Preclinical Evaluation of the Stability, Safety, and Efficacy of CD101, a Novel Echinocandin von Ong, Voon, Hough, Grayson, Schlosser, Michael, Bartizal, Ken, Balkovec, James M, James, Kenneth D, Krishnan, B Radha

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Discovery and development of first in class antifungal caspofungin (CANCIDAS®)-A case study von Balkovec, James M, Hughes, David L, Masurekar, Prakash S, Sable, Carole A, Schwartz, Robert E, Singh, Sheo B

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Ibrexafungerp: An orally active β-1,3-glucan synthesis inhibitor von Apgar, James M., Wilkening, Robert R., Parker, Dann L., Meng, Dongfang, Wildonger, Kenneth J., Sperbeck, Donald, Greenlee, Mark L., Balkovec, James M., Flattery, Amy M., Abruzzo, George K., Galgoci, Andrew M., Giacobbe, Robert A., Gill, Charles J., Hsu, Ming-Jo, Liberator, Paul, Misura, Andrew S., Motyl, Mary, Nielsen Kahn, Jennifer, Powles, Maryann, Racine, Fred, Dragovic, Jasminka, Fan, Weiming, Kirwan, Robin, Lee, Shu, Liu, Hao, Mamai, Ahmed, Nelson, Kingsley, Peel, Michael

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Development of Novel Immunoprophylactic Agents against Multidrug-Resistant Gram-Negative Bacterial Infections von Lovey, Arianne, Krel, Mila, Borchardt, Allen, Brady, Thomas, Cole, Jason N, Do, Quyen-Quyen, Fortier, Joanne, Hough, Grayson, Jiang, Wanlong, Noncovich, Alain, Tari, Les, Zhao, Qiping, Balkovec, James M, Zhao, Yanan, Perlin, David S

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Bifunctional Small Molecules Enhance Neutrophil Activities Against Aspergillus fumigatus in vivo and in vitro von Jones, Caroline N, Ellett, Felix, Robertson, Anne L, Forrest, Kevin M, Judice, Kevin, Balkovec, James M, Springer, Martin, Markmann, James F, Vyas, Jatin M, Warren, H Shaw, Irimia, Daniel

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MK-5204: An orally active β-1,3-glucan synthesis inhibitor von Apgar, James M., Wilkening, Robert R., Parker, Dann L., Meng, Dongfang, Wildonger, Kenneth J., Sperbeck, Donald, Greenlee, Mark L., Balkovec, James M., Flattery, Amy M., Abruzzo, George K., Galgoci, Andrew M., Giacobbe, Robert A., Gill, Charles J., Hsu, Ming-Jo, Liberator, Paul, Misura, Andrew S., Motyl, Mary, Kahn, Jennifer Nielsen, Powles, Maryann, Racine, Fred, Dragovic, Jasminka, Fan, Weiming, Kirwan, Robin, Lee, Shu, Liu, Hao, Mamai, Ahmed, Nelson, Kingsley, Peel, Michael

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CTC-177, a novel drug–Fc conjugate, shows promise as an immunoprophylactic agent against multidrug-resistant Gram-negative bacterial infections von Lovey, Arianne, Lee, Annie, Yu, Allison, Krel, Mila, Wang, Mingming, Paderu, Padmaja, Brady, Thomas, Hough, Grayson, Zhao, Qiping, Balkovec, James M, Perlin, David S, Zhao, Yanan

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Accelerating the discovery of DGAT1 inhibitors through the application of parallel medicinal chemistry (PMC) von Yu, Yang, Wu, Zhicai, Shi, Zhi-Cai, He, Shuwen, Lai, Zhong, Cernak, Timothy A., Vachal, Petr, Liu, Min, Liu, Jian, Hong, Qingmei, Jian, Tianying, Guiadeen, Deodial, Krikorian, Arto, Sperbeck, Donald M., Verras, Andreas, Sonatore, Lisa M., Murphy, Beth A., Wiltsie, Judyann, Chung, Christine C., Gorski, Judith N., Liu, Jinqi, Xiao, Jianying, Wolff, Michael, Tong, Sharon X., Madeira, Maria, Karanam, Bindhu V., Shen, Dong-Ming, Balkovec, James M., De Vita, Robert J., Pinto, Shirly, Nargund, Ravi P.

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The First Stereoselective Total Synthesis of Quinine von Stork, Gilbert, Niu, Deqiang, Fujimoto, A, Koft, Emil R, Balkovec, James M, Tata, James R, Dake, Gregory R

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Novel orally active inhibitors of β-1,3-glucan synthesis derived from enfumafungin von Apgar, James M., Wilkening, Robert R., Greenlee, Mark L., Balkovec, James M., Flattery, Amy M., Abruzzo, George K., Galgoci, Andrew M., Giacobbe, Robert A., Gill, Charles J., Hsu, Ming Jo, Liberator, Paul, Misura, Andrew S., Motyl, Mary, Nielsen Kahn, Jennifer, Powles, Maryann, Racine, Fred, Dragovic, Jasminka, Habulihaz, Bahanu, Fan, Weiming, Kirwan, Robin, Lee, Shu, Liu, Hao, Mamai, Ahmed, Nelson, Kingsley, Peel, Michael

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Benzimidazole-based DGAT1 inhibitors with a [3.1.0] bicyclohexane carboxylic acid moiety von He, Shuwen, Lai, Zhong, Hong, Qingmei, Shang, Jackie, Reibarkh, Mikhail, Kuethe, Jeffrey T., Liu, Jian, Guiadeen, Deodial, Krikorian, Arto D., Cernak, Timothy A., Dykstra, Kevin D., Sperbeck, Donald M., Wu, Zhicai, Yu, Yang, Yang, Ginger X., Jian, Tianying, Verras, Andreas, Sonatore, Lisa M., Wiltsie, Judyann, Chung, Christine C., Murphy, Beth A., Gorski, Judith N., Liu, Jinqi, Xiao, Jianying, Wolff, Michael, Tong, Sharon X., Madeira, Maria, Karanam, Bindhu V., Shen, Dong-Ming, Balkovec, James M., Pinto, Shirly, Nargund, Ravi P., DeVita, Robert J.

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11β-HSD1 inhibition ameliorates metabolic syndrome and prevents progression of atherosclerosis in mice von Hermanowski-Vosatka, Anne, Balkovec, James M., Cheng, Kang, Chen, Howard Y., Hernandez, Melba, Koo, Gloria C., Le Grand, Cheryl B., Li, Zhihua, Metzger, Joseph M., Mundt, Steven S., Noonan, Heather, Nunes, Christian N., Olson, Steven H., Pikounis, Bill, Ren, Ning, Robertson, Nancy, Schaeffer, James M., Shah, Kashmira, Springer, Martin S., Strack, Alison M., Strowski, Matthias, Wu, Kenneth, Wu, TsueiJu, Xiao, Jianying, Zhang, Bei B., Wright, Samuel D., Thieringer, Rolf

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Synthesis and biological evaluation of antifungal derivatives of enfumafungin as orally bioavailable inhibitors of β-1,3-glucan synthase von Heasley, Brian H., Pacofsky, Gregory J., Mamai, Ahmed, Liu, Hao, Nelson, Kingsley, Coti, Ghjuvanni, Peel, Michael R., Balkovec, James M., Greenlee, Mark L., Liberator, Paul, Meng, Dongfang, Parker, Dann L., Wilkening, Robert R., Apgar, James M., Racine, F., Hsu, Ming Jo, Giacobbe, Robert A., Kahn, Jennifer Nielsen

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The use of stable-isotopically labeled oleic acid to interrogate lipid assembly in vivo: assessing pharmacological effects in preclinical species von McLaren, David G., He, Timothy, Wang, Sheng-Ping, Mendoza, Vivienne, Rosa, Raymond, Gagen, Karen, Bhat, Gowri, Herath, Kithsiri, Miller, Paul L., Stribling, Sloan, Taggart, Andrew, Imbriglio, Jason, Liu, Jinqi, Chen, Dunlu, Pinto, Shirly, Balkovec, James M., DeVita, Robert J., Marsh, Donald J., Castro-Perez, Jose M., Strack, Alison, Johns, Douglas G., Previs, Stephen F., Hubbard, Brian K., Roddy, Thomas P.

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11 beta -HSD1 inhibition reduces atherosclerosis in mice by altering proinflammatory gene expression in the vasculature von Luo, Mingjuan J, Thieringer, Rolf, Springer, Martin S, Wright, Samuel D, Hermanowski-Vosatka, Anne, Plump, Andrew, Balkovec, James M, Cheng, Kang, Ding, Gloria J, Kawka, Douglas W

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Adamantyl triazoles as selective inhibitors of 11β-hydroxysteroid dehydrogenase type 1 von Olson, Steven, Aster, Susan D., Brown, Kai, Carbin, Linda, Graham, Donald W., Hermanowski-Vosatka, Anne, LeGrand, Cheryl B., Mundt, Steven S., Robbins, Michael A., Schaeffer, James M., Slossberg, Llnon H., Szymonifka, Michael J., Thieringer, Rolf, Wright, Samuel D., Balkovec, James M.

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Phenylcyclobutyl triazoles as selective inhibitors of 11β-hydroxysteroid dehydrogenase type I von Zhu, Yuping, Olson, Steven H., Graham, Donald, Patel, Gool, Hermanowski-Vosatka, Anne, Mundt, Steven, Shah, Kashmira, Springer, Marty, Thieringer, Rolf, Wright, Samuel, Xiao, Jianying, Zokian, Hratch, Dragovic, Jasminka, Balkovec, James M.

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11β-HSD1 inhibition reduces atherosclerosis in mice by altering proinflammatory gene expression in the vasculature von Luo, Mingjuan J, Thieringer, Rolf, Springer, Martin S, Wright, Samuel D, Hermanowski-Vosatka, Anne, Plump, Andrew, Balkovec, James M, Cheng, Kang, Ding, Gloria J, Kawka, Douglas W, Koo, Gloria C, Grand, Cheryl B Le, Luo, Qi, Maletic, Milana M, Malkowitz, Lorraine, Shah, Kashmira, Singer, Irwin, Waddell, Sherman T, Wu, Kenneth K, Yuan, Jeffrey, Zhu, Jun, Stepaniants, Serguei, Yang, Xia, Lum, Pek Yee, Wang, I-Ming

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Novel N-Arylpyrazolo[3,2-c]-Based Ligands for the Glucocorticoid Receptor:  Receptor Binding and in Vivo Activity von Ali, Amjad, Thompson, Christopher F, Balkovec, James M, Graham, Donald W, Hammond, Milton L, Quraishi, Nazia, Tata, James R, Einstein, Monica, Ge, Lan, Harris, Georgianna, Kelly, Terri M, Mazur, Paul, Pandit, Shilpa, Santoro, Joseph, Sitlani, Ayesha, Wang, Chuanlin, Williamson, Joanne, Miller, Douglas K, Thompson, Chris M, Zaller, Dennis M, Forrest, Michael J, Carballo-Jane, Ester, Luell, Silvi

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4-Methyl-5-phenyl triazoles as selective inhibitors of 11β-hydroxysteroid dehydrogenase type I von Zhu, Yuping, Olson, Steven H., Hermanowski-Vosatka, Anne, Mundt, Steven, Shah, Kashmira, Springer, Marty, Thieringer, Rolf, Wright, Samuel, Xiao, Jianying, Zokian, Hratch, Balkovec, James M.

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