Catalytically Active Peptide–Gold Nanoparticle Conjugates: Prospecting for Artificial Enzymes von Mikolajczak, Dorian J., Berger, Allison A., Koksch, Beate

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An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer von Soucy, Teresa A., Smith, Peter G., Milhollen, Michael A., Berger, Allison J., Gavin, James M., Adhikari, Sharmila, Brownell, James E., Burke, Kristine E., Cardin, David P., Critchley, Stephen, Cullis, Courtney A., Doucette, Amanda, Garnsey, James J., Gaulin, Jeffrey L., Gershman, Rachel E., Lublinsky, Anna R., McDonald, Alice, Mizutani, Hirotake, Narayanan, Usha, Olhava, Edward J., Peluso, Stephane, Rezaei, Mansoureh, Sintchak, Michael D., Talreja, Tina, Thomas, Michael P., Traore, Tary, Vyskocil, Stepan, Weatherhead, Gabriel S., Yu, Jie, Zhang, Julie, Dick, Lawrence R., Claiborne, Christopher F., Rolfe, Mark, Bolen, Joseph B., Langston, Steven P.

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Phase I Study of the Novel Investigational NEDD8-Activating Enzyme Inhibitor Pevonedistat (MLN4924) in Patients with Relapsed/Refractory Multiple Myeloma or Lymphoma von Shah, Jatin J, Jakubowiak, Andrzej J, O'Connor, Owen A, Orlowski, Robert Z, Harvey, R Donald, Smith, Mitchell R, Lebovic, Daniel, Diefenbach, Catherine, Kelly, Kevin, Hua, Zhaowei, Berger, Allison J, Mulligan, George, Faessel, Hélène M, Tirrell, Stephen, Dezube, Bruce J, Lonial, Sagar

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Phase I Study of the Investigational NEDD8-Activating Enzyme Inhibitor Pevonedistat (TAK-924/MLN4924) in Patients with Advanced Solid Tumors von Sarantopoulos, John, Shapiro, Geoffrey I, Cohen, Roger B, Clark, Jeffrey W, Kauh, John S, Weiss, Glen J, Cleary, James M, Mahalingam, Devalingam, Pickard, Michael D, Faessel, Hélène M, Berger, Allison J, Burke, Kristine, Mulligan, George, Dezube, Bruce J, Harvey, R Donald

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A conserved RpoS-dependent small RNA controls the synthesis of major porin OmpD von Fröhlich, Kathrin S, Papenfort, Kai, Berger, Allison A, Vogel, Jörg

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Cancer-Related Decision-Making Among Adolescents, Young Adults, Caregivers, and Oncology Providers von Darabos, Katie, Berger, Allison J., Barakat, Lamia P., Schwartz, Lisa A.

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Deciphering the Fluorine CodeThe Many Hats Fluorine Wears in a Protein Environment von Berger, Allison Ann, Völler, Jan-Stefan, Budisa, Nediljko, Koksch, Beate

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Evaluation of the Proteasome Inhibitor MLN9708 in Preclinical Models of Human Cancer von KUPPERMAN, Erik, LEE, Edmund C, BLANK, Jonathan, GARCIA, Khristofer, TSU, Christopher, DICK, Larry, FLEMING, Paul, LI YU, MANFREDI, Mark, ROLFE, Mark, BOLEN, Joe, YUEYING CAO, BANNERMAN, Bret, FITZGERALD, Michael, BERGER, Allison, JIE YU, YU YANG, BRUZZESE, Frank, LIU, Jane

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Investigational agent MLN9708/2238 targets tumor-suppressor miR33b in MM cells von Tian, Ze, Zhao, Jian-jun, Tai, Yu-Tzu, Amin, Samir B., Hu, Yiguo, Berger, Allison J., Richardson, Paul, Chauhan, Dharminder, Anderson, Kenneth C.

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Ubiquitin-activating enzyme inhibition induces an unfolded protein response and overcomes drug resistance in myeloma von Zhuang, Junling, Shirazi, Fazal, Singh, Ram Kumar, Kuiatse, Isere, Wang, Hua, Lee, Hans C., Berkova, Zuzana, Berger, Allison, Hyer, Marc, Chattopadhyay, Nibedita, Syed, Sakeena, Shi, Judy Qiuju, Yu, Jie, Shinde, Vaishali, Tirrell, Stephen, Jones, Richard Julian, Wang, Zhiqiang, Davis, R. Eric, Orlowski, Robert Z.

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T Cell-intrinsic Immunomodulatory Effects of TAK-981 (Subasumstat), a SUMO-activating Enzyme Inhibitor, in Chronic Lymphocytic Leukemia von Lam, Vi, Roleder, Carly, Liu, Tingting, Bruss, Nur, Best, Scott, Wang, Xiaoguang, Phillips, Tycel, Shouse, Geoffrey, Berger, Allison J, Alinari, Lapo, Wang, Lili, Siddiqi, Tanya, Pennock, Nathan D, Danilov, Alexey V

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KRAS Genotype Correlates with Proteasome Inhibitor Ixazomib Activity in Preclinical In Vivo Models of Colon and Non-Small Cell Lung Cancer: Potential Role of Tumor Metabolism von Chattopadhyay, Nibedita, Berger, Allison J, Koenig, Erik, Bannerman, Bret, Garnsey, James, Bernard, Hugues, Hales, Paul, Maldonado Lopez, Angel, Yang, Yu, Donelan, Jill, Jordan, Kristen, Tirrell, Stephen, Stringer, Bradley, Xia, Cindy, Hather, Greg, Galvin, Katherine, Manfredi, Mark, Rhodes, Nelson, Amidon, Ben

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Preclinical Activity of the Oral Proteasome Inhibitor MLN9708 in Myeloma Bone Disease von GARCIA-GOMEZ, Antonio, QUWAIDER, Dalia, GROEN, Richard W. J, MATEO-URDIALES, Joaquin, FRAILE, Susana, GALARRAGA, Miguel, CHAUHAN, Dharminder, SAN MIGUEL, Jesús F, RAJE, Noopur, GARAYOA, Mercedes, CANAVESE, Miriam, OCIO, Enrique M, ZE TIAN, BLANCO, Juan F, BERGER, Allison J, ORTIZ-DE-SOLORZANO, Carlos, HERNANDEZ-IGLESIAS, Teresa, MARTENS, Anton C. M

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Preclinical evaluation of the selective small-molecule UBA1 inhibitor, TAK-243, in acute myeloid leukemia von Barghout, Samir H., Patel, Parasvi S., Wang, Xiaoming, Xu, G. Wei, Kavanagh, Simon, Halgas, Ondrej, Zarabi, Sara F., Gronda, Marcela, Hurren, Rose, Jeyaraju, Danny V., MacLean, Neil, Brennan, Shawn, Hyer, Marc L., Berger, Allison, Traore, Tary, Milhollen, Michael, Smith, Adam C., Minden, Mark D., Pai, Emil F., Hakem, Razq, Schimmer, Aaron D.

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The NAE inhibitor pevonedistat interacts with the HDAC inhibitor belinostat to target AML cells by disrupting the DDR von Zhou, Liang, Chen, Shuang, Zhang, Yu, Kmieciak, Maciej, Leng, Yun, Li, Lihong, Lin, Hui, Rizzo, Kathryn A., Dumur, Catherine I., Ferreira-Gonzalez, Andrea, Rahmani, Mohamed, Povirk, Lawrence, Chalasani, Sri, Berger, Allison J., Dai, Yun, Grant, Steven

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Antitumor Activity of the Investigational Proteasome Inhibitor MLN9708 in Mouse Models of B-cell and Plasma Cell Malignancies von LEE, Edmund C, FITZGERALD, Michael, PICKARD, Michael, ZHI LI, TAYBER, Olga, PING LI, HALES, Paul, CARSILLO, Mary, NEPPALLI, Vishala T, BERGER, Allison J, KUPPERMAN, Erik, MANFREDI, Mark, BANNERMAN, Bret, BOLEN, Joseph B, NESS, Brian Van, JANZ, Siegfried, DONELAN, Jill, BANO, Kristen, TERKELSEN, Jennifer, BRADLEY, Daniel P, SUBAKAN, Ozlem, SILVA, Matthew D, LIU, Ray

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Coassembly Generates Peptide Hydrogel with Wound Dressing Material Properties von Thota, Chaitanya Kumar, Berger, Allison A, Elomaa, Laura, Nie, Chaunxiong, Böttcher, Christoph, Koksch, Beate

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The discovery of a reciprocal relationship between tyrosine-kinase signaling and cullin neddylation von Friend, Samantha F, Peterson, Lisa K, Treacy, Eric, Stefanski, Adrianne L, Sosinowski, Tomasz, Pennock, Nathan D, Berger, Allison J, Winn, Virginia D, Dragone, Leonard L

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Overcoming platinum resistance in preclinical models of ovarian cancer using the neddylation inhibitor MLN4924 von Jazaeri, Amir A, Shibata, Etsuko, Park, Jonghoon, Bryant, Jennifer L, Conaway, Mark R, Modesitt, Susan C, Smith, Peter G, Milhollen, Michael A, Berger, Allison J, Dutta, Anindya

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Phase 1 study of ixazomib, an investigational proteasome inhibitor, in advanced non-hematologic malignancies von Smith, David C., Kalebic, Thea, Infante, Jeffrey R., Siu, Lillian L., Sullivan, Daniel, Vlahovic, Gordana, Kauh, John S., Gao, Feng, Berger, Allison J., Tirrell, Stephen, Gupta, Neeraj, Di Bacco, Alessandra, Berg, Deborah, Liu, Guohui, Lin, Jianchang, Hui, Ai-Min, Thompson, John A.

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