Dysregulation of PRMT5 in chronic lymphocytic leukemia promotes progression with high risk of Richter’s transformation von Hing, Zachary A., Walker, Janek S., Whipp, Ethan C., Brinton, Lindsey, Cannon, Matthew, Zhang, Pu, Sher, Steven, Cempre, Casey B., Brown, Fiona, Smith, Porsha L., Agostinelli, Claudio, Pileri, Stefano A., Skinner, Jordan N., Williams, Katie, Phillips, Hannah, Shaffer, Jami, Beaver, Larry P., Pan, Alexander, Shin, Kyle, Gregory, Charles T., Ozer, Gulcin H., Yilmaz, Selen A., Harrington, Bonnie K., Lehman, Amy M., Yu, Lianbo, Coppola, Vincenzo, Yan, Pearlly, Scherle, Peggy, Wang, Min, Pitis, Philip, Xu, Chaoyi, Vaddi, Kris, Chen-Kiang, Selina, Woyach, Jennifer, Blachly, James S., Alinari, Lapo, Yang, Yiping, Byrd, John C., Baiocchi, Robert A., Blaser, Bradley W., Lapalombella, Rosa

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BRD4 Profiling Identifies Critical Chronic Lymphocytic Leukemia Oncogenic Circuits and Reveals Sensitivity to PLX51107, a Novel Structurally Distinct BET Inhibitor von Ozer, Hatice Gulcin, El-Gamal, Dalia, Powell, Ben, Hing, Zachary A, Blachly, James S, Harrington, Bonnie, Mitchell, Shaneice, Grieselhuber, Nicole R, Williams, Katie, Lai, Tzung-Huei, Alinari, Lapo, Baiocchi, Robert A, Brinton, Lindsey, Baskin, Elizabeth, Cannon, Matthew, Beaver, Larry, Goettl, Virginia M, Lucas, David M, Woyach, Jennifer A, Sampath, Deepa, Lehman, Amy M, Yu, Lianbo, Zhang, Jiazhong, Ma, Yan, Zhang, Ying, Spevak, Wayne, Shi, Songyuan, Severson, Paul, Shellooe, Rafe, Carias, Heidi, Tsang, Garson, Dong, Ken, Ewing, Todd, Marimuthu, Adhirai, Tantoy, Christina, Walters, Jason, Sanftner, Laura, Rezaei, Hamid, Nespi, Marika, Matusow, Bernice, Habets, Gaston, Ibrahim, Prabha, Zhang, Chao, Mathé, Ewy A, Bollag, Gideon, Byrd, John C, Lapalombella, Rosa

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Rare t(X;14)(q28;q32) translocation reveals link between MTCP1 and chronic lymphocytic leukemia von Walker, Janek S., Hing, Zachary A., Sher, Steven, Cronin, James, Williams, Katie, Harrington, Bonnie, Skinner, Jordan N., Cempre, Casey B., Gregory, Charles T., Pan, Alexander, Yano, Max, Beaver, Larry P., Walker, Brandi R., Labanowska, Jadwiga M., Heerema, Nyla A., Mrózek, Krzysztof, Woyach, Jennifer A., Ruppert, Amy S., Lehman, Amy, Ozer, Hatice Gulcin, Coppola, Vincenzo, Yan, Pearlly, Byrd, John C., Blachly, James S., Lapalombella, Rosa

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Synergistic effect of BCL2 and FLT3 co-inhibition in acute myeloid leukemia von Brinton, Lindsey T, Zhang, Pu, Williams, Katie, Canfield, Daniel, Orwick, Shelley, Sher, Steven, Wasmuth, Ronni, Beaver, Larry, Cempre, Casey, Skinner, Jordan, Cannon, Matthew, Govande, Mukul, Harrington, Bonnie, Lehman, Amy, Byrd, John C, Lapalombella, Rosa, Blachly, James S

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Anti-tumor NAMPT inhibitor, KPT-9274, mediates gender-dependent murine anemia and nephrotoxicity by regulating SIRT3-mediated SOD deacetylation von Mitchell, Shaneice, Zhang, Pu, Cannon, Matthew, Beaver, Larry, Lehman, Amy, Harrington, Bonnie, Sampath, Deepa, Byrd, John C, Lapalombella, Rosa

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Coordinated inhibition of nuclear export and Bcr-Abl1 selectively targets chronic myeloid leukemia stem cells von Than, Hein, Pomicter, Anthony D., Yan, Dongqing, Beaver, Larry P., Eiring, Anna M., Heaton, William L., Senina, Anna, Clair, Phillip M., Shacham, Sharon, Mason, Clinton C., Hare, Thomas O’, Deininger, Michael W.

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Recurrent XPO1 mutations alter pathogenesis of chronic lymphocytic leukemia von Walker, Janek S, Hing, Zachary A, Harrington, Bonnie, Baumhardt, Jordan, Ozer, Hatice Gulcin, Lehman, Amy, Giacopelli, Brian, Beaver, Larry, Williams, Katie, Skinner, Jordan N, Cempre, Casey B, Sun, Qingxiang, Shacham, Sharon, Stromberg, Benjamin R, Summers, Matthew K, Abruzzo, Lynne V, Rassenti, Laura, Kipps, Thomas J, Parikh, Sameer, Kay, Neil E, Rogers, Kerry A, Woyach, Jennifer A, Coppola, Vincenzo, Chook, Yuh Min, Oakes, Christopher, Byrd, John C, Lapalombella, Rosa

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DNA Origami Nanostructures Elicit Dose‐Dependent Immunogenicity and Are Nontoxic up to High Doses In Vivo von Lucas, Christopher R., Halley, Patrick D., Chowdury, Amjad A., Harrington, Bonnie K., Beaver, Larry, Lapalombella, Rosa, Johnson, Amy J., Hertlein, Erin K., Phelps, Mitch A., Byrd, John C., Castro, Carlos E.

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VIP152 is a selective CDK9 inhibitor with pre-clinical in vitro and in vivo efficacy in chronic lymphocytic leukemia von Sher, Steven, Whipp, Ethan, Walker, Janek, Zhang, Pu, Beaver, Larry, Williams, Katie, Orwick, Shelley, Ravikrishnan, Janani, Walker, Brandi, Perry, Elizabeth, Gregory, Charles, Purcell, Matthew, Pan, Alexander, Yan, Pearlly, Alinari, Lapo, Johnson, Amy J., Frigault, Melanie M., Greer, Joy M., Hamdy, Ahmed, Izumi, Raquel, Mo, Xiaokui, Sampath, Deepa, Woyach, Jennifer, Blachly, James, Byrd, John C., Lapalombella, Rosa

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PP2A is a therapeutically targetable driver of cell fate decisions via a c-Myc/p21 axis in human and murine acute myeloid leukemia von Goswami, Swagata, Mani, Rajeswaran, Nunes, Jessica, Chiang, Chi-Ling, Zapolnik, Kevan, Hu, Eileen, Frissora, Frank, Mo, Xiaokui, Walker, Logan A., Yan, Pearlly, Bundschuh, Ralf, Beaver, Larry, Devine, Raymond, Tsai, Yo-Ting, Ventura, Ann, Xie, Zhiliang, Chen, Min, Lapalombella, Rosa, Walker, Alison, Mims, Alice, Larkin, Karilyn, Grieselhuber, Nicole, Bennett, Chad, Phelps, Mitch, Hertlein, Erin, Behbehani, Gregory, Vasu, Sumithira, Byrd, John C., Muthusamy, Natarajan

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LP-118, a Selective Bcl-2 Inhibitor with Tuned Bcl-Xl Activity, Causes Myeloid Differentiation and Cell Death in Acute Myeloid Leukemia (AML) von Koenig, Kristin L, Brame, Colin, Sher, Steven, Beaver, Larry, Cempre, Casey B., Williams, Katie, Purcell, Matthew, Harrington, Bonnie, Chen, Yi, Tan, Felai, Anthony, Stephen P., Chen, Yu, Shen, Yue, Byrd, John C., Lapalombella, Rosa

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Leukemic B Cell CTLA-4 Suppresses Costimulation of T Cells von Do, Priscilla, Beckwith, Kyle A, Cheney, Carolyn, Tran, Minh, Beaver, Larry, Griffin, Brittany G, Mo, Xiaokui, Liu, Yang, Lapalombella, Rosa, Hertlein, Erin, Muthusamy, Natarajan, Byrd, John C

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DNA Origami Nanostructures Elicit Dose-Dependent Immunogenicity and are Non-toxic up to High Doses in vivo von Lucas, Christopher R, Halley, Patrick D, Chowdury, Amjad A, Harrington, Bonnie K, Beaver, Larry, Lapalombella, Rosa, Johnson, Amy J, Hertlein, Erin K, Phelps, Mitch A, Byrd, John C, Castro, Carlos E

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Genome-Wide CRISPR/Cas9 Knockout Screen Reveals Novel Gilteritinib Combinations Targeting Oxidative Phosphorylation and De-Novo Purine Biosynthesis Pathways for FLT3-ITD+ Acute Mye... von Sher, Steven, Zhang, Pu, Brinton, Lindsey, Gharghabi, Mehdi, Williams, Katie, Cannon, Matthew, Walker, Janek S., Canfield, Daniel, Beaver, Larry, Cempre, Casey B., Phillips, Hannah, Chen, Xuyong, Yan, Pearlly S., Lehman, Amy M., Scherle, Peggy, Wang, Min, Vaddi, Kris, Baiocchi, Robert A., Wang, Ruoning, Sampath, Deepa, Alinari, Lapo, Blachly, James S., Lapalombella, Rosa

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Dysregulation of PRMT5 in Chronic Lymphocytic Leukemia Supports Transformation to Diffuse Large B-Cell Lymphoma von Whipp, Ethan, Hing, Zachary A, Walker, Janek S., Sher, Steven, Cempre, Casey B., Brown, Fiona, Agostinelli, Claudio, Pileri, Stefano A, Williams, Katie, Beaver, Larry, Pan, Alexander, Gregory, Charles T., Yan, Pearlly S., Scherle, Peggy, Wang, Min, Vaddi, Kris, Chen-Kiang, Selina, Woyach, Jennifer A., Blachly, James S., Alinari, Lapo, Yang, Yiping, Baiocchi, Robert A., Blaser, Bradley W, Lapalombella, Rosa

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The Multi-CDK Inhibitor Dinaciclib Shows Synergistic Activity with the BET Inhibitor PLX51107 and Reverses BET Resistance through Inhibition of Canonical Wnt Signaling in Acute Mye... von Marr, Alexander, Karmahapatra, Soumendrakrishna, Corbin, Dominique, Asemelash, Yerdanos, Sher, Steven, Mitchell, Shaneice Renee, Harrington, Bonnie K, Orwick, Shelley, Beaver, Larry, Wasmuth, Ronni, Goettl, Virginia, Mims, Alice S., Larkin, Karilyn T., Vasu, Sumithira, Long, Meixiao, Blachly, James S., Garzon, Ramiro, Byrd, John C., Lapalombella, Rosa, Grieselhuber, Nicole

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Targeting DNA Damage Repair Functions of Two Histone Deacetylases, HDAC8 and SIRT6, Sensitizes Acute Myeloid Leukemia to NAMPT Inhibition von Zhang, Pu, Brinton, Lindsey T, Williams, Katie, Sher, Steven, Orwick, Shelley, Tzung-Huei, Lai, Mims, Alice S, Coss, Christopher C, Kulp, Samuel K, Youssef, Youssef, Chan, Wing Keung, Mitchell, Shaneice, Mustonen, Allison, Cannon, Matthew, Phillips, Hannah, Lehman, Amy M, Kauffman, Tierney, Beaver, Larry, Canfield, Daniel, Grieselhuber, Nicole R, Alinari, Lapo, Sampath, Deepa, Yan, Pearlly, Byrd, John C, Blachly, James S, Lapalombella, Rosa

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Abstract 371: Synthetic lethal and resistance pathways in midostaurin-treated AML von Brinton, Lindsey T., Williams, Katie, Orwick, Shelley, Beaver, Larry, Canfield, Daniel, Cempre, Casey, Skinner, Jordan, Wasmuth, Ronni, Hassan, Quais, Byrd, John C., Lapalombella, Rosa, Blachly, James S.

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Leukemic B Cell CTLA-4 Suppresses Co-stimulation of T cells von Do, Priscilla, Beckwith, Kyle A., Cheney, Carolyn, Tran, Minh, Beaver, Larry, Griffin, Brittany G., Mo, Xiaokui, Liu, Yang, Lapalombella, Rosa, Hertlein, Erin, Muthusamy, Natarajan, Byrd, John C.

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VIP152 Is a Novel CDK9 Inhibitor with Efficacy in Chronic Lymphocytic Leukemia von Sher, Steven, Beaver, Larry, Williams, Katie, Orwick, Shelley, Walker, Brandi R., Gregory, Charles Thomas, Purcell, Matthew, Pan, Alexander, Yan, Pearlly S., Johnson, Amy J., Frigault, Melanie M., Greer, Joy M., Hamdy, Ahmed, Izumi, Raquel, Hwang, Stuart, Blachly, James S., Byrd, John C., Lapalombella, Rosa

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