Preclinical Strategy to Reduce Clinical Hepatotoxicity Using in Vitro Bioactivation Data for >200 Compounds von Sakatis, Melanie Z, Reese, Melinda J, Harrell, Andrew W, Taylor, Maxine A, Baines, Ian A, Chen, Liangfu, Bloomer, Jackie C, Yang, Eric Y, Ellens, Harma M, Ambroso, Jeffrey L, Lovatt, Cerys A, Ayrton, Andrew D, Clarke, Stephen E

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Multidisciplinary Scientific Cruise to the Rio Grande Rise von Jovane, Luigi, Hein, James R., Yeo, Isobel A., Benites, Mariana, Bergo, Natascha M., Corrêa, Paulo V. F., Couto, Daniel M., Guimarães, Ayrton D., Howarth, Sarah A., Miguel, Henrique R., Mizell, Kira L., Moura, Denise S., Vicentini Neto, Francisco L., Pompeu, Mayza, Rodrigues, Ianco M. M., Santana, Frederico R., Serrao, Pedro F., Silva, Tomas E., Tura, Pedro M., Viscarra, Carolina L., Chuqui, Mateus G., Pellizari, Vivian H., Signori, Camila N., Da Silveira, Ilson C. A., Sumida, Paulo Y. G., Murton, Bramley J., Brandini, Frederico P.

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Biopharmaceutics Classification System: Validation and Learnings of an in Vitro Permeability Assay von Thiel-Demby, Victoria E, Humphreys, Joan E, St. John Williams, Lisa A, Ellens, Harma M, Shah, Nipa, Ayrton, Andrew D, Polli, Joseph W

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Pharmacokinetic/pharmacodynamic modelling of the EEG effects of opioids: The role of complex biophase distribution kinetics von Groenendaal, Dorien, Freijer, Jan, Rosier, Andrea, de Mik, Dennis, Nicholls, Glynis, Hersey, Anne, Ayrton, Andrew D., Danhof, Meindert, de Lange, Elizabeth C.M.

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Ketoconazole and sulphaphenazole as the respective selective inhibitors of P4503A and 2C9 von Baldwin, S. J., Bloomer, J. C., Smith, G. J., Ayrton, A. D., Clarke, S. E., Chenery, R. J.

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Expression, Purification, and Biochemical Characterization of A Human Cytochrome P450 CYP2D6-NADPH Cytochrome P450 Reductase Fusion Protein von Deeni, Yusuf Y., Paine, Mark J.I., Ayrton, Andrew D., Clarke, Stephen E., Chenery, Richard, Wolf, C.Roland

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Lauric acid as a model substrate for the simultaneous determination of cytochrome P450 2E1 and 4A in hepatic microsomes von Clarke, Stephen E, Baldwin, Sandra J, Bloomer, Jacqueline C, Ayrton, Andrew D, Sozio, Randall S, Chenery, Richard J

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Characterization of the inhibition of P4501A2 by furafylline von Clarke, S. E., Ayrton, A. D., Chenery, R. J.

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8-piperazinyl-2,3-dihydropyrrolo[3,2-g]isoquinolines : Potent, selective, orally bioavailable 5-HT1 receptor ligands von HEIGHTMAN, Tom D, GASTER, Laramie M, GORDON, Laurie J, HOLLAND, Vicky A, POWLES, Jenifer, RILEY, Graham J, STEAN, Tania O, TRAIL, Brenda K, UPTON, Neil, AUSTIN, Nigel E, AYRTON, Andrew D, COLEMAN, Tanya, PARDOE, Sarah L, CUTLER, Leanne, PILLEUX, Jean-Pierre, HADLEY, Michael S, MIDDLEMISS, Derek N, PRICE, Gary W, ROBERTS, Claire, SCOTT, Claire M, WATSON, Jeannette M

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Rivaroxaban compared with warfarin in patients with atrial fibrillation and previous stroke or transient ischaemic attack: a subgroup analysis of ROCKET AF von Hankey, Graeme J, Prof, Patel, Manesh R, MD, Stevens, Susanna R, MSc, Becker, Richard C, MD, Breithardt, Günter, MD, Carolei, Antonio, Prof, Diener, Hans-Christoph, MD, Donnan, Geoffrey A, MD, Halperin, Jonathan L, Prof, Mahaffey, Kenneth W, MD, Mas, Jean-Louis, MD, Massaro, Ayrton, MD, Norrving, Bo, MD, Nessel, Christopher C, MD, Paolini, John F, MD, Roine, Risto O, MD, Singer, Daniel E, Prof, Wong, Lawrence, MD, Califf, Robert M, Prof, Fox, Keith AA, Prof, Hacke, Werner, MD

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Antimutagenicity of ellagic acid towards the food mutagen IQ: Investigation into possible mechanisms of action von Ayrton, A.D., Lewis, D.F.V., Walker, R., Ioannides, C.

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Characterisation of the cytochrome P450 enzymes involved in the in vitro metabolism of granisetron von Bloomer, JC, Baldwin, SJ, Smith, GJ, Ayrton, AD, Clarke, SE, Chenery, RJ

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Aetiological diagnosis of ischaemic stroke in young adults von Ferro, José M, Prof, Massaro, Ayrton R, MD, Mas, Jean-Louis, Prof

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A cytosolic oxygenase activity involved in the bioactivation of 2-aminofluorene von Leist, M., Ayrton, A.D., Ioannides, C.

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Induction of the cytochrome P450 I and IV families and peroxisomal proliferation in the liver of rats treated with benoxaprofen: Possible implications in its hepatotoxicity von Ayrton, Andrew D., Ioannides, Costas, Parke, Dennis V.

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Induction of the P-450 I family of proteins by polycyclic aromatic hydrocarbons: possible relationship to their carcinogenicity von Ayrton, A.D., McFarlane, M., Walker, R., Neville, S., Coombs, M.M., Ioannides, C.

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The induction of P450 I proteins by aromatic amines may be related to their carcinogenic potential von Ayrton, Andrew David, McFarlane, Mary, Walker, Ron, Neville, Sally, Ioannides, Costas

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Induction of rat hepatic cytochrome P-450 I proteins by the antimutagen anthraflavic acid von Ayrton, A.D., Ioannides, C., Walker, R.

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Bioactivation of N-nitrosopiperidine to mutagens: role of hepatic cytochrome P-450 proteins and contribution of cytosolic fraction von Ayrton, Andrew D., Smith, Jonathan N., Ioannides, Costas

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Induction of the rat hepatic microsomal mixed-function oxidases by cimetidine von Ioannides, C., Rodrigues, A.D., Ayrton, A.D., Barnett, C.R., Chown, J., Parke, D.V.

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