Pten Positively Regulates Brown Adipose Function, Energy Expenditure, and Longevity von Ortega-Molina, Ana, Efeyan, Alejo, Lopez-Guadamillas, Elena, Muñoz-Martin, Maribel, Gómez-López, Gonzalo, Cañamero, Marta, Mulero, Francisca, Pastor, Joaquin, Martinez, Sonia, Romanos, Eduardo, Mar Gonzalez-Barroso, M., Rial, Eduardo, Valverde, Angela M., Bischoff, James R., Serrano, Manuel

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CDK inhibitors in cancer therapy: what is next? von Malumbres, Marcos, Pevarello, Paolo, Barbacid, Mariano, Bischoff, James R

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Evaluation of STK17B as a cancer immunotherapy target utilizing highly potent and selective small molecule inhibitors von Scheuplein, Felix, Renner, Florian, Campbell, John E, Campbell, Robert, De Savi, Chris, Eckmann, Jan, Fischer, Holger, Ge, Jie, Green, Luke, Jakob, Peter, Kim, Joseph L, Kinkema, Caitlin, McGinn, Katie, Medina, Ricardo, Müller, Annemarie, Perez, Nisha, Perola, Emanuele, Timsit, Yoav, Traore, Tary, Hopfer, Ulrike, Tyanova, Stefka, Tzouros, Manuel, Wang, Ruduan, Woessner, Richard, Dorsch, Marion, Bischoff, James R

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PIM2 inhibition as a rational therapeutic approach in B-cell lymphoma von Gómez-Abad, Cristina, Pisonero, Helena, Blanco-Aparicio, Carmen, Roncador, Giovanna, González-Menchén, Alberto, Martinez-Climent, Jose A., Mata, Eva, Rodríguez, María Elena, Muñoz-González, Guillermo, Sánchez-Beato, Margarita, Leal, Juan F., Bischoff, James R., Piris, Miguel A.

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The Aurora/Ipl1p kinase family: regulators of chromosome segregation and cytokinesis von Bischoff, James R, Plowman, Gregory D

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Chemical Interrogation of FOXO3a Nuclear Translocation Identifies Potent and Selective Inhibitors of Phosphoinositide 3-Kinases von Link, Wolfgang, Oyarzabal, Julen, Serelde, Beatriz G., Albarran, Maria Isabel, Rabal, Obdulia, Cebriá, Antonio, Alfonso, Patricia, Fominaya, Jesus, Renner, Oliver, Peregrina, Sandra, Soilán, David, Ceballos, Plácido A., Hernández, Ana-Isabel, Lorenzo, Milagros, Pevarello, Paolo, Granda, Teresa G., Kurz, Guido, Carnero, Amancio, Bischoff, James R.

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Vorinostat interferes with the signaling transduction pathway of T-cell receptor and synergizes with phosphoinositide-3 kinase inhibitors in cutaneous T-cell lymphoma von WOZNIAK, Magdalena B, VILLUENDAS, Raquel, HERRERA, Marta, PIRIS, Miguel A, ORTIZ-ROMERO, Pablo L, BISCHOFF, James R, BLANCO-APARICIO, Carmen, MARTINEZ LEAL, Juan F, DE LA CUEVA, Paloma, RODRIGUEZ, Maelena, HERREROS, Beatriz, MARTIN-PEREZ, Daniel, LONGO, Maria I

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Identification of novel PI3K inhibitors through a scaffold hopping strategy von Martínez González, Sonia, Hernández, Ana Isabel, Álvarez, Rosa María, Rodríguez, Antonio, Ramos-Lima, Francisco, Bischoff, James R., Albarrán, María Isabel, Cebriá, Antonio, Hernández-Encinas, Elena, García-Arocha, Jennifer, Cebrián, David, Blanco-Aparicio, Carmen, Pastor, Joaquín

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Cellular Resistance Mechanisms to Targeted Protein Degradation Converge Toward Impairment of the Engaged Ubiquitin Transfer Pathway von Ottis, Philipp, Palladino, Chiara, Thienger, Phillip, Britschgi, Adrian, Heichinger, Christian, Berrera, Marco, Julien-Laferriere, Alice, Roudnicky, Filip, Kam-Thong, Tony, Bischoff, James R, Martoglio, Bruno, Pettazzoni, Piergiorgio

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A cell-based screen identifies ATR inhibitors with synthetic lethal properties for cancer-associated mutations von Fernandez-Capetillo, Oscar, Toledo, Luis I, Murga, Matilde, Zur, Rafal, Soria, Rebeca, Rodriguez, Antonio, Martinez, Sonia, Oyarzabal, Julen, Pastor, Joaquin, Bischoff, James R

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Requirement for PAK4 in the Anchorage-independent Growth of Human Cancer Cell Lines von Callow, Marinella G., Clairvoyant, Felix, Zhu, Shirley, Schryver, Brian, Whyte, David B., Bischoff, James R., Jallal, Bahija, Smeal, Tod

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Fragment-hopping-based discovery of a novel chemical series of proto-oncogene PIM-1 kinase inhibitors von Saluste, Gustavo, Albarran, Maria I, Alvarez, Rosa M, Rabal, Obdulia, Ortega, Miguel Angel, Blanco, Carmen, Kurz, Guido, Salgado, Antonio, Pevarello, Paolo, Bischoff, James R, Pastor, Joaquin, Oyarzabal, Julen

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Discovery of Mitogen-Activated Protein Kinase-Interacting Kinase 1 Inhibitors by a Comprehensive Fragment-Oriented Virtual Screening Approach von Oyarzabal, Julen, Zarich, Natasha, Albarran, María Isabel, Palacios, Irene, Urbano-Cuadrado, Manuel, Mateos, Genoveva, Reymundo, Isabel, Rabal, Obdulia, Salgado, Antonio, Corrionero, Ana, Fominaya, Jesús, Pastor, Joaquin, Bischoff, James R

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Preclinical Characterization of a Next-Generation Brain Permeable, Paradox Breaker BRAF Inhibitor von Wichmann, Jürgen, Rynn, Caroline, Friess, Thomas, Petrig-Schaffland, Jeannine, Kornacker, Martin, Handl, Cornelia, Emmenegger, Jasmin, Eckmann, Jan, Herting, Frank, Frances, Nicolas, Hunziker, Daniel, Krummenacher, Daniela, Rüttinger, Dominik, Ribeiro, Alison, Bacac, Marina, Brigo, Alessandro, Hewings, David S, Dummer, Reinhard, Levesque, Mitchell P, Schnetzler, Gabriel, Martoglio, Bruno, Bischoff, James R, Pettazzoni, Piergiorgio

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Discovery of Novel Allosteric EGFR L858R Inhibitors for the Treatment of Non-Small-Cell Lung Cancer as a Single Agent or in Combination with Osimertinib von Obst-Sander, Ulrike, Ricci, Antonio, Kuhn, Bernd, Friess, Thomas, Koldewey, Philipp, Kuglstatter, Andreas, Hewings, David, Goergler, Annick, Steiner, Sandra, Rueher, Daniel, Imhoff, Marie-Paule, Raschetti, Noemi, Marty, Hans-Peter, Dietzig, Aline, Rynn, Caroline, Ehler, Andreas, Burger, Dominique, Kornacker, Martin, Schaffland, Jeannine Petrig, Herting, Frank, Pao, William, Bischoff, James R., Martoglio, Bruno, Alice Nagel, Yvonne, Jaeschke, Georg

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Discovery of JNJ-63576253: A Clinical Stage Androgen Receptor Antagonist for F877L Mutant and Wild-Type Castration-Resistant Prostate Cancer (mCRPC) von Zhang, Zhuming, Connolly, Peter J, Lim, Heng Keang, Pande, Vineet, Meerpoel, Lieven, Teleha, Christopher, Branch, Jonathan R, Ondrus, Janine, Hickson, Ian, Bush, Tammy, Luistro, Leopoldo, Packman, Kathryn, Bischoff, James R, Ibrahim, Salam, Parrett, Christopher, Chong, Yolanda, Gottardis, Marco M, Bignan, Gilles

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Modulating Androgen Receptor-Driven Transcription in Prostate Cancer with Selective CDK9 Inhibitors von Richters, André, Doyle, Shelby K., Freeman, David B., Lee, Christina, Leifer, Becky S., Jagannathan, Sajjeev, Kabinger, Florian, Koren, Jošt Vrabič, Struntz, Nicholas B., Urgiles, Julie, Stagg, Ryan A., Curtin, Brice H., Chatterjee, Deep, Mathea, Sebastian, Mikochik, Peter J., Hopkins, Tamara D., Gao, Hua, Branch, Jonathan R., Xin, Hong, Westover, Lori, Bignan, Gilles C., Rupnow, Brent A., Karlin, Kristen L., Olson, Calla M., Westbrook, Thomas F., Vacca, Joseph, Wilfong, Chris M., Trotter, B. Wesley, Saffran, Douglas C., Bischofberger, Norbert, Knapp, Stefan, Russo, Joshua W., Hickson, Ian, Bischoff, James R., Gottardis, Marco M., Balk, Steven P., Lin, Charles Y., Pop, Marius S., Koehler, Angela N.

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The STE20 Kinase HGK Is Broadly Expressed in Human Tumor Cells and Can Modulate Cellular Transformation, Invasion, and Adhesion von Wright, Jocelyn H., Wang, Xueyan, Manning, Gerard, LaMere, Brandon J., Le, Phuong, Zhu, Shirley, Khatry, Deepak, Flanagan, Peter M., Buckley, Sharon D., Whyte, David B., Howlett, Anthony R., Bischoff, James R., Lipson, Kenneth E., Jallal, Bahija

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Activity and resistance of a brain-permeable paradox breaker BRAF inhibitor in melanoma brain metastasis von Bonfill-Teixidor, Ester, Iurlaro, Raffaella, Handl, Cornelia, Wichmann, Jürgen, Arias, Alexandra, Cuartas, Isabel, Emmenegger, Jasmin, Romagnani, Andrea, Mangano, Luca, Lorber, Thomas, Berrera, Marco, Godfried Sie, Christina, Köchl, Fabian, Eckmann, Jan, Feddersen, Romi, Kornacker, Martin, Schnetzler, Gabriel, Cicuéndez, Marta, Cordero, Esteban, Topczewski, Thomaz E, Ferrés-Pijoan, Abel, Gonzalez, Josep, Martínez-Ricarte, Francisco, Muñoz-Couselo, Eva, Tabernero, Josep, Bischoff, James R, Pettazzoni, Piergiorgio, Seoane, Joan

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Discovery of JNJ-63576253, a Next-Generation Androgen Receptor Antagonist Active Against Wild-Type and Clinically Relevant Ligand Binding Domain Mutations in Metastatic Castration-... von Branch, Jonathan R, Bush, Tammy L, Pande, Vineet, Connolly, Peter J, Zhang, Zhuming, Hickson, Ian, Ondrus, Janine, Jaensch, Steffen, Bischoff, James R, Habineza, Georges, Van Hecke, Geert, Meerpoel, Lieven, Packman, Kathryn, Parrett, Christopher J, Chong, Yolanda T, Gottardis, Marco M, Bignan, Gilles

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