PheWAS: demonstrating the feasibility of a phenome-wide scan to discover gene–disease associations von Denny, Joshua C., Ritchie, Marylyn D., Basford, Melissa A., Pulley, Jill M., Bastarache, Lisa, Brown-Gentry, Kristin, Wang, Deede, Masys, Dan R., Roden, Dan M., Crawford, Dana C.

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Robust Replication of Genotype-Phenotype Associations across Multiple Diseases in an Electronic Medical Record von Ritchie, Marylyn D., Denny, Joshua C., Crawford, Dana C., Ramirez, Andrea H., Weiner, Justin B., Pulley, Jill M., Basford, Melissa A., Brown-Gentry, Kristin, Balser, Jeffrey R., Masys, Daniel R., Haines, Jonathan L., Roden, Dan M.

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Demonstrating paths for unlocking the value of cloud genomics through cross cohort analysis von Deflaux, Nicole, Selvaraj, Margaret Sunitha, Condon, Henry Robert, Mayo, Kelsey, Haidermota, Sara, Basford, Melissa A., Lunt, Chris, Philippakis, Anthony A., Roden, Dan M., Denny, Joshua C., Musick, Anjene, Collins, Rory, Allen, Naomi, Effingham, Mark, Glazer, David, Natarajan, Pradeep, Bick, Alexander G.

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Modulators of normal electrocardiographic intervals identified in a large electronic medical record von Ramirez, Andrea H., MD, Schildcrout, Jonathan S., PhD, Blakemore, Dana L., MS, Masys, Dan R., MD, Pulley, Jill M., MBA, Basford, Melissa A., MBA, Roden, Dan M., MD, FHRS, Denny, Joshua C., MD, MS

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Admixture mapping and subsequent fine-mapping suggests a biologically relevant and novel association on chromosome 11 for type 2 diabetes in African Americans von Jeff, Janina M, Armstrong, Loren L, Ritchie, Marylyn D, Denny, Joshua C, Kho, Abel N, Basford, Melissa A, Wolf, Wendy A, Pacheco, Jennifer A, Li, Rongling, Chisholm, Rex L, Roden, Dan M, Hayes, M Geoffrey, Crawford, Dana C

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The Electronic Medical Records and Genomics (eMERGE) Network: past, present, and future von Gottesman, Omri, Kuivaniemi, Helena, Tromp, Gerard, Faucett, W. Andrew, Li, Rongling, Manolio, Teri A., Sanderson, Saskia C., Kannry, Joseph, Zinberg, Randi, Basford, Melissa A., Brilliant, Murray, Carey, David J., Chisholm, Rex L., Chute, Christopher G., Connolly, John J., Crosslin, David, Denny, Joshua C., Gallego, Carlos J., Haines, Jonathan L., Hakonarson, Hakon, Harley, John, Jarvik, Gail P., Kohane, Isaac, Kullo, Iftikhar J., Larson, Eric B., McCarty, Catherine, Ritchie, Marylyn D., Roden, Dan M., Smith, Maureen E., Böttinger, Erwin P., Williams, Marc S.

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Genome- and Phenome-Wide Analyses of Cardiac Conduction Identifies Markers of Arrhythmia Risk von RITCHIE, Marylyn D, DENNY, Joshua C, BRADFORD, Yuki, RASMUSSEN, Luke V, PATHAK, Jyotishman, CHUTE, Christopher G, KULLO, Iftikhar J, MCCARTY, Catherine A, CHISHOLM, Rex L, KHO, Abel N, CARLSON, Christopher S, LARSON, Eric B, ZUVICH, Rebecca L, JARVIK, Gail P, SOTOODEHNIA, Nona, MANOLIO, Teri A, RONGLING LI, MASYS, Daniel R, HAINES, Jonathan L, RODEN, Dan M, CRAWFORD, Dana C, SCHILDCROUT, Jonathan S, BASTARACHE, Lisa, RAMIREZ, Andrea H, MOSLEY, Jonathan D, PULLEY, Jill M, BASFORD, Melissa A

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Variants Near FOXE1 Are Associated with Hypothyroidism and Other Thyroid Conditions: Using Electronic Medical Records for Genome- and Phenome-wide Studies von Denny, Joshua C., Crawford, Dana C., Ritchie, Marylyn D., Bielinski, Suzette J., Basford, Melissa A., Bradford, Yuki, Chai, High Seng, Bastarache, Lisa, Zuvich, Rebecca, Peissig, Peggy, Carrell, David, Ramirez, Andrea H., Pathak, Jyotishman, Wilke, Russell A., Rasmussen, Luke, Wang, Xiaoming, Pacheco, Jennifer A., Kho, Abel N., Hayes, M. Geoffrey, Weston, Noah, Matsumoto, Martha, Kopp, Peter A., Newton, Katherine M., Jarvik, Gail P., Li, Rongling, Manolio, Teri A., Kullo, Iftikhar J., Chute, Christopher G., Chisholm, Rex L., Larson, Eric B., McCarty, Catherine A., Masys, Daniel R., Roden, Dan M., de Andrade, Mariza

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Identification of Genomic Predictors of Atrioventricular Conduction: Using Electronic Medical Records as a Tool for Genome Science von DENNY, Joshua C, RITCHIE, Marylyn D, CRAWFORD, Dana C, SCHILDCROUT, Jonathan S, RAMIREZ, Andrea H, PULLEY, Jill M, BASFORD, Melissa A, MASYS, Daniel R, HAINES, Jonathan L, RODEN, Dan M

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A prognostic model based on readily available clinical data enriched a pre-emptive pharmacogenetic testing program von Schildcrout, Jonathan S, Shi, Yaping, Danciu, Ioana, Bowton, Erica, Field, Julie R, Pulley, Jill M, Basford, Melissa A, Gregg, William, Cowan, James D, Harrell, Frank E, Roden, Dan M, Peterson, Josh F, Denny, Joshua C

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The All of Us Data and Research Center: Creating a Secure, Scalable, and Sustainable Ecosystem for Biomedical Research von Mayo, Kelsey R, Basford, Melissa A, Carroll, Robert J, Dillon, Moira, Fullen, Heather, Leung, Jesse, Master, Hiral, Rura, Shimon, Sulieman, Lina, Kennedy, Nan, Banks, Eric, Bernick, David, Gauchan, Asmita, Lichtenstein, Lee, Mapes, Brandy M, Marginean, Kayla, Nyemba, Steve L, Ramirez, Andrea, Rotundo, Charissa, Wolfe, Keri, Xia, Weiyi, Azuine, Romuladus E, Cronin, Robert M, Denny, Joshua C, Kho, Abel, Lunt, Christopher, Malin, Bradley, Natarajan, Karthik, Wilkins, Consuelo H, Xu, Hua, Hripcsak, George, Roden, Dan M, Philippakis, Anthony A, Glazer, David, Harris, Paul A

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Genetic variants associated with serum thyroid stimulating hormone (TSH) levels in European Americans and African Americans from the eMERGE Network von Malinowski, Jennifer R, Denny, Joshua C, Bielinski, Suzette J, Basford, Melissa A, Bradford, Yuki, Peissig, Peggy L, Carrell, David, Crosslin, David R, Pathak, Jyotishman, Rasmussen, Luke, Pacheco, Jennifer, Kho, Abel, Newton, Katherine M, Li, Rongling, Kullo, Iftikhar J, Chute, Christopher G, Chisholm, Rex L, Jarvik, Gail P, Larson, Eric B, McCarty, Catherine A, Masys, Daniel R, Roden, Dan M, de Andrade, Mariza, Ritchie, Marylyn D, Crawford, Dana C

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Facilitating pharmacogenetic studies using electronic health records and natural-language processing: a case study of warfarin von Xu, Hua, Jiang, Min, Oetjens, Matt, Bowton, Erica A, Ramirez, Andrea H, Jeff, Janina M, Basford, Melissa A, Pulley, Jill M, Cowan, James D, Wang, Xiaoming, Ritchie, Marylyn D, Masys, Daniel R, Roden, Dan M, Crawford, Dana C, Denny, Joshua C

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Defining the role of common variation in the genomic and biological architecture of adult human height von Amin, Najaf, Croteau-Chonka, Damien C, Jackson, Anne U, Randall, Joshua C, Westra, Harm-Jan, Absher, Devin, Baron, Jeffrey, Feitosa, Mary F, Fischer, Krista, Kanoni, Stavroula, Leach, Irene Mateo, Palmer, Cameron D, Prokopenko, Inga, Ripke, Stephan, Stancáková, Alena, Sung, Yun Ju, Trompet, Stella, Blüher, Matthias, Bolton, Jennifer L, Claudi-Boehm, Simone, Cooper, Matthew, Daw, E Warwick, Dörr, Marcus, Folkersen, Lasse, Grönberg, Henrik, Hannemann, Anke, Helmer, Quinta, Hemani, Gibran, Hoffmann, Wolfgang, Holmen, Oddgeir, Kho, Abel N, Kratzer, Wolfgang, Magnusson, Patrik K E, McLaren, Paul J, Menni, Cristina, Merger, Sigrun, Milani, Lili, Nauck, Matthias, Oozageer, Laticia, Pilz, Stefan, Rayner, Nigel W, Renstrom, Frida, Scott, Robert A, Stringham, Heather M, Swertz, Morris A, Syvänen, Ann-Christine, van Dijk, Suzanne, Vonk, Judith M, Wennauer, Roman, Wilsgaard, Tom, Wong, Andrew, Wright, Alan F, Bergmann, Sven, Bornstein, Stefan R, Brambilla, Paolo, Brown, Morris J, Chakravarti, Aravinda, Danesh, John, de Faire, Ulf, Erbel, Raimund, Ferrières, Jean, Gejman, Pablo V, Heath, Andrew C, Hengstenberg, Christian, Hingorani, Aroon D, Kaprio, Jaakko, Madden, Pamela A F, Marette, André, Montgomery, Grant W, Nelis, Mari, Ong, Ken K, Peters, Annette, Qi, Lu, Rice, Treva K, Saramies, Jouko, Sebert, Sylvain, Steinthorsdottir, Valgerdur, Tardif, Jean-Claude, Tremblay, Angelo, Assimes, Themistocles L, Dedoussis, George, Franks, Paul W, Groop, Leif C, Hamsten, Anders, Kuh, Diana, Laakso, Markku, Munroe, Patricia B, Schlessinger, David, Slagboom, P Eline, Snieder, Harold, Spector, Tim D, Tuomilehto, Jaakko, Uusitupa, Matti, Walker, Mark, Thorsteinsdottir, Unnur, Barroso, Inês, Borecki, Ingrid B, McCarthy, Mark I, Visscher, Peter M, Frayling, Timothy M

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Generalization of Variants Identified by Genome‐Wide Association Studies for Electrocardiographic Traits in African Americans von Jeff, Janina M., Ritchie, Marylyn D., Denny, Joshua C., Kho, Abel N., Ramirez, Andrea H., Crosslin, David, Armstrong, Loren, Basford, Melissa A., Wolf, Wendy A., Pacheco, Jennifer A., Chisholm, Rex L., Roden, Dan M., Hayes, M. Geoffrey, Crawford, Dana C.

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Genomic data in the All of Us Research Program von Bick, Alexander G., Metcalf, Ginger A., Mayo, Kelsey R., Lichtenstein, Lee, Rura, Shimon, Carroll, Robert J., Musick, Anjene, Linder, Jodell E., Jordan, I. King, Nagar, Shashwat Deepali, Sharma, Shivam, Meller, Robert, Basford, Melissa, Boerwinkle, Eric, Cicek, Mine S., Doheny, Kimberly F., Eichler, Evan E., Gabriel, Stacey, Gibbs, Richard A., Glazer, David, Harris, Paul A., Jarvik, Gail P., Philippakis, Anthony, Rehm, Heidi L., Roden, Dan M., Thibodeau, Stephen N., Topper, Scott, Blegen, Ashley L., Wirkus, Samantha J., Wagner, Victoria A., Meyer, Jeffrey G., Muzny, Donna M., Venner, Eric, Mawhinney, Michelle Z., Griffith, Sean M. L., Hsu, Elvin, Ling, Hua, Adams, Marcia K., Walker, Kimberly, Hu, Jianhong, Doddapaneni, Harsha, Kovar, Christie L., Murugan, Mullai, Dugan, Shannon, Khan, Ziad, Lennon, Niall J., Austin-Tse, Christina, Banks, Eric, Gatzen, Michael, Gupta, Namrata, Henricks, Emma, Larsson, Katie, McDonough, Sheli, Harrison, Steven M., Kachulis, Christopher, Lebo, Matthew S., Neben, Cynthia L., Steeves, Marcie, Zhou, Alicia Y., Smith, Joshua D., Frazar, Christian D., Davis, Colleen P., Patterson, Karynne E., Wheeler, Marsha M., McGee, Sean, Lockwood, Christina M., Shirts, Brian H., Pritchard, Colin C., Murray, Mitzi L., Vasta, Valeria, Leistritz, Dru, Richardson, Matthew A., Buchan, Jillian G., Radhakrishnan, Aparna, Krumm, Niklas, Ehmen, Brenna W., Schwartz, Sophie, Aster, M. Morgan T., Cibulskis, Kristian, Haessly, Andrea, Asch, Rebecca, Cremer, Aurora, Degatano, Kylee, Shergill, Akum, Gauthier, Laura D., Lee, Samuel K., Hatcher, Aaron, Grant, George B., Brandt, Genevieve R., Covarrubias, Miguel, Able, Ashley, Green, Ashley E., Zhang, Jennifer, Condon, Henry R., Wang, Yuanyuan, Dillon, Moira K., Albach, C. H., Baalawi, Wail, Choi, Seung Hoan, Wang, Xin

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Harmonizing Clinical Sequencing and Interpretation for the eMERGE III Network von Venner, Eric, Muzny, Donna M., Abrams, Debra, Albertson-Junkans, Ladia, Ames, Darren C., Aronson, Samuel, Babb, Lawrence J., Balasubramanian, Adithya, Bastarache, Lisa, Behr, Meckenzie, Blout, Carrie, Bowser, Mark, Brilliant, Murray, Brodeur, Wendy, Caraballo, Pedro, Castro, Victor, Chisholm, Rex L., Chung, Wendy, Chute, Christopher G., City, Brittany, Connolly, John J., Crane, Paul, Crew, Katherine, De Andrade, Mariza, Denson, Shawn, Denny, Josh, DeSmet, Tim, Dikilitas, Ozan, Fullerton, Stephanie M., Gabriel, Stacey, Gainer, Vivian, Gharavi, Ali, Glazer, Andrew M., Goehringer, Jessica, Gordon, Adam S., Graham, Chet, Dayal, Jyoti, Hakonarson, Hakon, Harden, Maegan V., Harr, Margaret, Hayes, M. Geoffrey, Henrikson, Nora, Howell, Kayla M., Jiang, Yunyun, Joo, Yoonjung Yoonie, Justice, Anne E., Kalla, Sara E., Kalra, Divya, Kelly, Melissa A., Key, Dustin, Kiryluk, Krzysztof, Kullo, Iftikhar J., Larson, Eric B., Lin, Chiao-Feng, Linder, Jodell, Macbeth, Alyssa, Dinsmore, Michael J., Dodge, Sheila, Fasel, David, Fedotov, Alex, Feng, Qiping, McGowan, Michelle L., Meldrim, Jim, Mosley, Jonathan, Muniz, Jesse, Murdock, David R., Murugan, Mullai, Myers, Melanie F., Namjou, Bahram, Ni, Yizhao, Obeng, Aniwaa Owusu, Taylor, Casey Overby, Peterson, Josh F., Pratap, Siddharth, Prows, Cynthia A., Ralston, James D., Ramaprasan, Arvind, Rasmussen-Torvik, Laura, Schaid, Dan, Sengupta, Soumitra, Singh, Rajbir, Sleiman, Patrick M.A., Smoller, Jordan W., Stanaway, Ian B., Stroud, Mary, Tolwinski, Kasia, Van Driest, Sara L., Veenstra, David, Vicente, Gina, Wagner, Michael, Walunas, Theresa, Wells, Quinn, White, Peter S., Wiley, Ken L., Wilson, Michael W., Woolf, Betty, Yi, Victoria, Zhang, Ge, Zhang, Lan, Gibbs, Richard A.

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Clinical Characterization and Prediction of Clinical Severity of SARS-CoV-2 Infection Among US Adults Using Data From the US National COVID Cohort Collaborative von Bennett, Tellen D., Moffitt, Richard A., Hajagos, Janos G., Amor, Benjamin, Anand, Adit, Bissell, Mark M., Bradwell, Katie Rebecca, Bremer, Carolyn, Byrd, James Brian, Denham, Alina, DeWitt, Peter E., Gabriel, Davera, Garibaldi, Brian T., Girvin, Andrew T., Guinney, Justin, Hill, Elaine L., Hong, Stephanie S., Jimenez, Hunter, Kavuluru, Ramakanth, Kostka, Kristin, Lehmann, Harold P., Levitt, Eli, Mallipattu, Sandeep K., Manna, Amin, McMurry, Julie A., Morris, Michele, Muschelli, John, Neumann, Andrew J., Palchuk, Matvey B., Pfaff, Emily R., Qian, Zhenglong, Qureshi, Nabeel, Russell, Seth, Spratt, Heidi, Walden, Anita, Williams, Andrew E., Wooldridge, Jacob T., Yoo, Yun Jae, Zhang, Xiaohan Tanner, Zhu, Richard L., Austin, Christopher P., Saltz, Joel H., Gersing, Ken R., Haendel, Melissa A., Chute, Christopher G.

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The eMERGE Network: a consortium of biorepositories linked to electronic medical records data for conducting genomic studies von McCarty, Catherine A, Chisholm, Rex L, Chute, Christopher G, Kullo, Iftikhar J, Jarvik, Gail P, Larson, Eric B, Li, Rongling, Masys, Daniel R, Ritchie, Marylyn D, Roden, Dan M, Struewing, Jeffery P, Wolf, Wendy A

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An analytical approach to characterize morbidity profile dissimilarity between distinct cohorts using electronic medical records von Schildcrout, Jonathan S., Basford, Melissa A., Pulley, Jill M., Masys, Daniel R., Roden, Dan M., Wang, Deede, Chute, Christopher G., Kullo, Iftikhar J., Carrell, David, Peissig, Peggy, Kho, Abel, Denny, Joshua C.

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