Targeting the Hsp40/Hsp70 Chaperone Axis as a Novel Strategy to Treat Castration-Resistant Prostate Cancer von Moses, Michael A, Kim, Yeong Sang, Rivera-Marquez, Genesis M, Oshima, Nobu, Watson, Matthew J, Beebe, Kristin E, Wells, Catherine, Lee, Sunmin, Zuehlke, Abbey D, Shao, Hao, Bingman, 3rd, William E, Kumar, Vineet, Malhotra, Sanjay V, Weigel, Nancy L, Gestwicki, Jason E, Trepel, Jane B, Neckers, Leonard M

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HSP90 inhibitors disrupt a transient HSP90-HSF1 interaction and identify a noncanonical model of HSP90-mediated HSF1 regulation von Kijima, Toshiki, Prince, Thomas L., Tigue, Megan L., Yim, Kendrick H., Schwartz, Harvey, Beebe, Kristin, Lee, Sunmin, Budzynski, Marek A., Williams, Heinric, Trepel, Jane B., Sistonen, Lea, Calderwood, Stuart, Neckers, Len

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Molecular chaperone TRAP1 regulates a metabolic switch between mitochondrial respiration and aerobic glycolysis von Yoshida, Soichiro, Tsutsumi, Shinji, Muhlebach, Guillaume, Sourbier, Carole, Lee, Min-Jung, Lee, Sunmin, Vartholomaiou, Evangelia, Tatokoro, Manabu, Beebe, Kristin, Miyajima, Naoto, Mohney, Robert P, Chen, Yang, Hasumi, Hisashi, Xu, Wanping, Fukushima, Hiroshi, Nakamura, Ken, Koga, Fumitaka, Kihara, Kazunori, Trepel, Jane, Picard, Didier, Neckers, Leonard

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The mitochondrial HSP90 paralog TRAP1 forms an OXPHOS-regulated tetramer and is involved in mitochondrial metabolic homeostasis von Joshi, Abhinav, Dai, Li, Liu, Yanxin, Lee, Jungsoon, Ghahhari, Nastaran Mohammadi, Segala, Gregory, Beebe, Kristin, Jenkins, Lisa M, Lyons, Gaelyn C, Bernasconi, Lilia, Tsai, Francis T F, Agard, David A, Neckers, Len, Picard, Didier

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Hsp90 middle domain phosphorylation initiates a complex conformational program to recruit the ATPase-stimulating cochaperone Aha1 von Xu, Wanping, Beebe, Kristin, Chavez, Juan D., Boysen, Marta, Lu, YinYing, Zuehlke, Abbey D., Keramisanou, Dimitra, Trepel, Jane B., Prodromou, Christosomos, Mayer, Matthias P., Bruce, James E., Gelis, Ioannis, Neckers, Len

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An Acetylation Site in the Middle Domain of Hsp90 Regulates Chaperone Function von Scroggins, Bradley T., Robzyk, Kenneth, Wang, Dongxia, Marcu, Monica G., Tsutsumi, Shinji, Beebe, Kristin, Cotter, Robert J., Felts, Sara, Toft, David, Karnitz, Larry, Rosen, Neal, Neckers, Len

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Combinatorial drug design targeting multiple cancer signaling networks controlled by mitochondrial Hsp90 von Kang, Byoung Heon, Plescia, Janet, Song, Ho Young, Meli, Massimiliano, Colombo, Giorgio, Beebe, Kristin, Scroggins, Bradley, Neckers, Len, Altieri, Dario C

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Phosphorylation induced cochaperone unfolding promotes kinase recruitment and client class-specific Hsp90 phosphorylation von Bachman, Ashleigh B., Keramisanou, Dimitra, Xu, Wanping, Beebe, Kristin, Moses, Michael A., Vasantha Kumar, M. V., Gray, Geoffrey, Noor, Radwan Ebna, van der Vaart, Arjan, Neckers, Len, Gelis, Ioannis

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Activation of Hsp90 Enzymatic Activity and Conformational Dynamics through Rationally Designed Allosteric Ligands von Sattin, Sara, Tao, Jiahui, Vettoretti, Gerolamo, Moroni, Elisabetta, Pennati, Marzia, Lopergolo, Alessia, Morelli, Laura, Bugatti, Antonella, Zuehlke, Abbey, Moses, Mike, Prince, Thomas, Kijima, Toshiki, Beebe, Kristin, Rusnati, Marco, Neckers, Len, Zaffaroni, Nadia, Agard, David A., Bernardi, Anna, Colombo, Giorgio

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Client Proteins and Small Molecule Inhibitors Display Distinct Binding Preferences for Constitutive and Stress-Induced HSP90 Isoforms and Their Conformationally Restricted Mutants von Prince, Thomas L, Kijima, Toshiki, Tatokoro, Manabu, Lee, Sunmin, Tsutsumi, Shinji, Yim, Kendrick, Rivas, Candy, Alarcon, Sylvia, Schwartz, Harvey, Khamit-Kush, Kofi, Scroggins, Bradley T, Beebe, Kristin, Trepel, Jane B, Neckers, Len

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An Hsp90 co-chaperone protein in yeast is functionally replaced by site-specific posttranslational modification in humans von Zuehlke, Abbey D., Reidy, Michael, Lin, Coney, LaPointe, Paul, Alsomairy, Sarah, Lee, D. Joshua, Rivera-Marquez, Genesis M., Beebe, Kristin, Prince, Thomas, Lee, Sunmin, Trepel, Jane B., Xu, Wanping, Johnson, Jill, Masison, Daniel, Neckers, Len

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Pharmacologic dissection of the overlapping impact of heat shock protein family members on platelet function von Jackson, Joseph W., Rivera‐Marquez, Genesis M., Beebe, Kristin, Tran, Andy D., Trepel, Jane B., Gestwicki, Jason E., Blagg, Brian S. J., Ohkubo, Shuichi, Neckers, Leonard M.

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Mps1 Mediated Phosphorylation of Hsp90 Confers Renal Cell Carcinoma Sensitivity and Selectivity to Hsp90 Inhibitors von Woodford, Mark R., Truman, Andrew W., Dunn, Diana M., Jensen, Sandra M., Cotran, Richard, Bullard, Renee, Abouelleil, Mourad, Beebe, Kristin, Wolfgeher, Donald, Wierzbicki, Sara, Post, Dawn E., Caza, Tiffany, Tsutsumi, Shinji, Panaretou, Barry, Kron, Stephen J., Trepel, Jane B., Landas, Steve, Prodromou, Chrisostomos, Shapiro, Oleg, Stetler-Stevenson, William G., Bourboulia, Dimitra, Neckers, Len, Bratslavsky, Gennady, Mollapour, Mehdi

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Combined HSP90 and kinase inhibitor therapy: Insights from The Cancer Genome Atlas von Schwartz, Harvey, Scroggins, Brad, Zuehlke, Abbey, Kijima, Toshiki, Beebe, Kristin, Mishra, Alok, Neckers, Len, Prince, Thomas

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Azaspirene, a fungal product, inhibits angiogenesis by blocking Raf‐1 activation von Asami, Yukihiro, Kakeya, Hideaki, Komi, Yusuke, Kojima, Soichi, Nishikawa, Kiyohiro, Beebe, Kristin, Neckers, Len, Osada, Hiroyuki

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Loss of Hsp90 Association Up-Regulates Src-Dependent ErbB2 Activity von Xu, Wanping, Yuan, Xitong, Beebe, Kristin, Xiang, Zhexin, Neckers, Len

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Integration of gene dosage and gene expression in non-small cell lung cancer, identification of HSP90 as potential target von Gallegos Ruiz, Mariëlle I, Floor, Karijn, Roepman, Paul, Rodriguez, José A, Meijer, Gerrit A, Mooi, Wolter J, Jassem, Ewa, Niklinski, Jacek, Muley, Thomas, van Zandwijk, Nico, Smit, Egbert F, Beebe, Kristin, Neckers, Len, Ylstra, Bauke, Giaccone, Giuseppe

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Calcium‐dependent inhibition of polo‐like kinase 3 activity by CIB1 in breast cancer cells von Naik, Meghna U., Pham, Ngoc T., Beebe, Kristin, Dai, Wei, Naik, Ulhas P.

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Regulation and function of the human HSP90AA1 gene von Zuehlke, Abbey D., Beebe, Kristin, Neckers, Len, Prince, Thomas

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Divergent Synthesis of a Pochonin Library Targeting HSP90 and In Vivo Efficacy of an Identified Inhibitor von Barluenga, Sofia, Wang, Cuihua, Fontaine, Jean-Gonzague, Aouadi, Kaïss, Beebe, Kristin, Tsutsumi, Shinji, Neckers, Len, Winssinger, Nicolas

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