Small molecule inhibition of group I p21-activated kinases in breast cancer induces apoptosis and potentiates the activity of microtubule stabilizing agents von Ong, Christy C, Gierke, Sarah, Pitt, Cameron, Sagolla, Meredith, Cheng, Christine K, Zhou, Wei, Jubb, Adrian M, Strickland, Laura, Schmidt, Maike, Duron, Sergio G, Campbell, David A, Zheng, Wei, Dehdashti, Seameen, Shen, Min, Yang, Nora, Behnke, Mark L, Huang, Wenwei, McKew, John C, Chernoff, Jonathan, Forrest, William F, Haverty, Peter M, Chin, Suet-Feung, Rakha, Emad A, Green, Andrew R, Ellis, Ian O, Caldas, Carlos, O'Brien, Thomas, Friedman, Lori S, Koeppen, Hartmut, Rudolph, Joachim, Hoeflich, Klaus P

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Semisynthetic Cyclopamine Analogues as Potent and Orally Bioavailable Hedgehog Pathway Antagonists von Tremblay, Martin R, Nevalainen, Marta, Nair, Somarajan J, Porter, James R, Castro, Alfredo C, Behnke, Mark L, Yu, Lin-Chen, Hagel, Margit, White, Kerry, Faia, Kerrie, Grenier, Louis, Campbell, Matthew J, Cushing, Jill, Woodward, Caroline N, Hoyt, Jennifer, Foley, Michael A, Read, Margaret A, Sydor, Jens R, Tong, Jeffrey K, Palombella, Vito J, McGovern, Karen, Adams, Julian

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Discovery of a Potent and Orally Active Hedgehog Pathway Antagonist (IPI-926) von Tremblay, Martin R, Lescarbeau, André, Grogan, Michael J, Tan, Eddy, Lin, Grace, Austad, Brian C, Yu, Lin-Chen, Behnke, Mark L, Nair, Somarajan J, Hagel, Margit, White, Kerry, Conley, James, Manna, Joseph D, Alvarez-Diez, Teresa M, Hoyt, Jennifer, Woodward, Caroline N, Sydor, Jens R, Pink, Melissa, MacDougall, John, Campbell, Matthew J, Cushing, Jill, Ferguson, Jeanne, Curtis, Michael S, McGovern, Karen, Read, Margaret A, Palombella, Vito J, Adams, Julian, Castro, Alfredo C

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Indole Cytosolic Phospholipase A2 α Inhibitors: Discovery and in Vitro and in Vivo Characterization of 4-{3-[5-Chloro-2-(2-{[(3,4-dichlorobenzyl)sulfonyl]amino}ethyl)-1-(diphenylme... von McKew, John C, Lee, Katherine L, Shen, Marina W. H, Thakker, Paresh, Foley, Megan A, Behnke, Mark L, Hu, Baihua, Sum, Fuk-Wah, Tam, Steve, Hu, Yonghan, Chen, Lihren, Kirincich, Steven J, Michalak, Ronald, Thomason, Jennifer, Ipek, Manus, Wu, Kun, Wooder, Lane, Ramarao, Manjunath K, Murphy, Elizabeth A, Goodwin, Debra G, Albert, Leo, Xu, Xin, Donahue, Frances, Ku, M. Sherry, Keith, James, Nickerson-Nutter, Cheryl L, Abraham, William M, Williams, Cara, Hegen, Martin, Clark, James D

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Potent and selective inhibitors of the proteasome: Dipeptidyl boronic acids von Adams, Julian, Behnke, Mark, Chen, Shaowu, Cruickshank, Amy A., Dick, Lawrence R., Grenier, Louis, Klunder, Janice M., Ma, Yu-Ting, Plamondon, Louis, Stein, Ross L.

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Development of a Multi Kilogram-Scale, Tandem Cyclopropanation Ring-Expansion Reaction en Route to Hedgehog Antagonist IPI-926 von Austad, Brian C, Hague, Andrew B, White, Priscilla, Peluso, Stéphane, Nair, Somarajan J, Depew, Kristopher M, Grogan, Michael J, Charette, André B, Yu, Lin-Chen, Lory, Caroline D, Grenier, Louis, Lescarbeau, André, Lane, Benjamin S, Lombardy, Richard, Behnke, Mark L, Koney, Nii, Porter, James R, Campbell, Matthew J, Shaffer, Jeanne, Xiong, Jimin, Helble, Joseph C, Foley, Michael A, Adams, Julian, Castro, Alfredo C, Tremblay, Martin R

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Discovery of ecopladib, an indole inhibitor of cytosolic phospholipase A2α von LEE, Katherine L, FOLEY, Megan A, KHOR, Soopeang, XIN XU, GOODWIN, Debra G, RAMARAO, Manjunath K, NICKERSON-NUTTER, Cheryl, DONAHUE, Frances, SHERRY KU, M, DARK, James D, MCKEW, John C, CHEN, Lihren, BEHNKE, Mark L, LOVERING, Frank E, KIRINCICH, Steven J, WEIHENG WANG, SHIM, Jaechul, TAM, Steve, SHEN, Marina W. H

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Inhibition of Cytosolic Phospholipase A2α: Hit to Lead Optimization von McKew, John C, Foley, Megan A, Thakker, Paresh, Behnke, Mark L, Lovering, Frank E, Sum, Fuk-Wah, Tam, Steve, Wu, Kun, Shen, Marina W. H, Zhang, Wen, Gonzalez, Mario, Liu, Shanghao, Mahadevan, Anu, Sard, Howard, Khor, Soo Peang, Clark, James D

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A Novel and Efficient Synthesis of a Highly Active Analogue of clasto-Lactacystin β-Lactone von Soucy, François, Grenier, Louis, Behnke, Mark L, Destree, Antonia T, McCormack, Teresa A, Adams, Julian, Plamondon, Louis

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Benzenesulfonamide indole inhibitors of cytosolic phospholipase A2α : Optimization of in vitro potency and rat pharmacokinetics for oral efficacy von LEE, Katherine L, BEHNKE, Mark L, SHEN, Marina W. H, RAMARAO, Manjunath K, GOODWIN, Debra G, NICKERSON-NUTTER, Cheryl L, ABRAHAM, William M, WILLIAMS, Cara, CLARK, James D, MCKEW, John C, FOLEY, Megan A, CHEN, Lihren, WEIHENG WANG, VARGAS, Richard, NUNEZ, Jill, TAM, Steve, MOLLOVA, Nevena, XIN XU

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Thermodynamic characterization of cytosolic phospholipase A2 alpha inhibitors von Ramarao, Manjunath K, Shen, Marina W H, Murphy, Elizabeth A, Duan, Weili, Zhao, Yajuan, McKew, John, Lee, Katherine L, Thakker, Paresh, Behnke, Mark L, Clark, James D

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In Vivo Efficacy of VT-1129 against Experimental Cryptococcal Meningitis with the Use of a Loading Dose-Maintenance Dose Administration Strategy von Wiederhold, Nathan P, Xu, Xin, Wang, Amy, Najvar, Laura K, Garvey, Edward P, Ottinger, Elizabeth A, Alimardanov, Asaf, Cradock, Jim, Behnke, Mark, Hoekstra, William J, Brand, Stephen R, Schotzinger, Robert J, Jaramillo, Rosie, Olivo, Marcos, Kirkpatrick, William R, Patterson, Thomas F

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Discovery of Ecopladib, an Indole Inhibitor of Cytosolic Phospholipase Α2α von Lee, Katherine L, Foley, Megan A, Chen, Lihren, Behnke, Mark L, Lovering, Frank E, Kirincich, Steven J, Wang, Weiheng, Shim, Jaechul, Tam, Steve, Shen, Marina W. H, Khor, SooPeang, Xu, Xin, Goodwin, Debra G, Ramarao, Manjunath K, Nickerson-Nutter, Cheryl, Donahue, Frances, Ku, M. Sherry, Clark, James D, McKew, John C

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The Fungal Cyp51 Inhibitor VT-1129 Is Efficacious in an Experimental Model of Cryptococcal Meningitis von Wiederhold, Nathan P, Najvar, Laura K, Garvey, Edward P, Brand, Stephen R, Xu, Xin, Ottinger, Elizabeth A, Alimardanov, Asaf, Cradock, Jim, Behnke, Mark, Hoekstra, William J, Schotzinger, Robert J, Jaramillo, Rosie, Olivo, Marcos, Kirkpatrick, William R, Patterson, Thomas F

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Novel non-nucleoside inhibitors of HIV-1 reverse transcriptase. 2. Tricyclic pyridobenzoxazepinones and dibenzoxazepinones von Klunder, Janice M, Hargrave, Karl D, West, MaryAnn, Cullen, Ernest, Pal, Kollol, Behnke, Mark L, Kapadia, Suresh R, McNeil, Daniel W, Wu, Joe C, Chow, Grace C, Adams, Julian

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A general allylation procedure using trimethylallylsilane and fluoride catalysis von Majetich, George, Casares, Ada, Chapman, David, Behnke, Mark

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Synthesis and activity of quinolinylmethyl P1′ α-sulfone piperidine hydroxamate inhibitors of TACE von Zhang, Chunchun, Lovering, Frank, Behnke, Mark, Zask, Arie, Sandanayaka, Vincent, Sun, Linhong, Zhu, Yi, Xu, Weixin, Zhang, Yuhua, Levin, Jeremy I.

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Thermodynamic characterization of cytosolic phospholipase A 2 alpha inhibitors von Ramarao, Manjunath K., Shen, Marina W.H., Murphy, Elizabeth A., Duan, Weili, Zhao, Yajuan, McKew, John, Lee, Katherine L., Thakker, Paresh, Behnke, Mark L., Clark, James D.

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Indole Cytosolic Phospholipase A 2 α Inhibitors: Discovery and in Vitro and in Vivo Characterization of 4-{3-[5-Chloro-2-(2-{[(3,4-dichlorobenzyl)sulfonyl]amino}ethyl)-1-(diphenylm... von McKew, John C., Lee, Katherine L., Shen, Marina W. H., Thakker, Paresh, Foley, Megan A., Behnke, Mark L., Hu, Baihua, Sum, Fuk-Wah, Tam, Steve, Hu, Yonghan, Chen, Lihren, Kirincich, Steven J., Michalak, Ronald, Thomason, Jennifer, Ipek, Manus, Wu, Kun, Wooder, Lane, Ramarao, Manjunath K., Murphy, Elizabeth A., Goodwin, Debra G., Albert, Leo, Xu, Xin, Donahue, Frances, Ku, M. Sherry, Keith, James, Nickerson-Nutter, Cheryl L., Abraham, William M., Williams, Cara, Hegen, Martin, Clark, James D.

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Benzenesulfonamide indole inhibitors of cytosolic phospholipase A 2α: Optimization of in vitro potency and rat pharmacokinetics for oral efficacy von Lee, Katherine L., Behnke, Mark L., Foley, Megan A., Chen, Lihren, Wang, Weiheng, Vargas, Richard, Nunez, Jill, Tam, Steve, Mollova, Nevena, Xu, Xin, Shen, Marina W.H., Ramarao, Manjunath K., Goodwin, Debra G., Nickerson-Nutter, Cheryl L., Abraham, William M., Williams, Cara, Clark, James D., McKew, John C.

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