Translational PK/PD and the first-in-human dose selection of a PD1/IL15: an engineered recombinant targeted cytokine for cancer immunotherapy von Yadav, Rajbharan, Schubbert, Suzanne, Holder, Patrick G, Chiang, Eugene Y, Kiabi, Nargess, Bogaert, Liz, Leung, Irene, Rashid, Rumana, Avery, Kendra N, Bonzon, Christine, Desjarlais, John R, Sanjabi, Shomyseh, Sharma, Amy, Lepherd, Michelle, Shelton, Amy, Chan, Pam, Liu, Yanqiu, Joslyn, Louis, Hosseini, Iraj, Stefanich, Eric G, Kamath, Amrita V, Bernett, Matthew J, Shivva, Vittal

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Reduction of total IgE by targeted coengagement of IgE B-cell receptor and FcγRIIb with Fc-engineered antibody von Chu, Seung Y., PhD, Horton, Holly M., PhD, Pong, Erik, MS, Leung, Irene W.L., PhD, Chen, Hsing, MS, Nguyen, Duc-Hanh, BS, Bautista, Cristina, BS, Muchhal, Umesh S., PhD, Bernett, Matthew J., PhD, Moore, Gregory L., PhD, Szymkowski, David E., PhD, Desjarlais, John R., PhD

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Fc-engineered anti-CD40 antibody enhances multiple effector functions and exhibits potent in vitro and in vivo antitumor activity against hematologic malignancies von Horton, Holly M., Bernett, Matthew J., Peipp, Matthias, Pong, Erik, Karki, Sher, Chu, Seung Y., Richards, John O., Chen, Hsing, Repp, Roland, Desjarlais, John R., Zhukovsky, Eugene A.

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Potent in vitro and in vivo activity of an Fc-engineered humanized anti-HM1.24 antibody against multiple myeloma via augmented effector function von Tai, Yu-Tzu, Horton, Holly M., Kong, Sun-Young, Pong, Erik, Chen, Hsing, Cemerski, Saso, Bernett, Matthew J., Nguyen, Duc-Hanh T., Karki, Sher, Chu, Seung Y., Lazar, Greg A., Munshi, Nikhil C., Desjarlais, John R., Anderson, Kenneth C., Muchhal, Umesh S.

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Targeting Multiple Myeloma with AMG 424, a Novel Anti-CD38/CD3 Bispecific T-cell-recruiting Antibody Optimized for Cytotoxicity and Cytokine Release von Zuch de Zafra, Christina L, Fajardo, Flordeliza, Zhong, Wendy, Bernett, Matthew J, Muchhal, Umesh S, Moore, Gregory L, Stevens, Jennitte, Case, Ryan, Pearson, Joshua T, Liu, Siyuan, McElroy, Patricia L, Canon, Jude, Desjarlais, John R, Coxon, Angela, Balazs, Mercedesz, Nolan-Stevaux, Olivier

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Crystal Structure and Biochemical Characterization of Human Kallikrein 6 Reveals That a Trypsin-like Kallikrein Is Expressed in the Central Nervous System von Bernett, Matthew J., Blaber, Sachiko I., Scarisbrick, Isobel A., Dhanarajan, Pushparani, Thompson, Steven M., Blaber, Michael

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A robust heterodimeric Fc platform engineered for efficient development of bispecific antibodies of multiple formats von Moore, Gregory L., Bernett, Matthew J., Rashid, Rumana, Pong, Erik W., Nguyen, Duc-Hanh T., Jacinto, Jonathan, Eivazi, Araz, Nisthal, Alex, Diaz, Juan E., Chu, Seung Y., Muchhal, Umesh S., Desjarlais, John R.

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Potent In vitro and In vivo Activity of an Fc-Engineered Anti-CD19 Monoclonal Antibody against Lymphoma and Leukemia von HORTON, Holly M, BERNETT, Matthew J, DESJARLAIS, John R, ZHUKOVSKY, Eugene A, PONG, Erik, PEIPP, Matthias, KARKI, Sher, CHU, Seung Y, RICHARDS, John O, VOSTIAR, Igor, JOYCE, Patrick F, REPP, Roland

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Abstract 5549: Potency-reduced IL12 heterodimeric Fc-fusions exhibit strong anti-tumor activity von Varma, Rajat, Liu, Ke, Bonzon, Christine, Rashid, Rumana, Rodriguez, Nicole, Hassanzadeh-Kiabi, Nargess, Ardila, Connie, Chu, Seung Y., Muchhal, Umesh S., Desjarlais, John R., Bernett, Matthew J.

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Enzymatic Properties of Rat Myelencephalon-Specific Protease von Blaber, Sachiko I, Scarisbrick, Isobel A, Bernett, Matthew J, Dhanarajan, Pushparani, Seavy, Margaret A, Jin, Yonghao, Schwartz, Martin A, Rodriguez, Moses, Blaber, Michael

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1193 Synergistic targeting of multiple activating pathways with natural killer cell engagers von Zhang, Tian, Faber, Matthew S, Pong, Erik, Liu, Ke, Kim, Nahee, Bernett, Matthew J, Bonzon, Christine, Wieler, James, Diaz, Juan E, Avery, Kendra N, Henderson, Elizabeth, Yeh, William Y, Qi, Jing, Hao, Su-Shin, Rashid, Rumana, Bahjat, Rena, Desjarlais, John R, Bykova, Katrina

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Abstract 5000: Immunotherapy with anti-PSMA x anti-CD3 bispecific antibody stimulates potent killing of a human prostate cancer cell line and target-mediated T cell activation in m... von Chu, Seung Y., Pong, Erik W. K., Rashid, Rumana, Chen, Hsing, Chan, Emily W., Phung, Sheryl, Endo, Nancy A., Ardila, Maria C., Bonzon, Christine, Leung, Irene W. L., Muchhal, Umesh S., Moore, Gregory L., Bernett, Matthew J., Desjarlais, John R., Szymkowski, David E.

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Engineering Fully Human Monoclonal Antibodies from Murine Variable Regions von Bernett, Matthew J., Karki, Sher, Moore, Gregory L., Leung, Irene W.L., Chen, Hsing, Pong, Erik, Nguyen, Duc-Hanh T., Jacinto, Jonathan, Zalevsky, Jonathan, Muchhal, Umesh S., Desjarlais, John R., Lazar, Greg A.

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Targeting kallikrein 6‐proteolysis attenuates CNS inflammatory disease von Blaber, Sachiko I., Ciric, Bogoljub, Christophi, Geroge P., Bernett, Matthew J., Blaber, Michael, Rodriguez, Moses, Scarisbrick, Isobel A.

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Immune suppression in cynomolgus monkeys by XPro9523: An improved CTLA4-Ig fusion with enhanced binding to CD80, CD86 and neonatal Fc receptor FcRn von Bernett, Matthew J., Chu, Seung Y., Leung, Irene, Moore, Gregory L., Lee, Sung-Hyung, Pong, Erik, Chen, Hsing, Phung, Sheryl, Muchhal, Umesh S., Horton, Holly M., Lazar, Greg A., Desjarlais, John R, Szymkowski, David E.

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1.70 Å X-ray structure of human apo kallikrein 1: Structural changes upon peptide inhibitor/substrate binding von Laxmikanthan, Gurunathan, Blaber, Sachiko I., Bernett, Matthew J., Scarisbrick, Isobel A., Juliano, Maria Aparecida, Blaber, Michael

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An atomic resolution structure for human fibroblast growth factor 1 von Bernett, Matthew J., Somasundaram, Thayumanasamy, Blaber, Michael

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Targeting kallikrein 6‐proteolysis attenuates CNS inflammatory disease von Blaber, Sachiko I., Ciric, Bogoljub, Christophi, Geroge P., Bernett, Matthew J., Blaber, Michael, Rodriguez, Moses, Scarisbrick, Isobel A.

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Abstract 5654: Affinity tuned Xmab®2+1 anti-mesothelin x anti-CD3 bispecific antibody induces selective T cell-dependent cellular cytotoxicity of human ovarian cancer cells von Zeng, Veronica G., Faber, Matthew S., Bernett, Matthew J., Avery, Kendra N., Zeytounian, John L., Rashid, Rumana, Muchhal, Umesh S., Moore, Gregory L., Desjarlais, John R., Hedvat, Michael

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Abstract 1743: IL12 heterodimeric Fc-fusions engineered for reduced potency exhibit strong anti-tumor activity and improved therapeutic index compared to native IL12 agents von Bernett, Matthew J., Liu, Ke, Bonzon, Christine, Rashid, Rumana, Rodriguez, Nicole, Hassanzadeh-Kiabi, Nargess, Ardila, Connie, Bykova, Katrina, Hackett, Michael, Barlow, Norm, Leung, Irene, Nguyen, Duc-Hanh, Eivazi, Araz, Chu, Seung Y., Varma, Rajat, Muchhal, Umesh S., Desjarlais, John R.

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