Prediction of Protein Kinase–Ligand Interactions through 2.5D Kinochemometrics von Bosc, Nicolas, Wroblowski, Berthold, Meyer, Christophe, Bonnet, Pascal

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Kinetic profiling of novel spirobenzo-oxazinepiperidinone derivatives as equilibrative nucleoside transporter 1 inhibitors von Vlachodimou, Anna, Bouma, Jara, De Cleyn, Michel, Berthelot, Didier, Pype, Stefan, Bosmans, Jean-Paul, van Vlijmen, Herman, Wroblowski, Berthold, Heitman, Laura H., IJzerman, Adriaan P.

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Small Molecule Binding to Alzheimer Risk Factor CD33 Promotes Aβ Phagocytosis von Miles, Luke A., Hermans, Stefan J., Crespi, Gabriela A.N., Gooi, Jonathan H., Doughty, Larissa, Nero, Tracy L., Markulić, Jasmina, Ebneth, Andreas, Wroblowski, Berthold, Oehlrich, Daniel, Trabanco, Andrés A., Rives, Marie-Laure, Royaux, Ines, Hancock, Nancy C., Parker, Michael W.

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Assessment of the Fragment Docking Program SEED von Goossens, Kenneth, Wroblowski, Berthold, Langini, Cassiano, van Vlijmen, Herman, Caflisch, Amedeo, De Winter, Hans

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Discovery of an Allosteric, Inactive Conformation-Selective Inhibitor of Full-Length HPK1 Utilizing a Kinase Cascade Assay von Wang, Weixue, Mevellec, Laurence, Liu, Annie, Struble, Geoff, Miller, Robyn, Allen, Samantha J, Federowicz, Kelly, Wroblowski, Berthold, Vialard, Jorge, Ahn, Kay, Krosky, Daniel

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Assessment of the fragment docking program SEED von Goossens, Kenneth, Wroblowski, Berthold, Langini, Cassiano, van Vlijmen, Herman, Caflisch, Amedeo, De Winter, Hans

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Extending kinome coverage by analysis of kinase inhibitor broad profiling data von Jacoby, Edgar, Tresadern, Gary, Bembenek, Scott, Wroblowski, Berthold, Buyck, Christophe, Neefs, Jean-Marc, Rassokhin, Dmitrii, Poncelet, Alain, Hunt, Jeremy, van Vlijmen, Herman

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Abstract 4791: OMO-1, a potent, highly selective, orally bioavailable, MET kinase inhibitor with a favorable preclinical toxicity profile, shows both monotherapy activity, against... von Libouban, Marion, Jovcehva, Eleonora, Lange, Desiree De, Janssens, Boudewijn, Verhulst, Tinne, Ogata, Souichi, Wroblowski, Berthold, Mevellec, Laurence, Lu, Tianbao, Clack, Glen, Perera, Timothy

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Molecular mechanisms of pressure induced conformational changes in BPTI von Wroblowski, Berthold, Díaz, José Fernando, Heremans, Karel, Engelborghs, Yves

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Molecular mechanisms of pressure induced conformational changes in BPTI von Wroblowski, B, Díaz, J F, Heremans, K, Engelborghs, Y

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A Proteometric Analysis of Human Kinome: Insight into Discriminant Conformation-dependent Residues von Bosc, Nicolas, Wroblowski, Berthold, Aci-Sèche, Samia, Meyer, Christophe, Bonnet, Pascal

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Exploring Protein Kinase Conformation Using Swarm-Enhanced Sampling Molecular Dynamics von Atzori, Alessio, Bruce, Neil J, Burusco, Kepa K, Wroblowski, Berthold, Bonnet, Pascal, Bryce, Richard A

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Protocols for the Design of Kinase‐focused Compound Libraries von Jacoby, Edgar, Wroblowski, Berthold, Buyck, Christophe, Neefs, Jean‐Marc, Meyer, Christophe, Cummings, Maxwell D., van Vlijmen, Herman

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Abstract 4800: Covalent Flt3-Cys828 inhibition represents a novel therapeutic approach for the treatment of Flt3-ITD and Flt3-D835 mutant acute myeloid leukemia von Versele, Matthias, Haefner, Burkhard, Wroblowski, Berthold, Stansfield, Ian, Mevellec, Laurence, Gilissen, Ron, Neumann, Lars, Augustin, Martin, Jacobs, Kris, Cools, Jan, Barluenga, S, Röthlingshöfer, M, Karthikeyan, G, Attar, Ricardo, Meerpoel, Lieven, Winssinger, Nicolas

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Oligonucleotide Analogues with 4-Hydroxy-N-Acetylprolinol as Sugar Substitute von Ceulemans, Griet, Van Aerschot, Arthur, Wroblowski, Berthold, Rozenski, Jef, Hendrix, Chris, Herdewijn, Piet

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Abstract 3640: Discovery of quinazolinones as fibroblast growth factor receptor (FGFR1-4) kinase inhibitors von Querolle, Olivier, Angibaud, Patrick, Colombel, Hélène, Caron, Virginie, Pilatte, Isabelle, Poncelet, Virginie, Esser, Norbert, Gilissen, Ron, King, Peter, Meerpoel, Lieven, Verhulst, Tinne, Wroblowski, Berthold, Vialard, Jorge, Murray, Chris W., Rees, David C., Reningovolo, Anita, Saxty, Gordon

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Abstract 3641: Identification of naphthyridines as potent inhibitors of fibroblast growth factor receptor kinase family von Angibaud, Patrick R., Obringer, Michel, Marin, Julien, Jeanty, Matthieu, Esser, Norbert, Gilissen, Ron, King, Peter, Meerpoel, Lieven, Querolle, Olivier, Rees, David C., Roux, Bruno, Saxty, Gordon, Verhulst, Tinne, Wroblowski, Berthold, Murray, Christopher C., Vialard, Jorge

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Abstract 3229: Managing stress: Discovery of inhibitors of the atypical kinase eEF2K and the class III PI3K, VPS34 von Versele, Matthias, Moore, Claire, Proud, Christopher G., Rockx, Cindy, Weyer, Inez Van de, Baelen, Kurt Van, Blencke, Stephanie, Wanndinger, Sebastian K., Diels, Gaston, Berthelot, Didier, Viellevoye, Marcel, Schoentjes, Bruno, Wroblowski, Berthold, Meerpoel, Lieven, Hait, William N.

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Abstract 1738: JNJ-42756493 is an inhibitor of FGFR-1, 2, 3 and 4 with nanomolar affinity for targeted therapy von Perera, Timothy, Jovcheva, Eleanora, Vialard, Jorge, Verhulst, Tinne, Esser, Norbert, Wroblowski, Berthold, Gilissen, Ron, Freyne, Eddy, King, Peter, Platero, Suso, Querolle, Olivier, Mevellec, Laurence, Murray, Christopher, Fazal, Lynsey, Saxty, Gordon, Ward, George, Squires, Matthew, Thompson, Neil, Newell, David, Angibaud, Patrick

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Connecting gene expression data from connectivity map and in silico target predictions for small molecule mechanism-of-action analysis von Ravindranath, Aakash Chavan, Perualila-Tan, Nolen, Kasim, Adetayo, Drakakis, Georgios, Liggi, Sonia, Brewerton, Suzanne C, Mason, Daniel, Bodkin, Michael J, Evans, David A, Bhagwat, Aditya, Talloen, Willem, Göhlmann, Hinrich W H, Shkedy, Ziv, Bender, Andreas

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