The Drug Repurposing Hub: a next-generation drug library and information resource von Corsello, Steven M, Bittker, Joshua A, Liu, Zihan, Gould, Joshua, McCarren, Patrick, Hirschman, Jodi E, Johnston, Stephen E, Vrcic, Anita, Wong, Bang, Khan, Mariya, Asiedu, Jacob, Narayan, Rajiv, Mader, Christopher C, Subramanian, Aravind, Golub, Todd R

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Genetic and transcriptional evolution alters cancer cell line drug response von Ben-David, Uri, Siranosian, Benjamin, Ha, Gavin, Tang, Helen, Oren, Yaara, Hinohara, Kunihiko, Strathdee, Craig A., Dempster, Joshua, Lyons, Nicholas J., Burns, Robert, Nag, Anwesha, Kugener, Guillaume, Cimini, Beth, Tsvetkov, Peter, Maruvka, Yosef E., O’Rourke, Ryan, Garrity, Anthony, Tubelli, Andrew A., Bandopadhayay, Pratiti, Tsherniak, Aviad, Vazquez, Francisca, Wong, Bang, Birger, Chet, Ghandi, Mahmoud, Thorner, Aaron R., Bittker, Joshua A., Meyerson, Matthew, Getz, Gad, Beroukhim, Rameen, Golub, Todd R.

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An Interactive Resource to Identify Cancer Genetic and Lineage Dependencies Targeted by Small Molecules von Basu, Amrita, Bodycombe, Nicole E., Cheah, Jaime H., Price, Edmund V., Liu, Ke, Schaefer, Giannina I., Ebright, Richard Y., Stewart, Michelle L., Ito, Daisuke, Wang, Stephanie, Bracha, Abigail L., Liefeld, Ted, Wawer, Mathias, Gilbert, Joshua C., Wilson, Andrew J., Stransky, Nicolas, Kryukov, Gregory V., Dancik, Vlado, Barretina, Jordi, Garraway, Levi A., Hon, C. Suk-Yee, Munoz, Benito, Bittker, Joshua A., Stockwell, Brent R., Khabele, Dineo, Stern, Andrew M., Clemons, Paul A., Shamji, Alykhan F., Schreiber, Stuart L.

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Correlating chemical sensitivity and basal gene expression reveals mechanism of action von Rees, Matthew G, Seashore-Ludlow, Brinton, Cheah, Jaime H, Adams, Drew J, Price, Edmund V, Gill, Shubhroz, Javaid, Sarah, Coletti, Matthew E, Jones, Victor L, Bodycombe, Nicole E, Soule, Christian K, Alexander, Benjamin, Li, Ava, Montgomery, Philip, Kotz, Joanne D, Hon, C Suk-Yee, Munoz, Benito, Liefeld, Ted, Dančík, Vlado, Haber, Daniel A, Clish, Clary B, Bittker, Joshua A, Palmer, Michelle, Wagner, Bridget K, Clemons, Paul A, Shamji, Alykhan F, Schreiber, Stuart L

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Harnessing Connectivity in a Large-Scale Small-Molecule Sensitivity Dataset von Seashore-Ludlow, Brinton, Rees, Matthew G, Cheah, Jaime H, Cokol, Murat, Price, Edmund V, Coletti, Matthew E, Jones, Victor, Bodycombe, Nicole E, Soule, Christian K, Gould, Joshua, Alexander, Benjamin, Li, Ava, Montgomery, Philip, Wawer, Mathias J, Kuru, Nurdan, Kotz, Joanne D, Hon, C Suk-Yee, Munoz, Benito, Liefeld, Ted, Dančík, Vlado, Bittker, Joshua A, Palmer, Michelle, Bradner, James E, Shamji, Alykhan F, Clemons, Paul A, Schreiber, Stuart L

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Toward performance-diverse small-molecule libraries for cell-based phenotypic screening using multiplexed high-dimensional profiling von Wawer, Mathias J., Li, Kejie, Gustafsdottir, Sigrun M., Ljos, Vebjorn, Bodycombe, Nicole E., Marton, Melissa A., Sokolnicki, Katherine L., Bray, Mark-Anthony, Kemp, Melissa M., Winchester, Ellen, Taylor, Bradley, Grant, George B., Hon, C. Suk-Yee, Duvall, Jeremy R., Wilson, J. Anthony, Bittker, Joshua A., Dančík, Vlado, Narayan, Rajiv, Subramanian, Aravind, Winckler, Wendy, Golub, Todd R., Carpenter, Anne E., Shamji, Alykhan F., Schreiber, Stuart L., Clemons, Paul A.

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Selective Chemical Inhibition of PGC-1α Gluconeogenic Activity Ameliorates Type 2 Diabetes von Sharabi, Kfir, Lin, Hua, Tavares, Clint D.J., Dominy, John E., Camporez, Joao Paulo, Perry, Rachel J., Schilling, Roger, Rines, Amy K., Lee, Jaemin, Hickey, Marc, Bennion, Melissa, Palmer, Michelle, Nag, Partha P., Bittker, Joshua A., Perez, José, Jedrychowski, Mark P., Ozcan, Umut, Gygi, Steve P., Kamenecka, Theodore M., Shulman, Gerald I., Schreiber, Stuart L., Griffin, Patrick R., Puigserver, Pere

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Discovering the anti-cancer potential of non-oncology drugs by systematic viability profiling von Corsello, Steven M, Nagari, Rohith T, Spangler, Ryan D, Rossen, Jordan, Kocak, Mustafa, Bryan, Jordan G, Humeidi, Ranad, Peck, David, Wu, Xiaoyun, Tang, Andrew A, Wang, Vickie M, Bender, Samantha A, Lemire, Evan, Narayan, Rajiv, Montgomery, Philip, Ben-David, Uri, Garvie, Colin W, Chen, Yejia, Rees, Matthew G, Lyons, Nicholas J, McFarland, James M, Wong, Bang T, Wang, Li, Dumont, Nancy, O'Hearn, Patrick J, Stefan, Eric, Doench, John G, Harrington, Caitlin N, Greulich, Heidi, Meyerson, Matthew, Vazquez, Francisca, Subramanian, Aravind, Roth, Jennifer A, Bittker, Joshua A, Boehm, Jesse S, Mader, Christopher C, Tsherniak, Aviad, Golub, Todd R

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Diversity-oriented synthesis yields novel multistage antimalarial inhibitors von Kato, Nobutaka, Comer, Eamon, Sakata-Kato, Tomoyo, Sharma, Arvind, Sharma, Manmohan, Maetani, Micah, Bastien, Jessica, Brancucci, Nicolas M., Bittker, Joshua A., Corey, Victoria, Clarke, David, Derbyshire, Emily R., Dornan, Gillian L., Duffy, Sandra, Eckley, Sean, Itoe, Maurice A., Koolen, Karin M. J., Lewis, Timothy A., Lui, Ping S., Lukens, Amanda K., Lund, Emily, March, Sandra, Meibalan, Elamaran, Meier, Bennett C., McPhail, Jacob A., Mitasev, Branko, Moss, Eli L., Sayes, Morgane, Van Gessel, Yvonne, Wawer, Mathias J., Yoshinaga, Takashi, Zeeman, Anne-Marie, Avery, Vicky M., Bhatia, Sangeeta N., Burke, John E., Catteruccia, Flaminia, Clardy, Jon C., Clemons, Paul A., Dechering, Koen J., Duvall, Jeremy R., Foley, Michael A., Gusovsky, Fabian, Kocken, Clemens H. M., Marti, Matthias, Morningstar, Marshall L., Munoz, Benito, Neafsey, Daniel E., Sharma, Amit, Winzeler, Elizabeth A., Wirth, Dyann F., Scherer, Christina A., Schreiber, Stuart L.

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A dataset of images and morphological profiles of 30 000 small-molecule treatments using the Cell Painting assay von Bray, Mark-Anthony, Gustafsdottir, Sigrun M, Rohban, Mohammad H, Singh, Shantanu, Ljosa, Vebjorn, Sokolnicki, Katherine L, Bittker, Joshua A, Bodycombe, Nicole E, Dančík, Vlado, Hasaka, Thomas P, Hon, Cindy S, Kemp, Melissa M, Li, Kejie, Walpita, Deepika, Wawer, Mathias J, Golub, Todd R, Schreiber, Stuart L, Clemons, Paul A, Shamji, Alykhan F, Carpenter, Anne E

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Small-molecule inhibitors directly target CARD9 and mimic its protective variant in inflammatory bowel disease von Leshchiner, Elizaveta S., Rush, Jason S., Durney, Michael A., Cao, Zhifang, Dančík, Vlado, Chittick, Benjamin, Wu, Huixian, Petrone, Adam, Bittker, Joshua A., Phillips, Andrew, Perez, Jose R., Shamji, Alykhan F., Kaushik, Virendar K., Daly, Mark J., Graham, Daniel B., Schreiber, Stuart L., Xavier, Ramnik J.

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High-Throughput Screens To Identify Autophagy Inducers That Function by Disrupting Beclin 1/Bcl‑2 Binding von Chiang, Wei-Chung, Wei, Yongjie, Kuo, Yi-Chun, Wei, Shuguang, Zhou, Anwu, Zou, Zhongju, Yehl, Jenna, Ranaghan, Matthew J, Skepner, Adam, Bittker, Joshua A, Perez, Jose R, Posner, Bruce A, Levine, Beth

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Development of small-molecule probes that selectively kill cells induced to express mutant RAS von Weïwer, Michel, Bittker, Joshua A., Lewis, Timothy A., Shimada, Kenichi, Yang, Wan Seok, MacPherson, Lawrence, Dandapani, Sivaraman, Palmer, Michelle, Stockwell, Brent R., Schreiber, Stuart L., Munoz, Benito

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Niche-based screening identifies small-molecule inhibitors of leukemia stem cells von Hartwell, Kimberly A, Miller, Peter G, Mukherjee, Siddhartha, Kahn, Alissa R, Stewart, Alison L, Logan, David J, Negri, Joseph M, Duvet, Mildred, Järås, Marcus, Puram, Rishi, Dancik, Vlado, Al-Shahrour, Fatima, Kindler, Thomas, Tothova, Zuzana, Chattopadhyay, Shrikanta, Hasaka, Thomas, Narayan, Rajiv, Dai, Mingji, Huang, Christina, Shterental, Sebastian, Chu, Lisa P, Haydu, J Erika, Shieh, Jae Hung, Steensma, David P, Munoz, Benito, Bittker, Joshua A, Shamji, Alykhan F, Clemons, Paul A, Tolliday, Nicola J, Carpenter, Anne E, Gilliland, D Gary, Stern, Andrew M, Moore, Malcolm A S, Scadden, David T, Schreiber, Stuart L, Ebert, Benjamin L, Golub, Todd R

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Discovering the anticancer potential of non-oncology drugs by systematic viability profiling von Corsello, Steven M., Nagari, Rohith T., Spangler, Ryan D., Rossen, Jordan, Kocak, Mustafa, Bryan, Jordan G., Humeidi, Ranad, Peck, David, Wu, Xiaoyun, Tang, Andrew A., Wang, Vickie M., Bender, Samantha A., Lemire, Evan, Narayan, Rajiv, Montgomery, Philip, Ben-David, Uri, Garvie, Colin W., Chen, Yejia, Rees, Matthew G., Lyons, Nicholas J., McFarland, James M., Wong, Bang T., Wang, Li, Dumont, Nancy, O’Hearn, Patrick J., Stefan, Eric, Doench, John G., Harrington, Caitlin N., Greulich, Heidi, Meyerson, Matthew, Vazquez, Francisca, Subramanian, Aravind, Roth, Jennifer A., Bittker, Joshua A., Boehm, Jesse S., Mader, Christopher C., Tsherniak, Aviad, Golub, Todd R.

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Small-molecule inducers of insulin expression in pancreatic α-cells von Fomina-Yadlin, Dina, Kubicek, Stefan, Walpita, Deepika, Dančik, Vlado, Hecksher-Sørensen, Jacob, Bittker, Joshua A, Sharifnia, Tanaz, Shamji, Alykhan, Clemons, Paul A, Wagner, Bridget K, Schreiber, Stuart L

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Evolving BioAssay Ontology (BAO): modularization, integration and applications von Abeyruwan, Saminda, Vempati, Uma D, Küçük-McGinty, Hande, Visser, Ubbo, Koleti, Amar, Mir, Ahsan, Sakurai, Kunie, Chung, Caty, Bittker, Joshua A, Clemons, Paul A, Brudz, Steve, Siripala, Anosha, Morales, Arturo J, Romacker, Martin, Twomey, David, Bureeva, Svetlana, Lemmon, Vance, Schürer, Stephan C

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The Use of Informer Sets in Screening: Perspectives on an Efficient Strategy to Identify New Probes von Clemons, Paul A., Bittker, Joshua A., Wagner, Florence F., Hands, Allison, Dančík, Vlado, Schreiber, Stuart L., Choudhary, Amit, Wagner, Bridget K.

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High Throughput Screen Identifies Interferon γ‑Dependent Inhibitors of Toxoplasma gondii Growth von Radke, Joshua B., Carey, Kimberly L., Shaw, Subrata, Metkar, Shailesh R., Mulrooney, Carol, Gale, Jennifer P., Bittker, Joshua A., Hilgraf, Robert, Comer, Eamon, Schreiber, Stuart L., Virgin, Herbert W., Perez, Jose R., Sibley, L. David

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Overcoming fluconazole resistance in Candida albicans clinical isolates with tetracyclic indoles von Youngsaye, Willmen, Dockendorff, Chris, Vincent, Benjamin, Hartland, Cathy L., Bittker, Joshua A., Dandapani, Sivaraman, Palmer, Michelle, Whitesell, Luke, Lindquist, Susan, Schreiber, Stuart L., Munoz, Benito

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