Submicron Size Particles of a Murine Monoclonal Antibody Are More Immunogenic Than Soluble Oligomers or Micron Size Particles Upon Subcutaneous Administration in Mice von Kijanka, Grzegorz, Bee, Jared S., Korman, Samuel A., Wu, Yuling, Roskos, Lorin K., Schenerman, Mark A., Slütter, Bram, Jiskoot, Wim

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Gelation of a Monoclonal Antibody at the Silicone Oil–Water Interface and Subsequent Rupture of the Interfacial Gel Results in Aggregation and Particle Formation von Mehta, Shyam B., Lewus, Rachael, Bee, Jared S., Randolph, Theodore W., Carpenter, John F.

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Development of a stable lyophilized adeno-associated virus gene therapy formulation von Zhang, Yu (Zoe), DePaz, Roberto A., Bee, Jared S., Marshall, Tristan

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Comparative Thermodynamics of the Reversible Self-Association of Therapeutic mAbs Reveal Opposing Roles for Linked Proton- and Ion-Binding Events von Hopkins, Mandi M., Antonopoulos, Ioanna H., Parupudi, Arun, Bee, Jared S., Bain, David L.

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Protein Aggregation and Particle Formation in Prefilled Glass Syringes von Gerhardt, Alana, Mcgraw, Nicole R., Schwartz, Daniel K., Bee, Jared S., Carpenter, John F., Randolph, Theodore W.

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Quantitation of Trace Levels of DNA Released from Disrupted Adeno-Associated Virus Gene Therapy Vectors von Bee, Jared S., O'Berry, Kristin, Zhang, Yu (Zoe), Phillippi, Megan Kuhn, Kaushal, Akanksha, DePaz, Roberto A., Marshall, Tristan

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Structural insights into the mechanism of action of a biparatopic anti-HER2 antibody von Oganesyan, Vaheh, Peng, Li, Bee, Jared S., Li, John, Perry, Samuel R., Comer, Frank, Xu, Linda, Cook, Kimberly, Senthil, Kannaki, Clarke, Lori, Rosenthal, Kim, Gao, Changshou, Damschroder, Melissa, Wu, Herren, Dall’Acqua, William

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Trace levels of the CHO host cell protease cathepsin D caused particle formation in a monoclonal antibody product von Bee, Jared S., Tie, Liu, Johnson, Douglas, Dimitrova, Mariana N., Jusino, Kristin C., Afdahl, Christopher D.

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Effects of Surfaces and Leachables on the Stability of Biopharmaceuticals von Bee, Jared S., Randolph, Theodore W., Carpenter, John F., Bishop, Steven M., Dimitrova, Mariana N.

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Impact of Time Out of Intended Storage and Freeze-thaw Rates on the Stability of Adeno-associated Virus 8 and 9 von Bee, Jared S., Zhang, Yu (Zoe), Phillippi, Megan Kuhn, Finkner, Sheyla, Mezghebe, Tesfu, Webber, Keith, Cheung, Win Den, Marshall, Tristan

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Mechanistic Studies and Formulation Mitigations of Adeno-associated Virus Capsid Rupture During Freezing and Thawing: Mechanisms of Freeze/Thaw Induced AAV Rupture von Bee, Jared S, Zhang, Yu, Finkner, Sheyla, O'Berry, Kristin, Kaushal, Akanksha, Phillippi, Megan Kuhn, DePaz, Roberto A, Webber, Keith, Marshall, Tristan

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Ionic Strength Affects Tertiary Structure and Aggregation Propensity of a Monoclonal Antibody Adsorbed to Silicone Oil–Water Interfaces von Gerhardt, Alana, Bonam, Kurt, Bee, Jared S., Carpenter, John F., Randolph, Theodore W.

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Response of a concentrated monoclonal antibody formulation to high shear von Bee, Jared S, Stevenson, Jennifer L, Mehta, Bhavya, Svitel, Juraj, Pollastrini, Joey, Platz, Robert, Freund, Erwin, Carpenter, John F, Randolph, Theodore W

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Monoclonal Antibody Dimers Induced by Low pH, Heat, or Light Exposure Are Not Immunogenic Upon Subcutaneous Administration in a Mouse Model von Kijanka, Grzegorz, Bee, Jared S., Schenerman, Mark A., Korman, Samuel A., Wu, Yuling, Slütter, Bram, Jiskoot, Wim

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Energetic Dissection of Mab-Specific Reversible Self-Association Reveals Unique Thermodynamic Signatures von Hopkins, Mandi M., Parupudi, Arun, Bee, Jared S., Bain, David L.

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Generation and Characterization of an IgG4 Monomeric Fc Platform von Shan, Lu, Colazet, Magali, Rosenthal, Kim L, Yu, Xiang-Qing, Bee, Jared S, Ferguson, Andrew, Damschroder, Melissa M, Wu, Herren, Dall'Acqua, William F, Tsui, Ping, Oganesyan, Vaheh

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Determination of Interaction Parameters for Reversibly Self-Associating Antibodies: A Comparative Analysis von Hopkins, Mandi M., Lambert, Cherie L., Bee, Jared S., Parupudi, Arun, Bain, David L.

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Analytical characterization of coformulated antibodies as combination therapy von Kim, Jun, Kim, Yoen Joo, Cao, Mingyan, De Mel, Niluka, Albarghouthi, Methal, Miller, Kenneth, Bee, Jared S, Wang, Jihong, Wang, Xiangyang

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Aggregation of a monoclonal antibody induced by adsorption to stainless steel von Bee, Jared S, Davis, Michele, Freund, Erwin, Carpenter, John F, Randolph, Theodore W

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The future of protein particle characterization and understanding its potential to diminish the immunogenicity of biopharmaceuticals: A shared perspective von Bee, Jared S., Goletz, Theresa J., Ragheb, Jack A.

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