Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction von Simonetta, Kyle R., Taygerly, Joshua, Boyle, Kathleen, Basham, Stephen E., Padovani, Chris, Lou, Yan, Cummins, Thomas J., Yung, Stephanie L., von Soly, Szerenke Kiss, Kayser, Frank, Kuriyan, John, Rape, Michael, Cardozo, Mario, Gallop, Mark A., Bence, Neil F., Barsanti, Paul A., Saha, Anjanabha

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Structure-Based Drug Design of Novel Potent and Selective Tetrahydropyrazolo[1,5‑a]pyrazines as ATR Inhibitors von Barsanti, Paul A, Aversa, Robert J, Jin, Xianming, Pan, Yue, Lu, Yipin, Elling, Robert, Jain, Rama, Knapp, Mark, Lan, Jiong, Lin, Xiaodong, Rudewicz, Patrick, Sim, Janet, Taricani, Lorena, Thomas, George, Xiao, Linda, Yue, Qin

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Enantioselective Ring Opening of Epoxides with Silicon Tetrachloride in the Presence of a Chiral Lewis Base: Mechanism Studies von Denmark, Scott E., Barsanti, Paul A., Beutner, Gregory L., Wilson, Tyler W.

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Design and Discovery of N‑(3-(2-(2-Hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methylphenyl)-2-(trifluoromethyl)isonicotinamide, a Selective, Efficacious, and Well-Tolerated RAF Inh... von Ramurthy, Savithri, Taft, Benjamin R, Aversa, Robert J, Barsanti, Paul A, Burger, Matthew T, Lou, Yan, Nishiguchi, Gisele A, Rico, Alice, Setti, Lina, Smith, Aaron, Subramanian, Sharadha, Tamez, Victoriano, Tanner, Huw, Wan, Lifeng, Hu, Cheng, Appleton, Brent A, Mamo, Mulugeta, Tandeske, Laura, Tellew, John E, Huang, Shenlin, Yue, Qin, Chaudhary, Apurva, Tian, Hung, Iyer, Raman, Hassan, A. Quamrul, Mathews Griner, Lesley A, La Bonte, Laura R, Cooke, Vesselina G, Van Abbema, Anne, Merritt, Hanne, Gampa, Kalyani, Feng, Fei, Yuan, Jing, Mishina, Yuji, Wang, Yingyun, Haling, Jacob R, Vaziri, Sepideh, Hekmat-Nejad, Mohammad, Polyakov, Valery, Zang, Richard, Sethuraman, Vijay, Amiri, Payman, Singh, Mallika, Sellers, William R, Lees, Emma, Shao, Wenlin, Dillon, Michael P, Stuart, Darrin D

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The discovery of tetrahydro-β-carbolines as inhibitors of the kinesin Eg5 von Barsanti, Paul A., Wang, Weibo, Ni, Zhi-Jie, Duhl, David, Brammeier, Nathan, Martin, Eric, Bussiere, Dirksen, Walter, Annette O.

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Structure-Based Drug Design of Novel, Potent, and Selective Azabenzimidazoles (ABI) as ATR Inhibitors von Barsanti, Paul A, Pan, Yue, Lu, Yipin, Jain, Rama, Cox, Matthew, Aversa, Robert J, Dillon, Michael P, Elling, Robert, Hu, Cheng, Jin, Xianming, Knapp, Mark, Lan, Jiong, Ramurthy, Savithri, Rudewicz, Patrick, Setti, Lina, Subramanian, Sharadha, Mathur, Michelle, Taricani, Lorena, Thomas, George, Xiao, Linda, Yue, Qin

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Enantioselective Ring Opening of Epoxides with Silicon Tetrachloride in the Presence of a Chiral Lewis Base von Denmark, Scott E, Barsanti, Paul A, Wong, Ken-Tsung, Stavenger, Robert A

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Total Synthesis of (+)-Zaragozic Acid C von Armstrong, Alan, Barsanti, Paul A, Jones, Lyn H, Ahmed, Ghafoor

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Synthesis of the C1-side chain of zaragozic acid D and progress towards a total synthesis von Armstrong, Alan, Barsanti, Paul A, Blench, Toby J, Ogilvie, Ron

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Design and Discovery of N-(3-(2-(2-Hydroxyethoxy)-6morpholinopyridin-4-yl)-4-methylphenyl)-2-(trifluoromethyl)isonicotinamide, a Selective, Efficacious, and Well-Tolerated RAF Inhi... von Ramurthy, Savithri, Taft, Benjamin R., Aversa, Robert J., Barsanti, Paul A., Burger, Matthew T., Lou, Yan, Nishiguchi, Gisele A., Rico, Alice, Setti, Lina, Smith, Aaron, Subramanian, Sharadha, Tamez, Victoriano, Tanner, Huw, Wan, Lifeng, Hu, Cheng, Appleton, Brent A., Mamo, Mulugeta, Tandeske, Laura, Tellew, John E., Huang, Shenlin, Yue, Qn, Cliaudliary, Apurva, Tian, Hung, Iyer, Raman, Hassan, A. Quamrul, Griner, Lesley A. Mathews, La Bonte, Laura R., Cooke, Vesselina G., Van Abbema, Anne, Merritt, Hanne, Gampa, Kalyani, Feng, Fei, Yuan, Jing, Mishina, Yuji, Wang, Yingyun, Haling, Jacob R., Vaziri, Sepideh, Hekmat-Nejad, Mohammad, Polyakov, Valery, Zang, Richard, Sethuraman, Vijay, Amiri, Payman, Singh, Mallika, Sellers, William R., Lees, Emma, Shao, Wenlin, Dillon, Michael P., Stuart, Darrin D.

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Preparation of Chlorosilyl Enolates von Denmark, Scott E, Stavenger, Robert A, Winter, Stephen B. D, Wong, Ken-Tsung, Barsanti, Paul A

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Design and Discovery of N‑(2-Methyl-5′-morpholino-6′-((tetrahydro‑2H‑pyran-4-yl)oxy)-[3,3′-bipyridin]-5-yl)-3-(trifluoromethyl)benzamide (RAF709): A Potent, Selective, and Efficaci... von Nishiguchi, Gisele A, Rico, Alice, Tanner, Huw, Aversa, Robert J, Taft, Benjamin R, Subramanian, Sharadha, Setti, Lina, Burger, Matthew T, Wan, Lifeng, Tamez, Victoriano, Smith, Aaron, Lou, Yan, Barsanti, Paul A, Appleton, Brent A, Mamo, Mulugeta, Tandeske, Laura, Dix, Ina, Tellew, John E, Huang, Shenlin, Mathews Griner, Lesley A, Cooke, Vesselina G, Van Abbema, Anne, Merritt, Hanne, Ma, Sylvia, Gampa, Kalyani, Feng, Fei, Yuan, Jing, Wang, Yingyun, Haling, Jacob R, Vaziri, Sepideh, Hekmat-Nejad, Mohammad, Jansen, Johanna M, Polyakov, Valery, Zang, Richard, Sethuraman, Vijay, Amiri, Payman, Singh, Mallika, Lees, Emma, Shao, Wenlin, Stuart, Darrin D, Dillon, Michael P, Ramurthy, Savithri

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Abstract 2696: Genetic and pharmacologic evaluation of the ubiquitin ligase CBL-B as a small-molecule, tumor immunotherapy target von Gosling, Jennifa, Rountree, Ryan, Taherbhoy, Asad, Wang, Chenbo, Cummins, Thomas, Cohen, Frederick, Tanaka, Hiroko, Weiss, Dahlia, Cardozo, Mario, Karim, Christopher, Tan, May, Juan, Joseph, Tenn-McClellan, Austin, Soly, Szerenke Kiss von, Sheung, Julie, Boyle, Kathleen, Dhamnaskar, Ketki, Kurylo, Katherine, Bruffey, Jilliane, McKinnell, Jennifer, Karr, Dane, Christianson, Andria, Vries, Anne-Renee Van Der Vuurst de, Sivakumar, Pallavur, Gallop, Mark, Barsanti, Paul A., Saha, Anjanabha, Bence, Neil F., Zapf, Christoph W.

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Abstract 1628: A small-molecule inhibitor of WRN selectively kills MSI-H cancer cells and phenocopies WRN genetic defects von Rao, Yanhua, Srivatsan, Anjana, Liimatta, Marya, Munoz, Diana, Quirit, Jeanne, Shi, Jianxia, Nguyen, An, Linghu, Xin, Federowicz, Federowicz, Jones, Brian, Fleury, Melissa, Newby, Zach, Dillon, Michael P., Barsanti, Paul A., Lackner, Mark R., White, Michael A., Lee, Yang, Landis, Phil, Peng, Yang, Cicchini, Michelle, Cottom, Josh, Nickels, Leng, Brnardic, Ed, DeMartino, Michael, Taygerly, Josh

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The discovery of tetrahydro-b-carbolines as inhibitors of the kinesin Eg5 von Barsanti, Paul A, Wang, Weibo, Ni, Zhi-Jie, Duhl, David, Brammeier, Nathan, Martin, Eric, Bussiere, Dirksen, Walter, Annette O

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The intramolecular 1,3-dipolar cyclisation of mesoionic species generated by the thermolysis of the mixed anhydrides of acetic and N-alkynoyl-1,2,3,4-tetrahydroisoquinoline-3-carbo... von Sainsbury, Malcolm, Strange, Rosalind H., Woodward, Peter R., Barsanti, Paul A.

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2-AMINOQUINAZOLINONE DERIVATIVES AS METHIONINE ADENOSYLTRANSFERASE 2A INHIBITORS von STEEL, Richard, FLEURY, Melissa, BARSANTI, Paul A

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2-AMINOQUINAZOLINONE DERIVATIVES AS METHIONINE ADENOSYLTRANSFERASE 2A INHIBITORS von STEEL, Richard, FLEURY, Melissa, BARSANTI, Paul A

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Ketone-directed peracid epoxidation of cyclic alkenes von Armstrong, Alan, Barsanti, Paul A., Clarke, Paul A., Wood, Anthony

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METHIONINE ADENOSYLTRANSFERASE 2A INHIBITORS von FLEURY, Melissa, MCSPADDEN, Ethan DeNardo, BARSANTI, Paul A

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