Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis von Brinkmann, Volker, Billich, Andreas, Baumruker, Thomas, Heining, Peter, Schmouder, Robert, Francis, Gordon, Aradhye, Shreeram, Burtin, Pascale

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Second generation S1P pathway modulators: Research strategies and clinical developments von Bigaud, Marc, Guerini, Danilo, Billich, Andreas, Bassilana, Frederic, Brinkmann, Volker

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Persistent signaling induced by FTY720-phosphate is mediated by internalized S1P1 receptors von Mullershausen, Florian, Seuwen, Klaus, Zecri, Frédéric, Cetin, Cihan, Billich, Andreas, Guerini, Danilo

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Pharmacological inhibition of RORγt suppresses the Th17 pathway and alleviates arthritis in vivo von Guendisch, Ulf, Weiss, Jessica, Ecoeur, Florence, Riker, Julia Christina, Kaupmann, Klemens, Kallen, Joerg, Hintermann, Samuel, Orain, David, Dawson, Janet, Billich, Andreas, Guntermann, Christine

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Orally Active 7‑Substituted (4-Benzylphthalazin-1-yl)-2-methylpiperazin-1-yl]nicotinonitriles as Active-Site Inhibitors of Sphingosine 1‑Phosphate Lyase for the Treatment of Multip... von Weiler, Sven, Braendlin, Nadine, Beerli, Christian, Bergsdorf, Christian, Schubart, Anna, Srinivas, Honnappa, Oberhauser, Berndt, Billich, Andreas

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Phosphorylation of the Immunomodulatory Drug FTY720 by Sphingosine Kinases von Billich, Andreas, Bornancin, Frederic, Dévay, Piroska, Mechtcheriakova, Diana, Urtz, Nicole, Baumruker, Thomas

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A novel role of sphingosine 1-phosphate receptor S1pr1 in mouse thrombopoiesis von Zhang, Lin, Orban, Martin, Lorenz, Michael, Barocke, Verena, Braun, Daniel, Urtz, Nicole, Schulz, Christian, von Brühl, Marie-Luise, Tirniceriu, Anca, Gaertner, Florian, Proia, Richard L, Graf, Thomas, Bolz, Steffen-Sebastian, Montanez, Eloi, Prinz, Marco, Müller, Alexandra, von Baumgarten, Louisa, Billich, Andreas, Sixt, Michael, Fässler, Reinhard, von Andrian, Ulrich H, Junt, Tobias, Massberg, Steffen

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Sphingosine kinase type 2 is essential for lymphopenia induced by the immunomodulatory drug FTY720 von Zemann, Barbara, Kinzel, Bernd, Müller, Matthias, Reuschel, Roland, Mechtcheriakova, Diana, Urtz, Nicole, Bornancin, Frédéric, Baumruker, Thomas, Billich, Andreas

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Sphingosine 1-Phosphate Produced by Sphingosine Kinase 2 Intrinsically Controls Platelet Aggregation In Vitro and In Vivo von Urtz, Nicole, Gaertner, Florian, von Bruehl, Marie-Luise, Chandraratne, Sue, Rahimi, Faridun, Zhang, Lin, Orban, Mathias, Barocke, Verena, Beil, Johannes, Schubert, Irene, Lorenz, Michael, Legate, Kyle R, Huwiler, Andrea, Pfeilschifter, Josef M, Beerli, Christian, Ledieu, David, Persohn, Elke, Billich, Andreas, Baumruker, Thomas, Schnitzler, Michael Mederos y, Massberg, Steffen

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Interferon regulatory factor 5 and nuclear factor kappa‐B exhibit cooperating but also divergent roles in the regulation of pro‐inflammatory cytokines important for the development... von Stein, Thomas, Wollschlegel, Audrey, Te, Helene, Weiss, Jessica, Joshi, Kushal, Kinzel, Bernd, Billich, Andreas, Guntermann, Christine, Lehmann, Joachim C. U.

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Partial deficiency of sphingosine-1-phosphate lyase confers protection in experimental autoimmune encephalomyelitis von Billich, Andreas, Baumruker, Thomas, Beerli, Christian, Bigaud, Marc, Bruns, Christian, Calzascia, Thomas, Isken, Andrea, Kinzel, Bernd, Loetscher, Erika, Metzler, Barbara, Mueller, Matthias, Nuesslein-Hildesheim, Barbara, Kleylein-Sohn, Bernadette

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Synthesis of Borondipyrromethene (BODIPY)-Labeled Sphingosine Derivatives by Cross-metathesis Reaction von Peters, Carsten, Billich, Andreas, Ghobrial, Michael, Högenauer, Klemens, Ullrich, Thomas, Nussbaumer, Peter

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Targeting Ceramide Metabolism with a Potent and Specific Ceramide Kinase Inhibitor von Graf, Christine, Klumpp, Martin, Habig, Michael, Rovina, Philipp, Billich, Andreas, Baumruker, Thomas, Oberhauser, Berndt, Bornancin, Frédéric

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Pharmacological Inhibition of Stearoyl CoA Desaturase in the Skin Induces Atrophy of the Sebaceous Glands von Meingassner, Josef G., Aschauer, Heinrich, Winiski, Anthony P., Dales, Natalie, Yowe, David, Winther, Michael D., Zhang, Zaihui, Stütz, Anton, Billich, Andreas

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2-Substituted 4-(Thio)chromenone 6-O-Sulfamates:  Potent Inhibitors of Human Steroid Sulfatase von Nussbaumer, Peter, Lehr, Philipp, Billich, Andreas

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Sphingosine 1-phosphate phosphatase 2 is induced during inflammatory responses von Mechtcheriakova, Diana, Wlachos, Alexander, Sobanov, Jury, Kopp, Tamara, Reuschel, Roland, Bornancin, Frederic, Cai, Richard, Zemann, Barbara, Urtz, Nicole, Stingl, Georg, Zlabinger, Gerhard, Woisetschläger, Maximilian, Baumruker, Thomas, Billich, Andreas

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The role of sphingosine and ceramide kinases in inflammatory responses von Baumruker, Thomas, Bornancin, Frédéric, Billich, Andreas

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Retinoic-acid-orphan-receptor-C inhibition suppresses Th17 cells and induces thymic aberrations von Guntermann, Christine, Piaia, Alessandro, Hamel, Marie-Laure, Theil, Diethilde, Rubic-Schneider, Tina, Del Rio-Espinola, Alberto, Dong, Linda, Billich, Andreas, Kaupmann, Klemens, Dawson, Janet, Hoegenauer, Klemens, Orain, David, Hintermann, Samuel, Stringer, Rowan, Patel, Dhavalkumar D, Doelemeyer, Arno, Deurinck, Mark, Schümann, Jens

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Characterization of a ceramide kinase-like protein von Bornancin, Frédéric, Mechtcheriakova, Diana, Stora, Samantha, Graf, Christine, Wlachos, Alexander, Dévay, Piroska, Urtz, Nicole, Baumruker, Thomas, Billich, Andreas

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Early Activation of Sphingosine Kinase in Mast Cells and Recruitment to FcεRI Are Mediated by Its Interaction with Lyn Kinase von Urtz, Nicole, Olivera, Ana, Bofill-Cardona, Elisa, Csonga, Robert, Billich, Andreas, Mechtcheriakova, Diana, Bornancin, Frederic, Woisetschläger, Max, Rivera, Juan, Baumruker, Thomas

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