A Survey of the Role of Noncovalent Sulfur Interactions in Drug Design von Beno, Brett R, Yeung, Kap-Sun, Bartberger, Michael D, Pennington, Lewis D, Meanwell, Nicholas A

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Resistance profile of the HIV-1 maturation inhibitor GSK3532795 in vitro and in a clinical study von Dicker, Ira, Zhang, Sharon, Ray, Neelanjana, Beno, Brett R, Regueiro-Ren, Alicia, Joshi, Samit, Cockett, Mark, Krystal, Mark, Lataillade, Max

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Discovery of a Hepatitis C Virus NS5B Replicase Palm Site Allosteric Inhibitor (BMS-929075) Advanced to Phase 1 Clinical Studies von Yeung, Kap-Sun, Beno, Brett R, Parcella, Kyle, Bender, John A, Grant-Young, Katherine A, Nickel, Andrew, Gunaga, Prashantha, Anjanappa, Prakash, Bora, Rajesh Onkardas, Selvakumar, Kumaravel, Rigat, Karen, Wang, Ying-Kai, Liu, Mengping, Lemm, Julie, Mosure, Kathy, Sheriff, Steven, Wan, Changhong, Witmer, Mark, Kish, Kevin, Hanumegowda, Umesh, Zhuo, Xiaoliang, Shu, Yue-Zhong, Parker, Dawn, Haskell, Roy, Ng, Alicia, Gao, Qi, Colston, Elizabeth, Raybon, Joseph, Grasela, Dennis M, Santone, Kenneth, Gao, Min, Meanwell, Nicholas A, Sinz, Michael, Soars, Matthew G, Knipe, Jay O, Roberts, Susan B, Kadow, John F

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A Small Molecule Inhibitor Selectively Induces Apoptosis in Cells Transformed by High Risk Human Papilloma Viruses von Sheaffer, Amy K, Lee, Min S, Qi, Huilin, Chaniewski, Susan, Zheng, Xiaofan, Farr, Glen A, Esposito, Kim, Harden, David, Lei, Ming, Schweizer, Liang, Friborg, Jacques, Agler, Michele, McPhee, Fiona, Gentles, Robert, Beno, Brett R, Chupak, Lou, Mason, Stephen

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Epitope and Paratope Mapping of PD-1/Nivolumab by Mass Spectrometry-Based Hydrogen–Deuterium Exchange, Cross-linking, and Molecular Docking von Zhang, Mengru Mira, Huang, Richard Y.-C, Beno, Brett R, Deyanova, Ekaterina G, Li, Jing, Chen, Guodong, Gross, Michael L

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An Integrated Approach for Determining a Protein–Protein Binding Interface in Solution and an Evaluation of Hydrogen–Deuterium Exchange Kinetics for Adjudicating Candidate Docking... von Zhang, Mengru Mira, Beno, Brett R, Huang, Richard Y.-C, Adhikari, Jagat, Deyanova, Ekaterina G, Li, Jing, Chen, Guodong, Gross, Michael L

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Ligand-induced changes in hepatitis C virus NS5B polymerase structure von Rigat, Karen, Wang, Yi, Hudyma, Thomas W., Ding, Min, Zheng, Xiaofan, Gentles, Robert G., Beno, Brett R., Gao, Min, Roberts, Susan B.

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Syntheses and initial evaluation of a series of indolo-fused heterocyclic inhibitors of the polymerase enzyme (NS5B) of the hepatitis C virus von Zheng, Xiaofan, Hudyma, Thomas W., Martin, Scott W., Bergstrom, Carl, Ding, Min, He, Feng, Romine, Jeffrey, Poss, Michael A., Kadow, John F., Chang, Chong-Hwan, Wan, John, Witmer, Mark R., Morin, Paul, Camac, Daniel M., Sheriff, Steven, Beno, Brett R., Rigat, Karen L., Wang, Ying-Kai, Fridell, Robert, Lemm, Julie, Qiu, Dike, Liu, Mengping, Voss, Stacey, Pelosi, Lenore, Roberts, Susan B., Gao, Min, Knipe, Jay, Gentles, Robert G.

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Atropisomerism Observed in Galactose-Based Monosaccharide Inhibitors of Galectin‑3 Comprising 2‑Methyl-4-phenyl-2,4-dihydro‑3H‑1,2,4-triazole-3-thione von Yoon, David S., Liu, Chunjian, Jalagam, Prasada Rao, Feng, Jianxin, Wang, Wei, Swidorski, Jacob J., Xu, Li, Hartz, Richard A., Nair, Satheesh K., Beno, Brett R., Panda, Manoranjan, Ghosh, Kaushik, Kumar, Amit, Sale, Harinath, Shah, Devang, Mathur, Arvind, Ellsworth, Bruce A., Cheng, Dong, Regueiro-Ren, Alicia

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Atropisomerism Observed in Galactose-Based Monosaccharide Inhibitors of Galectin-3 Comprising 2-Methyl-4-phenyl-2,4-dihydro-3 H -1,2,4-triazole-3-thione von Yoon, David S, Liu, Chunjian, Jalagam, Prasada Rao, Feng, Jianxin, Wang, Wei, Swidorski, Jacob J, Xu, Li, Hartz, Richard A, Nair, Satheesh K, Beno, Brett R, Panda, Manoranjan, Ghosh, Kaushik, Kumar, Amit, Sale, Harinath, Shah, Devang, Mathur, Arvind, Ellsworth, Bruce A, Cheng, Dong, Regueiro-Ren, Alicia

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Orthogonal Mass Spectrometry-Based Footprinting for Epitope Mapping and Structural Characterization: The IL‑6 Receptor upon Binding of Protein Therapeutics von Li, Ke Sherry, Chen, Guodong, Mo, Jingjie, Huang, Richard Y.-C, Deyanova, Ekaterina G, Beno, Brett R, O’Neil, Steve R, Tymiak, Adrienne A, Gross, Michael L

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Synthesis, Structure–Activity Relationships, and In Vivo Evaluation of Novel Tetrahydropyran-Based Thiodisaccharide Mimics as Galectin‑3 Inhibitors von Xu, Li, Hartz, Richard A, Beno, Brett R, Ghosh, Kaushik, Shukla, Jinal K, Kumar, Amit, Patel, Dipal, Kalidindi, Narasimharaju, Lemos, Nadine, Gautam, Shashyendra Singh, Kumar, Anoop, Ellsworth, Bruce A, Shah, Devang, Sale, Harinath, Cheng, Dong, Regueiro-Ren, Alicia

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Synthesis and SAR studies of novel heteroaryl fused tetracyclic indole-diamide compounds: Potent allosteric inhibitors of the hepatitis C virus NS5B polymerase von Ding, Min, He, Feng, Hudyma, Thomas W., Zheng, Xiaofan, Poss, Michael A., Kadow, John F., Beno, Brett R., Rigat, Karen L., Wang, Ying-Kai, Fridell, Robert A., Lemm, Julie A., Qiu, Dike, Liu, Mengping, Voss, Stacey, Pelosi, Lenore A., Roberts, Susan B., Gao, Min, Knipe, Jay, Gentles, Robert G.

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High-throughput screening and rapid inhibitor triage using an infectious chimeric Hepatitis C virus von Wichroski, Michael J, Fang, Jie, Eggers, Betsy J, Rose, Ronald E, Mazzucco, Charles E, Pokornowski, Kevin A, Baldick, Carl J, Anthony, Monique N, Dowling, Craig J, Barber, Lauren E, Leet, John E, Beno, Brett R, Gerritz, Samuel W, Agler, Michele L, Cockett, Mark I, Tenney, Daniel J

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Design and exploration of C-3 benzoic acid bioisosteres and alkyl replacements in the context of GSK3532795 (BMS-955176) that exhibit broad spectrum HIV-1 maturation inhibition von Swidorski, Jacob J., Jenkins, Susan, Hanumegowda, Umesh, Parker, Dawn D., Beno, Brett R., Protack, Tricia, Ng, Alicia, Gupta, Anuradha, Shanmugam, Yoganand, Dicker, Ira B., Krystal, Mark, Meanwell, Nicholas A., Regueiro-Ren, Alicia

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Hydrogen-Deuterium Exchange and Hydroxyl Radical Footprinting for Mapping Hydrophobic Interactions of Human Bromodomain with a Small Molecule Inhibitor von Li, Ke Sherry, Schaper Bergman, Elizabeth T., Beno, Brett R., Huang, Richard Y.-C., Deyanova, Ekaterina, Chen, Guodong, Gross, Michael L.

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Conformationally Restricted Homotryptamines. Part 7: 3-cis-(3-Aminocyclopentyl)indoles As Potent Selective Serotonin Reuptake Inhibitors von King, H. Dalton, Meng, Zhaoxing, Deskus, Jeffrey A, Sloan, Charles P, Gao, Qi, Beno, Brett R, Kozlowski, Edward S, LaPaglia, Melissa A, Mattson, Gail K, Molski, Thaddeus F, Taber, Matthew T, Lodge, Nicholas J, Mattson, Ronald J, Macor, John E

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Synchronous or Asynchronous? An “Experimental” Transition State from a Direct Comparison of Experimental and Theoretical Kinetic Isotope Effects for a Diels−Alder Reaction von Beno, Brett R, Houk, K. N, Singleton, Daniel A

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Discovery and Preclinical Characterization of the Cyclopropylindolobenzazepine BMS-791325, A Potent Allosteric Inhibitor of the Hepatitis C Virus NS5B Polymerase von Gentles, Robert G., Ding, Min, Bender, John A., Bergstrom, Carl P., Grant-Young, Katharine, Hewawasam, Piyasena, Hudyma, Thomas, Martin, Scott, Nickel, Andrew, Regueiro-Ren, Alicia, Tu, Yong, Yang, Zhong, Yeung, Kap-Sun, Zheng, Xiaofan, Chao, Sam, Sun, Jung-Hui, Beno, Brett R., Camac, Daniel M., Chang, Chong-Hwan, Gao, Mian, Morin, Paul E., Sheriff, Steven, Tredup, Jeff, Wan, John, Witmer, Mark R., Xie, Dianlin, Hanumegowda, Umesh, Knipe, Jay, Mosure, Kathy, Santone, Kenneth S., Parker, Dawn D., Zhuo, Xiaoliang, Lemm, Julie, Liu, Mengping, Pelosi, Lenore, Rigat, Karen, Voss, Stacey, Wang, Yi, Wang, Ying-Kai, Colonno, Richard J., Gao, Min, Roberts, Susan B., Gao, Qi, Ng, Alicia, Meanwell, Nicholas A, Kadow, John F.

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Discovery and exploration of monosaccharide linked dimers of galectin-3 inhibitors to target fibrosis von Swidorski, Jacob J., Beno, Brett R., Liu, Chunjian, Yoon, David S., Ghosh, Kaushik, Sale, Harinath, Shah, Devang, Acharya, Kriti, Yanchunas, Joseph, Haldar, Priyanka, Kalidindi, Narasimharaju, Shukla, Jinal K., Argentieri, Matthew, Ellsworth, Bruce A., Cheng, Dong, Regueiro-Ren, Alicia

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