Protein typing of circulating microvesicles allows real-time monitoring of glioblastoma therapy von Shao, Huilin, Chung, Jaehoon, Balaj, Leonora, Charest, Alain, Bigner, Darell D, Carter, Bob S, Hochberg, Fred H, Breakefield, Xandra O, Weissleder, Ralph, Lee, Hakho

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Profiling the effects of isocitrate dehydrogenase 1 and 2 mutations on the cellular metabolome von Reitman, Zachary J, Jin, Genglin, Karoly, Edward D, Spasojevic, Ivan, Yang, Jian, Kinzler, Kenneth W, He, Yiping, Bigner, Darell D, Vogelstein, Bert, Yan, Hai

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The integrated landscape of driver genomic alterations in glioblastoma von Frattini, Veronique, Trifonov, Vladimir, Chan, Joseph Minhow, Castano, Angelica, Lia, Marie, Abate, Francesco, Keir, Stephen T, Ji, Alan X, Zoppoli, Pietro, Niola, Francesco, Danussi, Carla, Dolgalev, Igor, Porrati, Paola, Pellegatta, Serena, Heguy, Adriana, Gupta, Gaurav, Pisapia, David J, Canoll, Peter, Bruce, Jeffrey N, McLendon, Roger E, Yan, Hai, Aldape, Ken, Finocchiaro, Gaetano, Mikkelsen, Tom, Privé, Gilbert G, Bigner, Darell D, Lasorella, Anna, Rabadan, Raul, Iavarone, Antonio

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Very low mutation burden is a feature of inflamed recurrent glioblastomas responsive to cancer immunotherapy von Gromeier, Matthias, Brown, Michael C., Zhang, Gao, Lin, Xiang, Chen, Yeqing, Wei, Zhi, Beaubier, Nike, Yan, Hai, He, Yiping, Desjardins, Annick, Herndon, James E., Varn, Frederick S., Verhaak, Roel G., Zhao, Junfei, Bolognesi, Dani P., Friedman, Allan H., Friedman, Henry S., McSherry, Frances, Muscat, Andrea M., Lipp, Eric S., Nair, Smita K., Khasraw, Mustafa, Peters, Katherine B., Randazzo, Dina, Sampson, John H., McLendon, Roger E., Bigner, Darell D., Ashley, David M.

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Immunologic Escape After Prolonged Progression-Free Survival With Epidermal Growth Factor Receptor Variant III Peptide Vaccination in Patients With Newly Diagnosed Glioblastoma von SAMPSON, John H, HEIMBERGER, Amy B, REARDON, David A, SAWAYA, Raymond, SCHMITTLING, Robert J, WEIMING SHI, VREDENBURGH, James J, BIGNER, Darell D, ARCHER, Gary E, ALDAPE, Kenneth D, FRIEDMAN, Allan H, FRIEDMAN, Henry S, GILBERT, Mark R, HERNDON, James E, MCLENDON, Roger E, MITCHELL, Duane A

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Stem cell-like glioma cells promote tumor angiogenesis through vascular endothelial growth factor von SHIDENG BAO, QIULIAN WU, SATHORNSURNETEE, Sith, YUELING HAO, ZHIZHONG LI, HJELMELAND, Anita B, QING SHI, MCLENDON, Roger E, BIGNER, Darell D, RICH, Jeremy N

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Viral infection of cells within the tumor microenvironment mediates antitumor immunotherapy via selective TBK1-IRF3 signaling von Brown, Michael C., Mosaheb, Mubeen M., Mohme, Malte, McKay, Zachary P., Holl, Eda K., Kastan, Jonathan P., Yang, Yuanfan, Beasley, Georgia M., Hwang, E. Shelley, Ashley, David M., Bigner, Darell D., Nair, Smita K., Gromeier, Matthias

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The genomic landscape of TERT promoter wildtype-IDH wildtype glioblastoma von Diplas, Bill H., He, Xujun, Brosnan-Cashman, Jacqueline A., Liu, Heng, Chen, Lee H., Wang, Zhaohui, Moure, Casey J., Killela, Patrick J., Loriaux, Daniel B., Lipp, Eric S., Greer, Paula K., Yang, Rui, Rizzo, Anthony J., Rodriguez, Fausto J., Friedman, Allan H., Friedman, Henry S., Wang, Sizhen, He, Yiping, McLendon, Roger E., Bigner, Darell D., Jiao, Yuchen, Waitkus, Matthew S., Meeker, Alan K., Yan, Hai

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Mutant metabolic enzymes are at the origin of gliomas von Yan, Hai, Bigner, Darell D, Velculescu, Victor, Parsons, D Williams

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Bevacizumab Plus Irinotecan in Recurrent Glioblastoma Multiforme von VREDENBURGH, James J, DESJARDINS, Annick, WAGNER, Melissa, BAILEY, Leighann, BIGNER, Darell D, FRIEDMAN, Allan H, FRIEDMAN, Henry S, HERNDON, James E, MARCELLO, Jennifer, REARDON, David A, QUINN, Jennifer A, RICH, Jeremy N, SATHORNSUMETEE, Sith, GURURANGAN, Sridharan, SAMPSON, John

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Phase II Trial of Bevacizumab and Irinotecan in Recurrent Malignant Glioma von VREDENBURGH, James J, DESJARDINS, Annick, BIGNER, Darell D, FRIEDMAN, Allan H, FRIEDMAN, Henry S, HERNDON, James E, DOWELL, Jeannette M, REARDON, David A, QUINN, Jennifer A, RICH, Jeremy N, SATHORNSUMETEE, Sith, GURURANGAN, Sridharan, WAGNER, Melissa

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MiR-215 Is Induced Post-transcriptionally via HIF-Drosha Complex and Mediates Glioma-Initiating Cell Adaptation to Hypoxia by Targeting KDM1B von Hu, Jing, Sun, Tao, Wang, Hui, Chen, Zhengxin, Wang, Shuai, Yuan, Lifeng, Liu, Tingyu, Li, Hai-Ri, Wang, Pingping, Feng, Yukuan, Wang, Qinhong, McLendon, Roger E., Friedman, Allan H., Keir, Stephen T., Bigner, Darell D., Rathmell, Jeff, Fu, Xiang-dong, Li, Qi-Jing, Wang, Huibo, Wang, Xiao-Fan

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Mutations in IDH1, IDH2, and in the TERT promoter define clinically distinct subgroups of adult malignant gliomas von Killela, Patrick J, Pirozzi, Christopher J, Healy, Patrick, Reitman, Zachary J, Lipp, Eric, Rasheed, B Ahmed, Yang, Rui, Diplas, Bill H, Wang, Zhaohui, Greer, Paula K, Zhu, Huishan, Wang, Catherine Y, Carpenter, Austin B, Friedman, Henry, Friedman, Allan H, Keir, Stephen T, He, Jie, He, Yiping, McLendon, Roger E, Herndon, 2nd, James E, Yan, Hai, Bigner, Darell D

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Genetically stable poliovirus vectors activate dendritic cells and prime antitumor CD8 T cell immunity von Mosaheb, Mubeen M., Dobrikova, Elena Y., Brown, Michael C., Yang, Yuanfan, Cable, Jana, Okada, Hideho, Nair, Smita K., Bigner, Darell D., Ashley, David M., Gromeier, Matthias

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Systemic administration of a bispecific antibody targeting EGFRvIII successfully treats intracerebral glioma von Choi, Bryan D., Kuan, Chien-Tsun, Cai, Mingqing, Archer, Gary E., Mitchell, Duane A., Gedeon, Patrick C., Sanchez-Perez, Luis, Pastan, Ira, Bigner, Darell D., Sampson, John H.

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EGFRvIII-specific chimeric antigen receptor T cells migrate to and kill tumor deposits infiltrating the brain parenchyma in an invasive xenograft model of glioblastoma von Miao, Hongsheng, Choi, Bryan D, Suryadevara, Carter M, Sanchez-Perez, Luis, Yang, Shicheng, De Leon, Gabriel, Sayour, Elias J, McLendon, Roger, Herndon, 2nd, James E, Healy, Patrick, Archer, Gary E, Bigner, Darell D, Johnson, Laura A, Sampson, John H

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Synergistic antitumor effects of 9.2.27-PE38KDEL and ABT-737 in primary and metastatic brain tumors von Yu, Xin, Dobrikov, Mikhail, Keir, Stephen T, Gromeier, Matthias, Pastan, Ira H, Reisfeld, Ralph, Bigner, Darell D, Chandramohan, Vidyalakshmi

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Validation of an Immunohistochemistry Assay for Detection of CD155, the Poliovirus Receptor, in Malignant Gliomas von Chandramohan, Vidyalakshmi, Bryant, Jeffrey D, Piao, Hailan, Keir, Stephen T, Lipp, Eric S, Lefaivre, Michaela, Perkinson, Kathryn, Bigner, Darell D, Gromeier, Matthias, McLendon, Roger E

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Cic Loss Promotes Gliomagenesis via Aberrant Neural Stem Cell Proliferation and Differentiation von Yang, Rui, Chen, Lee H, Hansen, Landon J, Carpenter, Austin B, Moure, Casey J, Liu, Heng, Pirozzi, Christopher J, Diplas, Bill H, Waitkus, Matthew S, Greer, Paula K, Zhu, Huishan, McLendon, Roger E, Bigner, Darell D, He, Yiping, Yan, Hai

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2-hydroxyglutarate production, but not dominant negative function, is conferred by glioma-derived NADP-dependent isocitrate dehydrogenase mutations von Jin, Genglin, Reitman, Zachary J, Spasojevic, Ivan, Batinic-Haberle, Ines, Yang, Jian, Schmidt-Kittler, Oleg, Bigner, Darell D, Yan, Hai

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