Optimization of Lipid Nanoparticles for Intramuscular Administration of mRNA Vaccines von Hassett, Kimberly J., Benenato, Kerry E., Jacquinet, Eric, Lee, Aisha, Woods, Angela, Yuzhakov, Olga, Himansu, Sunny, Deterling, Jessica, Geilich, Benjamin M., Ketova, Tatiana, Mihai, Cosmin, Lynn, Andy, McFadyen, Iain, Moore, Melissa J., Senn, Joseph J., Stanton, Matthew G., Almarsson, Örn, Ciaramella, Giuseppe, Brito, Luis A.

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Systemic mRNA Therapy for the Treatment of Fabry Disease: Preclinical Studies in Wild-Type Mice, Fabry Mouse Model, and Wild-Type Non-human Primates von Zhu, Xuling, Yin, Ling, Theisen, Matt, Zhuo, Jenny, Siddiqui, Summar, Levy, Becca, Presnyak, Vladimir, Frassetto, Andrea, Milton, Jaclyn, Salerno, Timothy, Benenato, Kerry E., Milano, Joe, Lynn, Andy, Sabnis, Staci, Burke, Kristine, Besin, Gilles, Lukacs, Christine M., Guey, Lin T., Finn, Patrick F., Martini, Paolo G.V.

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Boosting Intracellular Delivery of Lipid Nanoparticle-Encapsulated mRNA von Patel, Siddharth, Ashwanikumar, N, Robinson, Emily, DuRoss, Allison, Sun, Conroy, Murphy-Benenato, Kerry E, Mihai, Cosmin, Almarsson, Örn, Sahay, Gaurav

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Dual mRNA therapy restores metabolic function in long-term studies in mice with propionic acidemia von Jiang, Lei, Park, Ji-Sun, Yin, Ling, Laureano, Rodrigo, Jacquinet, Eric, Yang, Jinsong, Liang, Shi, Frassetto, Andrea, Zhuo, Jenny, Yan, Xinhua, Zhu, Xuling, Fortucci, Steven, Hoar, Kara, Mihai, Cosmin, Tunkey, Christopher, Presnyak, Vlad, Benenato, Kerry E., Lukacs, Christine M., Martini, Paolo G. V., Guey, Lin T.

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mRNA Therapy Improves Metabolic and Behavioral Abnormalities in a Murine Model of Citrin Deficiency von Cao, Jingsong, An, Ding, Galduroz, Mikel, Zhuo, Jenny, Liang, Shi, Eybye, Marianne, Frassetto, Andrea, Kuroda, Eishi, Funahashi, Aki, Santana, Jordan, Mihai, Cosmin, Benenato, Kerry E., Kumarasinghe, E. Sathyajith, Sabnis, Staci, Salerno, Timothy, Coughlan, Kimberly, Miracco, Edward J., Levy, Becca, Besin, Gilles, Schultz, Joshua, Lukacs, Christine, Guey, Lin, Finn, Patrick, Furukawa, Tatsuhiko, Giangrande, Paloma H., Saheki, Takeyori, Martini, Paolo G.V.

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Systemic Messenger RNA Therapy as a Treatment for Methylmalonic Acidemia von An, Ding, Schneller, Jessica L., Frassetto, Andrea, Liang, Shi, Zhu, Xuling, Park, Ji-Sun, Theisen, Matt, Hong, Sue-Jean, Zhou, Jenny, Rajendran, Raj, Levy, Becca, Howell, Rebecca, Besin, Gilles, Presnyak, Vladimir, Sabnis, Staci, Murphy-Benenato, Kerry E., Kumarasinghe, E. Sathyajith, Salerno, Timothy, Mihai, Cosmin, Lukacs, Christine M., Chandler, Randy J., Guey, Lin T., Venditti, Charles P., Martini, Paolo G.V.

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Accelerated Blood Clearance of Lipid Nanoparticles Entails a Biphasic Humoral Response of B-1 Followed by B-2 Lymphocytes to Distinct Antigenic Moieties von Besin, Gilles, Milton, Jaclyn, Sabnis, Staci, Howell, Rebecca, Mihai, Cosmin, Burke, Kristine, Benenato, Kerry E, Stanton, Matthew, Smith, Peter, Senn, Joseph, Hoge, Stephen

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Discovery of a Novel Amino Lipid That Improves Lipid Nanoparticle Performance through Specific Interactions with mRNA von Cornebise, Mark, Narayanan, Elisabeth, Xia, Yan, Acosta, Edward, Ci, Lei, Koch, Hillary, Milton, Jaclyn, Sabnis, Staci, Salerno, Timothy, Benenato, Kerry E.

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Systemic messenger RNA as an etiological treatment for acute intermittent porphyria von Jiang, Lei, Berraondo, Pedro, Jericó, Daniel, Guey, Lin T., Sampedro, Ana, Frassetto, Andrea, Benenato, Kerry E., Burke, Kristine, Santamaría, Eva, Alegre, Manuel, Pejenaute, Álvaro, Kalariya, Mayur, Butcher, William, Park, Ji-Sun, Zhu, Xuling, Sabnis, Staci, Kumarasinghe, E. Sathyajith, Salerno, Timothy, Kenney, Matthew, Lukacs, Christine M., Ávila, Matías A., Martini, Paolo G. V., Fontanellas, Antonio

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A Novel Amino Lipid Series for mRNA Delivery: Improved Endosomal Escape and Sustained Pharmacology and Safety in Non-human Primates von Sabnis, Staci, Kumarasinghe, E. Sathyajith, Salerno, Timothy, Mihai, Cosmin, Ketova, Tatiana, Senn, Joseph J., Lynn, Andy, Bulychev, Alex, McFadyen, Iain, Chan, Joyce, Almarsson, Örn, Stanton, Matthew G., Benenato, Kerry E.

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Pharmacodynamic Profiling of a Siderophore-Conjugated Monocarbam in Pseudomonas aeruginosa: Assessing the Risk for Resistance and Attenuated Efficacy von Kim, Aryun, Kutschke, Amy, Ehmann, David E, Patey, Sara A, Crandon, Jared L, Gorseth, Elise, Miller, Alita A, McLaughlin, Robert E, Blinn, Christina M, Chen, April, Nayar, Asha S, Dangel, Brian, Tsai, Andy S, Rooney, Michael T, Murphy-Benenato, Kerry E, Eakin, Ann E, Nicolau, David P

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Systemic Messenger RNA Therapy as a Treatment for Methylmalonic Acidemia von An, Ding, Schneller, Jessica L., Frassetto, Andrea, Liang, Shi, Zhu, Xuling, Park, Ji-Sun, Theisen, Matt, Hong, Sue-Jean, Zhou, Jenny, Rajendran, Raj, Levy, Becca, Howell, Rebecca, Besin, Gilles, Presnyak, Vladimir, Sabnis, Staci, Murphy-Benenato, Kerry E., Kumarasinghe, E. Sathyajith, Salerno, Timothy, Mihai, Cosmin, Lukacs, Christine M., Chandler, Randy J., Guey, Lin T., Venditti, Charles P., Martini, Paolo G.V.

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Discovery of Efficacious Pseudomonas aeruginosa-Targeted Siderophore-Conjugated Monocarbams by Application of a Semi-mechanistic Pharmacokinetic/Pharmacodynamic Model von Murphy-Benenato, Kerry E, Bhagunde, Pratik R, Chen, April, Davis, Hajnalka E, Durand-Réville, Thomas F, Ehmann, David E, Galullo, Vincent, Harris, Jennifer J, Hatoum-Mokdad, Holia, Jahić, Haris, Kim, Aryun, Manjunatha, M. R, Manyak, Erika L, Mueller, John, Patey, Sara, Quiroga, Olga, Rooney, Michael, Sha, Li, Shapiro, Adam B, Sylvester, Mark, Tan, Beesan, Tsai, Andy S, Uria-Nickelsen, Maria, Wu, Ye, Zambrowski, Mark, Zhao, Shannon X

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Negishi cross-coupling enabled synthesis of novel NAD+-dependent DNA ligase inhibitors and SAR development von Murphy-Benenato, Kerry E., Gingipalli, Lakshmaiah, Boriack-Sjodin, P. Ann, Martinez-Botella, Gabriel, Carcanague, Dan, Eyermann, Charles J., Gowravaram, Madhu, Harang, Jenna, Hale, Michael R., Ioannidis, Georgine, Jahic, Harris, Johnstone, Michele, Kutschke, Amy, Laganas, Valerie A., Loch, James T., Miller, Matthew D., Oguto, Herbert, Patel, Sahil Joe

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Synthesis, Structure, and SAR of Tetrahydropyran-Based LpxC Inhibitors von Murphy-Benenato, Kerry E, Olivier, Nelson, Choy, Allison, Ross, Philip L, Miller, Matthew D, Thresher, Jason, Gao, Ning, Hale, Michael R

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SAR and Structural Analysis of Siderophore-Conjugated Monocarbam Inhibitors of Pseudomonas aeruginosa PBP3 von Murphy-Benenato, Kerry E, Dangel, Brian, Davis, Hajnalka E, Durand-Réville, Thomas F, Ferguson, Andrew D, Gao, Ning, Jahić, Haris, Mueller, John P, Manyak, Erika L, Quiroga, Olga, Rooney, Michael, Sha, Li, Sylvester, Mark, Wu, Frank, Zambrowski, Mark, Zhao, Shannon X

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Boosting intracellular delivery of lipid nanoparticle-encapsulated messenger RNA von Patel, Siddharth, Ashwanikumar, N, Robinson, Emily, DuRoss, Allison, Sun, Conroy, Murphy-Benenato, Kerry E., Mihai, Cosmin, Almarsson, Örn, Sahay, Gaurav

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Compuestos y composiciones para la administración intracelular de agentes von BUTCHER, William, BENENATO, Kerry E

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Compuestos y composiciones para la administración intracelular de agentes terapéuticos von CORNEBISE, Mark, KUMARASINGHE, Ellalahewage Sathyajith, BENENATO, Kerry E

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From fragments to leads: novel bacterial NAD+-dependent DNA ligase inhibitors von Hale, Michael R., Brassington, Claire, Carcanague, Dan, Embrey, Kevin, Eyermann, Charles J., Giacobbe, Robert A., Gingipalli, Lakshmaiah, Gowravaram, Madhusudhan, Harang, Jenna, Howard, Tina, Ioannidis, Georgine, Jahic, Haris, Kutschke, Amy, Laganas, Valerie A., Loch, James, Miller, Matthew D., Murphy-Benenato, Kerry E., Oguto, Herbert, Otterbein, Ludovic, Patel, Sahil Joe, Shapiro, Adam B., Boriack-Sjodin, P. Ann

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