The JAK2 Inhibitor AZD1480 Potently Blocks Stat3 Signaling and Oncogenesis in Solid Tumors von Hedvat, Michael, Huszar, Dennis, Herrmann, Andreas, Gozgit, Joseph M., Schroeder, Anne, Sheehy, Adam, Buettner, Ralf, Proia, David, Kowolik, Claudia M., Xin, Hong, Armstrong, Brian, Bebernitz, Geraldine, Weng, Shaobu, Wang, Lin, Ye, Minwei, McEachern, Kristen, Chen, Huawei, Morosini, Deborah, Bell, Kirsten, Alimzhanov, Marat, Ioannidis, Stephanos, McCoon, Patricia, Cao, Zhu A., Yu, Hua, Jove, Richard, Zinda, Michael

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The Effect of 1,3-Diaryl-[1H]-pyrazole-4-acetamides on Glucose Utilization in ob/ob Mice von Bebernitz, Gregory R, Argentieri, Greg, Battle, Beverly, Brennan, Christine, Balkan, Bork, Burkey, Bryan F, Eckhardt, Michele, Gao, Jiaping, Kapa, Prasad, Strohschein, Robert J, Schuster, Herbert F, Wilson, Mary, Xu, David D

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Abstract A31: Comparing IL-12 and IL-18 secreting CAR T-cell efficacy von Bebernitz, Christina E., Brentjens, Renier J.

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Excessive Costimulation Leads to Dysfunction of Adoptively Transferred T Cells von Wijewarnasuriya, Dinali, Bebernitz, Christina, Lopez, Andrea V, Rafiq, Sarwish, Brentjens, Renier J

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Effects of the JAK2 Inhibitor, AZ960, on Pim/BAD/BCL-xL Survival Signaling in the Human JAK2 V617F Cell Line SET-2 von Gozgit, Joseph M., Bebernitz, Geraldine, Patil, Pankaj, Ye, Minwei, Parmentier, Julie, Wu, Jiaquan, Su, Nancy, Wang, Tao, Ioannidis, Stephanos, Davies, Audrey, Huszar, Dennis, Zinda, Michael

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Discovery of (2R)‑N‑[3-[2-[(3-Methoxy-1-methyl-pyrazol-4-yl)amino]pyrimidin-4-yl]‑1H‑indol-7-yl]-2-(4-methylpiperazin-1-yl)propenamide (AZD4205) as a Potent and Selective Janus Kin... von Su, Qibin, Banks, Erica, Bebernitz, Geraldine, Bell, Kirsten, Borenstein, Cassandra F, Chen, Huawei, Chuaqui, Claudio E, Deng, Nanhua, Ferguson, Andrew D, Kawatkar, Sameer, Grimster, Neil P, Ruston, Linette, Lyne, Paul D, Read, Jon A, Peng, Xianyou, Pei, Xiaohui, Fawell, Stephen, Tang, Zhanlei, Throner, Scott, Vasbinder, Melissa M, Wang, Haoyu, Winter-Holt, Jon, Woessner, Richard, Wu, Allan, Yang, Wenzhan, Zinda, Michael, Kettle, Jason G

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Investigation of Functionally Liver Selective Glucokinase Activators for the Treatment of Type 2 Diabetes von Bebernitz, Gregory R, Beaulieu, Valerie, Dale, Bethany A, Deacon, Richard, Duttaroy, Alokesh, Gao, Jiaping, Grondine, Melissa S, Gupta, Ramesh C, Kakmak, Mesut, Kavana, Michael, Kirman, Louise C, Liang, Jinsheng, Maniara, Wieslawa M, Munshi, Siralee, Nadkarni, Sunil S, Schuster, Herbert F, Stams, Travis, St. Denny, Irene, Taslimi, Paul M, Vash, Brian, Caplan, Shari L

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Abstract 979: Discovery of the JAK1 selective kinase inhibitor AZD4205 von Kettle, Jason G., Su, Qibin, Grimster, Neil, Kawatkar, Sameer, Throner, Scott, Woessner, Richard, Chen, Huawei, Bebernitz, Geraldine, Bell, Kristen, Anderson, Erica, Ruston, Linette, Winter-Holt, Jon, Lyne, Paul, Vasbinder, Melissa, Chuaqui, Claudio

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Identification and Synthesis of D. athabasca Cuticular Hydrocarbons von Bebernitz, Christina, Kehlbeck, Joanne, Harvey, Taylor, Yukilevich, Roman

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Discovery of a brain-sparing GIRK1/4 inhibitor for pharmacological cardioversion of atrial fibrillation von Peukert, Stefan, Gulgeze Efthymiou, Hatice Belgin, Mo, Ruowei, Peng, Yunshan, Ma, Fupeng, Barbe, Guillaume, Bebernitz, Gregory, Fridrich, Cary, Buono, Chiara, Williams, Eric T., Daniels, Thomas, Li, Lisha, Zhang, Xia, Adachi, Yuichiro, Abe, Mie, Taggart, Andrew K.P.

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Discovery of 1-Methyl-1 H -imidazole Derivatives as Potent Jak2 Inhibitors von Su, Qibin, Ioannidis, Stephanos, Chuaqui, Claudio, Almeida, Lynsie, Alimzhanov, Marat, Bebernitz, Geraldine, Bell, Kirsten, Block, Michael, Howard, Tina, Huang, Shan, Huszar, Dennis, Read, Jon A., Rivard Costa, Caroline, Shi, Jie, Su, Mei, Ye, Minwei, Zinda, Michael

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Avoidance of the Ames test liability for aryl–amines via computation von McCarren, Patrick, Bebernitz, Gregory R., Gedeck, Peter, Glowienke, Susanne, Grondine, Melissa S., Kirman, Louise C., Klickstein, Jacob, Schuster, Herbert F., Whitehead, Lewis

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Discovery of 5-Chloro-N 2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-N 4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine (AZD1480) as a Novel Inhibitor of the Jak/Stat Pathway von Ioannidis, Stephanos, Lamb, Michelle L, Wang, Tao, Almeida, Lynsie, Block, Michael H, Davies, Audrey M, Peng, Bo, Su, Mei, Zhang, Hai-Jun, Hoffmann, Ethan, Rivard, Caroline, Green, Isabelle, Howard, Tina, Pollard, Hannah, Read, Jon, Alimzhanov, Marat, Bebernitz, Geraldine, Bell, Kirsten, Ye, Minwei, Huszar, Dennis, Zinda, Michael

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Abstract 4046: Targeting jak/stat adaptive mechanism with jak1 inhibitor azd4205 reduces residual disease and prolongs benefit of osimertinib von Chen, Huawei (Ray), Bebernitz, Geraldine, Bell, Kirsten, Anderson, Erica, Deng, Nanhua, Kettle, Jason, Lyne, Paul, Woessner, Richard

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Discovery of 1‑Methyl‑1H‑imidazole Derivatives as Potent Jak2 Inhibitors von Su, Qibin, Ioannidis, Stephanos, Chuaqui, Claudio, Almeida, Lynsie, Alimzhanov, Marat, Bebernitz, Geraldine, Bell, Kirsten, Block, Michael, Howard, Tina, Huang, Shan, Huszar, Dennis, Read, Jon A, Rivard Costa, Caroline, Shi, Jie, Su, Mei, Ye, Minwei, Zinda, Michael

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Discovery and Optimization of a Novel Series of Highly Selective JAK1 Kinase Inhibitors von Grimster, Neil P, Anderson, Erica, Alimzhanov, Marat, Bebernitz, Geraldine, Bell, Kirsten, Chuaqui, Claudio, Deegan, Tracy, Ferguson, Andrew D, Gero, Thomas, Harsch, Andreas, Huszar, Dennis, Kawatkar, Aarti, Kettle, Jason G, Lyne, Paul, Read, Jon A, Rivard Costa, Caroline, Ruston, Linette, Schroeder, Patricia, Shi, Jie, Su, Qibin, Throner, Scott, Toader, Dorin, Vasbinder, Melissa, Woessner, Richard, Wang, Haixia, Wu, Allan, Ye, Minwei, Zheng, Weijia, Zinda, Michael

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Evaluation of Mcl-1 Inhibitors in Preclinical Models of Multiple Myeloma von Belmonte, Matthew A, Adam, Ammar, Borrelli, Deanna, Bhavsar, Deepa, Bebernitz, Christina, Hird, Alexander, Secrist, Paul

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Discovery of (2 R )- N -[3-[2-[(3-Methoxy-1-methyl-pyrazol-4-yl)amino]pyrimidin-4-yl]-1 H -indol-7-yl]-2-(4-methylpiperazin-1-yl)propenamide (AZD4205) as a Potent and Selective Jan... von Su, Qibin, Banks, Erica, Bebernitz, Geraldine, Bell, Kirsten, Borenstein, Cassandra F, Chen, Huawei, Chuaqui, Claudio E, Deng, Nanhua, Ferguson, Andrew D, Kawatkar, Sameer, Grimster, Neil P, Ruston, Linette, Lyne, Paul D, Read, Jon A, Peng, Xianyou, Pei, Xiaohui, Fawell, Stephen, Tang, Zhanlei, Throner, Scott, Vasbinder, Melissa M, Wang, Haoyu, Winter-Holt, Jon, Woessner, Richard, Wu, Allan, Yang, Wenzhan, Zinda, Michael, Kettle, Jason G

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Identification of azabenzimidazoles as potent JAK1 selective inhibitors von Vasbinder, Melissa M., Alimzhanov, Marat, Augustin, Martin, Bebernitz, Geraldine, Bell, Kirsten, Chuaqui, Claudio, Deegan, Tracy, Ferguson, Andrew D., Goodwin, Kelly, Huszar, Dennis, Kawatkar, Aarti, Kawatkar, Sameer, Read, Jon, Shi, Jie, Steinbacher, Stefan, Steuber, Holger, Su, Qibin, Toader, Dorin, Wang, Haixia, Woessner, Richard, Wu, Allan, Ye, Minwei, Zinda, Michael

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Catching Out von Bebernitz, Eric

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