, Julian, Hoelder, Swen, Eccles, Suzanne A, Linardopoulos, Spiros

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Design, Synthesis and Characterization of Covalent KDM5 Inhibitors von Vazquez‐Rodriguez, Saleta, Wright, Miranda, Rogers, Catherine M., Cribbs, Adam P., Velupillai, Srikannathasan, Philpott, Martin, Lee, Henry, Dunford, James E., Huber, Kilian V. M., Robers, Matthew B., Vasta, James D., Thezenas, Marie‐Laetitia, Bonham, Sarah, Kessler, Benedikt, Bennett, James, Fedorov, Oleg, Raynaud, Florence, Donovan, Adam, Blagg, Julian, Bavetsias, Vassilios, Oppermann, Udo, Bountra, Chas, Kawamura, Akane, Brennan, Paul E.

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Characterization of Hedgehog Acyltransferase Inhibitors Identifies a Small Molecule Probe for Hedgehog Signaling by Cancer Cells von Rodgers, Ursula R, Lanyon-Hogg, Thomas, Masumoto, Naoko, Ritzefeld, Markus, Burke, Rosemary, Blagg, Julian, Magee, Anthony I, Tate, Edward W

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Diverse functionalization of Aurora-A kinase at specified surface and buried sites by native chemical modification von Rowan, Fiona, Richards, Meirion, Widya, Marcella, Bayliss, Richard, Blagg, Julian

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Discovery of potent and selective CDK8 inhibitors from an HSP90 pharmacophore von Schiemann, Kai, Mallinger, Aurélie, Wienke, Dirk, Esdar, Christina, Poeschke, Oliver, Busch, Michael, Rohdich, Felix, Eccles, Suzanne A., Schneider, Richard, Raynaud, Florence I., Czodrowski, Paul, Musil, Djordje, Schwarz, Daniel, Urbahns, Klaus, Blagg, Julian

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Structure-Based Design of Orally Bioavailable 1H‑Pyrrolo[3,2‑c]pyridine Inhibitors of Mitotic Kinase Monopolar Spindle 1 (MPS1) von Naud, Sébastien, Westwood, Isaac M, Faisal, Amir, Sheldrake, Peter, Bavetsias, Vassilios, Atrash, Butrus, Cheung, Kwai-Ming J, Liu, Manjuan, Hayes, Angela, Schmitt, Jessica, Wood, Amy, Choi, Vanessa, Boxall, Kathy, Mak, Grace, Gurden, Mark, Valenti, Melanie, de Haven Brandon, Alexis, Henley, Alan, Baker, Ross, McAndrew, Craig, Matijssen, Berry, Burke, Rosemary, Hoelder, Swen, Eccles, Suzanne A, Raynaud, Florence I, Linardopoulos, Spiros, van Montfort, Rob L. M, Blagg, Julian

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Mechanism-based screen for G1/S checkpoint activators identifies a selective activator of EIF2AK3/PERK signalling von Stockwell, Simon R, Platt, Georgina, Barrie, S Elaine, Zoumpoulidou, Georgia, Te Poele, Robert H, Aherne, G Wynne, Wilson, Stuart C, Sheldrake, Peter, McDonald, Edward, Venet, Mathilde, Soudy, Christelle, Elustondo, Frédéric, Rigoreau, Laurent, Blagg, Julian, Workman, Paul, Garrett, Michelle D, Mittnacht, Sibylle

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Molecular profiling and combinatorial activity of CCT068127: a potent CDK2 and CDK9 inhibitor von Whittaker, Steven R., Barlow, Clare, Martin, Mathew P., Mancusi, Caterina, Wagner, Steve, Self, Annette, Barrie, Elaine, Te Poele, Robert, Sharp, Swee, Brown, Nathan, Wilson, Stuart, Jackson, Wayne, Fischer, Peter M., Clarke, Paul A., Walton, Michael I., McDonald, Edward, Blagg, Julian, Noble, Martin, Garrett, Michelle D., Workman, Paul

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A Useful Approach to Identify Novel Small-Molecule Inhibitors of Wnt-Dependent Transcription von EWAN, Kenneth, PAJAK, Bożena, BATTERSBY, Alysia, RAYNAUD, Florence, ALLEN, Nicholas, WILSON, Stephen, LATINKIC, Branko, WORKMAN, Paul, MCDONALD, Edward, BLAGG, Julian, AHERNE, Wynne, DALE, Trevor, STUBBS, Mark, TODD, Helen, BARBEAU, Olivier, QUEVEDO, Camilo, BOTFIELD, Hannah, YOUNG, Rodrigo, RUDDLE, Ruth, SAMUEL, Lee

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Choose and Use Your Chemical Probe Wisely to Explore Cancer Biology von Blagg, Julian, Workman, Paul

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Combining Mutational Signatures, Clonal Fitness, and Drug Affinity to Define Drug-Specific Resistance Mutations in Cancer von Kaserer, Teresa, Blagg, Julian

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Scaffold-Focused Virtual Screening: Prospective Application to the Discovery of TTK Inhibitors von Langdon, Sarah R, Westwood, Isaac M, van Montfort, Rob L. M, Brown, Nathan, Blagg, Julian

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Development and evaluation of selective, reversible LSD1 inhibitors derived from fragments von Hitchin, James R., Blagg, Julian, Burke, Rosemary, Burns, Samantha, Cockerill, Mark J., Fairweather, Emma E., Hutton, Colin, Jordan, Allan M., McAndrew, Craig, Mirza, Amin, Mould, Daniel, Thomson, Graeme J., Waddell, Ian, Ogilvie, Donald J.

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A selective chemical probe for exploring the role of CDK8 and CDK19 in human disease von Dale, Trevor, Clarke, Paul A, Esdar, Christina, Waalboer, Dennis, Adeniji-Popoola, Olajumoke, Ortiz-Ruiz, Maria-Jesus, Mallinger, Aurélie, Samant, Rahul S, Czodrowski, Paul, Musil, Djordje, Schwarz, Daniel, Schneider, Klaus, Stubbs, Mark, Ewan, Ken, Fraser, Elizabeth, TePoele, Robert, Court, Will, Box, Gary, Valenti, Melanie, de Haven Brandon, Alexis, Gowan, Sharon, Rohdich, Felix, Raynaud, Florence, Schneider, Richard, Poeschke, Oliver, Blaukat, Andree, Workman, Paul, Schiemann, Kai, Eccles, Suzanne A, Wienke, Dirk, Blagg, Julian

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