Targeting Tumor-Associated Macrophages with Anti-CSF-1R Antibody Reveals a Strategy for Cancer Therapy von Ries, Carola H., Cannarile, Michael A., Hoves, Sabine, Benz, Jörg, Wartha, Katharina, Runza, Valeria, Rey-Giraud, Flora, Pradel, Leon P., Feuerhake, Friedrich, Klaman, Irina, Jones, Tobin, Jucknischke, Ute, Scheiblich, Stefan, Kaluza, Klaus, Gorr, Ingo H., Walz, Antje, Abiraj, Keelara, Cassier, Philippe A., Sica, Antonio, Gomez-Roca, Carlos, de Visser, Karin E., Italiano, Antoine, Le Tourneau, Christophe, Delord, Jean-Pierre, Levitsky, Hyam, Blay, Jean-Yves, Rüttinger, Dominik

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Discovery of 3‑Pyridyl Isoindolin-1-one Derivatives as Potent, Selective, and Orally Active Aldosterone Synthase (CYP11B2) Inhibitors von Liu, Yongfu, Wu, Jun, Zhou, Mingwei, Chen, Wenming, Li, Dongbo, Wang, Zhanguo, Hornsperger, Benoit, Aebi, Johannes D, Märki, Hans-Peter, Kuhn, Bernd, Wang, Lisha, Kuglstatter, Andreas, Benz, Jörg, Müller, Stephan, Hochstrasser, Remo, Ottaviani, Giorgio, Xin, Jian, Kirchner, Stephan, Mohr, Susanne, Verry, Philippe, Riboulet, William, Shen, Hong C, Mayweg, Alexander V, Amrein, Kurt, Tan, Xuefei

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Targeting intracellular WT1 in AML with a novel RMF-peptide-MHC-specific T-cell bispecific antibody von Augsberger, Christian, Hänel, Gerulf, Xu, Wei, Pulko, Vesna, Hanisch, Lydia Jasmin, Augustin, Angelique, Challier, John, Hunt, Katharina, Vick, Binje, Rovatti, Pier Eduardo, Krupka, Christina, Rothe, Maurine, Schönle, Anne, Sam, Johannes, Lezan, Emmanuelle, Ducret, Axel, Ortiz-Franyuti, Daniela, Walz, Antje-Christine, Benz, Jörg, Bujotzek, Alexander, Lichtenegger, Felix S., Gassner, Christian, Carpy, Alejandro, Lyamichev, Victor, Patel, Jigar, Konstandin, Nikola, Tunger, Antje, Schmitz, Marc, von Bergwelt-Baildon, Michael, Spiekermann, Karsten, Vago, Luca, Jeremias, Irmela, Marrer-Berger, Estelle, Umaña, Pablo, Klein, Christian, Subklewe, Marion

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Insight into steroid scaffold formation from the structure of human oxidosqualene cyclase von Ruf, Armin, Thoma, Ralf, Schulz-Gasch, Tanja, D'Arcy, Brigitte, Benz, Jörg, Aebi, Johannes, Dehmlow, Henrietta, Hennig, Michael, Stihle, Martine

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Unique carbohydrate–carbohydrate interactions are required for high affinity binding between FcγRIII and antibodies lacking core fucose von Ferrara, Claudia, Grau, Sandra, Jäger, Christiane, Sondermann, Peter, Brünker, Peter, Waldhauer, Inja, Hennig, Michael, Ruf, Armin, Rufer, Arne Christian, Stihle, Martine, Umaña, Pablo, Benz, Jörg

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Prospective Evaluation of Free Energy Calculations for the Prioritization of Cathepsin L Inhibitors von Kuhn, Bernd, Tichý, Michal, Wang, Lingle, Robinson, Shaughnessy, Martin, Rainer E, Kuglstatter, Andreas, Benz, Jörg, Giroud, Maude, Schirmeister, Tanja, Abel, Robert, Diederich, François, Hert, Jérôme

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Mapping the conformational space accessible to BACE2 using surface mutants and cocrystals with Fab fragments, Fynomers and Xaperones von Banner, David W., Gsell, Bernard, Benz, Jörg, Bertschinger, Julian, Burger, Dominique, Brack, Simon, Cuppuleri, Simon, Debulpaep, Maja, Gast, Alain, Grabulovski, Dragan, Hennig, Michael, Hilpert, Hans, Huber, Walter, Kuglstatter, Andreas, Kusznir, Eric, Laeremans, Toon, Matile, Hugues, Miscenic, Christian, Rufer, Arne C., Schlatter, Daniel, Steyaert, Jan, Stihle, Martine, Thoma, Ralf, Weber, Martin, Ruf, Armin

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Development of Potent and Selective Monoacylglycerol Lipase Inhibitors. SARs, Structural Analysis, and Biological Characterization von Butini, Stefania, Grether, Uwe, Jung, Kwang-Mook, Ligresti, Alessia, Allarà, Marco, Postmus, Annemarieke G. J., Maramai, Samuele, Brogi, Simone, Papa, Alessandro, Carullo, Gabriele, Sykes, David, Veprintsev, Dmitry, Federico, Stefano, Grillo, Alessandro, Di Guglielmo, Bruno, Ramunno, Anna, Stevens, Anna Floor, Heer, Dominik, Lamponi, Stefania, Gemma, Sandra, Benz, Jörg, Di Marzo, Vincenzo, van der Stelt, Mario, Piomelli, Daniele, Campiani, Giuseppe

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A potent and selective inhibitor for the modulation of MAGL activity in the neurovasculature von Kemble, Alicia M, Hornsperger, Benoit, Ruf, Iris, Richter, Hans, Benz, Jörg, Kuhn, Bernd, Heer, Dominik, Wittwer, Matthias, Engelhardt, Britta, Grether, Uwe, Collin, Ludovic

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Structure-Guided Discovery of cis-Hexahydro-pyrido-oxazinones as Reversible, Drug-like Monoacylglycerol Lipase Inhibitors von Kuhn, Bernd, Ritter, Martin, Hornsperger, Benoit, Bell, Charles, Kocer, Buelent, Rombach, Didier, Lutz, Marius D. R., Gobbi, Luca, Kuratli, Martin, Bartelmus, Christian, Bürkler, Markus, Koller, Raffael, Tosatti, Paolo, Ruf, Iris, Guerard, Melanie, Pavlovic, Anto, Stephanus, Juliane, O’Hara, Fionn, Wetzl, Dennis, Saal, Wiebke, Stihle, Martine, Roth, Doris, Hug, Melanie, Huber, Sylwia, Heer, Dominik, Kroll, Carsten, Topp, Andreas, Schneider, Manfred, Gertsch, Jürg, Glasmacher, Sandra, van der Stelt, Mario, Martella, Andrea, Wittwer, Matthias Beat, Collin, Ludovic, Benz, Jörg, Richter, Hans, Grether, Uwe

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Repurposing a Library of Human Cathepsin L Ligands: Identification of Macrocyclic Lactams as Potent Rhodesain and Trypanosoma brucei Inhibitors von Giroud, Maude, Dietzel, Uwe, Anselm, Lilli, Banner, David, Kuglstatter, Andreas, Benz, Jörg, Blanc, Jean-Baptiste, Gaufreteau, Delphine, Liu, Haixia, Lin, Xianfeng, Stich, August, Kuhn, Bernd, Schuler, Franz, Kaiser, Marcel, Brun, Reto, Schirmeister, Tanja, Kisker, Caroline, Diederich, François, Haap, Wolfgang

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Development of High Brain-Penetrant and Reversible Monoacylglycerol Lipase PET Tracers for Neuroimaging von He, Yingfang, Schild, Matthias, Grether, Uwe, Benz, Jörg, Leibrock, Lea, Heer, Dominik, Topp, Andreas, Collin, Ludovic, Kuhn, Bernd, Wittwer, Matthias, Keller, Claudia, Gobbi, Luca C, Schibli, Roger, Mu, Linjing

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Discovery of a microbial transglutaminase enabling highly site-specific labeling of proteins von Steffen, Wojtek, Ko, Fu Chong, Patel, Jigar, Lyamichev, Victor, Albert, Thomas J., Benz, Jörg, Rudolph, Markus G., Bergmann, Frank, Streidl, Thomas, Kratzsch, Peter, Boenitz-Dulat, Mara, Oelschlaegel, Tobias, Schraeml, Michael

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Mapping the conformational space accessible to catechol-O-methyltransferase von Ehler, Andreas, Benz, Jörg, Schlatter, Daniel, Rudolph, Markus G.

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Systematic Investigation of Halogen Bonding in Protein-Ligand Interactions von Hardegger, Leo A., Kuhn, Bernd, Spinnler, Beat, Anselm, Lilli, Ecabert, Robert, Stihle, Martine, Gsell, Bernard, Thoma, Ralf, Diez, Joachim, Benz, Jörg, Plancher, Jean-Marc, Hartmann, Guido, Banner, David W., Haap, Wolfgang, Diederich, François

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Prodrug-Activating Chain Exchange (PACE) converts targeted prodrug derivatives to functional bi- or multispecific antibodies von Dickopf, Steffen, Buldun, Can, Vasic, Vedran, Georges, Guy, Hage, Carina, Mayer, Klaus, Forster, Matthias, Wessels, Uwe, Stubenrauch, Kay-Gunnar, Benz, Jörg, Ehler, Andreas, Lauer, Matthias E., Ringler, Philippe, Kobold, Sebastian, Endres, Stefan, Klein, Christian, Brinkmann, Ulrich

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Novel potent and highly selective DDR1 inhibitors from integrated lead finding von Kuhn, Bernd, Ritter, Martin, Benz, Jörg, Kocer, Buelent, Sarie, Jérôme C., Hochstrasser, Remo, Rudolph, Markus G., Kadono, Shojiro, Matsuura, Tetsu, Murata, Takeshi, Richter, Hans, Prunotto, Marco

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Discovery, synthesis and evaluation of novel reversible monoacylglycerol lipase radioligands bearing a morpholine-3-one scaffold von He, Yingfang, Gobbi, Luca C., Herde, Adrienne Müller, Rombach, Didier, Ritter, Martin, Kuhn, Bernd, Wittwer, Matthias B., Heer, Dominik, Hornsperger, Benoit, Bell, Charles, O'Hara, Fionn, Benz, Jörg, Honer, Michael, Keller, Claudia, Collin, Ludovic, Richter, Hans, Schibli, Roger, Grether, Uwe, Mu, Linjing

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BACE1 inhibitors: A head group scan on a series of amides von Woltering, Thomas J., Wostl, Wolfgang, Hilpert, Hans, Rogers-Evans, Mark, Pinard, Emmanuel, Mayweg, Alexander, Göbel, Martin, Banner, David W., Benz, Jörg, Travagli, Massimiliano, Pollastrini, Martina, Marconi, Guido, Gabellieri, Emanuele, Guba, Wolfgang, Mauser, Harald, Andreini, Matteo, Jacobsen, Helmut, Power, Eoin, Narquizian, Robert

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Determination of Protein–Ligand Binding Constants of a Cooperatively Regulated Tetrameric Enzyme Using Electrospray Mass Spectrometry von Cubrilovic, Dragana, Haap, Wolfgang, Barylyuk, Konstantin, Ruf, Armin, Badertscher, Martin, Gubler, Marcel, Tetaz, Tim, Joseph, Catherine, Benz, Jörg, Zenobi, Renato

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