Evaluation of the echinocandin antifungal MK-0991 (L-743,872): efficacies in mouse models of disseminated aspergillosis, candidiasis, and cryptococcosis von ABRUZZO, G. K, FLATTERY, A. M, KROPP, H, BARTIZAL, K, GILL, C. J, KONG, L, SMITH, J. G, PIKOUNIS, V. B, BALKOVEC, J. M, BOUFFARD, A. F, DROPINSKI, J. F, ROSEN, H

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The First Stereoselective Total Synthesis of Quinine von Stork, Gilbert, Niu, Deqiang, Fujimoto, A, Koft, Emil R, Balkovec, James M, Tata, James R, Dake, Gregory R

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Efficacy of MK-991 (L-743,872), a semisynthetic pneumocandin, in murine models of Pneumocystis carinii von POWLES, M. A, LIBERATOR, P, SCHMATZ, D, ANDERSON, J, KARKHANIS, Y, DROPINSKI, J. F, BOUFFARD, F. A, BALKOVEC, J. M, FUJIOKA, H, AIKAWA, M, MCFADDEN, D

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Increased antifungal activity of L-733,560, a water-soluble, semisynthetic pneumocandin, is due to enhanced inhibition of cell wall synthesis von KURTZ, M. B, DOUGLAS, C, BOUFFARD, F. A, DROPINSKI, J. F, HAMMOND, M. L, ZAMBIAS, R. A, ABRUZZO, G, BARTIZAL, K, MCMANUS, O. B, GARCIA, M. L, MARRINAN, J, NOLLSTADT, K, ONISHI, J, DREIKORN, S, MILLIGAN, J, MANDALA, S, THOMPSON, J, BALKOVEC, J. M

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Attenuating pregnane X receptor (PXR) activation: A molecular modelling approach von Gao, Y.-D., Olson, S. H., Balkovec, J. M., Zhu, Y., Royo, I., Yabut, J., Evers, R., Tan, E. Y., Tang, W., Hartley, D. P., Mosley, R. T.

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Succinic acids as potent inhibitors of plasmid-borne IMP-1 metallo-beta-lactamase von Toney, J H, Hammond, G G, Fitzgerald, P M, Sharma, N, Balkovec, J M, Rouen, G P, Olson, S H, Hammond, M L, Greenlee, M L, Gao, Y D

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Synthesis and SAR of thioester and thiol inhibitors of IMP-1 Metallo-β-Lactamase von Greenlee, Mark L., Laub, Joanne B., Balkovec, James M., Hammond, Milton L., Hammond, Gail G., Pompliano, David L., Epstein-Toney, Jeffrey H.

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Alkyl side-chain derivatives of sordaricin as potent antifungal agents against yeast von Tse, Bruno, Balkovec, James M., Blazey, Charles M., Hsu, Ming-Jo, Nielsen, Jennifer, Schmatz, Dennis

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Inhibition of IMP-1 metallo-β-lactamase and sensitization of IMP-1-producing bacteria by thioester derivatives von Hammond, Gail G., Huber, Joann L., Greenlee, Mark L., Laub, Joanne B., Young, Katherine, Silver, Lynn L., Balkovec, James M., Pryor, KellyAnn D., Wu, Joseph K., Leiting, Barbara, Pompliano, David L., Toney, Jeffrey H.

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PNEUMOCANDINS FROM Zalerion arboricola: IV. BIOLOGICAL EVALUATION OF NATURAL AND SEMISYNTHETIC PNEUMOCANDINS FOR ACTIVITY AGAINST Pneumocystis carinii AND Candida SPECIES von SCHMATZ, D. M., ABRUZZO, G., POWLES, M. A., MCFADDEN, D. C., BALKOVEC, J. M., BLACK, R. M., NOLLSTADT, K., BARTIZAL, K.

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On the use of the O-methylmandelate ester for establishment of absolute configuration of secondary alcohols von Trost, Barry M, Belletire, John L, Godleski, Stephen, McDougal, Patrick G, Balkovec, James M, Baldwin, John J, Christy, Marcia E, Ponticello, Gerald S, Varga, Sandor L, Springer, James P

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11 beta -HSD1 inhibition ameliorates metabolic syndrome and prevents progression of atherosclerosis in mice von Hermanowski-Vosatka, Anne, Balkovec, James M, Cheng, Kang, Chen, Howard Y, Hernandez, Melba, Koo, Gloria C, Le Grand, Cheryl B, Li, Zhihua, Metzger, Joseph M, Mundt, Steven S, Noonan, Heather, Nunes, Christian N, Olson, Steven H, Pikounis, Bill, Ren, Ning, Robertson, Nancy, Schaeffer, James M, Shah, Kashmira, Springer, Martin S, Strack, Alison M, Strowski, Matthias, Wu, Kenneth, Wu, TsueiJu, Xiao, Jianying, Zhang, Bei B, Wright, Samuel D, Thieringer, Rolf

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Adamantyl triazoles as selective inhibitors of 11β-hydroxysteroid dehydrogenase type 1 von Olson, Steven, Aster, Susan D., Brown, Kai, Carbin, Linda, Graham, Donald W., Hermanowski-Vosatka, Anne, LeGrand, Cheryl B., Mundt, Steven S., Robbins, Michael A., Schaeffer, James M., Slossberg, Llnon H., Szymonifka, Michael J., Thieringer, Rolf, Wright, Samuel D., Balkovec, James M.

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Novel N-Arylpyrazolo[3,2-c]-Based Ligands for the Glucocorticoid Receptor:  Receptor Binding and in Vivo Activity von Ali, Amjad, Thompson, Christopher F, Balkovec, James M, Graham, Donald W, Hammond, Milton L, Quraishi, Nazia, Tata, James R, Einstein, Monica, Ge, Lan, Harris, Georgianna, Kelly, Terri M, Mazur, Paul, Pandit, Shilpa, Santoro, Joseph, Sitlani, Ayesha, Wang, Chuanlin, Williamson, Joanne, Miller, Douglas K, Thompson, Chris M, Zaller, Dennis M, Forrest, Michael J, Carballo-Jane, Ester, Luell, Silvi

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Discovery of 4-heteroarylbicyclo[2.2.2]octyltriazoles as potent and selective inhibitors of 11β-HSD1: Novel therapeutic agents for the treatment of metabolic syndrome von Gu, Xin, Dragovic, Jasminka, Koo, Gloria C., Koprak, Sam L., LeGrand, Cheryl, Mundt, Steven S., Shah, Kashmira, Springer, Marty S., Tan, Eugene Y., Thieringer, Rolf, Hermanowski-Vosatka, Anne, Zokian, Hratch J., Balkovec, James M., Waddell, Sherman T.

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Synthesis, stability, and biological evaluation of water-soluble prodrugs of a new echinocandin lipopeptide. Discovery of a potential clinical agent for the treatment of systemic c... von Balkovec, James M, Black, Regina M, Hammond, Milton L, Heck, James V, Zambias, Robert A, Abruzzo, George, Bartizal, Ken, Kropp, Helmut, Trainor, Charlotte

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Synthesis and structure-activity relationships of novel 3′-Hty-substituted pneumocandins von Black, Regina M, Balkovec, James M, Nollstadt, Karl M, Dreikorn, Sarah, Bartizal, Kenneth F, Abruzzo, George K

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Reduction studies of antifungal echinocandin lipopeptides. One step conversion of echinocandin B to echinocandin C von Balkovec, James M., Black, Regina M.

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Lipopeptide antifungal agents: Amine conjugates of the semi-synthetic pneumocandins L-731,373 and L-733,560 von Zambias, Robert A., James, Catherine, Abruzzo, George K., Bartizal, Kenneth F., Hajdu, Richard, Thompson, Randy, Nollstadt, Karl H., Marrinan, Jean, Balkovec, James M.

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Novel heterocyclic glucocorticoids: in vitro profile and in vivo efficacy von Thompson, Christopher F., Quraishi, Nazia, Ali, Amjad, Tata, James R., Hammond, Milton L., Balkovec, James M., Einstein, Monica, Ge, Lan, Harris, Georgianna, Kelly, Theresa M., Mazur, Paul, Pandit, Shilpa, Santoro, Joseph, Sitlani, Ayesha, Wang, Chuanlin, Williamson, Joanne, Miller, Douglas K., Yamin, Ting-ting D., Thompson, Chris M., O’Neill, Edward A., Zaller, Dennis, Forrest, Michael J., Carballo-Jane, Ester, Luell, Silvi

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