Specific Targeting of PEGylated Liposomal Doxorubicin (Doxil ® ) to Tumour Cells Using a Novel TIMP3 Peptide von Aldughaim, Mohammed S, Muthana, Munitta, Alsaffar, Fatimah, Barker, Michael D

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Coupling of a Novel TIMP3 Peptide to Carboxypeptidase G2 for Pro-Drug Activation at the Tumour Site von Aldughaim, Mohammed S, Alsaffar, Fatimah, Barker, Michael D

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Activity of matrix metalloproteinase‐9 against native collagen types I and III von Bigg, Heather F., Rowan, Andrew D., Barker, Michael D., Cawston, Tim E.

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Evidence that all Sorsby's fundus dystrophy mutations cause TIMP3 dimerization resulting in impaired inhibition of VEGFR2 von Alsaffar, Fatimah A., Mujamammi, Ahmed H., Aldughaim, Mohammed S.K., Nicklin, Martin J.H., Barker, Michael D.

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Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation von Lewis, Huw D, Liddle, John, Coote, Jim E, Atkinson, Stephen J, Barker, Michael D, Bax, Benjamin D, Bicker, Kevin L, Bingham, Ryan P, Campbell, Matthew, Chen, Yu Hua, Chung, Chun-wa, Craggs, Peter D, Davis, Rob P, Eberhard, Dirk, Joberty, Gerard, Lind, Kenneth E, Locke, Kelly, Maller, Claire, Martinod, Kimberly, Patten, Chris, Polyakova, Oxana, Rise, Cecil E, Rüdiger, Martin, Sheppard, Robert J, Slade, Daniel J, Thomas, Pamela, Thorpe, Jim, Yao, Gang, Drewes, Gerard, Wagner, Denisa D, Thompson, Paul R, Prinjha, Rab K, Wilson, David M

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Palladium-Catalyzed [1,3]-O-to-C Rearrangement of Pyrans toward Functionalized Cyclohexanones von Brioche, Julien C. R, Barker, Thomas A, Whatrup, David J, Barker, Michael D, Harrity, Joseph P. A

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Investigating the effects of the core nitrogen atom configuration on the thermodynamic solubility of 6,5-bicyclic heterocycles von Cosgrove, Brett, Down, Kenneth, Bertrand, Sophie, Tomkinson, Nicholas C.O., Barker, Michael D.

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Cell Penetrant Inhibitors of the KDM4 and KDM5 Families of Histone Lysine Demethylases. 2. Pyrido[3,4‑d]pyrimidin-4(3H)‑one Derivatives von Westaway, Susan M, Preston, Alex G. S, Barker, Michael D, Brown, Fiona, Brown, Jack A, Campbell, Matthew, Chung, Chun-wa, Drewes, Gerard, Eagle, Robert, Garton, Neil, Gordon, Laurie, Haslam, Carl, Hayhow, Thomas G, Humphreys, Philip G, Joberty, Gerard, Katso, Roy, Kruidenier, Laurens, Leveridge, Melanie, Pemberton, Michelle, Rioja, Inma, Seal, Gail A, Shipley, Tracy, Singh, Onkar, Suckling, Colin J, Taylor, Joanna, Thomas, Pamela, Wilson, David M, Lee, Kevin, Prinjha, Rab K

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Discovery of potent and selective Spleen Tyrosine Kinase inhibitors for the topical treatment of inflammatory skin disease von Barker, Michael D., Liddle, John, Atkinson, Francis L., Wilson, David Matthew, Dickson, Marion C., Ramirez-Molina, Cesar, Lewis, Huw, Davis, Rob P., Somers, Donald O., Neu, Margarete, Jones, Emma, Watson, Robert

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Cell Penetrant Inhibitors of the KDM4 and KDM5 Families of Histone Lysine Demethylases. 1. 3‑Amino-4-pyridine Carboxylate Derivatives von Westaway, Susan M, Preston, Alex G. S, Barker, Michael D, Brown, Fiona, Brown, Jack A, Campbell, Matthew, Chung, Chun-wa, Diallo, Hawa, Douault, Clement, Drewes, Gerard, Eagle, Robert, Gordon, Laurie, Haslam, Carl, Hayhow, Thomas G, Humphreys, Philip G, Joberty, Gerard, Katso, Roy, Kruidenier, Laurens, Leveridge, Melanie, Liddle, John, Mosley, Julie, Muelbaier, Marcel, Randle, Rebecca, Rioja, Inma, Rueger, Anne, Seal, Gail A, Sheppard, Robert J, Singh, Onkar, Taylor, Joanna, Thomas, Pamela, Thomson, Douglas, Wilson, David M, Lee, Kevin, Prinjha, Rab K

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Covalent targeting of non-cysteine residues in PI4KIIIβ von Cosgrove, Brett, Grant, Emma K, Bertrand, Sophie, Down, Kenneth D, Somers, Don O, Evans, John, Tomkinson, Nicholas C. O, Barker, Michael D

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A peptide derived from TIMP-3 inhibits multiple angiogenic growth factor receptors and tumour growth and inflammatory arthritis in mice von Chen, Yung-Yi, Brown, Nicola J., Jones, Rita, Lewis, Claire E., Mujamammi, Ahmed H., Muthana, Munitta, Seed, Michael P., Barker, Michael D.

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Optimisation of a novel series of potent and orally bioavailable azanaphthyridine SYK inhibitors von Garton, Neil S., Barker, Michael D., Davis, Rob P., Douault, Clement, Hooper-Greenhill, Edward, Jones, Emma, Lewis, Huw D., Liddle, John, Lugo, Dave, McCleary, Scott, Preston, Alex G.S., Ramirez-Molina, Cesar, Neu, Margarete, Shipley, Tracy J., Somers, Don O., Watson, Robert J., Wilson, David M.

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Discovery of GSK143, a highly potent, selective and orally efficacious spleen tyrosine kinase inhibitor von Liddle, John, Atkinson, Francis L., Barker, Michael D., Carter, Paul S., Curtis, Neil R., Davis, Rob P., Douault, Clement, Dickson, Marion C., Elwes, Dorothy, Garton, Neil S., Gray, Matthew, Hayhow, Thomas G., Hobbs, Clare I., Jones, Emma, Leach, Stuart, Leavens, Karen, Lewis, Huw D., McCleary, Scott, Neu, Margarete, Patel, Vipulkumar K., Preston, Alex G.S., Ramirez-Molina, Cesar, Shipley, Tracy J., Skone, Philip A., Smithers, Nick, Somers, Donald O., Walker, Ann L., Watson, Robert J., Weingarten, Gordon G.

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Quinolines as a novel structural class of potent and selective PDE4 inhibitors. Optimisation for inhaled administration von Woodrow, Michael D., Ballantine, Stuart P., Barker, Michael D., Clarke, Beth J., Dawson, John, Dean, Tony W., Delves, Christopher J., Evans, Brian, Gough, Sharon L., Guntrip, Steven B., Holman, Stuart, Holmes, Duncan S., Kranz, Michael, Lindvaal, Mika K., Lucas, Fiona S., Neu, Margarete, Ranshaw, Lisa E., Solanke, Yemisi E., Somers, Don O., Ward, Peter, Wiseman, Joanne O.

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4-Phenyl-7-azaindoles as potent, selective and bioavailable IKK2 inhibitors demonstrating good in vivo efficacy von Liddle, John, Bamborough, Paul, Barker, Michael D., Campos, Sebastien, Chung, Chun-Wa, Cousins, Rick P.C., Faulder, Paul, Heathcote, Michelle L., Hobbs, Heather, Holmes, Duncan S., Ioannou, Chris, Ramirez-Molina, Cesar, Morse, Mary A., Osborn, Ruth, Payne, Jeremy J., Pritchard, John M., Rumsey, William L., Tape, Daniel T., Vicentini, Giorgia, Whitworth, Caroline, Williamson, Rick A.

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The use of membrane translocating peptides to identify sites of interaction between the C5a receptor and downstream effector proteins von Auger, Graham A., Smith, Brenda M., Pease, James E., Barker, Michael D.

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4-Phenyl-7-azaindoles as potent and selective IKK2 inhibitors von Liddle, John, Bamborough, Paul, Barker, Michael D., Campos, Sebastien, Cousins, Rick P.C., Cutler, Geoffrey J., Hobbs, Heather, Holmes, Duncan S., Ioannou, Chris, Mellor, Geoff W., Morse, Mary A., Payne, Jeremy J., Pritchard, John M., Smith, Kathryn J., Tape, Daniel T., Whitworth, Caroline, Williamson, Richard A.

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Sorsby's fundus dystrophy mutations impair turnover of TIMP-3 by retinal pigment epithelial cells von Langton, Kevin P., McKie, Norman, Smith, Brenda M., Brown, Nicola J., Barker, Michael D.

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Lentiviral shRNA knock-down of ADAMTS-5 and -9 restores matrix deposition in 3D chondrocyte culture von Coughlan, Teresa C., Crawford, Aileen, Goldring, Mary B., Hatton, Paul V., Barker, Michael D

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