Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers von Mullarky, Edouard, Lucki, Natasha C., Zavareh, Reza Beheshti, Anglin, Justin L., Gomes, Ana P., Nicolay, Brandon N., Wong, Jenny C. Y., Christen, Stefan, Takahashi, Hidenori, Singh, Pradeep K., Blenis, John, Warren, J. David, Fendt, Sarah-Maria, Asara, John M., DeNicola, Gina M., Lyssiotis, Costas A., Lairson, Luke L., Cantley, Lewis C.

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The ubiquitin-activating enzyme E1 as a therapeutic target for the treatment of leukemia and multiple myeloma von Xu, G. Wei, Ali, Mohsin, Wood, Tabitha E., Wong, Derek, Maclean, Neil, Wang, Xiaoming, Gronda, Marcela, Skrtic, Marko, Li, Xiaoming, Hurren, Rose, Mao, Xinliang, Venkatesan, Meenakshi, Zavareh, Reza Beheshti, Ketela, Troy, Reed, John C., Rose, David, Moffat, Jason, Batey, Robert A., Dhe-Paganon, Sirano, Schimmer, Aaron D.

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The antihelmintic flubendazole inhibits microtubule function through a mechanism distinct from Vinca alkaloids and displays preclinical activity in leukemia and myeloma von Spagnuolo, Paul A., Hu, Jiayi, Hurren, Rose, Wang, Xiaoming, Gronda, Marcela, Sukhai, Mahadeo A., Di Meo, Ashley, Boss, Jonathan, Ashali, Iman, Beheshti Zavareh, Reza, Fine, Noah, Simpson, Craig D., Sharmeen, Sumaiya, Rottapel, Rob, Schimmer, Aaron D.

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Inhibition of the Sodium Potassium Adenosine Triphosphatase Pump Sensitizes Cancer Cells to Anoikis and Prevents Distant Tumor Formation von SIMPSON, Craig D, MAWJI, Imtiaz A, BEHESHTI ZAVAREH, Reza, DATTI, Alessandro, WRANA, Jeffrey L, EZZAT, Shereen, SCHIMMER, Aaron D, ANYIWE, Kika, WILLIAMS, Moyo A, XIAOMING WANG, VENUGOPAL, Amudha L, GRONDA, Marcela, HURREN, Rose, CHENG, Sonia, SERRA, Stefano

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Suppression of cancer progression by MGAT1 shRNA knockdown von Beheshti Zavareh, Reza, Sukhai, Mahadeo A, Hurren, Rose, Gronda, Marcela, Wang, Xiaoming, Simpson, Craig D, Maclean, Neil, Zih, Francis, Ketela, Troy, Swallow, Carol J, Moffat, Jason, Rose, David R, Schachter, Harry, Schimmer, Aaron D, Dennis, James W

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JAK inhibition enhances checkpoint blockade immunotherapy in patients with Hodgkin lymphoma von Zak, Jaroslav, Pratumchai, Isaraphorn, Marro, Brett S, Marquardt, Kristi L, Zavareh, Reza Beheshti, Lairson, Luke L, Oldstone, Michael B A, Varner, Judith A, Hegerova, Livia, Cao, Qing, Farooq, Umar, Kenkre, Vaishalee P, Bachanova, Veronika, Teijaro, John R

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Inhibition of the sodium/potassium ATPase impairs N-glycan expression and function von Beheshti Zavareh, Reza, Lau, Ken S, Hurren, Rose, Datti, Alessandro, Ashline, David J, Gronda, Marcela, Cheung, Pam, Simpson, Craig D, Liu, Wei, Wasylishen, Amanda R, Boutros, Paul C, Shi, Hui, Vengopal, Amudha, Jurisica, Igor, Penn, Linda Z, Reinhold, Vern N, Ezzat, Shereen, Wrana, Jeff, Rose, David R, Schachter, Harry, Dennis, James W, Schimmer, Aaron D

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Biochemical Characterization and Structure-Based Mutational Analysis Provide Insight into the Binding and Mechanism of Action of Novel Aspartate Aminotransferase Inhibitors von Holt, Melissa C, Assar, Zahra, Beheshti Zavareh, Reza, Lin, Lin, Anglin, Justin, Mashadova, Oksana, Haldar, Daniel, Mullarky, Edouard, Kremer, Daniel M, Cantley, Lewis C, Kimmelman, Alec C, Stein, Adam J, Lairson, Luke L, Lyssiotis, Costas A

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Discovery of Small Molecules for the Reversal of T Cell Exhaustion von Marro, Brett S., Zak, Jaroslav, Zavareh, Reza Beheshti, Teijaro, John R., Lairson, Luke L., Oldstone, Michael B.A.

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Protocol for high-throughput compound screening using flow cytometry in THP-1 cells von Spangenberg, Stephan H., Zavareh, Reza Beheshti, Lairson, Luke L.

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Molecular characterization of type I IFN-induced cytotoxicity in bladder cancer cells reveals biomarkers of resistance von Green, Jennifer L., Osterhout, Robin E., Klova, Amy L., Merkwirth, Carsten, McDonnell, Scott R.P., Zavareh, Reza Beheshti, Fuchs, Bryan C., Kamal, Adeela, Jakobsen, Jørn S.

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Cyproheptadine displays preclinical activity in myeloma and leukemia von Mao, Xinliang, Liang, Sheng-ben, Hurren, Rose, Gronda, Marcela, Chow, Sue, Xu, G. Wei, Wang, Xiaoming, Zavareh, Reza Beheshti, Jamal, Nazir, Messner, Hans, Hedley, David W., Datti, Alessandro, Wrana, Jeff L., Zhu, Yuanxiao, Shi, Chang-xin, Lee, Kyle, Tiedemann, Rodger, Trudel, Suzanne, Stewart, A. Keith, Schimmer, Aaron D.

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HSP90 Inhibition Enhances Cancer Immunotherapy by Modulating the Surface Expression of Multiple Immune Checkpoint Proteins von Zavareh, Reza Beheshti, Spangenberg, Stephan H., Woods, Ashley, Martínez-Peña, Francisco, Lairson, Luke L.

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novel diquinolonium displays preclinical anti-cancer activity and induces caspase-independent cell death von Hurren, Rose, Zavareh, Reza Beheshti, Dalili, Shadi, Wood, Tabitha, Rose, David, Chang, Hong, Jamal, Nazir, Messner, Hans, Batey, Robert A, Schimmer, Aaron D

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Reversing T cell Exhaustion Through Discovery of Small Molecules von Marro, Brett S., Zavareh, Reza Beheshti, Teijaro, John R., Lairson, Luke L., Oldstone, Michael B.A.

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Discovery and optimization of aspartate aminotransferase 1 inhibitors to target redox balance in pancreatic ductal adenocarcinoma von Anglin, Justin, Zavareh, Reza Beheshti, Sander, Philipp N., Haldar, Daniel, Mullarky, Edouard, Cantley, Lewis C., Kimmelman, Alec C., Lyssiotis, Costas A., Lairson, Luke L.

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Discovery and Development of a Selective Inhibitor of the ER Resident Chaperone Grp78 von Ambrose, Andrew J., Sivinski, Jared, Zerio, Christopher J., Zhu, Xiaoyi, Godek, Jack, Kumirov, Vlad K., Coma Brujas, Teresa, Torra Garcia, Joan, Annadurai, Anandhan, Schmidlin, Cody J., Werner, Alyssa, Shi, Taoda, Zavareh, Reza Beheshti, Lairson, Luke, Zhang, Donna D., Chapman, Eli

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Identification of small-molecule protein-protein interaction inhibitors for NKG2D von Thompson, Aaron A, Harbut, Michael B, Kung, Pei-Pei, Karpowich, Nathan K, Branson, Jeffrey D, Grant, Joanna C, Hagan, Deborah, Pascual, Heather A, Bai, Guoyun, Zavareh, Reza Beheshti, Coate, Heather R, Collins, Bernard C, Côte, Marjorie, Gelin, Christine F, Damm-Ganamet, Kelly L, Gholami, Hadi, Huff, Adam R, Limon, Luis, Lumb, Kevin J, Mak, Puiying A, Nakafuku, Kohki M, Price, Edmund V, Shih, Amy Y, Tootoonchi, Mandana, Vellore, Nadeem A, Wang, Jocelyn, Wei, Na, Ziff, Jeannie, Berger, Scott B, Edwards, James P, Gardet, Agnès, Sun, Siquan, Towne, Jennifer E, Venable, Jennifer D, Shi, Zhicai, Venkatesan, Hariharan, Rives, Marie-Laure, Sharma, Sujata, Shireman, Brock T, Allen, Samantha J

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Abstract 1484: Inhibition of the glycosylation enzyme Mgat1 blocks migration, invasion and metastasis of malignant cells von Zavareh, Reza Beheshti, Hurren, Rose, Gronda, Marcela, Sukhai, Mahadeo A., Simpson, Craig D., Wang, Xiaoming, MacLean, Neil A., Ketela, Troy, Moffat, Jason, Rose, David R., Schachter, Harry, Dennis, James W., Schimmer, Aaron D.

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Eyelid masses: A 10-year survey from a tertiary eye hospital in Tehran von Bagheri, Abbas, Tavakoli, Mehdi, Kanaani, Azadeh, Zavareh, Reza, Esfandiari, Hamed, Aletaha, Maryam, Salour, Hossein

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