Identification of (R)‑N‑((4-Methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)‑1H‑indole-3-carboxamide (CPI-1205),... von Vaswani, Rishi G, Gehling, Victor S, Dakin, Les A, Cook, Andrew S, Nasveschuk, Christopher G, Duplessis, Martin, Iyer, Priyadarshini, Balasubramanian, Srividya, Zhao, Feng, Good, Andrew C, Campbell, Robert, Lee, Christina, Cantone, Nico, Cummings, Richard T, Normant, Emmanuel, Bellon, Steven F, Albrecht, Brian K, Harmange, Jean-Christophe, Trojer, Patrick, Audia, James E, Zhang, Ying, Justin, Neil, Chen, Shuyang, Wilson, Jon R, Gamblin, Steven J

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Discovery of 1H‑Pyrazol-3(2H)‑ones as Potent and Selective Inhibitors of Protein Kinase R‑like Endoplasmic Reticulum Kinase (PERK) von Smith, Adrian L, Andrews, Kristin L, Beckmann, Holger, Bellon, Steven F, Beltran, Pedro J, Booker, Shon, Chen, Hao, Chung, Young-Ah, D’Angelo, Noel D, Dao, Jennifer, Dellamaggiore, Kenneth R, Jaeckel, Peter, Kendall, Richard, Labitzke, Katja, Long, Alexander M, Materna-Reichelt, Silvia, Mitchell, Petia, Norman, Mark H, Powers, David, Rose, Mark, Shaffer, Paul L, Wu, Michelle M, Lipford, J. Russell

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GNE-064: A Potent, Selective, and Orally Bioavailable Chemical Probe for the Bromodomains of SMARCA2 and SMARCA4 and the Fifth Bromodomain of PBRM1 von Taylor, Alexander M., Bailey, Chris, Belmont, Lisa D., Campbell, Robert, Cantone, Nico, Côté, Alexandre, Crawford, Terry D., Cummings, Richard, DeMent, Kevin, Duplessis, Martin, Flynn, Megan, Good, Andrew C., Huang, Hon-Ren, Joshi, Shivangi, Leblanc, Yves, Murray, Jeremy, Nasveschuk, Christopher G., Neiss, Adrianne, Poy, Florence, Romero, F. Anthony, Sandy, Peter, Tang, Yong, Tsui, Vickie, Zawadzke, Laura, Sims, Robert J., Audia, James E., Bellon, Steven F., Magnuson, Steven R., Albrecht, Brian K., Cochran, Andrea G.

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Structure-Based Design of Novel Class II c-Met Inhibitors: 2. SAR and Kinase Selectivity Profiles of the Pyrazolone Series von Liu, Longbin, Norman, Mark H, Lee, Matthew, Xi, Ning, Siegmund, Aaron, Boezio, Alessandro A, Booker, Shon, Choquette, Debbie, D’Angelo, Noel D, Germain, Julie, Yang, Kevin, Yang, Yajing, Zhang, Yihong, Bellon, Steven F, Whittington, Douglas A, Harmange, Jean-Christophe, Dominguez, Celia, Kim, Tae-Seong, Dussault, Isabelle

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Structure-Based Design of Novel Class II c-Met Inhibitors: 1. Identification of Pyrazolone-Based Derivatives von Norman, Mark H, Liu, Longbin, Lee, Matthew, Xi, Ning, Fellows, Ingrid, D’Angelo, Noel D, Dominguez, Celia, Rex, Karen, Bellon, Steven F, Kim, Tae-Seong, Dussault, Isabelle

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The Structure of Dimeric ROCK I Reveals the Mechanism for Ligand Selectivity von Jacobs, Marc, Hayakawa, Koto, Swenson, Lora, Bellon, Steven, Fleming, Mark, Taslimi, Paul, Doran, John

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c-Met Inhibitors with Novel Binding Mode Show Activity against Several Hereditary Papillary Renal Cell Carcinoma-related Mutations von Bellon, Steven F., Kaplan-Lefko, Paula, Yang, Yajing, Zhang, Yihong, Moriguchi, Jodi, Rex, Karen, Johnson, Carol W., Rose, Paul E., Long, Alexander M., O'Connor, Anne B., Gu, Yan, Coxon, Angela, Kim, Tae-Seong, Tasker, Andrew, Burgess, Teresa L., Dussault, Isabelle

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Discovery of Potent and Selective 8‑Fluorotriazolopyridine c‑Met Inhibitors von Peterson, Emily A, Teffera, Yohannes, Albrecht, Brian K, Bauer, David, Bellon, Steven F, Boezio, Alessandro, Boezio, Christiane, Broome, Martin A, Choquette, Deborah, Copeland, Katrina W, Dussault, Isabelle, Lewis, Richard, Lin, Min-Hwa Jasmine, Lohman, Julia, Liu, Jingzhou, Potashman, Michele, Rex, Karen, Shimanovich, Roman, Whittington, Douglas A, Vaida, Karina R, Harmange, Jean-Christophe

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Identification of potent, selective KDM5 inhibitors von Gehling, Victor S., Bellon, Steven F., Harmange, Jean-Christophe, LeBlanc, Yves, Poy, Florence, Odate, Shobu, Buker, Shane, Lan, Fei, Arora, Shilpi, Williamson, Kaylyn E., Sandy, Peter, Cummings, Richard T., Bailey, Christopher M., Bergeron, Louise, Mao, Weifeng, Gustafson, Amy, Liu, Yichin, VanderPorten, Erica, Audia, James E., Trojer, Patrick, Albrecht, Brian K.

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Discovery and Optimization of Triazolopyridazines as Potent and Selective Inhibitors of the c-Met Kinase von Albrecht, Brian K, Harmange, Jean-Christophe, Bauer, David, Berry, Loren, Bode, Christiane, Boezio, Alessandro A, Chen, April, Choquette, Deborah, Dussault, Isabelle, Fridrich, Cary, Hirai, Satoko, Hoffman, Doug, Larrow, Jay F, Kaplan-Lefko, Paula, Lin, Jasmine, Lohman, Julia, Long, Alexander M, Moriguchi, Jodi, O’Connor, Anne, Potashman, Michele H, Reese, Monica, Rex, Karen, Siegmund, Aaron, Shah, Kavita, Shimanovich, Roman, Springer, Stephanie K, Teffera, Yohannes, Yang, Yajing, Zhang, Yihong, Bellon, Steven F

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Discovery of (R)‑6-(1-(8-Fluoro-6-(1-methyl‑1H‑pyrazol-4-yl)-[1,2,4]triazolo[4,3‑a]pyridin-3-yl)ethyl)-3-(2-methoxyethoxy)-1,6-naphthyridin-5(6H)‑one (AMG 337), a Potent and Select... von Boezio, Alessandro A, Copeland, Katrina W, Rex, Karen, K. Albrecht, Brian, Bauer, David, Bellon, Steven F, Boezio, Christiane, Broome, Martin A, Choquette, Deborah, Coxon, Angela, Dussault, Isabelle, Hirai, Satoko, Lewis, Richard, Lin, Min-Hwa Jasmine, Lohman, Julia, Liu, Jingzhou, Peterson, Emily A, Potashman, Michele, Shimanovich, Roman, Teffera, Yohannes, Whittington, Douglas A, Vaida, Karina R, Harmange, Jean-Christophe

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Design and Synthesis of Styrenylcyclopropylamine LSD1 Inhibitors von Gehling, Victor S., Mcgrath, John P., Duplessis, Martin, Khanna, Avinash, Brucelle, Francois, Vaswani, Rishi G., Cote, Alexandre, Stuckey, Jacob, Watson, Venita, Cummings, Richard T., Balasubramanian, Srividya, Iyer, Priya, Sawant, Priyanka, Good, Andrew C., Albrecht, Brian K., Harmange, Jean-Christophe, Audia, James E., Bellon, Steven F., Trojer, Patrick, Levell, Julian R.

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Discovery of a Potent, Selective, and Orally Bioavailable c-Met Inhibitor: 1-(2-Hydroxy-2-methylpropyl)-N-(5-(7-methoxyquinolin-4-yloxy)pyridin-2-yl)-5-methyl-3-oxo-2-phenyl-2,3-di... von Liu, Longbin, Siegmund, Aaron, Xi, Ning, Kaplan-Lefko, Paula, Rex, Karen, Chen, April, Lin, Jasmine, Moriguchi, Jodi, Berry, Loren, Huang, Liyue, Teffera, Yohannes, Yang, Yajing, Zhang, Yihong, Bellon, Steven F, Lee, Matthew, Shimanovich, Roman, Bak, Annette, Dominguez, Celia, Norman, Mark H, Harmange, Jean-Christophe, Dussault, Isabelle, Kim, Tae-Seong

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c-Met inhibitors with different binding modes: Two is better than one von Dussault, Isabelle, Bellon, Steven F.

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Design, Synthesis, and Biological Evaluation of Potent c-Met Inhibitors von D’Angelo, Noel D, Bellon, Steven F, Booker, Shon K, Cheng, Yuan, Coxon, Angela, Dominguez, Celia, Fellows, Ingrid, Hoffman, Douglas, Hungate, Randall, Kaplan-Lefko, Paula, Lee, Matthew R, Li, Chun, Liu, Longbin, Rainbeau, Elizabeth, Reider, Paul J, Rex, Karen, Siegmund, Aaron, Sun, Yaxiong, Tasker, Andrew S, Xi, Ning, Xu, Shimin, Yang, Yajing, Zhang, Yihong, Burgess, Teresa L, Dussault, Isabelle, Kim, Tae-Seong

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Crystal Structures of Escherichia coli Topoisomerase IV ParE Subunit (24 and 43 Kilodaltons): a Single Residue Dictates Differences in Novobiocin Potency against Topoisomerase IV a... von BELLON, Steven, PARSONS, Jonathan D, YUNYI WEI, HAYAKAWA, Koto, SWENSON, Lora L, CHARIFSON, Paul S, LIPPKE, Judith A, ALDAPE, Robert, GROSS, Christian H

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The Discovery of VX-745: A Novel and Selective p38α Kinase Inhibitor von Duffy, John P, Harrington, Edmund M, Salituro, Francesco G, Cochran, John E, Green, Jeremy, Gao, Huai, Bemis, Guy W, Evindar, Ghotas, Galullo, Vincent P, Ford, Pamella J, Germann, Ursula A, Wilson, Keith P, Bellon, Steven F, Chen, Guanging, Taslimi, Paul, Jones, Peter, Huang, Cassey, Pazhanisamy, S, Wang, Yow-Ming, Murcko, Mark A, Su, Michael S.S

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Correction to Discovery of Potent and Selective 8‑Fluorotriazolopyridine c‑Met Inhibitors von Peterson, Emily A, Teffera, Yohannes, Albrecht, Brian K, Bauer, David, Bellon, Steven F, Boezio, Alessandro, Boezio, Christiane, Broome, Martin A, Choquette, Deborah, Copeland, Katrina W, Dussault, Isabelle, Lewis, Richard, Lin, Min-Hwa Jasmine, Lohman, Julia, Liu, Jingzhou, Potashman, Michele, Rex, Karen, Shimanovich, Roman, Whittington, Douglas A, Vaida, Karina R, Harmange, Jean-Christophe

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Discovery and optimization of potent and selective triazolopyridazine series of c-Met inhibitors von Boezio, Alessandro A., Berry, Loren, Albrecht, Brian K., Bauer, David, Bellon, Steven F., Bode, Christiane, Chen, April, Choquette, Deborah, Dussault, Isabelle, Hirai, Satoko, Kaplan-Lefko, Paula, Larrow, Jay F., Lin, Min-Hwa Jasmine, Lohman, Julia, Potashman, Michele H., Rex, Karen, Santostefano, Michael, Shah, Kavita, Shimanovich, Roman, Springer, Stephanie K., Teffera, Yohannes, Yang, Yajing, Zhang, Yihong, Harmange, Jean-Christophe

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Discovery and optimization of a potent and selective triazolopyridinone series of c-Met inhibitors von Bode, Christiane M., Boezio, Alessandro A., Albrecht, Brian K., Bellon, Steven F., Berry, Loren, Broome, Martin A., Choquette, Deborah, Dussault, Isabelle, Lewis, Richard T., Lin, Min-Hwa Jasmine, Rex, Karen, Whittington, Douglas A., Yang, Yajing, Harmange, Jean-Christophe

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