The Discovery and Development of Liraglutide and Semaglutide von Knudsen, Lotte Bjerre, Lau, Jesper

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The GLP-1 Analogs Liraglutide and Semaglutide Reduce Atherosclerosis in ApoE−/− and LDLr−/− Mice by a Mechanism That Includes Inflammatory Pathways von Rakipovski, Günaj, PhD, Rolin, Bidda, DVM, Nøhr, Jane, PhD, Klewe, Ib, PhD, Frederiksen, Klaus S., PhD, Augustin, Robert, PhD, Hecksher-Sørensen, Jacob, PhD, Ingvorsen, Camilla, PhD, Polex-Wolf, Joseph, PhD, Knudsen, Lotte Bjerre, DMSc

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Glucagon-Like Peptide-1 Receptor Agonists Activate Rodent Thyroid C-Cells Causing Calcitonin Release and C-Cell Proliferation von Bjerre Knudsen, Lotte, Madsen, Lars Wichmann, Andersen, Søren, Almholt, Kasper, de Boer, Anne S, Drucker, Daniel J, Gotfredsen, Carsten, Egerod, Frederikke Lihme, Hegelund, Anne Charlotte, Jacobsen, Helene, Jacobsen, Søren Dyring, Moses, Alan C, Mølck, Anne-Marie, Nielsen, Henriette S, Nowak, Jette, Solberg, Helene, Thi, Tu D. L, Zdravkovic, Milan

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Long-term characterization of the diet-induced obese and diet-resistant rat model: a polygenetic rat model mimicking the human obesity syndrome von Madsen, Andreas Nygaard, Hansen, Gitte, Paulsen, Sarah Juel, Lykkegaard, Kirsten, Tang-Christensen, Mads, Hansen, Harald S, Levin, Barry E, Larsen, Philip Just, Knudsen, Lotte Bjerre, Fosgerau, Keld, Vrang, Niels

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The arcuate nucleus mediates GLP-1 receptor agonist liraglutide-dependent weight loss von Secher, Anna, Jelsing, Jacob, Baquero, Arian F, Hecksher-Sørensen, Jacob, Cowley, Michael A, Dalbøge, Louise S, Hansen, Gitte, Grove, Kevin L, Pyke, Charles, Raun, Kirsten, Schäffer, Lauge, Tang-Christensen, Mads, Verma, Saurabh, Witgen, Brent M, Vrang, Niels, Bjerre Knudsen, Lotte

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Characterization of the Glucagonlike Peptide-1 Receptor in Male Mouse Brain Using a Novel Antibody and In Situ Hybridization von Jensen, Casper Bo, Pyke, Charles, Rasch, Morten Grønbech, Dahl, Anders Bjorholm, Knudsen, Lotte Bjerre, Secher, Anna

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Semaglutide lowers body weight in rodents via distributed neural pathways von Gabery, Sanaz, Salinas, Casper G, Paulsen, Sarah J, Ahnfelt-Rønne, Jonas, Alanentalo, Tomas, Baquero, Arian F, Buckley, Stephen T, Farkas, Erzsébet, Fekete, Csaba, Frederiksen, Klaus S, Helms, Hans Christian C, Jeppesen, Jacob F, John, Linu M, Pyke, Charles, Nøhr, Jane, Lu, Tess T, Polex-Wolf, Joseph, Prevot, Vincent, Raun, Kirsten, Simonsen, Lotte, Sun, Gao, Szilvásy-Szabó, Anett, Willenbrock, Hanni, Secher, Anna, Knudsen, Lotte Bjerre, Hogendorf, Wouter Frederik Johan

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The GLP-1 receptor agonist liraglutide reduces pathology-specific tau phosphorylation and improves motor function in a transgenic hTauP301L mouse model of tauopathy von Hansen, Henrik H, Barkholt, Pernille, Fabricius, Katrine, Jelsing, Jacob, Terwel, Dick, Pyke, Charles, Knudsen, Lotte Bjerre, Vrang, Niels

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Treatment with glucagon‐like peptide‐1 receptor agonists and incidence of dementia: Data from pooled double‐blind randomized controlled trials and nationwide disease and prescripti... von Nørgaard, Caroline Holm, Friedrich, Sarah, Hansen, Charlotte Thim, Gerds, Thomas, Ballard, Clive, Møller, Daniel Vega, Knudsen, Lotte Bjerre, Kvist, Kajsa, Zinman, Bernard, Holm, Ellen, Torp‐Pedersen, Christian, Mørch, Lina Steinrud

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The human GLP-1 analog liraglutide and the pancreas: evidence for the absence of structural pancreatic changes in three species von Nyborg, Niels C B, Mølck, Anne-Marie, Madsen, Lars W, Knudsen, Lotte Bjerre

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Crystal Structure of Glucagon-like Peptide-1 in Complex with the Extracellular Domain of the Glucagon-like Peptide-1 Receptor von Underwood, Christina Rye, Garibay, Patrick, Knudsen, Lotte Bjerre, Hastrup, Sven, Peters, Günther H., Rudolph, Rainer, Reedtz-Runge, Steffen

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Integrated Brain Atlas for Unbiased Mapping of Nervous System Effects Following Liraglutide Treatment von Salinas, Casper Bo Gravesen, Lu, Tess Tsai-Hsiu, Gabery, Sanaz, Marstal, Kasper, Alanentalo, Tomas, Mercer, Aaron Jeffrey, Cornea, Anda, Conradsen, Knut, Hecksher-Sørensen, Jacob, Dahl, Anders Bjorholm, Knudsen, Lotte Bjerre, Secher, Anna

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Suppression of food intake by Glp1r/Lepr-coexpressing neurons prevents obesity in mouse models von Rupp, Alan C, Tomlinson, Abigail J, Affinati, Alison H, Yacawych, Warren T, Duensing, Allison M, True, Cadence, Lindsley, Sarah R, Kirigiti, Melissa A, MacKenzie, Alexander, Polex-Wolf, Joseph, Li, Chien, Knudsen, Lotte Bjerre, Seeley, Randy J, Olson, David P, Kievit, Paul, Myers, Jr, Martin G

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Long-Term Treatment with Liraglutide, a Glucagon-Like Peptide-1 (GLP-1) Receptor Agonist, Has No Effect on β-Amyloid Plaque Load in Two Transgenic APP/PS1 Mouse Models of Alzheimer... von Hansen, Henrik H, Fabricius, Katrine, Barkholt, Pernille, Kongsbak-Wismann, Pernille, Schlumberger, Chantal, Jelsing, Jacob, Terwel, Dick, Termont, Annelies, Pyke, Charles, Knudsen, Lotte Bjerre, Vrang, Niels

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Distribution and ultrastructural localization of the glucagon-like peptide-1 receptor (GLP-1R) in the rat brain von Farkas, Erzsébet, Szilvásy-Szabó, Anett, Ruska, Yvette, Sinkó, Richárd, Rasch, Morten Grønbech, Egebjerg, Thomas, Pyke, Charles, Gereben, Balázs, Knudsen, Lotte Bjerre, Fekete, Csaba

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Expression of the GLP-1 Receptor in Mouse, Rat, and Human Pancreas von Tornehave, Ditte, Kristensen, Peter, Romer, John, Knudsen, Lotte Bjerre, Heller, R. Scott

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A survey of the mouse hindbrain in the fed and fasted states using single-nucleus RNA sequencing von Dowsett, Georgina K.C., Lam, Brian Y.H., Tadross, John A., Cimino, Irene, Rimmington, Debra, Coll, Anthony P., Polex-Wolf, Joseph, Knudsen, Lotte Bjerre, Pyke, Charles, Yeo, Giles S.H.

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Liraglutide, a Long-Acting Glucagon-Like Peptide-1 Analog, Reduces Body Weight and Food Intake in Obese Candy-Fed Rats, Whereas a Dipeptidyl Peptidase-IV Inhibitor, Vildagliptin, D... von RAUN, Kirsten, VON VOSS, Pia, GOTFREDSEN, Carsten F, GOLOZOUBOVA, Valeria, ROLIN, Bidda, KNUDSEN, Lotte Bjerre

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GLP-1 Receptor Agonists and the Thyroid: C-Cell Effects in Mice Are Mediated via the GLP-1 Receptor and not Associated with RET Activation von Madsen, Lars Wichmann, Knauf, Jeffrey A, Gotfredsen, Carsten, Pilling, Andrew, Sjögren, Ingrid, Andersen, Søren, Andersen, Lene, Sietske de Boer, Anne, Manova, Katia, Barlas, Afsar, Vundavalli, Sushil, Nyborg, Niels C. Berg, Bjerre Knudsen, Lotte, Moelck, Anne Marie, Fagin, James A

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GLP-1 for Treating Obesity—Origin, History, and Evolution: 2024 Lasker-DeBakey Clinical Medical Research Award von Knudsen, Lotte Bjerre

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