Monitoring Drug Self-Aggregation and Potential for Promiscuity in Off-Target In Vitro Pharmacology Screens by a Practical NMR Strategy von LaPlante, Steven R, Aubry, Norman, Bolger, Gordon, Bonneau, Pierre, Carson, Rebekah, Coulombe, René, Sturino, Claudio, Beaulieu, Pierre L

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Anesthetic implications of recreational drug use von Beaulieu, Pierre

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Enantiomeric Atropisomers Inhibit HCV Polymerase and/or HIV Matrix: Characterizing Hindered Bond Rotations and Target Selectivity von LaPlante, Steven R., Forgione, Pat, Boucher, Colette, Coulombe, René, Gillard, James, Hucke, Oliver, Jakalian, Araz, Joly, Marc-André, Kukolj, George, Lemke, Christopher, McCollum, Robert, Titolo, Steve, Beaulieu, Pierre L., Stammers, Timothy

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Pulmonary complications and mortality among COVID-19 patients undergoing a surgery: a multicentre cohort study von Amzallag, Eva, Panchadsaram, Thanushka, Girard, Martin, Lecluyse, Vincent, Couture, Etienne, D'Aragon, Frederick, Kandelman, Stanislas, Turgeon, Alexis F, Jodoin, Caroline, Beaulieu, Pierre, Richebé, Philippe, Carrier, Francois Martin

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Aza follow-ups to BI 207524, a thumb pocket 1 HCV NS5B polymerase inhibitor. Part 1: Mitigating the genotoxic liability of an aniline metabolite von Beaulieu, Pierre L., Bolger, Gordon, Duplessis, Martin, Gagnon, Alexandre, Garneau, Michel, Stammers, Timothy, Kukolj, George, Duan, Jianmin

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Postoperative outcomes in surgical COVID-19 patients: a multicenter cohort study von Carrier, Francois Martin, Amzallag, Eva, Lecluyse, Vincent, Cote, Genevieve, Couture, Etienne J., D'Aragon, Frederick, Kandelman, Stanislas, Turgeon, Alexis F., Deschamps, Alain, Nitulescu, Roy, Djade, Codjo Djignefa, Girard, Martin, Beaulieu, Pierre, Richebe, Philippe

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Conformation-Based Restrictions and Scaffold Replacements in the Design of Hepatitis C Virus Polymerase Inhibitors: Discovery of Deleobuvir (BI 207127) von LaPlante, Steven R., Bös, Michael, Brochu, Christian, Chabot, Catherine, Coulombe, René, Gillard, James R., Jakalian, Araz, Poirier, Martin, Rancourt, Jean, Stammers, Timothy, Thavonekham, Bounkham, Beaulieu, Pierre L., Kukolj, George, Tsantrizos, Youla S.

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Metal-Free Coupling of Azoles with 2- and 3-Haloindoles Providing Access to Novel 2- or 3-(Azol-1-yl)indole Derivatives von Poirier, Martin, Goudreau, Sébastien, Poulin, Jason, Savoie, Jolaine, Beaulieu, Pierre L

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La douleur en mouvement

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Binding Site Characterization and Resistance to a Class of Non-nucleoside Inhibitors of the Hepatitis C Virus NS5B Polymerase von Kukolj, George, McGibbon, Graham A., McKercher, Ginette, Marquis, Martin, Lefèbvre, Sylvain, Thauvette, Louise, Gauthier, Jean, Goulet, Sylvie, Poupart, Marc-André, Beaulieu, Pierre L.

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Non-Nucleoside Benzimidazole-Based Allosteric Inhibitors of the Hepatitis C Virus NS5B Polymerase:  Inhibition of Subgenomic Hepatitis C Virus RNA Replicons in Huh-7 Cells von Beaulieu, Pierre L, Bousquet, Yves, Gauthier, Jean, Gillard, James, Marquis, Martin, McKercher, Ginette, Pellerin, Charles, Valois, Serge, Kukolj, George

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Local interactions between anandamide, an endocannabinoid, and ibuprofen, a nonsteroidal anti-inflammatory drug, in acute and inflammatory pain von Guindon, Josée, De Léan, André, Beaulieu, Pierre

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Molecular Dynamics Simulations and Structure-Based Rational Design Lead to Allosteric HCV NS5B Polymerase Thumb Pocket 2 Inhibitor with Picomolar Cellular Replicon Potency von Hucke, Oliver, Coulombe, René, Bonneau, Pierre, Bertrand-Laperle, Mégan, Brochu, Christian, Gillard, James, Joly, Marc-André, Landry, Serge, Lepage, Olivier, Llinàs-Brunet, Montse, Pesant, Marc, Poirier, Martin, Poirier, Maude, McKercher, Ginette, Marquis, Martin, Kukolj, George, Beaulieu, Pierre L., Stammers, Timothy A.

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Multi-parameter optimization of aza-follow-ups to BI 207524, a thumb pocket 1 HCV NS5B polymerase inhibitor. Part 2: Impact of lipophilicity on promiscuity and in vivo toxicity von Beaulieu, Pierre L., Bolger, Gordon, Deon, Dan, Duplessis, Martin, Fazal, Gulrez, Gagnon, Alexandre, Garneau, Michel, LaPlante, Steven, Stammers, Timothy, Kukolj, George, Duan, Jianmin

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Effects of nabilone, a synthetic cannabinoid, on postoperative pain von BEAULIEU, Pierre

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From benzimidazole to indole-5-carboxamide Thumb Pocket I inhibitors of HCV NS5B polymerase. Part 1: Indole C-2 SAR and discovery of diamide derivatives with nanomolar potency in c... von Beaulieu, Pierre L., Gillard, James, Jolicoeur, Eric, Duan, Jianmin, Garneau, Michel, Kukolj, George, Poupart, Marc-André

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Discovery of BI 207524, an Indole Diamide NS5B Thumb Pocket 1 Inhibitor with Improved Potency for the Potential Treatment of Chronic Hepatitis C Virus Infection von Beaulieu, Pierre L, Anderson, Paul C, Bethell, Richard, Bös, Michael, Bousquet, Yves, Brochu, Christian, Cordingley, Michael G, Fazal, Gulrez, Garneau, Michel, Gillard, James R, Kawai, Stephen, Marquis, Martin, McKercher, Ginette, Poupart, Marc-André, Stammers, Timothy, Thavonekham, Bounkham, Wernic, Dominik, Duan, Jianmin, Kukolj, George

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A Highly Concise and Convergent Synthesis of HCV Polymerase Inhibitor Deleobuvir (BI 207127): Application of a One-Pot Borylation–Suzuki Coupling Reaction von Zhang, Yongda, Lu, Bruce Z, Li, Guisheng, Rodriguez, Sonia, Tan, Jonathan, Wei, Han-Xun, Liu, Jianxiu, Roschangar, Frank, Ding, Fei, Zhao, Wenyi, Qu, Bo, Reeves, Diana, Grinberg, Nelu, Lee, Heewon, Heckmann, Golo, Niemeier, Oliver, Brenner, Michael, Tsantrizos, Youla, Beaulieu, Pierre L, Hossain, Azad, Yee, Nathan, Farina, Vittorio, Senanayake, Chris H

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Improved replicon cellular activity of non-nucleoside allosteric inhibitors of HCV NS5B polymerase: From benzimidazole to indole scaffolds von Beaulieu, Pierre L., Gillard, James, Bykowski, Darren, Brochu, Christian, Dansereau, Nathalie, Duceppe, Jean-Simon, Haché, Bruno, Jakalian, Araz, Lagacé, Lisette, LaPlante, Steven, McKercher, Ginette, Moreau, Elaine, Perreault, Stéphane, Stammers, Timothy, Thauvette, Louise, Warrington, Jeff, Kukolj, George

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Comparison of three models of neuropathic pain in mice using a new method to assess cold allodynia: The double plate technique von Walczak, Jean-Sébastien, Beaulieu, Pierre

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