Machine learning prediction of cancer cell sensitivity to drugs based on genomic and chemical properties von Menden, Michael P, Iorio, Francesco, Garnett, Mathew, McDermott, Ultan, Benes, Cyril H, Ballester, Pedro J, Saez-Rodriguez, Julio

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Distinct but Concerted Roles of ATR, DNA-PK, and Chk1 in Countering Replication Stress during S Phase von Buisson, Rémi, Boisvert, Jessica L., Benes, Cyril H., Zou, Lee

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Passenger hotspot mutations in cancer driven by APOBEC3A and mesoscale genomic features von Buisson, Rémi, Langenbucher, Adam, Bowen, Danae, Kwan, Eugene E., Benes, Cyril H., Zou, Lee, Lawrence, Michael S.

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Abstract SY45-03: Capturing the therapeutic response heterogeneity at the functional level von Benes, Cyril, Benes, Cyril H.

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Effective drug combinations in breast, colon and pancreatic cancer cells von Jaaks, Patricia, Coker, Elizabeth A., Vis, Daniel J., Edwards, Olivia, Carpenter, Emma F., Leto, Simonetta M., Dwane, Lisa, Sassi, Francesco, Lightfoot, Howard, Barthorpe, Syd, van der Meer, Dieudonne, Yang, Wanjuan, Beck, Alexandra, Mironenko, Tatiana, Hall, Caitlin, Hall, James, Mali, Iman, Richardson, Laura, Tolley, Charlotte, Morris, James, Thomas, Frances, Lleshi, Ermira, Aben, Nanne, Benes, Cyril H., Bertotti, Andrea, Trusolino, Livio, Wessels, Lodewyk, Garnett, Mathew J.

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A Landscape of Pharmacogenomic Interactions in Cancer von Iorio, Francesco, Knijnenburg, Theo A., Vis, Daniel J., Bignell, Graham R., Menden, Michael P., Schubert, Michael, Aben, Nanne, Gonçalves, Emanuel, Barthorpe, Syd, Lightfoot, Howard, Cokelaer, Thomas, Greninger, Patricia, van Dyk, Ewald, Chang, Han, de Silva, Heshani, Heyn, Holger, Deng, Xianming, Egan, Regina K., Liu, Qingsong, Mironenko, Tatiana, Mitropoulos, Xeni, Richardson, Laura, Wang, Jinhua, Zhang, Tinghu, Moran, Sebastian, Sayols, Sergi, Soleimani, Maryam, Tamborero, David, Lopez-Bigas, Nuria, Ross-Macdonald, Petra, Esteller, Manel, Gray, Nathanael S., Haber, Daniel A., Stratton, Michael R., Benes, Cyril H., Wessels, Lodewyk F.A., Saez-Rodriguez, Julio, McDermott, Ultan, Garnett, Mathew J.

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APOBEC3A and APOBEC3B Activities Render Cancer Cells Susceptible to ATR Inhibition von Buisson, Rémi, Lawrence, Michael S, Benes, Cyril H, Zou, Lee

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ATR inhibition disrupts rewired homologous recombination and fork protection pathways in PARP inhibitor-resistant BRCA-deficient cancer cells von Yazinski, Stephanie A, Comaills, Valentine, Buisson, Rémi, Genois, Marie-Michelle, Nguyen, Hai Dang, Ho, Chu Kwen, Todorova Kwan, Tanya, Morris, Robert, Lauffer, Sam, Nussenzweig, André, Ramaswamy, Sridhar, Benes, Cyril H, Haber, Daniel A, Maheswaran, Shyamala, Birrer, Michael J, Zou, Lee

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Transcription Factor Activities Enhance Markers of Drug Sensitivity in Cancer von Garcia-Alonso, Luz, Iorio, Francesco, Matchan, Angela, Fonseca, Nuno, Jaaks, Patricia, Peat, Gareth, Pignatelli, Miguel, Falcone, Fiammetta, Benes, Cyril H, Dunham, Ian, Bignell, Graham, McDade, Simon S, Garnett, Mathew J, Saez-Rodriguez, Julio

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Detection of dysregulated protein-association networks by high-throughput proteomics predicts cancer vulnerabilities von Lapek, John D, Greninger, Patricia, Morris, Robert, Amzallag, Arnaud, Pruteanu-Malinici, Iulian, Benes, Cyril H, Haas, Wilhelm

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Synthetic Lethal Interaction of Combined BCL-XL and MEK Inhibition Promotes Tumor Regressions in KRAS Mutant Cancer Models von Corcoran, Ryan B., Cheng, Katherine A., Hata, Aaron N., Faber, Anthony C., Ebi, Hiromichi, Coffee, Erin M., Greninger, Patricia, Brown, Ronald D., Godfrey, Jason T., Cohoon, Travis J., Song, Youngchul, Lifshits, Eugene, Hung, Kenneth E., Shioda, Toshi, Dias-Santagata, Dora, Singh, Anurag, Settleman, Jeffrey, Benes, Cyril H., Mino-Kenudson, Mari, Wong, Kwok-Kin, Engelman, Jeffrey A.

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Alternative lengthening of telomeres renders cancer cells hypersensitive to ATR inhibitors von Flynn, Rachel Litman, Cox, Kelli E., Jeitany, Maya, Wakimoto, Hiroaki, Bryll, Alysia R., Ganem, Neil J., Bersani, Francesca, Pineda, Jose R., Suvà, Mario L., Benes, Cyril H., Haber, Daniel A., Boussin, Francois D., Zou, Lee

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Combined MEK and PI3K inhibition in a mouse model of pancreatic cancer von Alagesan, Brinda, Contino, Gianmarco, Guimaraes, Alex R, Corcoran, Ryan B, Deshpande, Vikram, Wojtkiewicz, Gregory R, Hezel, Aram F, Wong, Kwok-Kin, Loda, Massimo, Weissleder, Ralph, Benes, Cyril H, Engelman, Jeffrey, Bardeesy, Nabeel

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Statistical assessment and visualization of synergies for large-scale sparse drug combination datasets von Amzallag, Arnaud, Ramaswamy, Sridhar, Benes, Cyril H

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BRAF and AXL oncogenes drive RIPK3 expression loss in cancer von Najafov, Ayaz, Zervantonakis, Ioannis K, Mookhtiar, Adnan K, Greninger, Patricia, March, Ryan J, Egan, Regina K, Luu, Hoang Son, Stover, Daniel G, Matulonis, Ursula A, Benes, Cyril H, Yuan, Junying

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Measurement of PIP3 Levels Reveals an Unexpected Role for p110β in Early Adaptive Responses to p110α-Specific Inhibitors in Luminal Breast Cancer von Costa, Carlotta, Ebi, Hiromichi, Martini, Miriam, Beausoleil, Sean A., Faber, Anthony C., Jakubik, Charles T., Huang, Alan, Wang, Youzhen, Nishtala, Madhuri, Hall, Ben, Rikova, Klarisa, Zhao, Jean, Hirsch, Emilio, Benes, Cyril H., Engelman, Jeffrey A.

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Targeting FGFR overcomes EMT-mediated resistance in EGFR mutant non-small cell lung cancer von Raoof, Sana, Mulford, Iain J., Frisco-Cabanos, Heidie, Nangia, Varuna, Timonina, Daria, Labrot, Emma, Hafeez, Nafeeza, Bilton, Samantha J., Drier, Yotam, Ji, Fei, Greenberg, Max, Williams, August, Kattermann, Krystina, Damon, Leah, Sovath, Sosathya, Rakiec, Daniel P., Korn, Joshua M., Ruddy, David A., Benes, Cyril H., Hammerman, Peter S., Piotrowska, Zofia, Sequist, Lecia V., Niederst, Matthew J., Barretina, Jordi, Engelman, Jeffrey A., Hata, Aaron N.

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MET Alterations Are a Recurring and Actionable Resistance Mechanism in ALK-Positive Lung Cancer von Dagogo-Jack, Ibiayi, Yoda, Satoshi, Lennerz, Jochen K, Langenbucher, Adam, Lin, Jessica J, Rooney, Marguerite M, Prutisto-Chang, Kylie, Oh, Audris, Adams, Nathaniel A, Yeap, Beow Y, Chin, Emily, Do, Andrew, Marble, Hetal D, Stevens, Sara E, Digumarthy, Subba R, Saxena, Ashish, Nagy, Rebecca J, Benes, Cyril H, Azzoli, Christopher G, Lawrence, Michael S, Gainor, Justin F, Shaw, Alice T, Hata, Aaron N

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Patient-derived models of acquired resistance can identify effective drug combinations for cancer von Crystal, Adam S., Shaw, Alice T., Sequist, Lecia V., Friboulet, Luc, Niederst, Matthew J., Lockerman, Elizabeth L., Frias, Rosa L., Gainor, Justin F., Amzallag, Arnaud, Greninger, Patricia, Lee, Dana, Kalsy, Anuj, Gomez-Caraballo, Maria, Elamine, Leila, Howe, Emily, Hur, Wooyoung, Lifshits, Eugene, Robinson, Hayley E., Katayama, Ryohei, Faber, Anthony C., Awad, Mark M., Ramaswamy, Sridhar, Mino-Kenudson, Mari, Iafrate, A. John, Benes, Cyril H., Engelman, Jeffrey A.

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STAT3 Plays a Critical Role in KRAS-Induced Pancreatic Tumorigenesis von CORCORAN, Ryan B, CONTINO, Gianmarco, DESHPANDE, Vikram, TZATSOS, Alexandros, CONRAD, Claudius, BENES, Cyril H, LEVY, David E, SETTLEMAN, Jeffrey, ENGELMAN, Jeffrey A, BARDEESY, Nabeel

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