Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction von Simonetta, Kyle R., Taygerly, Joshua, Boyle, Kathleen, Basham, Stephen E., Padovani, Chris, Lou, Yan, Cummins, Thomas J., Yung, Stephanie L., von Soly, Szerenke Kiss, Kayser, Frank, Kuriyan, John, Rape, Michael, Cardozo, Mario, Gallop, Mark A., Bence, Neil F., Barsanti, Paul A., Saha, Anjanabha

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Global Impairment of the Ubiquitin-Proteasome System by Nuclear or Cytoplasmic Protein Aggregates Precedes Inclusion Body Formation von Bennett, Eric J., Bence, Neil F., Jayakumar, Rajadas, Kopito, Ron R.

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Impairment of the Ubiquitin-Proteasome System by Protein Aggregation von Bence, Neil F., Sampat, Roopal M., Kopito, Ron R.

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Treatment-Emergent Mutations in NAEβ Confer Resistance to the NEDD8-Activating Enzyme Inhibitor MLN4924 von Milhollen, Michael A., Thomas, Michael P., Narayanan, Usha, Traore, Tary, Riceberg, Jessica, Amidon, Benjamin S., Bence, Neil F., Bolen, Joseph B., Brownell, James, Dick, Lawrence R., Loke, Huay-Keng, McDonald, Alice A., Ma, Jingya, Manfredi, Mark G., Sells, Todd B., Sintchak, Mike D., Yang, Xiaofeng, Xu, Qing, Koenig, Erik M., Gavin, James M., Smith, Peter G.

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Intersecting pathways to neurodegeneration in Parkinson's disease: Effects of the pesticide rotenone on DJ-1, α-synuclein, and the ubiquitin–proteasome system von Betarbet, Ranjita, Canet-Aviles, Rosa M., Sherer, Todd B., Mastroberardino, Pier G., McLendon, Chris, Kim, Jin-Ho, Lund, Serena, Na, Hye-Mee, Taylor, Georgia, Bence, Neil F., Kopito, Ron, Seo, Byoung Boo, Yagi, Takao, Yagi, Akemi, Klinefelter, Gary, Cookson, Mark R., Greenamyre, J. Timothy

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A small-molecule inhibitor of the ubiquitin activating enzyme for cancer treatment von Hyer, Marc L, Milhollen, Michael A, Ciavarri, Jeff, Fleming, Paul, Traore, Tary, Sappal, Darshan, Huck, Jessica, Shi, Judy, Gavin, James, Brownell, Jim, Yang, Yu, Stringer, Bradley, Griffin, Robert, Bruzzese, Frank, Soucy, Teresa, Duffy, Jennifer, Rabino, Claudia, Riceberg, Jessica, Hoar, Kara, Lublinsky, Anya, Menon, Saurabh, Sintchak, Michael, Bump, Nancy, Pulukuri, Sai M, Langston, Steve, Tirrell, Stephen, Kuranda, Mike, Veiby, Petter, Newcomb, John, Li, Ping, Wu, Jing Tao, Powe, Josh, Dick, Lawrence R, Greenspan, Paul, Galvin, Katherine, Manfredi, Mark, Claiborne, Chris, Amidon, Benjamin S, Bence, Neil F

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A Rhodopsin Mutant Linked to Autosomal Dominant Retinitis Pigmentosa Is Prone to Aggregate and Interacts with the Ubiquitin Proteasome System von Illing, Michelle E., Rajan, Rahul S., Bence, Neil F., Kopito, Ron R.

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Characterization of the loss of SUMO pathway function on cancer cells and tumor proliferation von He, Xingyue, Riceberg, Jessica, Pulukuri, Sai M, Grossman, Steve, Shinde, Vaishali, Shah, Pooja, Brownell, James E, Dick, Larry, Newcomb, John, Bence, Neil

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Mechanistic Study of Uba5 Enzyme and the Ufm1 Conjugation Pathway von Gavin, James M., Hoar, Kara, Xu, Qing, Ma, Jingya, Lin, Yafang, Chen, Jiejin, Chen, Wei, Bruzzese, Frank J., Harrison, Sean, Mallender, William D., Bump, Nancy J., Sintchak, Michael D., Bence, Neil F., Li, Ping, Dick, Lawrence R., Gould, Alexandra E., Chen, Jesse J.

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Mechanistic Studies of Substrate-assisted Inhibition of Ubiquitin-activating Enzyme by Adenosine Sulfamate Analogues von Chen, Jesse J., Tsu, Christopher A., Gavin, James M., Milhollen, Michael A., Bruzzese, Frank J., Mallender, William D., Sintchak, Michael D., Bump, Nancy J., Yang, Xiaofeng, Ma, Jingya, Loke, Huay-Keng, Xu, Qing, Li, Ping, Bence, Neil F., Brownell, James E., Dick, Lawrence R.

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Formation of Morphologically Similar Globular Aggregates from Diverse Aggregation-Prone Proteins in Mammalian Cells von Mukai, Hideyuki, Isagawa, Takayuki, Goyama, Emiko, Tanaka, Shuhei, Bence, Neil F., Tamura, Atsuo, Ono, Yoshitaka, Kopito, Ron R., Ingram, Vernon Martin

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Genetic and pharmacological interrogation of cancer vulnerability using a multiplexed cell line screening platform von Xia, Yifeng, Ji, Xiaodong, Jang, In Sock, Surka, Christine, Hsu, Christy, Wang, Kai, Rolfe, Mark, Bence, Neil, Lu, Gang

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Specificity in Intracellular Protein Aggregation and Inclusion Body Formation von Rajan, Rahul S., Illing, Michelle E., Bence, Neil F., Kopito, Ron R.

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Probing the roles of SUMOylation in cancer cell biology by using a selective SAE inhibitor von He, Xingyue, Riceberg, Jessica, Soucy, Teresa, Koenig, Erik, Minissale, James, Gallery, Melissa, Bernard, Hugues, Yang, Xiaofeng, Liao, Hua, Rabino, Claudia, Shah, Pooja, Xega, Kristina, Yan, Zhong-hua, Sintchak, Mike, Bradley, John, Xu, He, Duffey, Matt, England, Dylan, Mizutani, Hirotake, Hu, Zhigen, Guo, Jianping, Chau, Ryan, Dick, Lawrence R, Brownell, James E, Newcomb, John, Langston, Steve, Lightcap, Eric S, Bence, Neil, Pulukuri, Sai M

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Highly Potent BTK Degradation Induced By NRX0492 As a Therapeutic Strategy for CLL von Zhang, Deyi, Harris, Hailey, Kelly, Aileen, Robbins, Daniel W, Tan, May, Ingallinera, Timothy, Bence, Neil, Sands, Arthur T, Baskar, Sivasubramanian, Herman, Sarah E.M., Wiestner, Adrian

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Targeted Protein Degradation of BTK As a Unique Therapeutic Approach for B Cell Malignancies von Kelly, Aileen, Robbins, Daniel W, Tan, May, Tenn-McClellan, Austin, McIntosh, Joel, Wu, Jeffrey, Konst, Zef, Kato, Daisuke, Perez, Luz, Tung, Jennifer, Kolobova, Anna, Ingallinera, Timothy, McKinnell, Jenny, Weiss, Dahlia, Noviski, Mark, Ye, Jordan, Peng, Ge, Cardozo, Mario, Mihalic, Jeff, Basham, Steve, Rountree, Ryan, Karr, Dane E, Bence, Neil, Zapf, Christoph W, Sands, Arthur T

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Abstract 2696: Genetic and pharmacologic evaluation of the ubiquitin ligase CBL-B as a small-molecule, tumor immunotherapy target von Gosling, Jennifa, Rountree, Ryan, Taherbhoy, Asad, Wang, Chenbo, Cummins, Thomas, Cohen, Frederick, Tanaka, Hiroko, Weiss, Dahlia, Cardozo, Mario, Karim, Christopher, Tan, May, Juan, Joseph, Tenn-McClellan, Austin, Soly, Szerenke Kiss von, Sheung, Julie, Boyle, Kathleen, Dhamnaskar, Ketki, Kurylo, Katherine, Bruffey, Jilliane, McKinnell, Jennifer, Karr, Dane, Christianson, Andria, Vries, Anne-Renee Van Der Vuurst de, Sivakumar, Pallavur, Gallop, Mark, Barsanti, Paul A., Saha, Anjanabha, Bence, Neil F., Zapf, Christoph W.

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Abstract A164: The small molecule UAE inhibitor TAK-243 (MLN7243) prevents DNA damage repair and reduces cell viability/tumor growth when combined with radiation, carboplatin and d... von Milhollen, Michael A., Shi, Judi, Traore, Tary, Huck, Jessica, Sappal, Darshan, Duffy, Jennifer, Lightcap, Eric, Ishii, Yuko, Ciavarri, Jeff, Fleming, Paul, Bence, Neil, Hyer, Marc L.

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Abstract LB-371: Evaluating the protein SUMOylation pathway as a potential cancer therapeutic target using inducible RNA interference von He, Xingyue, Bence, Neil, Dick, Larry, Veiby, Petter, Bolen, Joe

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Abstract 3719: TAK-243, a small molecule inhibitor of the ubiquitin activating enzyme (UAE), disrupts DNA damage repair and sensitizes tumor cells and xenografts to ionizing radiat... von Milhollen, Michael A., Shi, Judy Qiuju, Traore, Tary, Huck, Jessica, Sappal, Darshan, Iwai, Kenichi, Ohashi, Akihiro, Rabino, Claudia, Duffy, Jennifer A., Lightcap, Eric, Ishii, Yuko, Ciavarri, Jeffrey, Bence, Neil, Berger, Allison J., Hyer, Marc L.

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