A novel orally active proteasome inhibitor ONX 0912 triggers in vitro and in vivo cytotoxicity in multiple myeloma von Chauhan, Dharminder, Singh, Ajita V., Aujay, Monette, Kirk, Christopher J., Bandi, Madhavi, Ciccarelli, Bryan, Raje, Noopur, Richardson, Paul, Anderson, Kenneth C.

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Immunomodulatory effects of lenalidomide and pomalidomide on interaction of tumor and bone marrow accessory cells in multiple myeloma von Görgün, Güllü, Calabrese, Elisabetta, Soydan, Ender, Hideshima, Teru, Perrone, Giulia, Bandi, Madhavi, Cirstea, Diana, Santo, Loredana, Hu, Yiguo, Tai, Yu-Tzu, Nahar, Sabikun, Mimura, Naoya, Fabre, Claire, Raje, Noopur, Munshi, Nikhil, Richardson, Paul, Anderson, Kenneth C.

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Functional Genomics Reveals Synthetic Lethality between Phosphogluconate Dehydrogenase and Oxidative Phosphorylation von Sun, Yuting, Bandi, Madhavi, Lofton, Timothy, Smith, Melinda, Bristow, Christopher A., Carugo, Alessandro, Rogers, Norma, Leonard, Paul, Chang, Qing, Mullinax, Robert, Han, Jing, Shi, Xi, Seth, Sahil, Meyers, Brooke A., Miller, Meredith, Miao, Lili, Ma, Xiaoyan, Feng, Ningping, Giuliani, Virginia, Geck Do, Mary, Czako, Barbara, Palmer, Wylie S., Mseeh, Faika, Asara, John M., Jiang, Yongying, Morlacchi, Pietro, Zhao, Shuping, Peoples, Michael, Tieu, Trang N., Warmoes, Marc O., Lorenzi, Philip L., Muller, Florian L., DePinho, Ronald A., Draetta, Giulio F., Toniatti, Carlo, Jones, Philip, Heffernan, Timothy P., Marszalek, Joseph R.

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A duplexed high-throughput mass spectrometry assay for bifunctional POLB polymerase and lyase activity von Gurard-Levin, Zachary A., McMillan, Brian, Whittington, Douglas A., Doyon, Brian, Scholle, Michael D., Ermolieff, Jacques, Bandi, Madhavi, Liu, Mu-Sen, Amor, Alvaro, Mallender, William D.

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Mechanism-Specific Pharmacodynamics of a Novel Complex-I Inhibitor Quantified by Imaging Reversal of Consumptive Hypoxia with [ 18 F]FAZA PET In Vivo von Gammon, Seth T, Pisaneschi, Federica, Bandi, Madhavi L, Smith, Melinda G, Sun, Yuting, Rao, Yi, Muller, Florian, Wong, Franklin, De Groot, John, Ackroyd, Jeffrey, Mawlawi, Osama, Davies, Michael A, Gopal, Y N Vashisht, Di Francesco, M Emilia, Marszalek, Joseph R, Dewhirst, Mark, Piwnica-Worms, David

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BET Bromodomain Inhibition Suppresses Human T Cell Function von Georgiev, Peter, Wang, Yun, Muise, Eric S, Bandi, Madhavi L, Blumenschein, Wendy, Sathe, Manjiri, Pinheiro, Elaine M, Shumway, Stuart D

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An inhibitor of oxidative phosphorylation exploits cancer vulnerability von Molina, Jennifer R., Sun, Yuting, Protopopova, Marina, Gera, Sonal, Bandi, Madhavi, Bristow, Christopher, McAfoos, Timothy, Morlacchi, Pietro, Ackroyd, Jeffrey, Agip, Ahmed-Noor A., Al-Atrash, Gheath, Asara, John, Bardenhagen, Jennifer, Carrillo, Caroline C., Carroll, Christopher, Chang, Edward, Ciurea, Stefan, Cross, Jason B., Czako, Barbara, Deem, Angela, Daver, Naval, de Groot, John Frederick, Dong, Jian-Wen, Feng, Ningping, Gao, Guang, Gay, Jason, Do, Mary Geck, Greer, Jennifer, Giuliani, Virginia, Han, Jing, Han, Lina, Henry, Verlene K., Hirst, Judy, Huang, Sha, Jiang, Yongying, Kang, Zhijun, Khor, Tin, Konoplev, Sergej, Lin, Yu-Hsi, Liu, Gang, Lodi, Alessia, Lofton, Timothy, Ma, Helen, Mahendra, Mikhila, Matre, Polina, Mullinax, Robert, Peoples, Michael, Petrocchi, Alessia, Rodriguez-Canale, Jaime, Serreli, Riccardo, Shi, Thomas, Smith, Melinda, Tabe, Yoko, Theroff, Jay, Tiziani, Stefano, Xu, Quanyun, Zhang, Qi, Muller, Florian, DePinho, Ronald A., Toniatti, Carlo, Draetta, Giulio F., Heffernan, Timothy P., Konopleva, Marina, Jones, Philip, Di Francesco, M. Emilia, Marszalek, Joseph R.

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A novel Aurora-A kinase inhibitor MLN8237 induces cytotoxicity and cell-cycle arrest in multiple myeloma von Görgün, Güllü, Calabrese, Elisabetta, Hideshima, Teru, Ecsedy, Jeffrey, Perrone, Giulia, Mani, Mala, Ikeda, Hiroshi, Bianchi, Giada, Hu, Yiguo, Cirstea, Diana, Santo, Loredana, Tai, Yu-Tzu, Nahar, Sabikun, Zheng, Mei, Bandi, Madhavi, Carrasco, Ruben D., Raje, Noopur, Munshi, Nikhil, Richardson, Paul, Anderson, Kenneth C.

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Ubiquitinated PCNA Drives USP1 Synthetic Lethality in Cancer von Simoneau, Antoine, Engel, Justin L, Bandi, Madhavi, Lazarides, Katherine, Liu, Shangtao, Meier, Samuel R, Choi, Ashley H, Zhang, Hongxiang, Shen, Binzhang, Martires, Lauren, Gotur, Deepali, Pham, Truc V, Li, Fang, Gu, Lina, Gong, Shanzhong, Zhang, Minjie, Wilker, Erik, Pan, Xuewen, Whittington, Douglas A, Throner, Scott, Maxwell, John P, Chen, Yingnan, Yu, Yi, Huang, Alan, Andersen, Jannik N, Feng, Tianshu

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VRK1 Is a Synthetic-Lethal Target in VRK2-Deficient Glioblastoma von Shields, Julie A, Meier, Samuel R, Bandi, Madhavi, Mulkearns-Hubert, Erin E, Hajdari, Nicole, Ferdinez, Maria Dam, Engel, Justin L, Silver, Daniel J, Shen, Binzhang, Zhang, Wenhai, Hubert, Christopher G, Mitchell, Kelly, Shakya, Sajina, Zhao, Shan-Chuan, Bejnood, Alborz, Zhang, Minjie, Tjin Tham Sjin, Robert, Wilker, Erik, Lathia, Justin D, Andersen, Jannik N, Chen, Yingnan, Li, Fang, Weber, Barbara, Huang, Alan, Emmanuel, Natasha

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Functional Interaction of Plasmacytoid Dendritic Cells with Multiple Myeloma Cells: A Therapeutic Target von Chauhan, Dharminder, Singh, Ajita V., Brahmandam, Mohan, Carrasco, Ruben, Bandi, Madhavi, Hideshima, Teru, Bianchi, Giada, Podar, Klaus, Tai, Yu-Tzu, Mitsiades, Constantine, Raje, Noopur, Jaye, David L., Kumar, Shaji K., Richardson, Paul, Munshi, Nikhil, Anderson, Kenneth C.

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PR‐924, a selective inhibitor of the immunoproteasome subunit LMP‐7, blocks multiple myeloma cell growth both in vitro and in vivo von Singh, Ajita V., Bandi, Madhavi, Aujay, Monette A., Kirk, Christopher J., Hark, David E., Raje, Noopur, Chauhan, Dharminder, Anderson, Kenneth C.

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Abstract P182: VRK1 is a novel synthetic lethal target in VRK2-methylated glioblastoma von Shields, Julie, Meier, Samuel R., Engel, Justin, Bandi, Madhavi, Dam Ferdinez, Maria L., Zhang, Wenhai, Zhao, Shan-chuan, Zhang, Minjie, Choi, Ashley, Yu, Yi, Pan, Xuewen, McMillan, Brian, Williams, Brett, Sjin, Robert Tjin Tham, Whittington, Douglas, Wilker, Erik, Huang, Alan, Li, Fang, Emmanuel, Natasha

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CNSC-36. VRK1 IS A PARALOG SYNTHETIC LETHAL TARGET IN VRK2-METHYLATED GLIOBLASTOMA von Shields, Julie, Meier, Samuel, Bandi, Madhavi, Ferdinez, Maria Dam, Engel, Justin, Mulkearns-Hubert, Erin, Hajdari, Nicole, Shen, Binzhang, Hubert, Christopher, Mitchell, Kelly, Zhang, Wenhai, Zhao, Shan-chuan, Bejnood, Alborz, Zhang, Minjie, Sjin, Robert Tjin Tham, Wilker, Erik, Lathia, Justin, Andersen, Jannik, Chen, Yingnan, Li, Fang, Weber, Barbara, Huang, Alan, Emmanuel, Natasha

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Abstract LB-367: [18F]FAZA PET imaging reveals precise pharmacodynamics in vivo of the novel chemotherapeutic IACS-010759 von Gammon, Seth T., Pisaneschi, Federica, Bandi, Madhavi, Smith, Melinda, Rao, Yi, Nanda, Vashisht G. Yennu, Sun, Yuting, Davies, Michael, Francesco, Emilia Di, Marszalek, Joseph, Piwnica-Worms, David

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Antimyeloma Activity of a Multitargeted Kinase Inhibitor, AT9283, via Potent Aurora Kinase and STAT3 Inhibition Either Alone or in Combination with Lenalidomide von SANTO, Loredana, HIDESHIMA, Teru, UNITT, Christine, SQUIRES, Matt, YIGUO HU, CHAUHAN, Dharminder, MAHINDRA, Anuj, MUNSHI, Nikhil C, ANDERSON, Kenneth C, RAJE, Noopur, CIRSTEA, Diana, BANDI, Madhavi, NELSON, Erik A, GORGUN, Gullu, RODIG, Scott, VALLET, Sonia, POZZI, Samantha, PATEL, Kishan

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Cytokinesis failure generating tetraploids promotes tumorigenesis in p53 -null cells von Pellman, David, Fujiwara, Takeshi, Bandi, Madhavi, Nitta, Masayuki, Ivanova, Elena V, Bronson, Roderick T

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Abstract 1655: Discovery and development of IACS-010759, a novel inhibitor of Complex I currently in phase I studies to exploit oxidative phosphorylation dependency in acute myeloi... von Francesco, Maria Emilia Di, Marszalek, Joseph R., McAfoos, Timothy, Carroll, Christopher L., Kang, Zhijun, Liu, Gang, Theroff, Jay P., Bardenhager, Jennifer P., Bandi, Madhavi L., Molina, Jennifer R., Gera, Sonal, Protopopova, Marina, Sun, Yuting, Do, Mary K. Geck, Feng, Ningping, Gay, Jason P., Muller, Florian, Konopleva, Marina, Meric-Bernstam, Funda, Toniatti, Carlo, Heffernan, Timothy P., Draetta, Giulio F., Jones, Philip

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