Importance of Assessing Cardiorespiratory Fitness in Clinical Practice: A Case for Fitness as a Clinical Vital Sign: A Scientific Statement From the American Heart Association von Ross, Robert, Blair, Steven N, Arena, Ross, Church, Timothy S, Després, Jean-Pierre, Franklin, Barry A, Haskell, William L, Kaminsky, Leonard A, Levine, Benjamin D, Lavie, Carl J, Myers, Jonathan, Niebauer, Josef, Sallis, Robert, Sawada, Susumu S, Sui, Xuemei, Wisløff, Ulrik

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Drosophila Lung Cancer Models Identify Trametinib plus Statin as Candidate Therapeutic von Levine, Benjamin D., Cagan, Ross L.

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Impact of Lifelong Exercise “Dose” on Left Ventricular Compliance and Distensibility von Bhella, Paul S., MD, Hastings, Jeffrey L., MD, Fujimoto, Naoki, MD, Shibata, Shigeki, MD, PhD, Carrick-Ranson, Graeme, PhD, Palmer, M. Dean, MS, Boyd, Kara N., MS, Adams-Huet, Beverley, MS, Levine, Benjamin D., MD

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Cardiac Remodeling in Response to 1 Year of Intensive Endurance Training von Arbab-Zadeh, Armin, Perhonen, Merja, Howden, Erin, Peshock, Ronald M, Zhang, Rong, Adams-Huet, Beverly, Haykowsky, Mark J, Levine, Benjamin D

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Effect of gravity and microgravity on intracranial pressure von Lawley, Justin S., Petersen, Lonnie G., Howden, Erin J., Sarma, Satyam, Cornwell, William K., Zhang, Rong, Whitworth, Louis A., Williams, Michael A., Levine, Benjamin D.

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Assessment of the 12-Lead Electrocardiogram as a Screening Test for Detection of Cardiovascular Disease in Healthy General Populations of Young People (12–25 Years of Age) von Maron, Barry J., MD, FACC, Friedman, Richard A., MD, FACC, Kligfield, Paul, MD, FAHA, Levine, Benjamin D., MD, Viskin, Sami, MD, Chaitman, Bernard R., MD, FAHA, Okin, Peter M., MD, FAHA, FACC, Saul, J. Philip, MD, FAHA, FACC, Salberg, Lisa, Van Hare, George F., MD, Soliman, Elsayed Z., MD, FAHA, FACC, Chen, Jersey, MD, MPH, Matherne, G. Paul, MD, FAHA, FACC, Bolling, Steven F., MD, FAHA, Mitten, Matthew J., JD, Caplan, Arthur, PhD, Balady, Gary J., MD, FAHA, Thompson, Paul D., MD, FAHA, FACC

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The overlooked significance of plasma volume for successful adaptation to high altitude in Sherpa and Andean natives von Stembridge, Mike, Williams, Alexandra M., Gasho, Christopher, Dawkins, Tony G., Drane, Aimee, Villafuerte, Francisco C., Levine, Benjamin D., Shave, Rob, Ainslie, Philip N.

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The effect of lifelong exercise frequency on arterial stiffness von Shibata, Shigeki, Fujimoto, Naoki, Hastings, Jeffrey L., Carrick‐Ranson, Graeme, Bhella, Paul S., Hearon, Christopher M., Levine, Benjamin D.

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Physical Activity Versus Cardiorespiratory Fitness: Two (Partly) Distinct Components of Cardiovascular Health? von DeFina, Laura F, Haskell, William L, Willis, Benjamin L, Barlow, Carolyn E, Finley, Carrie E, Levine, Benjamin D, Cooper, Kenneth H

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Cardiac Origins of the Postural Orthostatic Tachycardia Syndrome von Fu, Qi, MD, PhD, VanGundy, Tiffany B., MS, Galbreath, M. Melyn, PhD, Shibata, Shigeki, MD, PhD, Jain, Manish, MD, Hastings, Jeffrey L., MD, Bhella, Paul S., MD, Levine, Benjamin D., MD

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Iron insufficiency diminishes the erythropoietic response to moderate altitude exposure von Okazaki, Kazunobu, Stray-Gundersen, James, Chapman, Robert F, Levine, Benjamin D

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Life-long aerobic exercise preserved baseline cerebral blood flow but reduced vascular reactivity to CO2 von Thomas, Binu P., Yezhuvath, Uma S., Tseng, Benjamin Y., Liu, Peiying, Levine, Benjamin D., Zhang, Rong, Lu, Hanzhang

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The international POTS registry: Evaluating the efficacy of an exercise training intervention in a community setting von George, Stephen A., MD, PhD, Bivens, Tiffany B., MS, Howden, Erin J., PhD, Saleem, Yasir, MD, Galbreath, M. Melyn, PhD, Hendrickson, Dianne, MS, APRN, FNP-C, Fu, Qi, MD, PhD, Levine, Benjamin D., MD

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Impact of Prolonged Spaceflight on Orthostatic Tolerance During Ambulation and Blood Pressure Profiles in Astronauts von Fu, Qi, Shibata, Shigeki, Hastings, Jeffrey L, Platts, Steven H, Hamilton, Douglas M, Bungo, Michael W, Stenger, Michael B, Ribeiro, Christine, Adams-Huet, Beverley, Levine, Benjamin D

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Lower body negative pressure to safely reduce intracranial pressure von Petersen, Lonnie G., Lawley, Justin S., Lilja‐Cyron, Alexander, Petersen, Johan C. G., Howden, Erin J., Sarma, Satyam, Cornwell, William K., Zhang, Rong, Whitworth, Louis A., Williams, Michael A., Juhler, Marianne, Levine, Benjamin D.

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Females have a blunted cardiovascular response to one year of intensive supervised endurance training von Howden, Erin J, Perhonen, Merja, Peshock, Ronald M, Zhang, Rong, Arbab-Zadeh, Armin, Adams-Huet, Beverley, Levine, Benjamin D

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The effect of lifelong endurance exercise on cardiovascular structure and exercise function in women von Carrick‐Ranson, Graeme, Sloane, Nikita M., Howden, Erin J., Bhella, Paul S., Sarma, Satyam, Shibata, Shigeki, Fujimoto, Naoki, Hastings, Jeffrey L., Levine, Benjamin D.

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Astronaut Cardiovascular Health and Risk Modification (Astro-CHARM) Coronary Calcium Atherosclerotic Cardiovascular Disease Risk Calculator von Khera, Amit, Budoff, Matthew J, O’Donnell, Christopher J, Ayers, Colby A, Locke, James, de Lemos, James A, Massaro, Joseph M, McClelland, Robyn L, Taylor, Allen, Levine, Benjamin D

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Left atrial structure and function and clinical outcomes in the general population von Gupta, Sachin, Matulevicius, Susan A, Ayers, Colby R, Berry, Jarett D, Patel, Parag C, Markham, David W, Levine, Benjamin D, Chin, Kelly M, de Lemos, James A, Peshock, Ronald M, Drazner, Mark H

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Exercise in the postural orthostatic tachycardia syndrome von Fu, Qi, Levine, Benjamin D

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