Capivasertib Plus Paclitaxel Versus Placebo Plus Paclitaxel As First-Line Therapy for Metastatic Triple-Negative Breast Cancer: The PAKT Trial von Schmid, Peter, Abraham, Jacinta, Chan, Stephen, Wheatley, Duncan, Brunt, Adrian Murray, Nemsadze, Gia, Baird, Richard D, Park, Yeon Hee, Hall, Peter S, Perren, Timothy, Stein, Robert C, Mangel, László, Ferrero, Jean-Marc, Phillips, Melissa, Conibear, John, Cortes, Javier, Foxley, Andrew, de Bruin, Elza C, McEwen, Robert, Stetson, Daniel, Dougherty, Brian, Sarker, Shah-Jalal, Prendergast, Aaron, McLaughlin-Callan, Max, Burgess, Matthew, Lawrence, Cheryl, Cartwright, Hayley, Mousa, Kelly, Turner, Nicholas C

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Genetic heterogeneity in breast cancer: the road to personalized medicine? von Baird, Richard D, Caldas, Carlos

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The poly(ADP-ribose) polymerase inhibitor niraparib (MK4827) in BRCA mutation carriers and patients with sporadic cancer: a phase 1 dose-escalation trial von Sandhu, Shahneen K, MD, Schelman, William R, MD, Wilding, George, MD, Moreno, Victor, MD, Baird, Richard D, PhD, Miranda, Susana, BSc, Hylands, Lucy, BSc, Riisnaes, Ruth, FIBMS, Forster, Martin, PhD, Omlin, Aurelius, MD, Kreischer, Nathan, MSc, Thway, Khin, MD, Gevensleben, Heidrun, MD, Sun, Linda, PhD, Loughney, John, PhD, Chatterjee, Manash, PhD, Toniatti, Carlo, PhD, Carpenter, Christopher L, MD, Iannone, Robert, MD, Kaye, Stan B, Prof, de Bono, Johann S, Prof, Wenham, Robert M

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Genomic profile of advanced breast cancer in circulating tumour DNA von Kingston, Belinda, Cutts, Rosalind J., Bye, Hannah, Beaney, Matthew, Walsh-Crestani, Giselle, Hrebien, Sarah, Swift, Claire, Kilburn, Lucy S., Kernaghan, Sarah, Moretti, Laura, Wilkinson, Katie, Wardley, Andrew M., Macpherson, Iain R., Baird, Richard D., Roylance, Rebecca, Reis-Filho, Jorge S., Hubank, Michael, Faull, Iris, Banks, Kimberly C., Lanman, Richard B., Garcia-Murillas, Isaac, Bliss, Judith M., Ring, Alistair, Turner, Nicholas C.

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Circulating tumour DNA analysis to direct therapy in advanced breast cancer (plasmaMATCH): a multicentre, multicohort, phase 2a, platform trial von Turner, Nicholas C, Kingston, Belinda, Kilburn, Lucy S, Kernaghan, Sarah, Wardley, Andrew M, Macpherson, Iain R, Baird, Richard D, Roylance, Rebecca, Stephens, Peter, Oikonomidou, Olga, Braybrooke, Jeremy P, Tuthill, Mark, Abraham, Jacinta, Winter, Matthew C, Bye, Hannah, Hubank, Michael, Gevensleben, Heidrun, Cutts, Ros, Snowdon, Claire, Rea, Daniel, Cameron, David, Shaaban, Abeer, Randle, Katrina, Martin, Sue, Wilkinson, Katie, Moretti, Laura, Bliss, Judith M, Ring, Alistair

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First-in-Man Clinical Trial of the Oral Pan-AKT Inhibitor MK-2206 in Patients With Advanced Solid Tumors von YAP, Timothy A, LI YAN, RIISNAES, Ruth, POPE, Lorna L, HEATON, Simon P, THOMAS, George, GARRETT, Michelle D, SULLIVAN, Daniel M, DE BONO, Johann S, TOLCHER, Anthony W, PATNAIK, Amita, FEAREN, Ivy, OLMOS, David, PAPADOPOULOS, Kyriakos, BAIRD, Richard D, DELGADO, Liliana, TAYLOR, Adekemi, LUPINACCI, Lisa

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Adaptive enrichment trial designs using joint modelling of longitudinal and time-to-event data von Burdon, Abigail J, Baird, Richard D, Jaki, Thomas

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Characteristics, origin, and potential for cancer diagnostics of ultrashort plasma cell-free DNA von Hudecova, Irena, Smith, Christopher G, Hänsel-Hertsch, Robert, Chilamakuri, Chandra S, Morris, James A, Vijayaraghavan, Aadhitthya, Heider, Katrin, Chandrananda, Dineika, Cooper, Wendy N, Gale, Davina, Garcia-Corbacho, Javier, Pacey, Simon, Baird, Richard D, Rosenfeld, Nitzan, Mouliere, Florent

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Dose escalation and expansion cohorts in patients with advanced breast cancer in a Phase I study of the CDK7-inhibitor samuraciclib von Coombes, R. C., Howell, Sacha, Lord, Simon R., Kenny, Laura, Mansi, Janine, Mitri, Zahi, Palmieri, Carlo, Chap, Linnea I., Richards, Paul, Gradishar, William, Sardesai, Sagar, Melear, Jason, O’Shaughnessy, Joyce, Ward, Patrick, Chalasani, Pavani, Arkenau, Tobias, Baird, Richard D., Jeselsohn, Rinath, Ali, Simak, Clack, Glen, Bahl, Ashwani, McIntosh, Stuart, Krebs, Matthew G.

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Antitumor activity in RAS-driven tumors by blocking AKT and MEK von Tolcher, Anthony W, Khan, Khurum, Ong, Michael, Banerji, Udai, Papadimitrakopoulou, Vassiliki, Gandara, David R, Patnaik, Amita, Baird, Richard D, Olmos, David, Garrett, Christopher R, Skolnik, Jeffrey M, Rubin, Eric H, Smith, Paul D, Huang, Pearl, Learoyd, Maria, Shannon, Keith A, Morosky, Anne, Tetteh, Ernestina, Jou, Ying-Ming, Papadopoulos, Kyriakos P, Moreno, Victor, Kaiser, Brianne, Yap, Timothy A, Yan, Li, de Bono, Johann S

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NMR-based metabolomics of plasma from dairy calves infected with two primary causal agents of bovine respiratory disease (BRD) von Santos-Rivera, Mariana, Fitzkee, Nicholas C., Hill, Rebecca A., Baird, Richard E., Blair, Ellianna, Thoresen, Merrilee, Woolums, Amelia R., Meyer, Florencia, Vance, Carrie K.

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Eight-year blight (Cryphonectria parasitica) resistance of backcross-generation American chestnuts (Castanea dentata) planted in the southeastern United States von Clark, Stacy L., Schlarbaum, Scott E., Saxton, Arnold M., Baird, Richard

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A phase I/II study of epertinib plus trastuzumab with or without chemotherapy in patients with HER2-positive metastatic breast cancer von Macpherson, Iain R, Spiliopoulou, Pavlina, Rafii, Saeed, Saggese, Matilde, Baird, Richard D, Garcia-Corbacho, Javier, Italiano, Antoine, Bonneterre, Jacques, Campone, Mario, Cresti, Nicola, Posner, John, Takeda, Yousuke, Arimura, Akinori, Spicer, James

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PI3K/AKT/mTOR signaling transduction pathway and targeted therapies in cancer von Glaviano, Antonino, Foo, Aaron S C, Lam, Hiu Y, Yap, Kenneth C H, Jacot, William, Jones, Robert H, Eng, Huiyan, Nair, Madhumathy G, Makvandi, Pooyan, Geoerger, Birgit, Kulke, Matthew H, Baird, Richard D, Prabhu, Jyothi S, Carbone, Daniela, Pecoraro, Camilla, Teh, Daniel B L, Sethi, Gautam, Cavalieri, Vincenzo, Lin, Kevin H, Javidi-Sharifi, Nathalie R, Toska, Eneda, Davids, Matthew S, Brown, Jennifer R, Diana, Patrizia, Stebbing, Justin, Fruman, David A, Kumar, Alan P

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A First-in-Human Study of the New Oral Selective Estrogen Receptor Degrader AZD9496 for ER + /HER2 - Advanced Breast Cancer von Hamilton, Erika P, Patel, Manish R, Armstrong, Anne C, Baird, Richard D, Jhaveri, Komal, Hoch, Matthias, Klinowska, Teresa, Lindemann, Justin P O, Morgan, Shethah R, Schiavon, Gaia, Weir, Hazel M, Im, Seock-Ah

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Metabolic Imaging Detects Resistance to PI3Kα Inhibition Mediated by Persistent FOXM1 Expression in ER+ Breast Cancer von Ros, Susana, Wright, Alan J., D'Santos, Paula, Hu, De-en, Hesketh, Richard L., Lubling, Yaniv, Georgopoulou, Dimitra, Lerda, Giulia, Couturier, Dominique-Laurent, Razavi, Pedram, Pelossof, Rapahel, Batra, Ankita S., Mannion, Elizabeth, Lewis, David Y., Martin, Alistair, Baird, Richard D., Oliveira, Mafalda, de Boo, Leonora W., Linn, Sabine C., Scaltriti, Maurizio, Rueda, Oscar M., Bruna, Alejandra, Caldas, Carlos, Brindle, Kevin M.

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A Road Map for Designing Phase I Clinical Trials of Radiotherapy-Novel Agent Combinations von Brown, Sarah R, Hinsley, Samantha, Hall, Emma, Hurt, Chris, Baird, Richard D, Forster, Martin, Scarsbrook, Andrew F, Adams, Richard A

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Clinical Development of Novel Drug-Radiotherapy Combinations von Ahmad, Saif S, Crittenden, Marka R, Tran, Phuoc T, Kluetz, Paul G, Blumenthal, Gideon M, Bulbeck, Helen, Baird, Richard D, Williams, Kaye J, Illidge, Tim, Hahn, Stephen M, Lawrence, Theodore S, Spears, Patricia A, Walker, Amanda J, Sharma, Ricky A

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The Molecular Tumor Board Portal supports clinical decisions and automated reporting for precision oncology von Tamborero, David, Dienstmann, Rodrigo, Rachid, Maan Haj, Boekel, Jorrit, Lopez-Fernandez, Adria, Jonsson, Markus, Razzak, Ali, Braña, Irene, De Petris, Luigi, Yachnin, Jeffrey, Baird, Richard D, Loriot, Yohann, Massard, Christophe, Martin-Romano, Patricia, Opdam, Frans, Schlenk, Richard F, Vernieri, Claudio, Masucci, Michele, Villalobos, Xenia, Chavarria, Elena, Balmaña, Judith, Apolone, Giovanni, Caldas, Carlos, Bergh, Jonas, Ernberg, Ingemar, Fröhling, Stefan, Garralda, Elena, Karlsson, Claes, Tabernero, Josep, Voest, Emile, Rodon, Jordi, Lehtiö, Janne

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Author Correction: Dose escalation and expansion cohorts in patients with advanced breast cancer in a Phase I study of the CDK7-inhibitor samuraciclib von Coombes, R. C., Howell, Sacha, Lord, Simon R., Kenny, Laura, Mansi, Janine, Mitri, Zahi, Palmieri, Carlo, Chap, Linnea I., Richards, Paul, Gradishar, William, Sardesai, Sagar, Melear, Jason, O’Shaughnessy, Joyce, Ward, Patrick, Chalasani, Pavani, Arkenau, Tobias, Baird, Richard D., Jeselsohn, Rinath, Ali, Simak, Clack, Glen, Bahl, Ashwani, McIntosh, Stuart, Krebs, Matthew G.

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