Epidermal Growth Factor Receptor Extracellular Domain Mutations in Glioblastoma Present Opportunities for Clinical Imaging and Therapeutic Development von Binder, Zev A., Thorne, Amy Haseley, Bakas, Spyridon, Wileyto, E. Paul, Bilello, Michel, Akbari, Hamed, Rathore, Saima, Ha, Sung Min, Zhang, Logan, Ferguson, Cole J., Dahiya, Sonika, Bi, Wenya Linda, Reardon, David A., Idbaih, Ahmed, Felsberg, Joerg, Hentschel, Bettina, Weller, Michael, Bagley, Stephen J., Morrissette, Jennifer J.D., Nasrallah, MacLean P., Ma, Jianhui, Zanca, Ciro, Scott, Andrew M., Orellana, Laura, Davatzikos, Christos, Furnari, Frank B., O'Rourke, Donald M.

Volltext

PD1 Expression in EGFRvIII-Directed CAR T Cell Infusion Product for Glioblastoma Is Associated with Clinical Response von Tang, Oliver Y, Tian, Lifeng, Yoder, Todd, Xu, Rong, Kulikovskaya, Irina, Gupta, Minnal, Melenhorst, Jan Joseph, Lacey, Simon F, O'Rourke, Donald M, Binder, Zev A

Volltext

The University of Pennsylvania glioblastoma (UPenn-GBM) cohort: advanced MRI, clinical, genomics, & radiomics von Bakas, Spyridon, Sako, Chiharu, Akbari, Hamed, Bilello, Michel, Sotiras, Aristeidis, Shukla, Gaurav, Rudie, Jeffrey D., Santamaría, Natali Flores, Kazerooni, Anahita Fathi, Pati, Sarthak, Rathore, Saima, Mamourian, Elizabeth, Ha, Sung Min, Parker, William, Doshi, Jimit, Baid, Ujjwal, Bergman, Mark, Binder, Zev A., Verma, Ragini, Lustig, Robert A., Desai, Arati S., Bagley, Stephen J., Mourelatos, Zissimos, Morrissette, Jennifer, Watt, Christopher D., Brem, Steven, Wolf, Ronald L., Melhem, Elias R., Nasrallah, MacLean P., Mohan, Suyash, O’Rourke, Donald M., Davatzikos, Christos

Volltext

Integrating imaging and genomic data for the discovery of distinct glioblastoma subtypes: a joint learning approach von Guo, Jun, Fathi Kazerooni, Anahita, Toorens, Erik, Akbari, Hamed, Yu, Fanyang, Sako, Chiharu, Mamourian, Elizabeth, Shinohara, Russell T., Koumenis, Constantinos, Bagley, Stephen J., Morrissette, Jennifer J. D., Binder, Zev A., Brem, Steven, Mohan, Suyash, Lustig, Robert A., O’Rourke, Donald M., Ganguly, Tapan, Bakas, Spyridon, Nasrallah, MacLean P., Davatzikos, Christos

Volltext

Genomic analysis identifies frequent deletions of Dystrophin in olfactory neuroblastoma von Gallia, Gary L., Zhang, Ming, Ning, Yi, Haffner, Michael C., Batista, Denise, Binder, Zev A., Bishop, Justin A., Hann, Christine L., Hruban, Ralph H., Ishii, Masaru, Klein, Alison P., Reh, Douglas D., Rooper, Lisa M., Salmasi, Vafi, Tamargo, Rafael J., Wang, Qing, Williamson, Tara, Zhao, Tianna, Zou, Ying, Meeker, Alan K., Agrawal, Nishant, Vogelstein, Bert, Kinzler, Kenneth W., Papadopoulos, Nickolas, Bettegowda, Chetan

Volltext

Establishment and Biological Characterization of a Panel of Glioblastoma Multiforme (GBM) and GBM Variant Oncosphere Cell Lines von Binder, Zev A, Wilson, Kelli M, Salmasi, Vafi, Orr, Brent A, Eberhart, Charles G, Siu, I-Mei, Lim, Michael, Weingart, Jon D, Quinones-Hinojosa, Alfredo, Bettegowda, Chetan, Kassam, Amin B, Olivi, Alessandro, Brem, Henry, Riggins, Gregory J, Gallia, Gary L

Volltext

High-Affinity Chimeric Antigen Receptor With Cross-Reactive scFv to Clinically Relevant EGFR Oncogenic Isoforms von Thokala, Radhika, Binder, Zev A., Yin, Yibo, Zhang, Logan, Zhang, Jiasi Vicky, Zhang, Daniel Y., Milone, Michael C., Ming, Guo-li, Song, Hongjun, O’Rourke, Donald M.

Volltext

Checkpoint Blockade Reverses Anergy in IL-13Rα2 Humanized scFv-Based CAR T Cells to Treat Murine and Canine Gliomas von Yin, Yibo, Boesteanu, Alina C., Binder, Zev A., Xu, Chong, Reid, Reiss A., Rodriguez, Jesse L., Cook, Danielle R., Thokala, Radhika, Blouch, Kristin, McGettigan-Croce, Bevin, Zhang, Logan, Konradt, Christoph, Cogdill, Alexandria P., Panjwani, M. Kazim, Jiang, Shuguang, Migliorini, Denis, Dahmane, Nadia, Posey, Avery D., June, Carl H., Mason, Nicola J., Lin, Zhiguo, O’Rourke, Donald M., Johnson, Laura A.

Volltext

Novel tri-specific T-cell engager targeting IL-13Rα2 and EGFRvIII provides long-term survival in heterogeneous GBM challenge and promotes antitumor cytotoxicity with patient immune... von Park, Daniel H, Bhojnagarwala, Pratik S, Liaw, Kevin, Bordoloi, Devivasha, Tursi, Nicholas J, Zhao, Shushu, Binder, Zev A, O’Rourke, Donald, Weiner, David B

Volltext

The IAP antagonist birinapant enhances chimeric antigen receptor T cell therapy for glioblastoma by overcoming antigen heterogeneity von Song, Edward Z., Wang, Xin, Philipson, Benjamin I., Zhang, Qian, Thokala, Radhika, Zhang, Logan, Assenmacher, Charles-Antoine, Binder, Zev A., Ming, Guo-li, O’Rourke, Donald M., Song, Hongjun, Milone, Michael C.

Volltext

Clinical activity of the EGFR tyrosine kinase inhibitor osimertinib in EGFR -mutant glioblastoma von Makhlin, Igor, Salinas, Ryan D, Zhang, Daniel, Jacob, Fadi, Ming, Gou-li, Song, Hongjun, Saxena, Deeksha, Dorsey, Jay F, Nasrallah, MacLean P, Morrissette, Jennifer JD, Binder, Zev A, O’Rourke, Donald M, Desai, Arati S, Brem, Steven, Bagley, Stephen J

Volltext

Podocalyxin-like protein is expressed in glioblastoma multiforme stem-like cells and is associated with poor outcome von Binder, Zev A, Siu, I-Mei, Eberhart, Charles G, Ap Rhys, Colette, Bai, Ren-Yuan, Staedtke, Verena, Zhang, Hao, Smoll, Nicolas R, Piantadosi, Steven, Piccirillo, Sara G, Dimeco, Francesco, Weingart, Jon D, Vescovi, Angelo, Olivi, Alessandro, Riggins, Gregory J, Gallia, Gary L

Volltext

Glioblastoma: The Current State of Biology and Therapeutic Strategies von Binder, Zev A, O'Rourke, Donald M

Volltext

A Patient-Derived Glioblastoma Organoid Model and Biobank Recapitulates Inter- and Intra-tumoral Heterogeneity von Jacob, Fadi, Salinas, Ryan D., Zhang, Daniel Y., Nguyen, Phuong T.T., Schnoll, Jordan G., Wong, Samuel Zheng Hao, Thokala, Radhika, Sheikh, Saad, Saxena, Deeksha, Prokop, Stefan, Liu, Di-ao, Qian, Xuyu, Petrov, Dmitriy, Lucas, Timothy, Chen, H. Isaac, Dorsey, Jay F., Christian, Kimberly M., Binder, Zev A., Nasrallah, MacLean, Brem, Steven, O’Rourke, Donald M., Ming, Guo-li, Song, Hongjun

Volltext

Exomic sequencing of four rare central nervous system tumor types von Bettegowda, Chetan, Agrawal, Nishant, Jiao, Yuchen, Wang, Yuxuan, Wood, Laura D, Rodriguez, Fausto J, Hruban, Ralph H, Gallia, Gary L, Binder, Zev A, Riggins, Callen J, Salmasi, Vafi, Riggins, Gregory J, Reitman, Zachary J, Rasheed, Ahmed, Keir, Stephen, Shinjo, Sueli, Marie, Suely, McLendon, Roger, Jallo, George, Vogelstein, Bert, Bigner, Darell, Yan, Hai, Kinzler, Kenneth W, Papadopoulos, Nickolas

Volltext

Radiomic MRI signature reveals three distinct subtypes of glioblastoma with different clinical and molecular characteristics, offering prognostic value beyond IDH1 von Rathore, Saima, Akbari, Hamed, Rozycki, Martin, Abdullah, Kalil G., Nasrallah, MacLean P., Binder, Zev A., Davuluri, Ramana V., Lustig, Robert A., Dahmane, Nadia, Bilello, Michel, O’Rourke, Donald M., Davatzikos, Christos

Volltext

Intrathecal bivalent CAR T cells targeting EGFR and IL13Rα2 in recurrent glioblastoma: phase 1 trial interim results von Bagley, Stephen J., Logun, Meghan, Fraietta, Joseph A., Wang, Xin, Desai, Arati S., Bagley, Linda J., Nabavizadeh, Ali, Jarocha, Danuta, Martins, Rene, Maloney, Eileen, Lledo, Lester, Stein, Carly, Marshall, Amy, Leskowitz, Rachel, Jadlowsky, Julie K., Christensen, Shannon, Oner, Bike Su, Plesa, Gabriela, Brennan, Andrea, Gonzalez, Vanessa, Chen, Fang, Sun, Yusha, Gladney, Whitney, Barrett, David, Nasrallah, MacLean P., Hwang, Wei-Ting, Ming, Guo-Li, Song, Hongjun, Siegel, Donald L., June, Carl H., Hexner, Elizabeth O., Binder, Zev A., O’Rourke, Donald M.

Volltext

Single-cell RNA-seq-based proteogenomics identifies glioblastoma-specific transposable elements encoding HLA-I-presented peptides von Bonté, Pierre-Emmanuel, Arribas, Yago A, Merlotti, Antonela, Carrascal, Montserrat, Zhang, Jiasi Vicky, Zueva, Elina, Binder, Zev A, Alanio, Cécile, Goudot, Christel, Amigorena, Sebastian

Volltext

Locally secreted BiTEs complement CAR T cells by enhancing killing of antigen heterogeneous solid tumors von Yin, Yibo, Rodriguez, Jesse L., Li, Nannan, Thokala, Radhika, Nasrallah, MacLean P., Hu, Li, Zhang, Logan, Zhang, Jiasi Vicky, Logun, Meghan T., Kainth, Devneet, Haddad, Leila, Zhao, Yang, Wu, Tong, Johns, Emily X., Long, Yu, Liang, Hongsheng, Qi, Jiping, Zhang, Xiangtong, Binder, Zev A., Lin, Zhiguo, O’Rourke, Donald M.

Volltext

Clinical Utility of Plasma Cell-Free DNA in Adult Patients with Newly Diagnosed Glioblastoma: A Pilot Prospective Study von Bagley, Stephen J, Nabavizadeh, S Ali, Mays, Jazmine J, Till, Jacob E, Ware, Jeffrey B, Levy, Scott, Sarchiapone, Whitney, Hussain, Jasmin, Prior, Timothy, Guiry, Samantha, Christensen, Theresa, Yee, Stephanie S, Nasrallah, MacLean P, Morrissette, Jennifer J D, Binder, Zev A, O'Rourke, Donald M, Cucchiara, Andrew J, Brem, Steven, Desai, Arati S, Carpenter, Erica L

Volltext