Glioblastoma: The Current State of Biology and Therapeutic Strategies von Binder, Zev A, O'Rourke, Donald M

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A Patient-Derived Glioblastoma Organoid Model and Biobank Recapitulates Inter- and Intra-tumoral Heterogeneity von Jacob, Fadi, Salinas, Ryan D., Zhang, Daniel Y., Nguyen, Phuong T.T., Schnoll, Jordan G., Wong, Samuel Zheng Hao, Thokala, Radhika, Sheikh, Saad, Saxena, Deeksha, Prokop, Stefan, Liu, Di-ao, Qian, Xuyu, Petrov, Dmitriy, Lucas, Timothy, Chen, H. Isaac, Dorsey, Jay F., Christian, Kimberly M., Binder, Zev A., Nasrallah, MacLean, Brem, Steven, O’Rourke, Donald M., Ming, Guo-li, Song, Hongjun

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Epidermal Growth Factor Receptor Extracellular Domain Mutations in Glioblastoma Present Opportunities for Clinical Imaging and Therapeutic Development von Binder, Zev A., Thorne, Amy Haseley, Bakas, Spyridon, Wileyto, E. Paul, Bilello, Michel, Akbari, Hamed, Rathore, Saima, Ha, Sung Min, Zhang, Logan, Ferguson, Cole J., Dahiya, Sonika, Bi, Wenya Linda, Reardon, David A., Idbaih, Ahmed, Felsberg, Joerg, Hentschel, Bettina, Weller, Michael, Bagley, Stephen J., Morrissette, Jennifer J.D., Nasrallah, MacLean P., Ma, Jianhui, Zanca, Ciro, Scott, Andrew M., Orellana, Laura, Davatzikos, Christos, Furnari, Frank B., O'Rourke, Donald M.

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Single-cell RNA-seq-based proteogenomics identifies glioblastoma-specific transposable elements encoding HLA-I-presented peptides von Bonté, Pierre-Emmanuel, Arribas, Yago A, Merlotti, Antonela, Carrascal, Montserrat, Zhang, Jiasi Vicky, Zueva, Elina, Binder, Zev A, Alanio, Cécile, Goudot, Christel, Amigorena, Sebastian

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Radiomic MRI signature reveals three distinct subtypes of glioblastoma with different clinical and molecular characteristics, offering prognostic value beyond IDH1 von Rathore, Saima, Akbari, Hamed, Rozycki, Martin, Abdullah, Kalil G., Nasrallah, MacLean P., Binder, Zev A., Davuluri, Ramana V., Lustig, Robert A., Dahmane, Nadia, Bilello, Michel, O’Rourke, Donald M., Davatzikos, Christos

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Intrathecal bivalent CAR T cells targeting EGFR and IL13Rα2 in recurrent glioblastoma: phase 1 trial interim results von Bagley, Stephen J., Logun, Meghan, Fraietta, Joseph A., Wang, Xin, Desai, Arati S., Bagley, Linda J., Nabavizadeh, Ali, Jarocha, Danuta, Martins, Rene, Maloney, Eileen, Lledo, Lester, Stein, Carly, Marshall, Amy, Leskowitz, Rachel, Jadlowsky, Julie K., Christensen, Shannon, Oner, Bike Su, Plesa, Gabriela, Brennan, Andrea, Gonzalez, Vanessa, Chen, Fang, Sun, Yusha, Gladney, Whitney, Barrett, David, Nasrallah, MacLean P., Hwang, Wei-Ting, Ming, Guo-Li, Song, Hongjun, Siegel, Donald L., June, Carl H., Hexner, Elizabeth O., Binder, Zev A., O’Rourke, Donald M.

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Locally secreted BiTEs complement CAR T cells by enhancing killing of antigen heterogeneous solid tumors von Yin, Yibo, Rodriguez, Jesse L., Li, Nannan, Thokala, Radhika, Nasrallah, MacLean P., Hu, Li, Zhang, Logan, Zhang, Jiasi Vicky, Logun, Meghan T., Kainth, Devneet, Haddad, Leila, Zhao, Yang, Wu, Tong, Johns, Emily X., Long, Yu, Liang, Hongsheng, Qi, Jiping, Zhang, Xiangtong, Binder, Zev A., Lin, Zhiguo, O’Rourke, Donald M.

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Clinical Utility of Plasma Cell-Free DNA in Adult Patients with Newly Diagnosed Glioblastoma: A Pilot Prospective Study von Bagley, Stephen J, Nabavizadeh, S Ali, Mays, Jazmine J, Till, Jacob E, Ware, Jeffrey B, Levy, Scott, Sarchiapone, Whitney, Hussain, Jasmin, Prior, Timothy, Guiry, Samantha, Christensen, Theresa, Yee, Stephanie S, Nasrallah, MacLean P, Morrissette, Jennifer J D, Binder, Zev A, O'Rourke, Donald M, Cucchiara, Andrew J, Brem, Steven, Desai, Arati S, Carpenter, Erica L

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PD1 Expression in EGFRvIII-Directed CAR T Cell Infusion Product for Glioblastoma Is Associated with Clinical Response von Tang, Oliver Y, Tian, Lifeng, Yoder, Todd, Xu, Rong, Kulikovskaya, Irina, Gupta, Minnal, Melenhorst, Jan Joseph, Lacey, Simon F, O'Rourke, Donald M, Binder, Zev A

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Establishment and Biological Characterization of a Panel of Glioblastoma Multiforme (GBM) and GBM Variant Oncosphere Cell Lines von Binder, Zev A, Wilson, Kelli M, Salmasi, Vafi, Orr, Brent A, Eberhart, Charles G, Siu, I-Mei, Lim, Michael, Weingart, Jon D, Quinones-Hinojosa, Alfredo, Bettegowda, Chetan, Kassam, Amin B, Olivi, Alessandro, Brem, Henry, Riggins, Gregory J, Gallia, Gary L

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The University of Pennsylvania glioblastoma (UPenn-GBM) cohort: advanced MRI, clinical, genomics, & radiomics von Bakas, Spyridon, Sako, Chiharu, Akbari, Hamed, Bilello, Michel, Sotiras, Aristeidis, Shukla, Gaurav, Rudie, Jeffrey D., Santamaría, Natali Flores, Kazerooni, Anahita Fathi, Pati, Sarthak, Rathore, Saima, Mamourian, Elizabeth, Ha, Sung Min, Parker, William, Doshi, Jimit, Baid, Ujjwal, Bergman, Mark, Binder, Zev A., Verma, Ragini, Lustig, Robert A., Desai, Arati S., Bagley, Stephen J., Mourelatos, Zissimos, Morrissette, Jennifer, Watt, Christopher D., Brem, Steven, Wolf, Ronald L., Melhem, Elias R., Nasrallah, MacLean P., Mohan, Suyash, O’Rourke, Donald M., Davatzikos, Christos

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Armored bicistronic CAR T cells with dominant-negative TGF-β receptor II to overcome resistance in glioblastoma von Li, Nannan, Rodriguez, Jesse L., Yin, Yibo, Logun, Meghan T., Zhang, Logan, Yu, Shengkun, Hicks, Kelly A., Zhang, Jiasi Vicky, Zhang, Laura, Xie, Chuncheng, Wang, Jiabin, Wang, Tianyu, Xu, Jiayi, Fraietta, Joseph A., Binder, Zev A., Lin, Zhiguo, O’Rourke, Donald M.

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Integrating imaging and genomic data for the discovery of distinct glioblastoma subtypes: a joint learning approach von Guo, Jun, Fathi Kazerooni, Anahita, Toorens, Erik, Akbari, Hamed, Yu, Fanyang, Sako, Chiharu, Mamourian, Elizabeth, Shinohara, Russell T., Koumenis, Constantinos, Bagley, Stephen J., Morrissette, Jennifer J. D., Binder, Zev A., Brem, Steven, Mohan, Suyash, Lustig, Robert A., O’Rourke, Donald M., Ganguly, Tapan, Bakas, Spyridon, Nasrallah, MacLean P., Davatzikos, Christos

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EGFR, the Lazarus target for precision oncology in glioblastoma von Lin, Benjamin, Ziebro, Julia, Smithberger, Erin, Skinner, Kasey R, Zhao, Eva, Cloughesy, Timothy F, Binder, Zev A, O'Rourke, Donald M, Nathanson, David A, Furnari, Frank B, Miller, C Ryan

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EGFRvIII upregulates DNA mismatch repair resulting in increased temozolomide sensitivity of MGMT promoter methylated glioblastoma von Struve, Nina, Binder, Zev A., Stead, Lucy F., Brend, Tim, Bagley, Stephen J., Faulkner, Claire, Ott, Leonie, Müller-Goebel, Justus, Weik, Anna-Sophie, Hoffer, Konstantin, Krug, Leonie, Rieckmann, Thorsten, Bußmann, Lara, Henze, Marvin, Morrissette, Jennifer J. D., Kurian, Kathreena M., Schüller, Ulrich, Petersen, Cordula, Rothkamm, Kai, O´ Rourke, Donald M., Short, Susan C., Kriegs, Malte

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Genomic analysis identifies frequent deletions of Dystrophin in olfactory neuroblastoma von Gallia, Gary L., Zhang, Ming, Ning, Yi, Haffner, Michael C., Batista, Denise, Binder, Zev A., Bishop, Justin A., Hann, Christine L., Hruban, Ralph H., Ishii, Masaru, Klein, Alison P., Reh, Douglas D., Rooper, Lisa M., Salmasi, Vafi, Tamargo, Rafael J., Wang, Qing, Williamson, Tara, Zhao, Tianna, Zou, Ying, Meeker, Alan K., Agrawal, Nishant, Vogelstein, Bert, Kinzler, Kenneth W., Papadopoulos, Nickolas, Bettegowda, Chetan

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High-Affinity Chimeric Antigen Receptor With Cross-Reactive scFv to Clinically Relevant EGFR Oncogenic Isoforms von Thokala, Radhika, Binder, Zev A., Yin, Yibo, Zhang, Logan, Zhang, Jiasi Vicky, Zhang, Daniel Y., Milone, Michael C., Ming, Guo-li, Song, Hongjun, O’Rourke, Donald M.

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Targeting PAK4 to reprogram the vascular microenvironment and improve CAR-T immunotherapy for glioblastoma von Ma, Wenjuan, Wang, Yanling, Zhang, Rongxin, Yang, Fan, Zhang, Duo, Huang, Menggui, Zhang, Lin, Dorsey, Jay F, Binder, Zev A, O'Rourke, Donald M, Fraietta, Joseph A, Gong, Yanqing, Fan, Yi

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Optimizing CAR-T Therapy for Glioblastoma von Tang, Oliver Y., Binder, Zev A., O’Rourke, Donald M., Bagley, Stephen J.

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Checkpoint Blockade Reverses Anergy in IL-13Rα2 Humanized scFv-Based CAR T Cells to Treat Murine and Canine Gliomas von Yin, Yibo, Boesteanu, Alina C., Binder, Zev A., Xu, Chong, Reid, Reiss A., Rodriguez, Jesse L., Cook, Danielle R., Thokala, Radhika, Blouch, Kristin, McGettigan-Croce, Bevin, Zhang, Logan, Konradt, Christoph, Cogdill, Alexandria P., Panjwani, M. Kazim, Jiang, Shuguang, Migliorini, Denis, Dahmane, Nadia, Posey, Avery D., June, Carl H., Mason, Nicola J., Lin, Zhiguo, O’Rourke, Donald M., Johnson, Laura A.

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