Optimization of a Series of Triazole Containing Mammalian Target of Rapamycin (mTOR) Kinase Inhibitors and the Discovery of CC-115 von Mortensen, Deborah S., Perrin-Ninkovic, Sophie M., Shevlin, Graziella, Elsner, Jan, Zhao, Jingjing, Whitefield, Brandon, Tehrani, Lida, Sapienza, John, Riggs, Jennifer R., Parnes, Jason S., Papa, Patrick, Packard, Garrick, Lee, Branden G.S., Harris, Roy, Correa, Matthew, Bahmanyar, Sogole, Richardson, Samantha J., Peng, Sophie X., Leisten, Jim, Khambatta, Godrej, Hickman, Matt, Gamez, James C., Bisonette, René R., Apuy, Julius, Cathers, Brian E., Canan, Stacie S., Moghaddam, Mehran F., Raymon, Heather K., Worland, Peter, Narla, Rama Krishna, Fultz, Kimberly E., Sankar, Sabita

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Structure-based optimization of aminothiadiazole inhibitors of AKT von Mortensen, Deborah S., Hegde, Sayee G., Perrin-Ninkovic, Sophie M., Bahmanyar, Sogole, McCarrick, Meg, Harris, Roy, Hilgraf, Robert, Lee, Branden G. S., McKie, Jeff, Nadolny, Lisa, Sapienza, John, Collette, Alice, Cox, Sarah, Gamez, James C., Hensel, Jennifer L., Hua, Xuequn Helen, Leisten, Jim, Raymon, Heather K., Tran, Tam, Narla, Rama Krishna

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Fluorination-Free Synthesis of a 4,4-Difluoro-3,3-Dimethylproline Derivative von Chen, Lijian, Kim, Young Mi, Kucera, David J, Harrison, Katheryn E, Bahmanyar, Sogole, Scott, Jill M, Yazbeck, Daniel

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Discovery of the c‑Jun N‑Terminal Kinase Inhibitor CC-90001 von Nagy, Mark A, Hilgraf, Robert, Mortensen, Deborah S, Elsner, Jan, Norris, Stephen, Tikhe, Jayashree, Yoon, Won, Paisner, David, Delgado, Mercedes, Erdman, Paul, Haelewyn, Jason, Khambatta, Godrej, Xu, Li, Romanow, William J, Condroski, Kevin, Bahmanyar, Sogole, McCarrick, Meg, Benish, Brent, Blease, Kate, LeBrun, Laurie, Moghaddam, Mehran F, Apuy, Julius, Canan, Stacie S, Bennett, Brydon L, Satoh, Yoshitaka

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Correction to "Discovery of the Selective Protein Kinase C-θ Kinase Inhibitor, CC-90005" von Papa, Patrick, Whitefield, Brandon, Mortensen, Deborah S, Cashion, Dan, Huang, Dehua, Torres, Eduardo, Parnes, Jason, Sapienza, John, Hansen, Joshua, Correa, Matthew, Delgado, Mercedes, Harris, Roy, Hegde, Sayee, Norris, Stephen, Bahmanyar, Sogole, Plantevin-Krenitsky, Veronique, Liu, Zheng, Leftheris, Katerina, Kulkarni, Ashutosh, Bennett, Brydon, Hur, Eun Mi, Ringheim, Garth, Khambatta, Godrej, Chan, Henry, Muir, Jeffrey, Blease, Kate, Burnett, Kelven, LeBrun, Laurie, Morrison, Lisa, Celeridad, Maria, Khattri, Roli, Cathers, Brian E

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The Discovery of a Dual TTK Protein Kinase/CDC2-Like Kinase (CLK2) Inhibitor for the Treatment of Triple Negative Breast Cancer Initiated from a Phenotypic Screen von Riggs, Jennifer R, Nagy, Mark, Elsner, Jan, Erdman, Paul, Cashion, Dan, Robinson, Dale, Harris, Roy, Huang, Dehua, Tehrani, Lida, Deyanat-Yazdi, Gordafaried, Narla, Rama Krishna, Peng, Xiaohui, Tran, Tam, Barnes, Leo, Miller, Terra, Katz, Jason, Tang, Yang, Chen, Ming, Moghaddam, Mehran F, Bahmanyar, Sogole, Pagarigan, Barbra, Delker, Silvia, LeBrun, Laurie, Chamberlain, Philip P, Calabrese, Andrew, Canan, Stacie S, Leftheris, Katerina, Zhu, Dan, Boylan, John F

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Structure-Guided Optimization Provides a Series of TTK Protein Inhibitors with Potent Antitumor Activity von Elsner, Jan, Cashion, Dan, Robinson, Dale, Bahmanyar, Sogole, Tehrani, Lida, Fultz, Kimberly E, Narla, Rama Krishna, Peng, Xiaohui, Tran, Tam, Apuy, Julius, LeBrun, Laurie, Leftheris, Katerina, Boylan, John F, Zhu, Dan, Riggs, Jennifer R

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Design and Optimization Leading to an Orally Active TTK Protein Kinase Inhibitor with Robust Single Agent Efficacy von Riggs, Jennifer R, Elsner, Jan, Cashion, Dan, Robinson, Dale, Tehrani, Lida, Nagy, Mark, Fultz, Kimberly E, Krishna Narla, Rama, Peng, Xiaohui, Tran, Tam, Kulkarni, Ashutosh, Bahmanyar, Sogole, Condroski, Kevin, Pagarigan, Barbra, Fenalti, Gustavo, LeBrun, Laurie, Leftheris, Katerina, Zhu, Dan, Boylan, John F

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Discovery of the Selective Protein Kinase C-θ Kinase Inhibitor, CC-90005 von Papa, Patrick, Whitefield, Brandon, Mortensen, Deborah S, Cashion, Dan, Huang, Dehua, Torres, Eduardo, Parnes, Jason, Sapienza, John, Hansen, Joshua, Correa, Matthew, Delgado, Mercedes, Harris, Roy, Hegde, Sayee, Norris, Stephen, Bahmanyar, Sogole, Plantevin-Krenitsky, Veronique, Liu, Zheng, Leftheris, Katerina, Kulkarni, Ashutosh, Bennett, Brydon, Hur, Eun Mi, Ringheim, Garth, Khambatta, Godrej, Chan, Henry, Muir, Jeffrey, Blease, Kate, Burnett, Kelven, LeBrun, Laurie, Morrison, Lisa, Celeridad, Maria, Khattri, Roli, Cathers, Brian E

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Discovery of CC-930, an orally active anti-fibrotic JNK inhibitor von Plantevin Krenitsky, Véronique, Nadolny, Lisa, Delgado, Mercedes, Ayala, Leticia, Clareen, Steven S., Hilgraf, Robert, Albers, Ronald, Hegde, Sayee, D’Sidocky, Neil, Sapienza, John, Wright, Jonathan, McCarrick, Meg, Bahmanyar, Sogole, Chamberlain, Philip, Delker, Silvia L., Muir, Jeff, Giegel, David, Xu, Li, Celeridad, Maria, Lachowitzer, Jeff, Bennett, Brydon, Moghaddam, Mehran, Khatsenko, Oleg, Katz, Jason, Fan, Rachel, Bai, April, Tang, Yang, Shirley, Michael A., Benish, Brent, Bodine, Tracey, Blease, Kate, Raymon, Heather, Cathers, Brian E., Satoh, Yoshitaka

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Discovery of Mammalian Target of Rapamycin (mTOR) Kinase Inhibitor CC-223 von Mortensen, Deborah S, Perrin-Ninkovic, Sophie M, Shevlin, Graziella, Zhao, Jingjing, Packard, Garrick, Bahmanyar, Sogole, Correa, Matthew, Elsner, Jan, Harris, Roy, Lee, Branden G. S, Papa, Patrick, Parnes, Jason S, Riggs, Jennifer R, Sapienza, John, Tehrani, Lida, Whitefield, Brandon, Apuy, Julius, Bisonette, René R, Gamez, James C, Hickman, Matt, Khambatta, Godrej, Leisten, Jim, Peng, Sophie X, Richardson, Samantha J, Cathers, Brian E, Canan, Stacie S, Moghaddam, Mehran F, Raymon, Heather K, Worland, Peter, Narla, Rama Krishna, Fultz, Kimberly E, Sankar, Sabita

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Abstract 1180: Discovery of CC-91516, a potent and selective ERK/NLK inhibitor, with anti-tumor activity in preclinical cancer models harboring BRAF or CTNNB1 mutation von Xu, Shuichan, Tran, Tam, Zhu, Dan, Shi, Tao, Mikolon, David, Leisten, Jim, Chamberlain, Philip, LeBrun, Laurie, Bahmanyar, Sogole, Jiang, Ning, Zhao, Jingjing, Malek, Mehnaz, Filvaroff, Ellen, Raymon, Heather, Hubbard, Robert, Boylan, John

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Aminopurine based JNK inhibitors for the prevention of ischemia reperfusion injury von Krenitsky, Véronique Plantevin, Delgado, Mercedes, Nadolny, Lisa, Sahasrabudhe, Kiran, Ayala, Leticia, Clareen, Steven S., Hilgraf, Robert, Albers, Ronald, Kois, Adam, Hughes, Kevin, Wright, Jonathan, Nowakowski, Jacek, Sudbeck, Elise, Ghosh, Sutapa, Bahmanyar, Sogole, Chamberlain, Philip, Muir, Jeff, Cathers, Brian E., Giegel, David, Xu, Li, Celeridad, Maria, Moghaddam, Mehran, Khatsenko, Oleg, Omholt, Paul, Katz, Jason, Pai, Sema, Fan, Rachel, Tang, Yang, Shirley, Michael A., Benish, Brent, Blease, Kate, Raymon, Heather, Bhagwat, Shripad, Henderson, Ian, Cole, Andrew G., Bennett, Brydon, Satoh, Yoshitaka

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Crystal Structures of Orotidine Monophosphate Decarboxylase: Does the Structure Reveal the Mechanism of Nature's Most Proficient Enzyme? von Houk, Kendall N., Lee, Jeehiun K., Tantillo, Dean J., Bahmanyar, Sogole, Hietbrink, Bruce N.

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SYNTHETIC INTERMEDIATES USEFUL FOR PREPARING SUBSTITUTED AMINOPURINE COMPOUNDS von TORRES, Eduardo, BOYLAN, John Frederick, Schwarz, Kimberly, TRAN, Tam Minh, HUBBARD, Robert, HANSEN, Joshua, BAHMANYAR, Sogole, XU, Shuichan, RAHEJA, Raj Kumar, HUANG, Dehua, JEFFY, Brandon David, SLOSS, Marianne, ALEXANDER, Matthew, LEISTEN, Jim, ZHAO, Jingjing, MOGHADDAM, Mehran, RAYMON, Heather

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Substituted aminopurine compounds, compositions thereof, and methods of treatment therewith von Xu, Shuichan, Hansen, Joshua, Schwarz, Kimberly, Hubbard, Robert, Torres, Eduardo, Huang, Dehua, Raheja, Raj, Bahmanyar, Sogole, Sloss, Marianne, Moghaddam, Mehran, Alexander, Matthew, Raymon, Heather, Zhao, Jingjing, Leisten, Jim, Tran, Tam, Jeffy, Brandon, Boylan, John

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Substituted aminopurine compounds, compositions thereof, and methods of treatment therewith von Xu, Shuichan, Hansen, Joshua, Schwarz, Kimberly, Hubbard, Robert, Torres, Eduardo, Huang, Dehua, Raheja, Raj, Bahmanyar, Sogole, Sloss, Marianne, Moghaddam, Mehran, Alexander, Matthew, Raymon, Heather, Zhao, Jingjing, Leisten, Jim, Tran, Tam, Jeffy, Brandon, Boylan, John

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SUBSTITUTED 3-((3-AMINOPHENYL)AMINO)PIPERIDINE-2,6-DIONE COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH von Hansen, Joshua, Xu, Shuichan, Plantevin-Krenitsky, Veronique, Ammirante, Massimo, Horn, Evan J, Papa, Patrick, Whitefield, Brandon W, Bahmanyar, Sogole, Mayne, Christopher, Norris, Stephen, Narla, Rama Krishna, Kercher, Timothy S, Nayak, Surendra, Correa, Matthew D, Grant, Virginia Heather Sharron, Nagy, Mark A, Sapienza, John J

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SUBSTITUTED AMINOPURINE COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH von JEFFY, BRANDON, HUANG, DEHUA, RAHEJA, RAJ K, ZHAO, JINGJING, MOGHADDAM, MEHRAN, LEISTEN, JIM, TORRES, EDUARDO, TRAN, TAM MINH, ALEXANDER, MATTHEW, BOYLAN, JOHN FREDERICK, SLOSS, MARIANNE, SCHWARZ, KIMBERLY, HANSEN, JOSHUA, BAHMANYAR, SOGOLE, HUBBARD, ROBERT, RAYMON, HEATHER, XU, SHUICHAN

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SUBSTITUTED AMINOPURINE COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH von Hansen, Joshua, Xu, Shuichan, Schwarz, Kimberly, Hubbard, Robert, Tran, Tam Minh, Torres, Eduardo, Boylan, John Frederick, Huang, Dehua, Bahmanyar, Sogole, Sloss, Marianne, Moghaddam, Mehran, Raheja, Raj K, Alexander, Matthew, Raymon, Heather, Zhao, Jingjing, Leisten, Jim, Jeffy, Brandon

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