Identification and Characterization of MEDI4736, an Antagonistic Anti-PD-L1 Monoclonal Antibody von Stewart, Ross, Morrow, Michelle, Hammond, Scott A, Mulgrew, Kathy, Marcus, Danielle, Poon, Edmund, Watkins, Amanda, Mullins, Stefanie, Chodorge, Matthieu, Andrews, John, Bannister, David, Dick, Emily, Crawford, Nicola, Parmentier, Julie, Alimzhanov, Marat, Babcook, John S, Foltz, Ian N, Buchanan, Andrew, Bedian, Vahe, Wilkinson, Robert W, McCourt, Matthew

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A Human Monoclonal Anti-ANG2 Antibody Leads to Broad Antitumor Activity in Combination with VEGF Inhibitors and Chemotherapy Agents in Preclinical Models von Brown, Jeffrey L, Cao, Z Alexander, Pinzon-Ortiz, Maria, Kendrew, Jane, Reimer, Corinne, Wen, Shenghua, Zhou, Joe Q, Tabrizi, Mohammad, Emery, Steve, McDermott, Brenda, Pablo, Lourdes, McCoon, Patricia, Bedian, Vahe, Blakey, David C

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Engineering a therapeutic IgG molecule to address cysteinylation, aggregation and enhance thermal stability and expression von Buchanan, Andrew, Clementel, Veronica, Woods, Rob, Harn, Nicholas, Bowen, Michael A, Mo, Wenjun, Popovic, Bojana, Bishop, Steven M., Dall'Acqua, William, Minter, Ralph, Jermutus, Lutz, Bedian, Vahe

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MEDI0639: a novel therapeutic antibody targeting Dll4 modulates endothelial cell function and angiogenesis in vivo von Jenkins, David W, Ross, Sarah, Veldman-Jones, Margaret, Foltz, Ian N, Clavette, Brandon C, Manchulenko, Kathy, Eberlein, Cath, Kendrew, Jane, Petteruti, Philip, Cho, Song, Damschroder, Melissa, Peng, Li, Baker, Dawn, Smith, Neil R, Weir, Hazel M, Blakey, David C, Bedian, Vahe, Barry, Simon T

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6580 Inhibition of IGF-1 Receptor Signaling and Ocular Fibroblast Cell Growth by VRDN-001 vs Teprotumumab von Newell, Rachel, Nguyen, Tricia, Bedian, Vahe

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Neuroanatomical studies of period gene expression in the hawkmoth, Manduca sexta von Wise, Sarah, Davis, Norman T., Tyndale, Elizabeth, Noveral, Jocelyne, Folwell, Mary Grace, Bedian, Vahe, Emery, Ivette F., Siwicki, Kathleen K.

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Phase 1 Safety and Pharmacodynamic Results of VRDN-001, a Full Antagonist Antibody to the Insulin-Like Growth Factor-1 Receptor (IGF-1R) in Development for Thyroid Eye Disease (TED... von She, Angela, Katz, Barrett, Summerfelt, Rochelle, O’Shaughnessy, Denis, Dickinson, Brent, Foster, Kelly, Bedian, Vahe

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The CD40 agonist antibody CP-870,893 enhances dendritic cell and B-cell activity and promotes anti-tumor efficacy in SCID-hu mice von GLADUE, Ronald P, PARADIS, Timothy, BEDIAN, Vahe, COLE, Susan H, DONOVAN, Carol, NELSON, Robin, ALPERT, Robbin, GARDNER, Joe, NATOLI, Ed, ELLIOTT, Eileen, SHEPARD, Richard

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QLS-215 is a Long-Acting Monoclonal Antibody Plasma Kallikrein Inhibitor in Development for Treatment of HAE von Bista, Pradeep, Kiselak, Tomas, Harwin, Peter, Violin, Jonathan, Omer, Charles, Bedian, Vahe

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STAR-0215 is a Novel, Long-Acting Monoclonal Antibody Inhibitor of Plasma Kallikrein for the Potential Treatment of Hereditary Angioedema von Bedian, Vahe, Biris, Nikolaos, Omer, Charles, Chung, Jou-Ku, Fuller, James, Dagher, Rafif, Chandran, Sachin, Harwin, Peter, Kiselak, Tomas, Violin, Jonathan, Nichols, Andrew, Bista, Pradeep

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OR26-02 VRDN-001, A Full Antagonist Antibody To IGF-1 Receptor In Development For Thyroid Eye Disease (TED), Binds To A Distinct Epitope From Teprotumumab von Bedian, Vahe, Tsai, Jordan C, Newell, Rachel N, Zhao, Yang

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Biochemical and pharmacological characterization of human c-Met neutralizing monoclonal antibody CE-355621 von Michaud, Neil R., Jani, Jitesh P., Hillerman, Stephen, Tsaparikos, Konstantinos E., Barbacci-Tobin, Elsa G., Knauth, Elisabeth, Putz Jr, Henry, Campbell, Mary, Karam, George A., Chrunyk, Boris, Gebhard, David F., Green, Larry L., Xu, Jinghai J., Dunn, Margaret C., Coskran, Tim M., Lapointe, Jean-Martin, Cohen, Bruce D., Coleman, Kevin G., Bedian, Vahe, Vincent, Patrick, Kajiji, Shama, Steyn, Stefan J., Borzillo, Gary V., Los, Gerrit

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6461 VRDN-003, a Full Antagonist Antibody to the IGF-1 Receptor for Thyroid Eye Disease (TED): Safety and Pharmacokinetic Results of Subcutaneous Administration in Healthy Voluntee... von Foster, Kelly, Dickinson, Brent, Matthew, Abiola, Vijayaraghavan, Jyothi, Michalsky, Cathy, Bedian, Vahe

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6461 VRDN-003, A Full Antagonist Antibody To The IGF-1 Receptor For Thyroid Eye Disease (TED): Safety And Pharmacokinetic Results Of Subcutaneous Administration In Healthy Voluntee... von Foster, Kelly, Dickinson, Brent, Matthew, Abiola, Vijayaraghavan, Jyothi, Michalsky, Cathy, Bedian, Vahe

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FRI546 VRDN-001, A Full Antagonist Antibody To IGF-1 Receptor In Development For Thyroid Eye Disease (TED): Pharmacodynamic Responses In Healthy Volunteers And Patients With Active... von Foster, Kelly, Dickinson, Brent A, Summerfelt, Rochelle M, She, Angela, Bedian, Vahe, Katz, Barrett

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Structure–Cytotoxicity Relationships of Analogues of N 14-Desacetoxytubulysin H von Toader, Dorin, Wang, Fengjiang, Gingipalli, Lakshmaiah, Vasbinder, Melissa, Roth, Mark, Mao, Shenlan, Block, Michael, Harper, Jay, Thota, Sambaiah, Su, Mei, Ma, Jianquo, Bedian, Vahe, Kamal, Adeela

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Rump white Inversion in the Mouse Disrupts Dipeptidyl Aminopeptidase-Like Protein 6 and Causes Dysregulation of Kit Expression von Hough, R. Barry, Lengeling, Andreas, Bedian, Vahe, Lo, Cecilia, Bucan, Maja

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Phenotypic screening reveals TNFR2 as a promising target for cancer immunotherapy von Williams, Geoffrey S, Mistry, Bina, Guillard, Sandrine, Ulrichsen, Jane Coates, Sandercock, Alan M, Wang, Jun, González-Muñoz, Andrea, Parmentier, Julie, Black, Chelsea, Soden, Jo, Freeth, Jim, Jovanović, Jelena, Leyland, Rebecca, Al-Lamki, Rafia S, Leishman, Andrew J, Rust, Steven J, Stewart, Ross, Jermutus, Lutz, Bradley, John R, Bedian, Vahe, Valge-Archer, Viia, Minter, Ralph, Wilkinson, Robert W

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The CD40 agonist antibody CP-870,893 enhances dendritic cell and B-cell activity and promotes anti-tumor efficacy in SCID-hu mice von Gladue, Ronald P., Paradis, Timothy, Cole, Susan H., Donovan, Carol, Nelson, Robin, Alpert, Robbin, Gardner, Joe, Natoli, Ed, Elliott, Eileen, Shepard, Richard, Bedian, Vahe

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ANTIBODIES THAT BIND TO C1S AND USES THEREOF von BEDIAN, Vahe

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