The First Stereoselective Total Synthesis of Quinine von Stork, Gilbert, Niu, Deqiang, Fujimoto, A, Koft, Emil R, Balkovec, James M, Tata, James R, Dake, Gregory R

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Evaluation of the echinocandin antifungal MK-0991 (L-743,872): efficacies in mouse models of disseminated aspergillosis, candidiasis, and cryptococcosis von ABRUZZO, G. K, FLATTERY, A. M, KROPP, H, BARTIZAL, K, GILL, C. J, KONG, L, SMITH, J. G, PIKOUNIS, V. B, BALKOVEC, J. M, BOUFFARD, A. F, DROPINSKI, J. F, ROSEN, H

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In vitro preclinical evaluation studies with the echinocandin antifungal MK-0991 (L-743,872) von BARTIZAL, K, GILL, C. J, BALKOVEC, J, ABRUZZO, G. K, FLATTERY, A. M, KONG, L, SCOTT, P. M, SMITH, J. G, LEIGHTON, C. E, BOUFFARD, A, DROPINSKI, J. F

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Attenuating pregnane X receptor (PXR) activation: A molecular modelling approach von Gao, Y.-D., Olson, S. H., Balkovec, J. M., Zhu, Y., Royo, I., Yabut, J., Evers, R., Tan, E. Y., Tang, W., Hartley, D. P., Mosley, R. T.

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Efficacy of MK-991 (L-743,872), a semisynthetic pneumocandin, in murine models of Pneumocystis carinii von POWLES, M. A, LIBERATOR, P, SCHMATZ, D, ANDERSON, J, KARKHANIS, Y, DROPINSKI, J. F, BOUFFARD, F. A, BALKOVEC, J. M, FUJIOKA, H, AIKAWA, M, MCFADDEN, D

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Succinic acids as potent inhibitors of plasmid-borne IMP-1 metallo-beta-lactamase von Toney, J H, Hammond, G G, Fitzgerald, P M, Sharma, N, Balkovec, J M, Rouen, G P, Olson, S H, Hammond, M L, Greenlee, M L, Gao, Y D

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Synthesis and SAR of thioester and thiol inhibitors of IMP-1 Metallo-β-Lactamase von Greenlee, Mark L., Laub, Joanne B., Balkovec, James M., Hammond, Milton L., Hammond, Gail G., Pompliano, David L., Epstein-Toney, Jeffrey H.

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Increased antifungal activity of L-733,560, a water-soluble, semisynthetic pneumocandin, is due to enhanced inhibition of cell wall synthesis von KURTZ, M. B, DOUGLAS, C, BOUFFARD, F. A, DROPINSKI, J. F, HAMMOND, M. L, ZAMBIAS, R. A, ABRUZZO, G, BARTIZAL, K, MCMANUS, O. B, GARCIA, M. L, MARRINAN, J, NOLLSTADT, K, ONISHI, J, DREIKORN, S, MILLIGAN, J, MANDALA, S, THOMPSON, J, BALKOVEC, J. M

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Inhibition of IMP-1 metallo-β-lactamase and sensitization of IMP-1-producing bacteria by thioester derivatives von Hammond, Gail G., Huber, Joann L., Greenlee, Mark L., Laub, Joanne B., Young, Katherine, Silver, Lynn L., Balkovec, James M., Pryor, KellyAnn D., Wu, Joseph K., Leiting, Barbara, Pompliano, David L., Toney, Jeffrey H.

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Alkyl side-chain derivatives of sordaricin as potent antifungal agents against yeast von Tse, Bruno, Balkovec, James M., Blazey, Charles M., Hsu, Ming-Jo, Nielsen, Jennifer, Schmatz, Dennis

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In vitro antifungal activities and in vivo efficacies of 1,3-beta-D-glucan synthesis inhibitors L-671,329, L-646,991, tetrahydroechinocandin B, and L-687,781, a papulacandin von BARTIZAL, K, ABRUZZO, G, TRAINOR, C, KRUPA, D, NOLLSTADT, K, SCHMATZ, D, SCHWARTZ, R, HAMMOND, M, BALKOVEC, J, VANMIDDLESWORTH, F

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On the use of the O-methylmandelate ester for establishment of absolute configuration of secondary alcohols von Trost, Barry M, Belletire, John L, Godleski, Stephen, McDougal, Patrick G, Balkovec, James M, Baldwin, John J, Christy, Marcia E, Ponticello, Gerald S, Varga, Sandor L, Springer, James P

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11 beta -HSD1 inhibition ameliorates metabolic syndrome and prevents progression of atherosclerosis in mice von Hermanowski-Vosatka, Anne, Balkovec, James M, Cheng, Kang, Chen, Howard Y, Hernandez, Melba, Koo, Gloria C, Le Grand, Cheryl B, Li, Zhihua, Metzger, Joseph M, Mundt, Steven S, Noonan, Heather, Nunes, Christian N, Olson, Steven H, Pikounis, Bill, Ren, Ning, Robertson, Nancy, Schaeffer, James M, Shah, Kashmira, Springer, Martin S, Strack, Alison M, Strowski, Matthias, Wu, Kenneth, Wu, TsueiJu, Xiao, Jianying, Zhang, Bei B, Wright, Samuel D, Thieringer, Rolf

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Elongation factor 2 as a novel target for selective inhibition of fungal protein synthesis von Justice, M.C, Hsu, M.J, Tse, B, Ku, T, Balkovec, J, Schmatz, D, Nielsen, J

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PNEUMOCANDINS FROM Zalerion arboricola: IV. BIOLOGICAL EVALUATION OF NATURAL AND SEMISYNTHETIC PNEUMOCANDINS FOR ACTIVITY AGAINST Pneumocystis carinii AND Candida SPECIES von SCHMATZ, D. M., ABRUZZO, G., POWLES, M. A., MCFADDEN, D. C., BALKOVEC, J. M., BLACK, R. M., NOLLSTADT, K., BARTIZAL, K.

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Determination of the Absolute Stereochemistry of (−)-Galbonolide A von Tse, Bruno, Blazey, Charles M, Tu, Ben, Balkovec, James

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Adamantyl triazoles as selective inhibitors of 11β-hydroxysteroid dehydrogenase type 1 von Olson, Steven, Aster, Susan D., Brown, Kai, Carbin, Linda, Graham, Donald W., Hermanowski-Vosatka, Anne, LeGrand, Cheryl B., Mundt, Steven S., Robbins, Michael A., Schaeffer, James M., Slossberg, Llnon H., Szymonifka, Michael J., Thieringer, Rolf, Wright, Samuel D., Balkovec, James M.

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Antipneumocystis activity of water-soluble lipopeptide L-693,989 in rats von SCHMATZ, D. M, POWLES, M. A, MCFADDEN, D. C, PITTARELLI, L, BALKOVEC, J, HAMMOND, M, ZAMBIAS, R, LIBERATOR, P, ANDERSON, J

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Novel N-Arylpyrazolo[3,2-c]-Based Ligands for the Glucocorticoid Receptor:  Receptor Binding and in Vivo Activity von Ali, Amjad, Thompson, Christopher F, Balkovec, James M, Graham, Donald W, Hammond, Milton L, Quraishi, Nazia, Tata, James R, Einstein, Monica, Ge, Lan, Harris, Georgianna, Kelly, Terri M, Mazur, Paul, Pandit, Shilpa, Santoro, Joseph, Sitlani, Ayesha, Wang, Chuanlin, Williamson, Joanne, Miller, Douglas K, Thompson, Chris M, Zaller, Dennis M, Forrest, Michael J, Carballo-Jane, Ester, Luell, Silvi

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Discovery of 4-heteroarylbicyclo[2.2.2]octyltriazoles as potent and selective inhibitors of 11β-HSD1: Novel therapeutic agents for the treatment of metabolic syndrome von Gu, Xin, Dragovic, Jasminka, Koo, Gloria C., Koprak, Sam L., LeGrand, Cheryl, Mundt, Steven S., Shah, Kashmira, Springer, Marty S., Tan, Eugene Y., Thieringer, Rolf, Hermanowski-Vosatka, Anne, Zokian, Hratch J., Balkovec, James M., Waddell, Sherman T.

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