Targeting the MAPK Pathway in KRAS-Driven Tumors von Drosten, Matthias, Barbacid, Mariano

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Targeting KRAS mutant lung cancer: light at the end of the tunnel von Drosten, Matthias, Barbacid, Mariano

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Genetically engineered mouse models of pancreatic adenocarcinoma von Guerra, Carmen, Barbacid, Mariano

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KRAS inhibitors: going noncovalent von Drosten, Matthias, Barbacid, Mariano

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A Pericyte Origin of Spinal Cord Scar Tissue von Göritz, Christian, Dias, David O., Tomilin, Nikolay, Barbacid, Mariano, Shupliakov, Oleg, Frisén, Jonas

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EGF Receptor Signaling Is Essential for K-Ras Oncogene-Driven Pancreatic Ductal Adenocarcinoma von Navas, Carolina, Hernández-Porras, Isabel, Schuhmacher, Alberto J., Sibilia, Maria, Guerra, Carmen, Barbacid, Mariano

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A Synthetic Lethal Interaction between K-Ras Oncogenes and Cdk4 Unveils a Therapeutic Strategy for Non-small Cell Lung Carcinoma von Puyol, Marta, Martín, Alberto, Dubus, Pierre, Mulero, Francisca, Pizcueta, Pilar, Khan, Gulfaraz, Guerra, Carmen, Santamaría, David, Barbacid, Mariano

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RAF inhibitor PLX8394 selectively disrupts BRAF dimers and RAS-independent BRAF-mutant-driven signaling von Yao, Zhan, Gao, Yijun, Su, Wenjing, Yaeger, Rona, Tao, Jessica, Na, Na, Zhang, Ying, Zhang, Chao, Rymar, Andrey, Tao, Anthony, Timaul, Neilawattie M., Mcgriskin, Rory, Outmezguine, Nathaniel A., Zhao, HuiYong, Chang, Qing, Qeriqi, Besnik, Barbacid, Mariano, de Stanchina, Elisa, Hyman, David M, Bollag, Gideon, Rosen, Neal

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Pancreatitis-Induced Inflammation Contributes to Pancreatic Cancer by Inhibiting Oncogene-Induced Senescence von Guerra, Carmen, Collado, Manuel, Navas, Carolina, Schuhmacher, Alberto J., Hernández-Porras, Isabel, Cañamero, Marta, Rodriguez-Justo, Manuel, Serrano, Manuel, Barbacid, Mariano

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Identification of cancer initiating cells in K-Ras driven lung adenocarcinoma von Mainardi, Sara, Mijimolle, Nieves, Francoz, Sarah, Vicente-Dueñas, Carolina, Sánchez-García, Isidro, Barbacid, Mariano

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c-RAF Ablation Induces Regression of Advanced Kras/Trp53 Mutant Lung Adenocarcinomas by a Mechanism Independent of MAPK Signaling von Sanclemente, Manuel, Francoz, Sarah, Esteban-Burgos, Laura, Bousquet-Mur, Emilie, Djurec, Magdolna, Lopez-Casas, Pedro P., Hidalgo, Manuel, Guerra, Carmen, Drosten, Matthias, Musteanu, Monica, Barbacid, Mariano

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Saa3 is a key mediator of the protumorigenic properties of cancer-associated fibroblasts in pancreatic tumors von Djurec, Magdolna, Graña, Osvaldo, Lee, Albert, Troulé, Kevin, Espinet, Elisa, Cabras, Lavinia, Navas, Carolina, Blasco, María Teresa, Martín-Díaz, Laura, Burdiel, Miranda, Li, Jing, Liu, Zhaoqi, Vallespinós, Mireia, Sanchez-Bueno, Francisco, Sprick, Martin R., Trumpp, Andreas, Sainz, Bruno, Al-Shahrour, Fátima, Rabadan, Raul, Guerra, Carmen, Barbacid, Mariano

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A Braf kinase-inactive mutant induces lung adenocarcinoma von Nieto, Patricia, Ambrogio, Chiara, Esteban-Burgos, Laura, Gómez-López, Gonzalo, Blasco, María Teresa, Yao, Zhan, Marais, Richard, Rosen, Neal, Chiarle, Roberto, Pisano, David G., Barbacid, Mariano, Santamaría, David

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Chronic Pancreatitis Is Essential for Induction of Pancreatic Ductal Adenocarcinoma by K-Ras Oncogenes in Adult Mice von Guerra, Carmen, Schuhmacher, Alberto J., Cañamero, Marta, Grippo, Paul J., Verdaguer, Lena, Pérez-Gallego, Lucía, Dubus, Pierre, Sandgren, Eric P., Barbacid, Mariano

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Complete Regression of Advanced Pancreatic Ductal Adenocarcinomas upon Combined Inhibition of EGFR and C-RAF von Blasco, María Teresa, Navas, Carolina, Martín-Serrano, Guillermo, Graña-Castro, Osvaldo, Lechuga, Carmen G., Martín-Díaz, Laura, Djurec, Magdolna, Li, Jing, Morales-Cacho, Lucia, Esteban-Burgos, Laura, Perales-Patón, Javier, Bousquet-Mur, Emilie, Castellano, Eva, Jacob, Harrys K.C., Cabras, Lavinia, Musteanu, Monica, Drosten, Matthias, Ortega, Sagrario, Mulero, Francisca, Sainz, Bruno, Dusetti, Nelson, Iovanna, Juan, Sánchez-Bueno, Francisco, Hidalgo, Manuel, Khiabanian, Hossein, Rabadán, Raul, Al-Shahrour, Fátima, Guerra, Carmen, Barbacid, Mariano

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Exploiting oncogene-induced replicative stress for the selective killing of Myc-driven tumors von Murga, Matilde, Campaner, Stefano, Lopez-Contreras, Andres J, Toledo, Luis I, Soria, Rebeca, Montaña, Maria F, D'Artista, Luana, Schleker, Thomas, Guerra, Carmen, Garcia, Elena, Barbacid, Mariano, Hidalgo, Manuel, Amati, Bruno, Fernandez-Capetillo, Oscar

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CDK inhibitors in cancer therapy: what is next? von Malumbres, Marcos, Pevarello, Paolo, Barbacid, Mariano, Bischoff, James R

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Combined inhibition of DDR1 and Notch signaling is a therapeutic strategy for KRAS-driven lung adenocarcinoma von Ambrogio, Chiara, Gómez-López, Gonzalo, Falcone, Mattia, Vidal, August, Nadal, Ernest, Crosetto, Nicola, Blasco, Rafael B, Fernández-Marcos, Pablo J, Sánchez-Céspedes, Montserrat, Ren, Xiaomei, Wang, Zhen, Ding, Ke, Hidalgo, Manuel, Serrano, Manuel, Villanueva, Alberto, Santamaría, David, Barbacid, Mariano

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Myc stimulates cell cycle progression through the activation of Cdk1 and phosphorylation of p27 von García-Gutiérrez, Lucía, Bretones, Gabriel, Molina, Ester, Arechaga, Ignacio, Symonds, Catherine, Acosta, Juan C., Blanco, Rosa, Fernández, Adrián, Alonso, Leticia, Sicinski, Piotr, Barbacid, Mariano, Santamaría, David, León, Javier

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Genetically Engineered Mouse Models of K-Ras-Driven Lung and Pancreatic Tumors: Validation of Therapeutic Targets von Drosten, Matthias, Guerra, Carmen, Barbacid, Mariano

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