TCR microclusters form spatially segregated domains and sequentially assemble in calcium-dependent kinetic steps von Yi, Jason, Balagopalan, Lakshmi, Nguyen, Tiffany, McIntire, Katherine M., Samelson, Lawrence E.

Volltext

Plasma membrane LAT activation precedes vesicular recruitment defining two phases of early T-cell activation von Balagopalan, Lakshmi, Yi, Jason, Nguyen, Tiffany, McIntire, Katherine M., Harned, Adam S., Narayan, Kedar, Samelson, Lawrence E.

Volltext

Bypassing ubiquitination enables LAT recycling to the cell surface and enhanced signaling in T cells von Balagopalan, Lakshmi, Malik, Hiba, McIntire, Katherine M, Garvey, Joseph A, Nguyen, Tiffany, Rodriguez-Peña, Ana B, Samelson, Lawrence E

Volltext

Microclusters as T Cell Signaling Hubs: Structure, Kinetics, and Regulation von Balagopalan, Lakshmi, Raychaudhuri, Kumarkrishna, Samelson, Lawrence E

Volltext

Multipoint Binding of the SLP-76 SH2 Domain to ADAP Is Critical for Oligomerization of SLP-76 Signaling Complexes in Stimulated T Cells von Coussens, Nathan P., Hayashi, Ryo, Brown, Patrick H., Balagopalan, Lakshmi, Balbo, Andrea, Akpan, Itoro, Houtman, Jon C. D., Barr, Valarie A., Schuck, Peter, Appella, Ettore, Samelson, Lawrence E.

Volltext

Endocytic events in TCR signaling: focus on adapters in microclusters von Balagopalan, Lakshmi, Barr, Valarie A, Samelson, Lawrence E

Volltext

c-Cbl-Mediated Regulation of LAT-Nucleated Signaling Complexes von Balagopalan, Lakshmi, Barr, Valarie A., Sommers, Connie L., Barda-Saad, Mira, Goyal, Amrita, Isakowitz, Matthew S., Samelson, Lawrence E.

Volltext

Enhanced T-cell signaling in cells bearing linker for activation of T-cell (LAT) molecules resistant to ubiquitylation von Balagopalan, Lakshmi, Ashwell, Benjamin A, Bernot, Kelsie M, Akpan, Itoro O, Quasba, Naeha, Barr, Valarie A, Samelson, Lawrence E

Volltext

Cytoskeletal forces during signaling activation in Jurkat T-cells von Hui, King Lam, Balagopalan, Lakshmi, Samelson, Lawrence E, Upadhyaya, Arpita

Volltext

The CDM Superfamily Protein MBC Directs Myoblast Fusion through a Mechanism That Requires Phosphatidylinositol 3,4,5-Triphosphate Binding but Is Independent of Direct Interaction w... von Balagopalan, Lakshmi, Chen, Mei-Hui, Geisbrecht, Erika R., Abmayr, Susan M.

Volltext

The Linker for Activation of T Cells (LAT) Signaling Hub: From Signaling Complexes to Microclusters von Balagopalan, Lakshmi, Kortum, Robert L., Coussens, Nathan P., Barr, Valarie A., Samelson, Lawrence E.

Volltext

SLP-76 interaction with PLC-γ1 fine-tunes TCR signal strength for appropriate thymocyte selection, T cell homeostasis, and Ag-specific T cell response von Stassenko, Elizabeth, Wada, Junya, Lee, Mariah, Li, Wenmei, Balagopalan, Lakshmi, Evans, Christine, Hagenau, Herbert, Awasthi, Parirokh, Chari, Raj, Yamane, Hidehiro, Samelson, Lawrence E

Volltext

Generation of novel anti-tumor chimeric antigen receptors incorporating downstream T-cell signaling proteins von Angeles, Benjamin C, Moreno, Taylor, Balagopalan, Lakshmi, Yi, Jason, Qin, Haiying, Alvinez, Neriah, Yamane, Hide, Lee, Mariah, Pallikkuth, Sandeep, Tran, Andy, McIntire, Katherine, Taylor, Naomi, Samelson, Lawrence E

Volltext

Functional Nanoscale Organization of Signaling Molecules Downstream of the T Cell Antigen Receptor von Sherman, Eilon, Barr, Valarie, Manley, Suliana, Patterson, George, Balagopalan, Lakshmi, Akpan, Itoro, Regan, Carole K., Merrill, Robert K., Sommers, Connie L., Lippincott-Schwartz, Jennifer, Samelson, Lawrence E.

Volltext

Cish actively silences TCR signaling in CD8+ T cells to maintain tumor tolerance von Palmer, Douglas C, Guittard, Geoffrey C, Franco, Zulmarie, Crompton, Joseph G, Eil, Robert L, Patel, Shashank J, Ji, Yun, Van Panhuys, Nicholas, Klebanoff, Christopher A, Sukumar, Madhusudhanan, Clever, David, Chichura, Anna, Roychoudhuri, Rahul, Varma, Rajat, Wang, Ena, Gattinoni, Luca, Marincola, Francesco M, Balagopalan, Lakshmi, Samelson, Lawrence E, Restifo, Nicholas P

Volltext

Imaging techniques for assaying lymphocyte activation in action von Balagopalan, Lakshmi, Sherman, Eilon, Barr, Valarie A., Samelson, Lawrence E.

Volltext

Cooperative assembly of a four-molecule signaling complex formed upon T cell antigen receptor activation von Manna, Asit, Zhao, Huaying, Wada, Junya, Balagopalan, Lakshmi, Tagad, Harichandra D., Appella, Ettore, Schuck, Peter, Samelson, Lawrence E.

Volltext

The LAT story: a tale of cooperativity, coordination, and choreography von Balagopalan, Lakshmi, Coussens, Nathan P, Sherman, Eilon, Samelson, Lawrence E, Sommers, Connie L

Volltext

Generation of antitumor chimeric antigen receptors incorporating T cell signaling motifs von Balagopalan, Lakshmi, Moreno, Taylor, Qin, Haiying, Angeles, Benjamin C, Kondo, Taisuke, Yi, Jason, McIntire, Katherine M, Alvinez, Neriah, Pallikkuth, Sandeep, Lee, Mariah E, Yamane, Hidehiro, Tran, Andy D, Youkharibache, Philippe, Cachau, Raul E, Taylor, Naomi, Samelson, Lawrence E

Volltext

Adaptive evolution drives divergence of a hybrid inviability gene between two species of Drosophila von PRESGRAVES, Daven C, BALAGOPALAN, Lakshmi, ABMAYR, Susan M, ORR, H. Allen

Volltext