Functional Genomics Reveals Synthetic Lethality between Phosphogluconate Dehydrogenase and Oxidative Phosphorylation von Sun, Yuting, Bandi, Madhavi, Lofton, Timothy, Smith, Melinda, Bristow, Christopher A., Carugo, Alessandro, Rogers, Norma, Leonard, Paul, Chang, Qing, Mullinax, Robert, Han, Jing, Shi, Xi, Seth, Sahil, Meyers, Brooke A., Miller, Meredith, Miao, Lili, Ma, Xiaoyan, Feng, Ningping, Giuliani, Virginia, Geck Do, Mary, Czako, Barbara, Palmer, Wylie S., Mseeh, Faika, Asara, John M., Jiang, Yongying, Morlacchi, Pietro, Zhao, Shuping, Peoples, Michael, Tieu, Trang N., Warmoes, Marc O., Lorenzi, Philip L., Muller, Florian L., DePinho, Ronald A., Draetta, Giulio F., Toniatti, Carlo, Jones, Philip, Heffernan, Timothy P., Marszalek, Joseph R.

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Screening of Hydrocarbon-Stapled Peptides for Inhibition of Calcium-Triggered Exocytosis von Lai, Ying, Tuvim, Michael J, Leitz, Jeremy, Peters, John, Pfuetzner, Richard A, Esquivies, Luis, Zhou, Qiangjun, Czako, Barbara, Cross, Jason B, Jones, Philip, Dickey, Burton F, Brunger, Axel T

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An enolase inhibitor for the targeted treatment of ENO1-deleted cancers von Lin, Yu-Hsi, Satani, Nikunj, Hammoudi, Naima, Yan, Victoria C., Barekatain, Yasaman, Khadka, Sunada, Ackroyd, Jeffrey J., Georgiou, Dimitra K., Pham, Cong-Dat, Arthur, Kenisha, Maxwell, David, Peng, Zhenghong, Leonard, Paul G., Czako, Barbara, Pisaneschi, Federica, Mandal, Pijus, Sun, Yuting, Zielinski, Rafal, Pando, Susana Castro, Wang, Xiaobo, Tran, Theresa, Xu, Quanyu, Wu, Qi, Jiang, Yongying, Kang, Zhijun, Asara, John M., Priebe, Waldemar, Bornmann, William, Marszalek, Joseph R., DePinho, Ronald A., Muller, Florian L.

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The 3S Enantiomer Drives Enolase Inhibitory Activity in SF2312 and Its Analogues von Pisaneschi, Federica, Lin, Yu-Hsi, Leonard, Paul G., Satani, Nikunj, Yan, Victoria C., Hammoudi, Naima, Raghavan, Sudhir, Link, Todd M., K. Georgiou, Dimitra, Czako, Barbara, Muller, Florian L.

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An inhibitor of oxidative phosphorylation exploits cancer vulnerability von Molina, Jennifer R., Sun, Yuting, Protopopova, Marina, Gera, Sonal, Bandi, Madhavi, Bristow, Christopher, McAfoos, Timothy, Morlacchi, Pietro, Ackroyd, Jeffrey, Agip, Ahmed-Noor A., Al-Atrash, Gheath, Asara, John, Bardenhagen, Jennifer, Carrillo, Caroline C., Carroll, Christopher, Chang, Edward, Ciurea, Stefan, Cross, Jason B., Czako, Barbara, Deem, Angela, Daver, Naval, de Groot, John Frederick, Dong, Jian-Wen, Feng, Ningping, Gao, Guang, Gay, Jason, Do, Mary Geck, Greer, Jennifer, Giuliani, Virginia, Han, Jing, Han, Lina, Henry, Verlene K., Hirst, Judy, Huang, Sha, Jiang, Yongying, Kang, Zhijun, Khor, Tin, Konoplev, Sergej, Lin, Yu-Hsi, Liu, Gang, Lodi, Alessia, Lofton, Timothy, Ma, Helen, Mahendra, Mikhila, Matre, Polina, Mullinax, Robert, Peoples, Michael, Petrocchi, Alessia, Rodriguez-Canale, Jaime, Serreli, Riccardo, Shi, Thomas, Smith, Melinda, Tabe, Yoko, Theroff, Jay, Tiziani, Stefano, Xu, Quanyun, Zhang, Qi, Muller, Florian, DePinho, Ronald A., Toniatti, Carlo, Draetta, Giulio F., Heffernan, Timothy P., Konopleva, Marina, Jones, Philip, Di Francesco, M. Emilia, Marszalek, Joseph R.

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Discovery of Potent and Practical Antiangiogenic Agents Inspired by Cortistatin A von Czakó, Barbara, Kürti, László, Mammoto, Akiko, Ingber, Donald E, Corey, E. J

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A General Route toward the Synthesis of the Cladiellin Skeleton Utilizing a SmI2-Mediated Cyclization von Molander, Gary A, Czakó, Barbara, St. Jean, David J

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Construction of Bicyclic Ring Systems via a Transannular SmI2-Mediated Ketone−Olefin Cyclization Strategy von Molander, Gary A, Czakó, Barbara, Rheam, Michael

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Abstract P207: BBP-398, a potent, small molecule inhibitor of SHP2, enhances the response of established NSCLC xenografts to KRASG12C and mutEGFR inhibitors von Stice, James P., Donovan, Sofia, Sun, Yuting, Kohl, Nancy, Czako, Barbara, Mseeh, Faika, Leonard, Paul, Wade, Anna, Lim, Justin, Jones, Phil, Wallace, Eli, Sinkevicius, Kerstin, Beltran, Pedro

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Allosteric SHP2 Inhibitor, IACS-13909, Overcomes EGFR-Dependent and EGFR-Independent Resistance Mechanisms toward Osimertinib von Sun, Yuting, Meyers, Brooke A, Czako, Barbara, Leonard, Paul, Mseeh, Faika, Harris, Angela L, Wu, Qi, Johnson, Sarah, Parker, Connor A, Cross, Jason B, Di Francesco, Maria Emilia, Bivona, Benjamin J, Bristow, Christopher A, Burke, Jason P, Carrillo, Caroline C, Carroll, Christopher L, Chang, Qing, Feng, Ningping, Gao, Guang, Gera, Sonal, Giuliani, Virginia, Huang, Justin K, Jiang, Yongying, Kang, Zhijun, Kovacs, Jeffrey J, Liu, Chiu-Yi, Lopez, Anastasia M, Ma, Xiaoyan, Mandal, Pijus K, McAfoos, Timothy, Miller, Meredith A, Mullinax, Robert A, Peoples, Michael, Ramamoorthy, Vandhana, Seth, Sahil, Spencer, Nakia D, Suzuki, Erika, Williams, Christopher C, Yu, Simon S, Zuniga, Andy M, Draetta, Giulio F, Marszalek, Joseph R, Heffernan, Timothy P, Kohl, Nancy E, Jones, Philip

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A Short, Scalable Synthesis of the Carbocyclic Core of the Anti-Angiogenic Cortistatins from (+)-Estrone by B-Ring Expansion von Kürti, László, Czakó, Barbara, Corey, E. J

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SF2312 is a natural phosphonate inhibitor of enolase von Leonard, Paul G, Satani, Nikunj, Maxwell, David, Lin, Yu-Hsi, Hammoudi, Naima, Peng, Zhenghong, Pisaneschi, Federica, Link, Todd M, Lee, Gilbert R, Sun, Duoli, Prasad, Basvoju A Bhanu, Di Francesco, Maria Emilia, Czako, Barbara, Asara, John M, Wang, Y Alan, Bornmann, William, DePinho, Ronald A, Muller, Florian L

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A novel molecular class that recruits HDAC/MECP2 complexes to PU.1 motifs reduces neuroinflammation von Ralvenius, William T, Mungenast, Alison E, Woolf, Hannah, Huston, Margaret M, Gillingham, Tyler Z, Godin, Stephen K, Penney, Jay, Cam, Hugh P, Gao, Fan, Fernandez, Celia G, Czako, Barbara, Lightfoot, Yaima, Ray, William J, Beckmann, Adrian, Goate, Alison M, Marcora, Edoardo, Romero-Molina, Carmen, Ayata, Pinar, Schaefer, Anne, Gjoneska, Elizabeta, Tsai, Li-Huei

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Discovery of IPN60090, a Clinical Stage Selective Glutaminase‑1 (GLS-1) Inhibitor with Excellent Pharmacokinetic and Physicochemical Properties von Soth, Michael J, Le, Kang, Di Francesco, Maria Emilia, Hamilton, Matthew M, Liu, Gang, Burke, Jason P, Carroll, Chris L, Kovacs, Jeffrey J, Bardenhagen, Jennifer P, Bristow, Christopher A, Cardozo, Mario, Czako, Barbara, de Stanchina, Elisa, Feng, Ningping, Garvey, Jill R, Gay, Jason P, Do, Mary K. Geck, Greer, Jennifer, Han, Michelle, Harris, Angela, Herrera, Zachary, Huang, Sha, Giuliani, Virginia, Jiang, Yongying, Johnson, Sarah B, Johnson, Troy A, Kang, Zhijun, Leonard, Paul G, Liu, Zhen, McAfoos, Timothy, Miller, Meredith, Morlacchi, Pietro, Mullinax, Robert A, Palmer, Wylie S, Pang, Jihai, Rogers, Norma, Rudin, Charles M, Shepard, Hannah E, Spencer, Nakia D, Theroff, Jay, Wu, Qi, Xu, Alan, Yau, Ju Anne, Draetta, Giulio, Toniatti, Carlo, Heffernan, Timothy P, Jones, Philip

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Discovery of 6‑[(3S,4S)‑4-Amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl]-3-(2,3-dichlorophenyl)-2-methyl-3,4-dihydropyrimidin-4-one (IACS-15414), a Potent and Orally Bioavailable... von Czako, Barbara, Sun, Yuting, McAfoos, Timothy, Cross, Jason B, Leonard, Paul G, Burke, Jason P, Carroll, Christopher L, Feng, Ningping, Harris, Angela L, Jiang, Yongying, Kang, Zhijun, Kovacs, Jeffrey J, Mandal, Pijus, Meyers, Brooke A, Mseeh, Faika, Parker, Connor A, Yu, Simon S, Williams, Christopher C, Wu, Qi, Di Francesco, Maria Emilia, Draetta, Giulio, Heffernan, Timothy, Marszalek, Joseph. R, Kohl, Nancy E, Jones, Philip

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Prodrugs of a 1‑Hydroxy-2-oxopiperidin-3-yl Phosphonate Enolase Inhibitor for the Treatment of ENO1-Deleted Cancers von Yan, Victoria C., Pham, Cong-Dat, Ballato, Elliot S., Yang, Kristine L., Arthur, Kenisha, Khadka, Sunada, Barekatain, Yasaman, Shrestha, Prakriti, Tran, Theresa, Poral, Anton H., Washington, Mykia, Raghavan, Sudhir, Czako, Barbara, Pisaneschi, Federica, Lin, Yu-Hsi, Satani, Nikunj, Hammoudi, Naima, Ackroyd, Jeffrey J., Georgiou, Dimitra K., Millward, Steven W., Muller, Florian L.

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Discovery of IACS-9779 and IACS-70465 as Potent Inhibitors Targeting Indoleamine 2,3-Dioxygenase 1 (IDO1) Apoenzyme von Hamilton, Matthew M, Mseeh, Faika, McAfoos, Timothy J, Leonard, Paul G, Reyna, Naphtali J, Harris, Angela L, Xu, Alan, Han, Michelle, Soth, Michael J, Czako, Barbara, Theroff, Jay P, Mandal, Pijus K, Burke, Jason P, Virgin-Downey, Brett, Petrocchi, Alessia, Pfaffinger, Dana, Rogers, Norma E, Parker, Connor A, Yu, Simon S, Jiang, Yongying, Krapp, Stephan, Lammens, Alfred, Trevitt, Graham, Tremblay, Martin R, Mikule, Keith, Wilcoxen, Keith, Cross, Jason B, Jones, Philip, Marszalek, Joseph R, Lewis, Richard T

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Discovery of IACS-9439, a Potent, Exquisitely Selective, and Orally Bioavailable Inhibitor of CSF1R von Czako, Barbara, Marszalek, Joseph. R, Burke, Jason P, Mandal, Pijus, Leonard, Paul G, Cross, Jason B, Mseeh, Faika, Jiang, Yongying, Chang, Edward Q, Suzuki, Erika, Kovacs, Jeffrey J, Feng, Ningping, Gera, Sonal, Harris, Angela L, Liu, Zhen, Mullinax, Robert A, Pang, Jihai, Parker, Connor A, Spencer, Nakia D, Yu, Simon S, Wu, Qi, Tremblay, Martin R, Mikule, Keith, Wilcoxen, Keith, Heffernan, Timothy P, Draetta, Giulio F, Jones, Philip

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Abstract 2831: Collateral lethality: A new target for personalized oncology von Lin, Yu-Hsi, Hammoudi, Naima, Satani, Nikunj, Ackroyd, Jeffrey, Khadka, Sunada, Georgiou, Dimitra, Marszalek, Joe, Sun, Yuting, Protopopova, Marina, Francesco, Maria E. Di, Czako, Barbara, Wang, Alan Y., DePinho, Ronald A., Muller, Florian L.

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Allosteric SHP2 inhibitor IACS-13909 overcomes EGFR-dependent and EGFR-independent resistance mechanisms towards osimertinib von Sun, Yuting, Meyers, Brooke A., Czako, Barbara, Leonard, Paul, Mseeh, Faika, Harris, Angela L., Wu, Qi, Johnson, Sarah, Parker, Connor A., Cross, Jason B., Francesco, Maria Emilia Di, Bivona, Benjamin J., Bristow, Christopher A., Burke, Jason P., Carrillo, Caroline C., Carroll, Christopher L., Chang, Qing, Feng, Ningping, Gao, Guang, Gera, Sonal, Giuliani, Virginia, Huang, Justin K., Jiang, Yongying, Kang, Zhijun, Kovacs, Jeffrey J., Liu, Chiu-Yi, Lopez, Anastasia M., Ma, Xiaoyan, Mandal, Pijus K., McAfoos, Timothy, Miller, Meredith A., Mullinax, Robert A., Peoples, Michael, Ramamoorthy, Vandhana, Seth, Sahil, Spencer, Nakia D., Suzuki, Erika, Williams, Christopher C., Yu, Simon S., Zuniga, Andy M., Draetta, Giulio F., Marszalek, Joseph R., Heffernan, Timothy P., Kohl, Nancy E., Jones, Philip

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