Total Syntheses of (+)-Lyconadin A and (−)-Lyconadin B von Beshore, Douglas C, Smith, Amos B

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Conserved allosteric inhibitory site on the respiratory syncytial virus and human metapneumovirus RNA-dependent RNA polymerases von Kleiner, Victoria A., O. Fischmann, Thierry, Howe, John A., Beshore, Douglas C., Eddins, Michael J., Hou, Yan, Mayhood, Todd, Klein, Daniel, Nahas, Debbie D., Lucas, Bob J., Xi, He, Murray, Edward, Ma, Daphne Y., Getty, Krista, Fearns, Rachel

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MK-7622: A First-in-Class M1 Positive Allosteric Modulator Development Candidate von Beshore, Douglas C., N. Di Marco, Christina, Chang, Ronald K., Greshock, Thomas J., Ma, Lei, Wittmann, Marion, Seager, Matthew A., Koeplinger, Kenneth A., Thompson, Charles D., Fuerst, Joy, Hartman, George D., Bilodeau, Mark T., Ray, William J., Kuduk, Scott D.

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The Lyconadins: Enantioselective Total Syntheses of (+)-Lyconadin A and (−)-Lyconadin B von Beshore, Douglas C, Smith, Amos B

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Design and Synthesis of Novel Isoquinoline-3-nitriles as Orally Bioavailable Kv1.5 Antagonists for the Treatment of Atrial Fibrillation von Trotter, B. Wesley, Nanda, Kausik K, Kett, Nathan R, Regan, Christopher P, Lynch, Joseph J, Stump, Gary L, Kiss, Laszlo, Wang, Jixin, Spencer, Robert H, Kane, Stefanie A, White, Rebecca B, Zhang, Rena, Anderson, Kenneth D, Liverton, Nigel J, McIntyre, Charles J, Beshore, Douglas C, Hartman, George D, Dinsmore, Christopher J

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Building a Culture of Medicinal Chemistry Knowledge Sharing von Beshore, Douglas C, Haidle, Andrew M, Arasappan, Ashok, Lim, Yeon-Hee, Raheem, Izzat, Roecker, Anthony J, Shockley, Samantha E, Simov, Vladimir

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Evaluation of a non-nucleoside inhibitor of the RSV RNA-dependent RNA polymerase in translatable animal models von Citron, Michael P, Zang, Xiaowei, Leithead, Andrew, Meng, Shi, Rose Ii, William A, Murray, Edward, Fontenot, Jane, Bilello, John P, Beshore, Douglas C, Howe, John A

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Evaluation of a non-nucleoside inhibitor of the RSV RNA-dependent RNA polymerase in translatable animals models von Citron, Michael P., Zang, Xiaowei, Leithead, Andrew, Meng, Shi, Rose II, William A., Murray, Edward, Fontenot, Jane, Bilello, John P., Beshore, Douglas C., Howe, John A.

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Preclinical to Human Translational Pharmacology of the Novel M 1 Positive Allosteric Modulator MK-7622 von Uslaner, Jason M, Kuduk, Scott D, Wittmann, Marion, Lange, Henry S, Fox, Steven V, Min, Chris, Pajkovic, Natasa, Harris, Dawn, Cilissen, Caroline, Mahon, Chantal, Mostoller, Kate, Warrington, Steve, Beshore, Douglas C

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Cerastecin Inhibition of the Lipooligosaccharide Transporter MsbA to Combat Acinetobacter baumannii : From Screening Impurity to In Vivo Efficacy von Skudlarek, Jason W, Cooke, Andrew J, Mitchell, Helen J, Babaoglu, Kerim, Shaw, Anthony W, Tong, Ling, Nomland, Ashley B, Labroli, Marc, Sha, Deyou, Mulhearn, James J, Wu, Chengwei, Li, Sarah W, Beshore, Douglas C, Hughes, Jonathan M E, Jouffroy, Matthieu, Wang, Hao, Balibar, Carl J, Painter, Ronald E, Shen, Pamela, Lange, Henry S, Ishchenko, Andrii, Chen, Yun-Ting, Klein, Daniel J, Tracy, Rodger W, Miller, Randy R, Cabalu, Tamara D, Wu, Zhe, Leithead, Andrew, Scapin, Giovanna, Hruza, Alan W, Dzhekieva, Liudmila, Bukhtiyarova, Marina, Homsher, Michelle F, Xu, Min, Bahnck-Teets, Carolyn, McKenney, David, Buevich, Alexei V, Liu, Jian, Zhang, Li-Kang, Meng, Tao, Kelly, Terri, DiNunzio, Edward, Soisson, Stephen, Cheng, Robert K Y, Hennig, Michael, Raheem, Izzat, Walker, Scott S

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A Phenotypic Screen Identifies Potent DPP9 Inhibitors Capable of Killing HIV‑1 Infected Cells von Moore, Keith P., Schwaid, Adam G., Tudor, Matthew, Park, Sangho, Beshore, Douglas C., Converso, Antonella, Shipe, William D., Anand, Rajan, Lan, Ping, Moningka, Remond, Rothman, Deborah M., Sun, Wanying, Chi, An, Cornella-Taracido, Ivan, Adam, Gregory C., Bahnck-Teets, Carolyn, Carroll, Steven S., Fay, John F., Goh, Shih Lin, Lusen, Jeffrey, Quan, Shuo, Rodriguez, Silveria, Xu, Min, Andrews, Christine L., Song, Cheng, Filzen, Tracey, Li, Jing, Hollenstein, Kaspar, Klein, Daniel J., Lammens, Alfred, Lim, U-Ming, Fang, Zhiyu, McHale, Carolyn, Li, Yuan, Lu, Meiqing, Diamond, Tracy L., Howell, Bonnie J., Zuck, Paul, Balibar, Carl J.

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Rapid Affinity and Microsomal Stability Ranking of Crude Mixture Libraries of Histone Deacetylase Inhibitors von Tyagarajan, Sriram, Andrews, Christine L., Beshore, Douglas C., Buevich, Alexei V., Curran, Patrick J., Dandliker, Peter, Greshock, Thomas J., Hoar, Jason, Kim, Alex, Karnachi, Prabha, Knemeyer, Ian, Kozlowski, Joseph, Liu, Jian, Maletic, Milana, Myers, Robert, Rada, Vanessa, Sha, Deyou, Sauvagnat, Berengere, Vachal, Petr, Wolkenberg, Scott, Yu, Wensheng, Yu, Younong, Krska, Shane W.

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Informing the Selection of Screening Hit Series with in Silico Absorption, Distribution, Metabolism, Excretion, and Toxicity Profiles von Sanders, John M, Beshore, Douglas C, Culberson, J Christopher, Fells, James I, Imbriglio, Jason E, Gunaydin, Hakan, Haidle, Andrew M, Labroli, Marc, Mattioni, Brian E, Sciammetta, Nunzio, Shipe, William D, Sheridan, Robert P, Suen, Linda M, Verras, Andreas, Walji, Abbas, Joshi, Elizabeth M, Bueters, Tjerk

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Discovery of triarylethanolamine inhibitors of the Kv1.5 potassium channel von Beshore, Douglas C., Liverton, Nigel J., McIntyre, Charles J., Claiborne, Christopher F., Libby, Brian, Culberson, J. Christopher, Salata, Joseph J., Regan, Christopher P., Lynch, Joseph J., Kiss, Laszlo, Spencer, Robert H., Kane, Stephanie A., White, Rebecca B., Yeh, Suzie, Hartman, George D., Dinsmore, Christopher J.

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Redefining the Histone Deacetylase Inhibitor Pharmacophore: High Potency with No Zinc Cofactor Interaction von Beshore, Douglas C., Adam, Gregory C., Barnard, Richard J. O., Burlein, Christine, Gallicchio, Steven N., Holloway, M. Katharine, Krosky, Daniel, Lemaire, Wei, Myers, Robert W., Patel, Sangita, Plotkin, Michael A., Powell, David A., Rada, Vanessa, Cox, Christopher D., Coleman, Paul J., Klein, Daniel J., Wolkenberg, Scott E.

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Preparation of Substituted Piperazinones via Tandem Reductive Amination−(N,N‘-Acyl Transfer)−Cyclization von Beshore, Douglas C, Dinsmore, Christopher J

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MK-7622: A First-in-Class M 1 Positive Allosteric Modulator Development Candidate von Beshore, Douglas C, N Di Marco, Christina, Chang, Ronald K, Greshock, Thomas J, Ma, Lei, Wittmann, Marion, Seager, Matthew A, Koeplinger, Kenneth A, Thompson, Charles D, Fuerst, Joy, Hartman, George D, Bilodeau, Mark T, Ray, William J, Kuduk, Scott D

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Preclinical to Human Translational Pharmacology of the Novel M1 Positive Allosteric Modulator MK-7622 von Uslaner, Jason M., Kuduk, Scott D., Wittmann, Marion, Lange, Henry S., Fox, Steve V., Min, Chris, Pajkovic, Natasa, Harris, Dawn, Cilissen, Caroline, Mahon, Chantal, Mostoller, Kate, Warrington, Steve, Beshore, Douglas C.

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Informing the Selection of Screening Hit Series with in Silico Absorption, Distribution, Metabolism, Excretion, and Toxicity Profiles: Miniperspective von Sanders, John M, Beshore, Douglas C, Culberson, J. Christopher, Fells, James I, Imbriglio, Jason E, Gunaydin, Hakan, Haidle, Andrew M, Labroli, Marc, Mattioni, Brian E, Sciammetta, Nunzio, Shipe, William D, Sheridan, Robert P, Suen, Linda M, Verras, Andreas, Walji, Abbas, Joshi, Elizabeth M, Bueters, Tjerk

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2,5‐Disubstituted Pyrazolo[4,3‐c]cinnolin‐3‐ones von Beshore, Douglas C., Johnson, Adam W., DiPardo, Robert M., Pitts, Daniel R., Cofre, Victoria, Kuduk, Scott D.

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