Apilimod inhibits the production of IL-12 and IL-23 and reduces dendritic cell infiltration in psoriasis von Wada, Yumiko, Cardinale, Irma, Khatcherian, Artemis, Chu, John, Kantor, Aaron B, Gottlieb, Alice B, Tatsuta, Noriaki, Jacobson, Eric, Barsoum, James, Krueger, James G

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Ganetespib, a unique triazolone-containing Hsp90 inhibitor, exhibits potent antitumor activity and a superior safety profile for cancer therapy von Ying, Weiwen, Du, Zhenjian, Sun, Lijun, Foley, Kevin P, Proia, David A, Blackman, Ronald K, Zhou, Dan, Inoue, Takayo, Tatsuta, Noriaki, Sang, Jim, Ye, Shuxia, Acquaviva, Jamie, Ogawa, Luisa Shin, Wada, Yumiko, Barsoum, James, Koya, Keizo

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Gene activation of SMN by selective disruption of lncRNA-mediated recruitment of PRC2 for the treatment of spinal muscular atrophy von Woo, Caroline J., Maier, Verena K., Davey, Roshni, Brennan, James, Li, Guangde, Brothers, John, Schwartz, Brian, Gordo, Susana, Kasper, Anne, Okamoto, Trevor R., Johansson, Hans E., Mandefro, Berhan, Sareen, Dhruv, Bialek, Peter, Chau, B. Nelson, Bhat, Balkrishen, Bullough, David, Barsoum, James

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Elesclomol induces cancer cell apoptosis through oxidative stress von Kirshner, Jessica R, He, Suqin, Balasubramanyam, Vishwasenani, Kepros, Jane, Yang, Chin-Yu, Zhang, Mei, Du, Zhenjian, Barsoum, James, Bertin, John

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Ganetespib (STA-9090), a Nongeldanamycin HSP90 Inhibitor, Has Potent Antitumor Activity in In Vitro and In Vivo Models of Non―Small Cell Lung Cancer von SHIMAMURA, Takeshi, PERERA, Samanthi A, SINHA, Papiya, CAREY, Christopher D, BORGMAN, Christa L, JIMENEZ, John-Paul, MEYERSON, Matthew, WEIWEN YING, BARSOUM, James, WONG, Kwok-Kin, SHAPIRO, Geoffrey I, FOLEY, Kevin P, JIM SANG, RODIG, Scott J, INOUE, Takayo, LIANG CHEN, DANAN LI, CARRETERO, Julian, LI, Yu-Chen

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The novel HSP90 inhibitor STA-9090 exhibits activity against Kit-dependent and -independent malignant mast cell tumors von Lin, Tzu-Yin, Bear, Misty, Du, Zhenjian, Foley, Kevin P, Ying, Weiwen, Barsoum, James, London, Cheryl

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Multifaceted intervention by the Hsp90 inhibitor ganetespib (STA-9090) in cancer cells with activated JAK/STAT signaling von Proia, David A, Foley, Kevin P, Korbut, Tim, Sang, Jim, Smith, Don, Bates, Richard C, Liu, Yuan, Rosenberg, Alex F, Zhou, Dan, Koya, Keizo, Barsoum, James, Blackman, Ronald K

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Phase I evaluation of STA-1474, a prodrug of the novel HSP90 inhibitor ganetespib, in dogs with spontaneous cancer von London, Cheryl A, Bear, Misty D, McCleese, Jennifer, Foley, Kevin P, Paalangara, Reji, Inoue, Takayo, Ying, Weiwen, Barsoum, James

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Selective abrogation of Th1 response by STA-5326, a potent IL-12/IL-23 inhibitor von Wada, Yumiko, Lu, Rongzhen, Zhou, Dan, Chu, John, Przewloka, Teresa, Zhang, Shijie, Li, Long, Wu, Yaming, Qin, June, Balasubramanyam, Vishwasenani, Barsoum, James, Ono, Mitsunori

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Sequestration of Adenoviral Vector by Kupffer Cells Leads to a Nonlinear Dose Response of Transduction in Liver von Tao, Nianjun, Gao, Guang-Ping, Parr, Michael, Johnston, Julie, Baradet, Timothy, Wilson, James M., Barsoum, James, Fawell, Stephen E.

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The vascular disrupting agent STA-9584 exhibits potent antitumor activity by selectively targeting microvasculature at both the center and periphery of tumors von Foley, Kevin P, Zhou, Dan, Borella, Chris, Wu, Yaming, Zhang, Mei, Jiang, Jun, Li, Hao, Sang, Jim, Korbut, Tim, Ye, Josephine, Zhang, Xuemei, Barsoum, James, Sonderfan, Andrew J

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Concentration of Recombinant Baculovirus by Cation-Exchange Chromatography von Barsoum, James

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Efficient transduction of mammalian cells by a recombinant baculovirus having the vesicular stomatitis virus G glycoprotein von Barsoum, J, Brown, R, McKee, M, Boyce, F M

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Interferon-β Gene Therapy Inhibits Tumor Formation and Causes Regression of Established Tumors in Immune-Deficient Mice von Qin, Xiao-Qiang, Tao, Nianjun, Dergay, Amie, Moy, Pamela, Fawell, Stephen, Davis, Alan, Wilson, James M., Barsoum, James

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Combined 5-Fluorouracil/Systemic Interferon-β Gene Therapy Results in Long-Term Survival in Mice with Established Colorectal Liver Metastases von CHOI, Eugene A, HANQIN LEI, MARON, David J, MICK, Rosemarie, BARSOUM, James, YU, Qian-Chun, FRAKER, Douglas L, WILSON, James M, SPITZ, Francis R

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The oncology drug elesclomol selectively transports copper to the mitochondria to induce oxidative stress in cancer cells von Nagai, Masazumi, Vo, Nha H., Shin Ogawa, Luisa, Chimmanamada, Dinesh, Inoue, Takayo, Chu, John, Beaudette-Zlatanova, Britte C., Lu, Rongzhen, Blackman, Ronald K., Barsoum, James, Koya, Keizo, Wada, Yumiko

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Successful Transduction of Mammalian Astrocytes and Oligodendrocytes by "Pseudotyped" Baculovirus Vector in Vitro and in Vivo von Hiroshi KOBAYASHI, Kazuhiko WATABE, Sayoko IZUKA, Hideki TANI, Yoshiharu MATSUURA, James BARSOUM, Campbell KAYNOR, Yoya OHASHI, Yoshikatsu ETOH

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The novel HSP90 inhibitor STA‐1474 exhibits biologic activity against osteosarcoma cell lines von McCleese, Jennifer K., Bear, Misty D., Fossey, Stacey L., Mihalek, Robert M., Foley, Kevin P., Ying, Weiwen, Barsoum, James, London, Cheryl A.

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Heat shock protein 90 regulates the expression of Wilms tumor 1 protein in myeloid leukemias von Bansal, Hima, Bansal, Sanjay, Rao, Manjeet, Foley, Kevin P., Sang, Jim, Proia, David A., Blackman, Ronald K., Ying, Weiwen, Barsoum, James, Baer, Maria R., Kelly, Kevin, Swords, Ronan, Tomlinson, Gail E., Battiwalla, Minoo, Giles, Francis J., Lee, Kelvin P., Padmanabhan, Swaminathan

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COMPOSITIONS AND METHODS FOR MODULATING FOXP3 EXPRESSION von BARSOUM JAMES, SEVERGNINI MARIANO, MCSWIGGEN JAMES

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