Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging von Steelman, Linda S, Chappell, William H, Abrams, Stephen L, Kempf, Ruth C, Long, Jacquelyn, Laidler, Piotr, Mijatovic, Sanja, Maksimovic-Ivanic, Danijela, Stivala, Franca, Mazzarino, Maria C, Donia, Marco, Fagone, Paolo, Malaponte, Graziella, Nicoletti, Ferdinando, Libra, Massimo, Milella, Michele, Tafuri, Agostino, Bonati, Antonio, Bäsecke, Jörg, Cocco, Lucio, Evangelisti, Camilla, Martelli, Alberto M, Montalto, Giuseppe, Cervello, Melchiorre, McCubrey, James A

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Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascade inhibitors: how mutations can result in therapy resistance and how to overcome resistance von McCubrey, James A, Steelman, Linda S, Chappell, William H, Abrams, Stephen L, Franklin, Richard A, Montalto, Giuseppe, Cervello, Melchiorre, Libra, Massimo, Candido, Saverio, Malaponte, Grazia, Mazzarino, Maria C, Fagone, Paolo, Nicoletti, Ferdinando, Bäsecke, Jörg, Mijatovic, Sanja, Maksimovic-Ivanic, Danijela, Milella, Michele, Tafuri, Agostino, Chiarini, Francesca, Evangelisti, Camilla, Cocco, Lucio, Martelli, Alberto M

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Mutations and deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascades which alter therapy response von McCubrey, James A, Steelman, Linda S, Chappell, William H, Abrams, Stephen L, Montalto, Giuseppe, Cervello, Melchiorre, Nicoletti, Ferdinando, Fagone, Paolo, Malaponte, Grazia, Mazzarino, Maria C, Candido, Saverio, Libra, Massimo, Bäsecke, Jörg, Mijatovic, Sanja, Maksimovic-Ivanic, Danijela, Milella, Michele, Tafuri, Agostino, Cocco, Lucio, Evangelisti, Camilla, Chiarini, Francesca, Martelli, Alberto M

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Therapeutic resistance resulting from mutations in Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR signaling pathways von McCubrey, James A., Steelman, Linda S., Kempf, C. Ruth, Chappell, William H., Abrams, Stephen L., Stivala, Franca, Malaponte, Graziella, Nicoletti, Ferdinando, Libra, Massimo, Bäsecke, Jörg, Maksimovic-Ivanic, Danijela, Mijatovic, Sanja, Montalto, Giuseppe, Cervello, Melchiorre, Cocco, Lucio, Martelli, Alberto M.

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Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR inhibitors: rationale and importance to inhibiting these pathways in human health von Chappell, William H, Steelman, Linda S, Long, Jacquelyn M, Kempf, Ruth C, Abrams, Stephen L, Franklin, Richard A, Bäsecke, Jörg, Stivala, Franca, Donia, Marco, Fagone, Paolo, Malaponte, Graziella, Mazzarino, Maria C, Nicoletti, Ferdinando, Libra, Massimo, Maksimovic-Ivanic, Danijela, Mijatovic, Sanja, Montalto, Giuseppe, Cervello, Melchiorre, Laidler, Piotr, Milella, Michele, Tafuri, Agostino, Bonati, Antonio, Evangelisti, Camilla, Cocco, Lucio, Martelli, Alberto M, McCubrey, James A

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The Raf/MEK/ERK pathway can govern drug resistance, apoptosis and sensitivity to targeted therapy von Abrams, Stephen L., Steelman, Linda S., Shelton, John G., Wong, Ellis W.T., Chappell, William H., Bäsecke, Jörg, Stivala, Franca, Donia, Marco, Nicoletti, Ferdinando, Libra, Massimo, Martelli, Alberto M., McCubrey, James A

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Early versus Delayed Tumor-Specific Therapy and Survival in Patients with Lung Cancer: A Retrospective Study von Geiken-Weinstock, Rike, Reyners, Anna K.L., Griesinger, Frank, Otremba, Burkhard Joerg, Hoheisel, Michael, Bäsecke, Jörg

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Advances in targeting signal transduction pathways von McCubrey, James A, Steelman, Linda S, Chappell, William H, Sun, Lin, Davis, Nicole M, Abrams, Stephen L, Franklin, Richard A, Cocco, Lucio, Evangelisti, Camilla, Chiarini, Francesca, Martelli, Alberto M, Libra, Massimo, Candido, Saverio, Ligresti, Giovanni, Malaponte, Grazia, Mazzarino, Maria C, Fagone, Paolo, Donia, Marco, Nicoletti, Ferdinando, Polesel, Jerry, Talamini, Renato, Bäsecke, Jörg, Mijatovic, Sanja, Maksimovic-Ivanic, Danijela, Michele, Michele, Tafuri, Agostino, Dulińska-Litewka, Joanna, Laidler, Piotr, D'Assoro, Antonio B, Drobot, Lyudmyla, Umezawa, Drobot, Montalto, Giuseppe, Cervello, Melchiorre, Demidenko, Zoya N

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Akt as a therapeutic target in cancer von Steelman, Linda S, Stadelman, Kristin M, Chappell, William H, Horn, Stefan, Bäsecke, Jörg, Cervello, Melchiorre, Nicoletti, Ferdinando, Libra, Massimo, Stivala, Franca, Martelli, Alberto M, McCubrey, James A

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Primary osteomyelofibrosis and an XX‐male genotype von Schanz, Julie, Haase, Detlef, Steuernagel, Peter, Shirneshan, Katayoo, Bäsecke, Jörg

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Dominant roles of the Raf/MEK/ERK pathway in cell cycle progression, prevention of apoptosis and sensitivity to chemotherapeutic drugs von Steelman, Linda S., Abrams, Stephen L., Shelton, John G., Chappell, William H., Bäsecke, Jörg, Stivala, Franca, Donia, Marco, Nicoletti, Ferdinando, Libra, Massimo, Martelli, Alberto M., McCubrey, James A

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Enhancing therapeutic efficacy by targeting non-oncogene addicted cells with combinations of signal transduction inhibitors and chemotherapy von Abrams, Stephen L., Steelman, Linda S., Shelton, John G., Chappell, William, Bäsecke, Jörg, Stivala, Franca, Donia, Marco, Nicoletti, Ferdinando, Libra, Massimo, Martelli, Alberto M., McCubrey, James A

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The Glycogensynthase Kinase 3b (GSK-3β) Is Involved in Leukemic Transformation von Bäsecke, Jörg, Lehmann, Anneke, Bergholz, Ulla, McCubrey, James, Trümper, Lorenz, Stocking, Carol, Horn, Stefan

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GSK-3β is a critical mediator of tetrandrine induced cell cycle arrest and cytotoxicity von McCubrey, James A, Bäsecke, Jörg, Cervello, Melchiorre, M. Martelli, Alberto, Franklin, Richard A.

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Lifelong persistence of AML associated MLL partial tandem duplications (MLL-PTD) in healthy adults von Bäsecke, Jörg, Podleschny, Martina, Clemens, Robert, Schnittger, Susanne, Viereck, Volker, Trümper, Lorenz, Griesinger, Frank

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AML1/ETO promotes the maintenance of early hematopoietic progenitors in NOD/SCID mice but does not abrogate their lineage specific differentiation von Bäsecke, Jörg, Schwieger, Maike, Griesinger, Frank, Schiedlmeier, Bernd, Wulf, Gerald, TRümper, Lorenz, Stocking, Carol

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A case of pulmonary aspergillosis with lack of response to caspofungin von Rüchel, Reinhard, Perske, Christine, Glass, Bertram, Bäsecke, Jörg

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GSK-3beta is a critical mediator of tetrandrine induced cell cycle arrest and cytotoxicity von McCubrey, James A, Bäsecke, Jörg, Cervello, Melchiorre, Martelli, Alberto M, Franklin, Richard A

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Cancer therapy and treatments during COVID-19 era von Akula, Shaw M., Abrams, Stephen L., Steelman, Linda S., Candido, Saverio, Libra, Massimo, Lerpiriyapong, Kvin, Cocco, Lucio, Ramazzotti, Giulia, Ratti, Stefano, Follo, Matilde Y., Martelli, Alberto M., Blalock, William L., Piazzi, Manuela, Montalto, Giuseppe, Cervello, Melchiorre, Notarbartolo, Monica, Basecke, Jorg, McCubrey, James A.

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Bioreactors Crunch Nitrates von Bäsecke, Jörg

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