MicroRNA-130b Promotes Tumor Development and Is Associated with Poor Prognosis in Colorectal Cancer von Colangelo, Tommaso, Fucci, Alessandra, Votino, Carolina, Sabatino, Lina, Pancione, Massimo, Laudanna, Carmelo, Binaschi, Monica, Bigioni, Mario, Alberto Maggi, Carlo, Parente, Domenico, Forte, Nicola, Colantuoni, Vittorio

Volltext

Targeting CD205 with the antibody drug conjugate MEN1309/OBT076 is an active new therapeutic strategy in lymphoma models von Gaudio, Eugenio, Tarantelli, Chiara, Spriano, Filippo, Guidetti, Francesca, Sartori, Giulio, Bordone, Roberta, Arribas, Alberto J, Cascione, Luciano, Bigioni, Mario, Merlino, Giuseppe, Fiascarelli, Alessio, Bressan, Alessandro, Mensah, Afua Adjeiwaa, Golino, Gaetanina, Lucchini, Renzo, Bernasconi, Elena, Rossi, Davide, Zucca, Emanuele, Stussi, Georg, Stathis, Anastasios, Boyd, Robert S, Dusek, Rachel L, Bisht, Arnima, Attanasio, Nickolas, Rohlff, Christian, Pellacani, Andrea, Binaschi, Monica, Bertoni, Francesco

Volltext

The activity of a PI3K δ-sparing inhibitor, MEN1611, in non-small cell lung cancer cells with constitutive activation of the PI3K/AKT/mTOR pathway von Papoff, Giuliana, Presutti, Dario, Fustaino, Valentina, Parente, Andrea, Calandriello, Clelia, Alemà, Stefano, Scavizzi, Ferdinando, Raspa, Marcello, Merlino, Giuseppe, Salerno, Massimiliano, Bigioni, Mario, Binaschi, Monica, Ruberti, Giovina

Volltext

MEN1309/OBT076, a First-In-Class Antibody-Drug Conjugate Targeting CD205 in Solid Tumors von Merlino, Giuseppe, Fiascarelli, Alessio, Bigioni, Mario, Bressan, Alessandro, Carrisi, Corrado, Bellarosa, Daniela, Salerno, Massimiliano, Bugianesi, Rossana, Manno, Rosanna, Bernadó Morales, Cristina, Arribas, Joaquin, Dusek, Rachel L, Ackroyd, James E, Pham, Phuoc Huy, Awdew, Rahel, Aud, Dee, Trang, Michael, Lynch, Carmel M, Terrett, Jonathan, Wilson, Keith E, Rohlff, Christian, Manzini, Stefano, Pellacani, Andrea, Binaschi, Monica

Volltext

ACE inhibition and protection from doxorubicin-induced cardiotoxicity in the rat von Sacco, Giuseppe, Bigioni, Mario, Lopez, Giuseppe, Evangelista, Stefano, Manzini, Stefano, Maggi, Carlo Alberto

Volltext

Antiproliferative and Differentiating Activities of a Novel Series of Histone Deacetylase Inhibitors von Binaschi, Monica, Boldetti, Andrea, Gianni, Maurizio, Maggi, Carlo Alberto, Gensini, Martina, Bigioni, Mario, Parlani, Massimo, Giolitti, Alessandro, Fratelli, Maddalena, Valli, Claudia, Terao, Mineko, Garattini, Enrico

Volltext

Cardioprotective effects of zofenopril, a new angiotensin-converting enzyme inhibitor, on doxorubicin-induced cardiotoxicity in the rat von Sacco, Giuseppe, Bigioni, Mario, Evangelista, Stefano, Goso, Cristina, Manzini, Stefano, Maggi, Carlo A.

Volltext

Abstract 1376: Dosing frequency/PD/efficacy relationship of MEN1611 in HER2 amplified, PIK3CA mutated, and refractory to Trastuzumab xenograft model of breast cancer von Fiascarelli, Alessio, Merlino, Giuseppe, Capano, Stefania, Bressan, Alessandro, Bigioni, Mario, Pellacani, Andrea, Binaschi, Monica, Salerno, Massimiliano

Volltext

Normal-weight obese syndrome: early inflammation von De Lorenzo, Antonino, Del Gobbo, Vera, Premrov, Maria Grazia, Bigioni, Mario, Galvano, Fabio, Di Renzo, Laura

Volltext

Abstract PS18-26: Men1611 promotes immune activating myeloid cell polarization von Capano, Stefania, Paoli, Alessandro, Fiascarelli, Alessio, Tomirotti, Andrea Massimiliano, Bigioni, Mario, Bressan, Alessandro, Bellarosa, Daniela, Salerno, Massimiliano, Binaschi, Monica

Volltext

The Dual PIM/FLT3 Inhibitor MEN1703 Combines Synergistically With Gilteritinib in FLT3‐ITD‐Mutant Acute Myeloid Leukaemia von Zicari, Sonia, Merlino, Giuseppe, Paoli, Alessandro, Fiascarelli, Alessio, Tunici, Patrizia, Bisignano, Diego, Belli, Francesco, Irrissuto, Clelia, Talucci, Simone, Cirigliano, Elena, Iannitto, Maria Luisa, Bigioni, Mario, Bressan, Alessandro, Brzózka, Krzysztof, Ghiaur, Gabriel, Bellarosa, Daniela, Binaschi, Monica

Volltext

Antitumor activity of the PI3K δ-sparing inhibitor MEN1611 in PIK3CA mutated, trastuzumab-resistant HER2 + breast cancer von Fiascarelli, Alessio, Merlino, Giuseppe, Capano, Stefania, Talucci, Simone, Bisignano, Diego, Bressan, Alessandro, Bellarosa, Daniela, Carrisi, Corrado, Paoli, Alessandro, Bigioni, Mario, Tunici, Patrizia, Irrissuto, Clelia, Salerno, Massimiliano, Arribas, Joaquin, de Stanchina, Elisa, Scaltriti, Maurizio, Binaschi, Monica

Volltext

PIM Inhibition By SEL24/MEN1703 Combines Synergistically with Gilteritinib in FLT3-ITD Preclinical Models of Acute Myeloid Leukemia von Bellarosa, Daniela, Zicari, Sonia, Merlino, Giuseppe, Fiascarelli, Alessio, Bisignano, Diego, Belli, Francesco, Irrissuto, Clelia, Talucci, Simone, Iannitto, Maria Luisa, Bigioni, Mario, Bressan, Alessandro, Brzózka, Krzysztof, Ghiaur, Gabriel, Binaschi, Monica

Volltext

Abstract PS18-13: Men1611 is a pi3k α/β selective and δ sparing inhibitor with long-lasting antitumor activity in different genetic backgrounds of pik3ca mutant breast cancer model... von Fiascarelli, Alessio, Carrisi, Corrado, Merlino, Giuseppe, Capano, Stefania, Bisignano, Diego, Talucci, Simone, Bressan, Alessandro, Bellarosa, Daniele, Bigioni, Mario, Scaltriti, Maurizio, Arribas, Joaquin, Pellacani, Andrea, Salerno, Massimiliano, Binaschi, Monica

Volltext

Abstract 2160: MEN1611, a novel α-selective PI3K inhibitor in solid tumors von Merlino, Giuseppe, Fiascarelli, Alessio, Bigioni, Mario, Bressan, Alessandro, Irrissuto, Clelia, Pellacani, Andrea, Scaltriti, Maurizio, Binaschi, Monica

Volltext

Antitumor activity of the PI3K δ-sparing inhibitor MEN1611 in PIK3CA mutated, trastuzumab-resistant HER2 + breast cancer von Fiascarelli, Alessio, Merlino, Giuseppe, Capano, Stefania, Talucci, Simone, Bisgnano, Diego, Bressan, Alessandro, Bellarosa, Daniela, Carrisi, Corrado, Paoli, Alessandro, Bigioni, Mario, Tunici, Patrizia, Irrissuto, Clelia, Salerno, Massimiliano, Arribas, Joaquín, de Stanchina, Elisa, Scaltriti, Maurizio, Binaschi, Monica

Volltext

Targeting CD205 with the antibody drug conjugate MEN1309/OBT076 is an active new therapeutic strategy in lymphoma models von Gaudio, Eugenio, Tarantelli, Chiara, Spriano, Filippo, Guidetti, Francesca, Sartori, Giulio, Bordone, Roberta, Arribas, Alberto J, Cascione, Luciano, Bigioni, Mario, Merlino, Giuseppe, Fiascarelli, Alessio, Bressan, Alessandro, Adjeiwaa Mensah, Afua, Golino, Gaetanina, Lucchini, Renzo, Bernasconi, Elena, Rossi, Davide, Zucca, Emanuele, Stussi, Georg, Stathis, Anastasios, Boyd, Robert S, Dusek, Rachel L, Bisht, Arnima, Attanasio, Nickolas, Rohlff, Christian, Pellacani, Andrea, Binaschi, Monica, Bertoni, Francesco

Volltext

Abstract 2145: The role of MEN1611, a class I PI3-kinases (PI3Ks) inhibitor, in reprogramming the pro-tumoral inflammatory environment von Capano, Stefania, Fiascarelli, Alessio, Tomirotti, Andrea M, Bigioni, Mario, Bressan, Alessandro, Bellarosa, Daniela, Pellacani, Andrea, Binaschi, Monica

Volltext

Abstract 2849: The oral SERD Elacestrant in combination with the PI3K inhibitor MEN1611 inhibits tumor growth in ER+/HER2- breast cancer in vitro and in PDX models von Merlino, Giuseppe, Fiascarelli, Alessio, Talucci, Simone, Tunici, Patrizia, Bigioni, Mario, Bressan, Alessandro, Binaschi, Monica

Volltext

Topoisomerase Poisoning Activity of Novel Disaccharide Anthracyclines von Guano, F, Pourquier, P, Tinelli, S, Binaschi, M, Bigioni, M, Animati, F, Manzini, S, Zunino, F, Kohlhagen, G, Pommier, Y, Capranico, G

Volltext