Pyroptosis and Apoptosis Pathways Engage in Bidirectional Crosstalk in Monocytes and Macrophages von Taabazuing, Cornelius Y., Okondo, Marian C., Bachovchin, Daniel A.

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The NLRP1 and CARD8 inflammasomes von Taabazuing, Cornelius Y., Griswold, Andrew R., Bachovchin, Daniel A.

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DPP8 and DPP9 inhibition induces pro-caspase-1-dependent monocyte and macrophage pyroptosis von Okondo, Marian C, Johnson, Darren C, Sridharan, Ramya, Go, Eun Bin, Chui, Ashley J, Wang, Mitchell S, Poplawski, Sarah E, Wu, Wengen, Liu, Yuxin, Lai, Jack H, Sanford, David G, Arciprete, Michael O, Golub, Todd R, Bachovchin, William W, Bachovchin, Daniel A

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NLRP1: a jack of all trades, or a master of one? von Bachovchin, Daniel A.

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DPP8/DPP9 inhibitor-induced pyroptosis for treatment of acute myeloid leukemia von Johnson, Darren C., Taabazuing, Cornelius Y., Okondo, Marian C., Chui, Ashley J., Rao, Sahana D., Brown, Fiona C., Reed, Casie, Peguero, Elizabeth, de Stanchina, Elisa, Kentsis, Alex, Bachovchin, Daniel A.

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A high-throughput, multiplexed assay for superfamily-wide profiling of enzyme activity von Bachovchin, Daniel A, Koblan, Luke W, Wu, Wengen, Liu, Yuxin, Li, Youhua, Zhao, Peng, Woznica, Iwona, Shu, Ying, Lai, Jack H, Poplawski, Sarah E, Kiritsy, Christopher P, Healey, Sarah E, DiMare, Matthew, Sanford, David G, Munford, Robert S, Bachovchin, William W, Golub, Todd R

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N-terminal degradation activates the NLRP1B inflammasome von Chui, Ashley J., Okondo, Marian C., Rao, Sahana D., Gai, Kuo, Griswold, Andrew R., Johnson, Darren C., Ball, Daniel P., Taabazuing, Cornelius Y., Orth, Elizabeth L., Vittimberga, Brooke A., Bachovchin, Daniel A.

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Inhibition of Dpp8/9 Activates the Nlrp1b Inflammasome von Okondo, Marian C., Rao, Sahana D., Taabazuing, Cornelius Y., Chui, Ashley J., Poplawski, Sarah E., Johnson, Darren C., Bachovchin, Daniel A.

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Introducing new group leaders: Cornelius Taabazuing

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Quantitative reactivity profiling predicts functional cysteines in proteomes von Weerapana, Eranthie, Wang, Chu, Simon, Gabriel M., Richter, Florian, Khare, Sagar, Dillon, Myles B. D., Bachovchin, Daniel A., Mowen, Kerri, Baker, David, Cravatt, Benjamin F.

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The pharmacological landscape and therapeutic potential of serine hydrolases von Bachovchin, Daniel A., Cravatt, Benjamin F.

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Human FGF-21 Is a Substrate of Fibroblast Activation Protein von Coppage, Andrew L, Heard, Kathryn R, DiMare, Matthew T, Liu, Yuxin, Wu, Wengen, Lai, Jack H, Bachovchin, William W

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Meet the authors: Lydia P. Tsamouri and Daniel A. Bachovchin von Tsamouri, Lydia P., Bachovchin, Daniel A.

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DPP9 sequesters the C terminus of NLRP1 to repress inflammasome activation von Hollingsworth, L. Robert, Sharif, Humayun, Griswold, Andrew R., Fontana, Pietro, Mintseris, Julian, Dagbay, Kevin B., Paulo, Joao A., Gygi, Steven P., Bachovchin, Daniel A., Wu, Hao

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Mechanism of filament formation in UPA-promoted CARD8 and NLRP1 inflammasomes von Robert Hollingsworth, L., David, Liron, Li, Yang, Griswold, Andrew R., Ruan, Jianbin, Sharif, Humayun, Fontana, Pietro, Orth-He, Elizabeth L., Fu, Tian-Min, Bachovchin, Daniel A., Wu, Hao

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The serine protease DPP9 and the redox sensor KEAP1 form a mutually inhibitory complex von Tsamouri, Lydia P., Hsiao, Jeffrey C., Bachovchin, Daniel A.

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The NLRP1 Inflammasome Induces Pyroptosis in Human Corneal Epithelial Cells von Griswold, Andrew R, Huang, Hsin-Che, Bachovchin, Daniel A

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Dipeptidyl peptidase 9 sets a threshold for CARD8 inflammasome formation by sequestering its active C-terminal fragment von Sharif, Humayun, Hollingsworth, L. Robert, Griswold, Andrew R., Hsiao, Jeffrey C., Wang, Qinghui, Bachovchin, Daniel A., Wu, Hao

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Superfamily-wide portrait of serine hydrolase inhibition achieved by library-versus-library screening von Bachovchin, Daniel A., Ji, Tianyang, Li, Weiwei, Simon, Gabriel M., Blankman, Jacqueline L., Adibekian, Alexander, Hoover, Heather, Niessen, Sherry, Cravatt, Benjamin F., Shokat, Kevan M.

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Click-generated triazole ureas as ultrapotent in vivo–active serine hydrolase inhibitors von Adibekian, Alexander, Martin, Brent R, Wang, Chu, Hsu, Ku-Lung, Bachovchin, Daniel A, Niessen, Sherry, Hoover, Heather, Cravatt, Benjamin F

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