Fragment-Based Design of a Potent MAT2a Inhibitor and in Vivo Evaluation in an MTAP Null Xenograft Model von De Fusco, Claudia, Schimpl, Marianne, Börjesson, Ulf, Cheung, Tony, Collie, Iain, Evans, Laura, Narasimhan, Priyanka, Stubbs, Christopher, Vazquez-Chantada, Mercedes, Wagner, David J, Grondine, Michael, Sanders, Matthew G, Tentarelli, Sharon, Underwood, Elizabeth, Argyrou, Argyrides, Smith, James M, Lynch, James T, Chiarparin, Elisabetta, Robb, Graeme, Bagal, Sharan K, Scott, James S

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Structure-Based Optimization of a Series of Covalent, Cell Active Bfl‑1 Inhibitors von Lucas, Simon C. C., Blackwell, J. Henry, Börjesson, Ulf, Hargreaves, David, Milbradt, Alexander G., Bostock, Mark J., Ahmed, Samiyah, Beaumont, Kevin, Cheung, Tony, Demanze, Sylvain, Gohlke, Andrea, Guerot, Carine, Haider, Afreen, Kantae, Vasudev, Kauffman, Gregory W., Kinzel, Olaf, Kupcova, Lea, Lainchbury, Michael D., Lamb, Michelle L., Leon, Leonardo, Palisse, Adeline, Sacchetto, Claudia, Storer, R. Ian, Su, Nancy, Thomson, Clare, Vales, John, Chen, Yunhua, Hu, Xiaolong

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Design of a Lead-Like Cysteine-Targeting Covalent Library and the Identification of Hits to Cys55 of Bfl-1 von Lucas, Simon C. C., Milbradt, Alexander G., Blackwell, J. Henry, Bonomo, Silvia, Brierley, Andrew, Cassar, Doyle J., Freeman, Jared, Hadfield, Thomas E., Morrill, Lucas A., Riemens, Rick, Sarda, Sunil, Schiesser, Stefan, Wiktelius, Daniel, Ahmed, Samiyah, Bostock, Mark J., Börjesson, Ulf, De Fusco, Claudia, Guerot, Carine, Hargreaves, David, Hewitt, Sarah, Lamb, Michelle L., Su, Nancy, Whatling, Ryan, Wheeler, Matthew, Kettle, Jason G.

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Discovery and Optimization of the First ATP Competitive Type-III c‑MET Inhibitor von Michaelides, Iacovos N., Collie, Gavin W., Börjesson, Ulf, Vasalou, Christina, Alkhatib, Omar, Barlind, Louise, Cheung, Tony, Dale, Ian L., Embrey, Kevin J., Hennessy, Edward J., Khurana, Puneet, Koh, Cheryl M., Lamb, Michelle L., Liu, Jianming, Moss, Thomas A., O’Neill, Daniel J., Phillips, Christopher, Shaw, Joseph, Snijder, Arjan, Storer, R. Ian, Stubbs, Christopher J., Han, Fujin, Li, Chengzhi, Qiao, Jingchuan, Sun, Dong-Qing, Wang, Jingwen, Wang, Peng, Yang, Wenzhen

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Surprising lipophilicity observations identify unexpected conformational effects von Perry, Matthew W.D., Börjesson, Ulf, Nikitidis, Antonios, Tyrchan, Christian

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Industrial scale high-throughput screening delivers multiple fast acting macrofilaricides von Clare, Rachel H., Bardelle, Catherine, Harper, Paul, Hong, W. David, Börjesson, Ulf, Johnston, Kelly L., Collier, Matthew, Myhill, Laura, Cassidy, Andrew, Plant, Darren, Plant, Helen, Clark, Roger, Cook, Darren A. N., Steven, Andrew, Archer, John, McGillan, Paul, Charoensutthivarakul, Sitthivut, Bibby, Jaclyn, Sharma, Raman, Nixon, Gemma L., Slatko, Barton E., Cantin, Lindsey, Wu, Bo, Turner, Joseph, Ford, Louise, Rich, Kirsty, Wigglesworth, Mark, Berry, Neil G., O’Neill, Paul M., Taylor, Mark J., Ward, Stephen A.

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Identification and Evaluation of Reversible Covalent Binders to Cys55 of Bfl‑1 from a DNA-Encoded Chemical Library Screen von Lucas, Simon C. C., Blackwell, J. Henry, Börjesson, Ulf, Hargreaves, David, Milbradt, Alexander G., Ahmed, Samiyah, Bostock, Mark J., Guerot, Carine, Gohlke, Andrea, Kinzel, Olaf, Lamb, Michelle L., Selmi, Nidhal, Stubbs, Christopher J., Su, Nancy, Su, Qibin, Luo, Haiou, Xiong, Ting, Zuo, Xiaoqian, Bazzaz, Sana, Bienstock, Corey, Centrella, Paolo A., Denton, Kyle E., Gikunju, Diana, Guié, Marie-Aude, Guilinger, John P., Hupp, Christopher, Keefe, Anthony D., Satoh, Takashi, Zhang, Ying, Rivers, Emma L.

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Structural Basis for Targeting the Folded P-Loop Conformation of c-MET von Collie, Gavin W., Michaelides, Iacovos N., Embrey, Kevin, Stubbs, Christopher J., Borjesson, Ulf, Dale, Ian L., Snijder, Arjan, Barlind, Louise, Song, Kun, Khurana, Puneet, Phillips, Christopher, Storer, R. Ian

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Phenotypic high-throughput screening platform identifies novel chemotypes for necroptosis inhibition von Brito, Hugo, Marques, Vanda, Afonso, Marta B., Brown, Dean G., Börjesson, Ulf, Selmi, Nidhal, Smith, David M., Roberts, Ieuan O., Fitzek, Martina, Aniceto, Natália, Guedes, Rita C., Moreira, Rui, Rodrigues, Cecília M. P.

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Explicit-solvent molecular dynamics simulation at constant pH: Methodology and application to small amines von Börjesson, Ulf, Hünenberger, Philippe H.

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ProSAR: A New Methodology for Combinatorial Library Design von Chen, Hongming, Börjesson, Ulf, Engkvist, Ola, Kogej, Thierry, Svensson, Mats A, Blomberg, Niklas, Weigelt, Dirk, Burrows, Jeremy N, Lange, Tim

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Discovery of AZD8154, a Dual PI3K gamma delta Inhibitor for the Treatment of Asthma von Perry, Matthew W. D., Bjorhall, Karin, Bold, Peter, Brulls, Mikael, Borjesson, Ulf, Carlsson, Johan, Chang, Hui-Fang Amy, Chen, Yunhua, Eriksson, Anders, Fihn, Britt-Marie, Fransson, Rebecca, Fredlund, Linda, Ge, Hongbin, Huang, Haijuan, Karabelas, Kostas, Bergstrom, Eva Lamm, Lever, Sarah, Lindmark, Helena, Mogemark, Mickael, Nikitidis, Antonios, Palmgren, Anna-Pia, Pemberton, Nils, Petersen, Jens, Blomqvist, Mio Rodrigo, Smith, Reed W., Thomas, Matthew J., Ullah, Victoria, Tyrchan, Christian, Wennberg, Tiiu, Eriksson, Annika Westin, Yang, Wenzhen, Zhao, Shuchun, Oster, Linda

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Structure-Based Discovery of a Series of Covalent, Orally Bioavailable, and Selective BFL1 Inhibitors von Palisse, Adeline, Cheung, Tony, Blokhuis, Aileen, Cogswell, Thomas, Martins, Bruna S, Riemens, Rick, Schellekens, Rick, Battocchio, Giovanni, Jansen, Chimed, Cottee, Matthew A, Ornell, Kimberly, Sacchetto, Claudia, Leon, Leonardo, van Hoek-Emmelot, Maaike, Bostock, Mark, Brauer, Brooke Leann, Beaumont, Kevin, Lucas, Simon C C, Ahmed, Samiyah, Blackwell, J Henry, Börjesson, Ulf, Gohlke, Andrea, Gramatikov, Iva Monique T, Hargreaves, David, van Hoeven, Vera, Kantae, Vasudev, Kupcova, Lea, Milbradt, Alexander G, Seneviratne, Uthpala, Su, Nancy, Vales, John, Wang, Haiyun, White, Michael J, Kinzel, Olaf

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COMPOUNDS AND THEIR USE IN TREATING CANCER von STORER, Robert, PERRY, Matthew, MICHAELIDES, Iacovos, KETTLE, Jason, HAYHOW, Thomas, FALLAN, Charlene, GREBNER, Christoph, COLLIE, Gavin, BAGAL, Sharanjeet, BŐRJESSON, Ulf

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COMPOUNDS AND THEIR USE IN TREATING CANCER von STORER, Robert, PERRY, Matthew, MICHAELIDES, Iacovos, KETTLE, Jason, HAYHOW, Thomas, FALLAN, Charlene, GREBNER, Christoph, COLLIE, Gavin, BAGAL, Sharanjeet, BŐRJESSON, Ulf

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pH-Dependent Stability of a Decalysine α-Helix Studied by Explicit-Solvent Molecular Dynamics Simulations at Constant pH von Börjesson, Ulf, Hünenberger, Philippe H

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COMPOUNDS AND THEIR USE IN TREATING CANCER von STORER, Robert, PERRY, Matthew, MICHAELIDES, Iacovos, KETTLE, Jason, HAYHOW, Thomas, FALLAN, Charlene, GREBNER, Christoph, COLLIE, Gavin, BAGAL, Sharanjeet, BŐRJESSON, Ulf

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COMPOUNDS AND THEIR USE IN TREATING CANCER von STORER, Robert, PERRY, Matthew, MICHAELIDES, Iacovos, KETTLE, Jason, HAYHOW, Thomas, FALLAN, Charlene, GREBNER, Christoph, COLLIE, Gavin, BAGAL, Sharanjeet, BŐRJESSON, Ulf

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Compuestos y su uso en el tratamiento del cáncer von COLLIE, Gavin William, FALLAN, Charlene, PERRY, Matthew William Dampier, GREBNER, Christoph, BAGAL, Sharanjeet Kaur, STORER, Robert Ian, KETTLE, Jason Grant, HAYHOW, Thomas George Christopher, MICHAELIDES, Iacovos Neal, BŐRJESSON, Ulf

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Designing a Combinatorial Library by Using Reagent Pharmacophore Fingerprint von Chen, Hongming, Börjesson, Ulf, Engkvist, Ola, Kogej, Thierry, Svensson, Mats A., Blomberg, Niklas, Weigelt, Dirk, Burrows, Jeremy N., Lange, Tim

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