Noninvasive Interrogation of DLL3 Expression in Metastatic Small Cell Lung Cancer von Sharma, Sai Kiran, Pourat, Jacob, Abdel-Atti, Dalya, Carlin, Sean D, Piersigilli, Alessandra, Bankovich, Alexander J, Gardner, Eric E, Hamdy, Omar, Isse, Kumiko, Bheddah, Sheila, Sandoval, Joseph, Cunanan, Kristen M, Johansen, Eric B, Allaj, Viola, Sisodiya, Vikram, Liu, David, Zeglis, Brian M, Rudin, Charles M, Dylla, Scott J, Poirier, John T, Lewis, Jason S

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Rovalpituzumab tesirine, a DLL3-targeted antibody-drug conjugate, in recurrent small-cell lung cancer: a first-in-human, first-in-class, open-label, phase 1 study von Rudin, Charles M, Prof, Pietanza, M Catherine, MD, Bauer, Todd M, MD, Ready, Neal, Prof, Morgensztern, Daniel, MD, Glisson, Bonnie S, Prof, Byers, Lauren A, MD, Johnson, Melissa L, MD, Burris, Howard A, MD, Robert, Francisco, Prof, Han, Tae H, PhD, Bheddah, Sheila, BA, Theiss, Noah, MS, Watson, Sky, BS, Mathur, Deepan, MD, Vennapusa, Bharathi, MD, Zayed, Hany, PhD, Lally, Satwant, MS, Strickland, Donald K, MD, Govindan, Ramaswamy, Prof, Dylla, Scott J, PhD, Peng, Stanford L, MD, Spigel, David R, MD

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Ubiquitin ligase RNF146 regulates tankyrase and Axin to promote Wnt signaling von Callow, Marinella G, Tran, Hoanh, Phu, Lilian, Lau, Ted, Lee, James, Sandoval, Wendy N, Liu, Peter S, Bheddah, Sheila, Tao, Janet, Lill, Jennie R, Hongo, Jo-Anne, Davis, David, Kirkpatrick, Donald S, Polakis, Paul, Costa, Mike

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Initiation and characterization of small cell lung cancer patient-derived xenografts from ultrasound-guided transbronchial needle aspirates von Anderson, Wade C, Boyd, Michael B, Aguilar, Jorge, Pickell, Brett, Laysang, Amy, Pysz, Marybeth A, Bheddah, Sheila, Ramoth, Johanna, Slingerland, Brian C, Dylla, Scott J, Rubio, Edmundo R

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COP1, the negative regulator of p53, is overexpressed in breast and ovarian adenocarcinomas von DORNAN, David, BHEDDAH, Sheila, NEWTON, Kim, INCE, William, FRANTZ, Gretchen D, DOWD, Patrick, KOEPPEN, Hartmut, DIXIT, Vishva M, FRENCH, Dorothy M

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EphB2 is a Prognostic Factor in Colorectal Cancer von JUBB, Adrian M, ZHONG, Fiona, BHEDDAH, Sheila, GRABSCH, Heike I, FRANTZ, Gretchen D, MUELLER, Wolfram, KAVI, Vidya, QUIRKE, Phil, POLAKIS, Paul, KOEPPEN, Hartmut

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Prevalence of Delta-like protein 3 expression in patients with small cell lung cancer von Tanaka, Kentaro, Isse, Kumiko, Fujihira, Tomomichi, Takenoyama, Mitsuhiro, Saunders, Laura, Bheddah, Sheila, Nakanishi, Yoichi, Okamoto, Isamu

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An open-label study of rovalpituzumab tesirine in patients with DLL3-expressing advanced solid tumors von Kavalerchik, Edward, Lally, Satwant, Han, Tae H., Saunders, Laura R., Bheddah, Sheila, Dylla, Scott J.

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Protein expression of TTF1 and cMYC define distinct molecular subgroups of small cell lung cancer with unique vulnerabilities to aurora kinase inhibition, DLL3 targeting, and other... von Cardnell, Robert J, Li, Lerong, Sen, Triparna, Bara, Rasha, Tong, Pan, Fujimoto, Junya, Ireland, Abbie S, Guthrie, Matthew R, Bheddah, Sheila, Banerjee, Upasana, Kalu, Nene N, Fan, You-Hong, Dylla, Scott J, Johnson, Faye M, Wistuba, Ignacio I, Oliver, Trudy G, Heymach, John V, Glisson, Bonnie S, Wang, Jing, Byers, Lauren A

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Effects of anti-VEGF on pharmacokinetics, biodistribution, and tumor penetration of trastuzumab in a preclinical breast cancer model von Pastuskovas, Cinthia V, Mundo, Eduardo E, Williams, Simon P, Nayak, Tapan K, Ho, Jason, Ulufatu, Sheila, Clark, Suzanna, Ross, Sarajane, Cheng, Eric, Parsons-Reponte, Kathryn, Cain, Gary, Van Hoy, Marjie, Majidy, Nicholas, Bheddah, Sheila, dela Cruz Chuh, Josefa, Kozak, Katherine R, Lewin-Koh, Nicholas, Nauka, Peter, Bumbaca, Daniela, Sliwkowski, Mark, Tibbitts, Jay, Theil, Frank-Peter, Fielder, Paul J, Khawli, Leslie A, Boswell, C Andrew

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Abstract NT-113: SC-003, AN ANTIBODY-DRUG CONJUGATE TARGETING DIPEPTIDASE 3, EXHIBITS POTENT ANTI-TUMOR ACTIVITY IN PATIENT-DERIVED XENOGRAFT MODELS OF HIGH GRADE SEROUS OVARIAN CA... von Wiedemeyer, Wolf R., Bheddah, Sheila, Saechao, Christine, French, Dorothy, Huntzicker, Erik, Kempema, Aaron, Gavrilyuk, Julia, Liu, David, Sisodiya, Vikram, He, Alina, Zhang, Zhaomei, Aujay, Monette A., Hayashi, Kristyn, Vivona, Sandro, Zhao, Xi, Walter, Kimberly, Saunders, Laura R., Hampl, Johannes, Madhavan, Shravanthi, Pysz, Marybeth, Bankovich, Alexander J., Karsunky, Holger, Dylla, Scott J.

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Armed antibodies targeting the mucin repeats of the ovarian cancer antigen, MUC16, are highly efficacious in animal tumor models von YOUJUN CHEN, CLARK, Suzanna, GOGINENI, Alvin, POLAKIS, Paul, MALLET, William, WONG, Terence, YONGMEI CHEN, CHEN, Yvonne, DENNIS, Mark S, LUIS, Elizabeth, ZHONG, Fiona, BHEDDAH, Sheila, KOEPPEN, Hartmut

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Non-invasive Interrogation of DLL3 Expression in Metastatic Small Cell Lung Cancer von Sharma, Sai Kiran, Pourat, Jacob, Abdel-Atti, Dalya, Carlin, Sean D., Piersigilli, Alessandra, Bankovich, Alexander J., Gardner, Eric E., Hamdy, Omar, Isse, Kumiko, Bheddah, Sheila, Sandoval, Joseph, Cunanan, Kristen M., Johansen, Eric B., Allaj, Viola, Sisodiya, Vikram, Liu, David, Zeglis, Brian M., Rudin, Charles M., Dylla, Scott J., Poirier, John T., Lewis, Jason S.

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Prognostic value of DLL3 expression and clinicopathologic features in small cell bladder cancer (SCBC) von Koshkin, Vadim S., Elson, Paul, Magi-Galluzzi, Cristina, McKenney, Jesse, Smith, Karen Streator, Shadrach, Bonnie, Emamekhoo, Hamid, Isse, Kumiko, Saunders, Laura, Kavalerchik, Edward, Dylla, Scott, Bheddah, Sheila, Theiss, Noah, Watson, Sky, Stephenson, Andrew J., Fergany, Amr Farouk, Rini, Brian I., Garcia, Jorge A., Grivas, Petros

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Abstract 3093: Expression of DLL3 in metastatic melanoma, glioblastoma and high-grade extrapulmonary neuroendocrine carcinomas as potential indications for rovalpituzumab tesirine... von Saunders, Laura R., Williams, Samuel A., Bheddah, Sheila, Isse, Kumiko, Fong, Sarah, Pysz, Marybeth A., Beltran, Himisha, Puca, Loredana, Sailer, Verena, Mosquera, Juan M., Yin, Yu, Huang, Jiaoti, Armstrong, Andrew J., Garcia, Jorge, Magi-Galluzzi, Cristina, Koshkin, Vadim, Grivas, Petros, Kosari, Farhad, Cheville, John, Moser, Justin C., Flotte, Thomas J., Halfdanarson, Thorvardur, Mansfield, Aaron, Leventakos, Konstantinos N., Molina, Julian R., Ball, Douglas W., Nelkin, Barry D., Shea, Jill E., Scaife, Courtney L., Dylla, Scott J.

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Metastatic melanoma, glioblastoma and high-grade extrapulmonary neuroendocrine carcinomas (NECs) as novel indications for rovalpituzumab tesirine: A delta-like protein 3 (DLL3)-tar... von Peng, Stanford L., Saunders, Laura, Bheddah, Sheila, Williams, Sam, Aggarwal, Rahul Raj, Shea, Jill E., Lee, Eun Y, Huang, Jiaoti, Zemek, Allison J, Longacre, Teri A., Ball, Douglas Wilmot, Scaife, Courtney L., Nelkin, Barry, Anthony, Lowell Brian, Kunz, Pamela L., Small, Eric Jay, Dylla, Scott

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Fluorescence Compared to Brightfield Detection of CD35 in Lymphoid Follicles of the Monkey to Assess Immunomodulatory Treatment Effect von Brodbeck, Jens, Chu, Felix, Edick, Melissa Gonzales, Rangell, Linda, Bheddah, Sheila, Cain, Gary

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OA05.03 Single-Agent Rovalpituzumab Tesirine, a Delta-Like Protein 3 (DLL3)-Targeted Antibody-Drug Conjugate (ADC), in Small-Cell Lung Cancer (SCLC) von Spigel, David, Pietanza, M Catherine, Bauer, Todd, Ready, Neal, Morgensztern, Daniel, Glisson, Bonnie S., Byers, Lauren Averett, Johnson, Melissa, Burris, Howard, Robert, Francisco, Han, Tae, Bheddah, Sheila, Theiss, Noah, Watson, Sky, Mathur, Deepan, Vennapusa, Bharathi, Strickland, Donald, Zayed, Hany, Dylla, Scott, Peng, Stanford, Govindan, Ramaswamy, Rudin, Charles

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Negative Regulation of Oligodendrocyte Differentiation by Galactosphingolipids von Bansal, Rashmi, Winkler, Susan, Bheddah, Sheila

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Phosphorous Dysregulation Induced by MEK Small Molecule Inhibitors in the Rat Involves Blockade of FGF-23 Signaling in the Kidney von Diaz, Dolores, Allamneni, Krishna, Tarrant, Jacqueline M., Lewin-Koh, Sock-Cheng, Pai, Rama, Dhawan, Preeti, Cain, Gary R., Kozlowski, Cleopatra, Hiraragi, Hajime, La, Nghi, Hartley, Dylan P., Ding, Xiao, Dean, Brian J., Bheddah, Sheila, Dambach, Donna M.

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