SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate von Olagnier, David, Farahani, Ensieh, Thyrsted, Jacob, Blay-Cadanet, Julia, Herengt, Angela, Idorn, Manja, Hait, Alon, Hernaez, Bruno, Knudsen, Alice, Iversen, Marie Beck, Schilling, Mirjam, Jørgensen, Sofie E., Thomsen, Michelle, Reinert, Line S., Lappe, Michael, Hoang, Huy-Dung, Gilchrist, Victoria H., Hansen, Anne Louise, Ottosen, Rasmus, Nielsen, Camilla G., Møller, Charlotte, van der Horst, Demi, Peri, Suraj, Balachandran, Siddharth, Huang, Jinrong, Jakobsen, Martin, Svenningsen, Esben B., Poulsen, Thomas B., Bartsch, Lydia, Thielke, Anne L., Luo, Yonglun, Alain, Tommy, Rehwinkel, Jan, Alcamí, Antonio, Hiscott, John, Mogensen, Trine H., Paludan, Søren R., Holm, Christian K.

Volltext

Benefits and Perils of Necroptosis in Influenza Virus Infection von Balachandran, Siddharth, Rall, Glenn F

Volltext

ADAR1 masks the cancer immunotherapeutic promise of ZBP1-driven necroptosis von Zhang, Ting, Yin, Chaoran, Fedorov, Aleksandr, Qiao, Liangjun, Bao, Hongliang, Beknazarov, Nazar, Wang, Shiyu, Gautam, Avishekh, Williams, Riley M., Crawford, Jeremy Chase, Peri, Suraj, Studitsky, Vasily, Beg, Amer A., Thomas, Paul G., Walkley, Carl, Xu, Yan, Poptsova, Maria, Herbert, Alan, Balachandran, Siddharth

Volltext

RIPK3‐driven cell death during virus infections von Upton, Jason W., Shubina, Maria, Balachandran, Siddharth

Volltext

Interferon-induced RIP1/RIP3-mediated necrosis requires PKR and is licensed by FADD and caspases von Thapa, Roshan J, Nogusa, Shoko, Chen, Peirong, Maki, Jenny L, Lerro, Anthony, Andrake, Mark, Rall, Glenn F, Degterev, Alexei, Balachandran, Siddharth

Volltext

Z-DNA enhances immunotherapy by triggering death of inflammatory cancer-associated fibroblasts von Herbert, Alan, Balachandran, Siddharth

Volltext

RIPK1 and RIPK3 Kinases Promote Cell-Death-Independent Inflammation by Toll-like Receptor 4 von Najjar, Malek, Saleh, Danish, Zelic, Matija, Nogusa, Shoko, Shah, Saumil, Tai, Albert, Finger, Joshua N., Polykratis, Apostolos, Gough, Peter J., Bertin, John, Whalen, Michael J., Pasparakis, Manolis, Balachandran, Siddharth, Kelliher, Michelle, Poltorak, Alexander, Degterev, Alexei

Volltext

Nrf2 negatively regulates STING indicating a link between antiviral sensing and metabolic reprogramming von Olagnier, David, Brandtoft, Aske M., Gunderstofte, Camilla, Villadsen, Nikolaj L., Krapp, Christian, Thielke, Anne L., Laustsen, Anders, Peri, Suraj, Hansen, Anne Louise, Bonefeld, Lene, Thyrsted, Jacob, Bruun, Victor, Iversen, Marie B., Lin, Lin, Artegoitia, Virginia M., Su, Chenhe, Yang, Long, Lin, Rongtuan, Balachandran, Siddharth, Luo, Yonglun, Nyegaard, Mette, Marrero, Bernadette, Goldbach-Mansky, Raphaela, Motwani, Mona, Ryan, Dylan G., Fitzgerald, Katherine A., O’Neill, Luke A., Hollensen, Anne K., Damgaard, Christian K., de Paoli, Frank v., Bertram, Hanne C., Jakobsen, Martin R., Poulsen, Thomas B., Holm, Christian K.

Volltext

Cellular oxidative stress response controls the antiviral and apoptotic programs in dengue virus-infected dendritic cells von Olagnier, David, Peri, Suraj, Steel, Courtney, van Montfoort, Nadine, Chiang, Cindy, Beljanski, Vladimir, Slifker, Michael, He, Zhong, Nichols, Carmen N, Lin, Rongtuan, Balachandran, Siddharth, Hiscott, John

Volltext

RIPK3 Activates Parallel Pathways of MLKL-Driven Necroptosis and FADD-Mediated Apoptosis to Protect against Influenza A Virus von Nogusa, Shoko, Thapa, Roshan J., Dillon, Christopher P., Liedmann, Swantje, Oguin, Thomas H., Ingram, Justin P., Rodriguez, Diego A., Kosoff, Rachelle, Sharma, Shalini, Sturm, Oliver, Verbist, Katherine, Gough, Peter J., Bertin, John, Hartmann, Boris M., Sealfon, Stuart C., Kaiser, William J., Mocarski, Edward S., López, Carolina B., Thomas, Paul G., Oberst, Andrew, Green, Douglas R., Balachandran, Siddharth

Volltext

Netrin G1 Promotes Pancreatic Tumorigenesis through Cancer-Associated Fibroblast-Driven Nutritional Support and Immunosuppression von Francescone, Ralph, Barbosa Vendramini-Costa, Débora, Franco-Barraza, Janusz, Wagner, Jessica, Muir, Alexander, Lau, Allison N, Gabitova, Linara, Pazina, Tatiana, Gupta, Sapna, Luong, Tiffany, Rollins, Dustin, Malik, Ruchi, Thapa, Roshan J, Restifo, Diana, Zhou, Yan, Cai, Kathy Q, Hensley, Harvey H, Tan, Yinfei, Kruger, Warren D, Devarajan, Karthik, Balachandran, Siddharth, Klein-Szanto, Andres J, Wang, Huamin, El-Deiry, Wafik S, Vander Heiden, Matthew G, Peri, Suraj, Campbell, Kerry S, Astsaturov, Igor, Cukierman, Edna

Volltext

RIP1 suppresses innate immune necrotic as well as apoptotic cell death during mammalian parturition von Kaiser, William J., Daley-Bauer, Lisa P., Thapa, Roshan J., Mandal, Pratyusha, Berger, Scott B., Huang, Chunzi, Sundararajan, Aarthi, Guo, Hongyan, Roback, Linda, Speck, Samuel H., Bertin, John, Gough, Peter J., Balachandran, Siddharth, Mocarski, Edward S.

Volltext

Defining emerging roles for NF-κB in antivirus responses: revisiting the interferon-β enhanceosome paradigm von Balachandran, Siddharth, Beg, Amer A

Volltext

Protein Kinase C Epsilon Is a Key Regulator of Mitochondrial Redox Homeostasis in Acute Myeloid Leukemia von Di Marcantonio, Daniela, Martinez, Esteban, Sidoli, Simone, Vadaketh, Jessica, Nieborowska-Skorska, Margaret, Gupta, Anushk, Meadows, Jake M, Ferraro, Francesca, Masselli, Elena, Challen, Grant A, Milsom, Michael D, Scholl, Claudia, Fröhling, Stefan, Balachandran, Siddharth, Skorski, Tomasz, Garcia, Benjamin A, Mirandola, Prisco, Gobbi, Giuliana, Garzon, Ramiro, Vitale, Marco, Sykes, Stephen M

Volltext

Kinase Activities of RIPK1 and RIPK3 Can Direct IFN-β Synthesis Induced by Lipopolysaccharide von Saleh, Danish, Najjar, Malek, Zelic, Matija, Shah, Saumil, Nogusa, Shoko, Polykratis, Apostolos, Paczosa, Michelle K, Gough, Peter J, Bertin, John, Whalen, Michael, Fitzgerald, Katherine A, Slavov, Nikolai, Pasparakis, Manolis, Balachandran, Siddharth, Kelliher, Michelle, Mecsas, Joan, Degterev, Alexei

Volltext

Reovirus Activated Cell Death Pathways von DeAntoneo, Carly, Danthi, Pranav, Balachandran, Siddharth

Volltext

Structure Guided Design of Potent and Selective Ponatinib-Based Hybrid Inhibitors for RIPK1 von Najjar, Malek, Suebsuwong, Chalada, Ray, Soumya S., Thapa, Roshan J., Maki, Jenny L., Nogusa, Shoko, Shah, Saumil, Saleh, Danish, Gough, Peter J., Bertin, John, Yuan, Junying, Balachandran, Siddharth, Cuny, Gregory D., Degterev, Alexei

Volltext

Targeted Blockade of JAK/STAT3 Signaling Inhibits Ovarian Carcinoma Growth von Gritsina, Galina, Xiao, Fang, O'Brien, Shane W, Gabbasov, Rashid, Maglaty, Marisa A, Xu, Ren-Huan, Thapa, Roshan J, Zhou, Yan, Nicolas, Emmanuelle, Litwin, Samuel, Balachandran, Siddharth, Sigal, Luis J, Huszar, Dennis, Connolly, Denise C

Volltext

Inactivation of ribosomal protein L22 promotes transformation by induction of the stemness factor, Lin28B von Rao, Shuyun, Lee, Sang-Yun, Gutierrez, Alejandro, Perrigoue, Jacqueline, Thapa, Roshan J., Tu, Zhigang, Jeffers, John R., Rhodes, Michele, Anderson, Stephen, Oravecz, Tamas, Hunger, Stephen P., Timakhov, Roman A., Zhang, Rugang, Balachandran, Siddharth, Zambetti, Gerard P., Testa, Joseph R., Look, A. Thomas, Wiest, David L.

Volltext

NF-κB Protects Cells from Gamma Interferon-Induced RIP1-Dependent Necroptosis von Thapa, Roshan J., Basagoudanavar, Suresh H., Nogusa, Shoko, Irrinki, Krishna, Mallilankaraman, Karthik, Slifker, Michael J., Beg, Amer A., Madesh, Muniswamy, Balachandran, Siddharth

Volltext