Preclinical Strategy to Reduce Clinical Hepatotoxicity Using in Vitro Bioactivation Data for >200 Compounds von Sakatis, Melanie Z, Reese, Melinda J, Harrell, Andrew W, Taylor, Maxine A, Baines, Ian A, Chen, Liangfu, Bloomer, Jackie C, Yang, Eric Y, Ellens, Harma M, Ambroso, Jeffrey L, Lovatt, Cerys A, Ayrton, Andrew D, Clarke, Stephen E

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Biopharmaceutics Classification System: Validation and Learnings of an in Vitro Permeability Assay von Thiel-Demby, Victoria E, Humphreys, Joan E, St. John Williams, Lisa A, Ellens, Harma M, Shah, Nipa, Ayrton, Andrew D, Polli, Joseph W

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Pharmacokinetic/pharmacodynamic modelling of the EEG effects of opioids: The role of complex biophase distribution kinetics von Groenendaal, Dorien, Freijer, Jan, Rosier, Andrea, de Mik, Dennis, Nicholls, Glynis, Hersey, Anne, Ayrton, Andrew D., Danhof, Meindert, de Lange, Elizabeth C.M.

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Lauric acid as a model substrate for the simultaneous determination of cytochrome P450 2E1 and 4A in hepatic microsomes von Clarke, Stephen E, Baldwin, Sandra J, Bloomer, Jacqueline C, Ayrton, Andrew D, Sozio, Randall S, Chenery, Richard J

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8-piperazinyl-2,3-dihydropyrrolo[3,2-g]isoquinolines : Potent, selective, orally bioavailable 5-HT1 receptor ligands von HEIGHTMAN, Tom D, GASTER, Laramie M, GORDON, Laurie J, HOLLAND, Vicky A, POWLES, Jenifer, RILEY, Graham J, STEAN, Tania O, TRAIL, Brenda K, UPTON, Neil, AUSTIN, Nigel E, AYRTON, Andrew D, COLEMAN, Tanya, PARDOE, Sarah L, CUTLER, Leanne, PILLEUX, Jean-Pierre, HADLEY, Michael S, MIDDLEMISS, Derek N, PRICE, Gary W, ROBERTS, Claire, SCOTT, Claire M, WATSON, Jeannette M

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Expression, Purification, and Biochemical Characterization of A Human Cytochrome P450 CYP2D6-NADPH Cytochrome P450 Reductase Fusion Protein von Deeni, Yusuf Y., Paine, Mark J.I., Ayrton, Andrew D., Clarke, Stephen E., Chenery, Richard, Wolf, C.Roland

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Bioactivation of N-nitrosopiperidine to mutagens: role of hepatic cytochrome P-450 proteins and contribution of cytosolic fraction von Ayrton, Andrew D., Smith, Jonathan N., Ioannides, Costas

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8-Piperazinyl-2,3-dihydropyrrolo[3,2- g]isoquinolines: Potent, selective, orally bioavailable 5-HT 1 receptor ligands von Heightman, Tom D., Gaster, Laramie M., Pardoe, Sarah L., Pilleux, Jean-Pierre, Hadley, Michael S., Middlemiss, Derek N., Price, Gary W., Roberts, Claire, Scott, Claire M., Watson, Jeannette M., Gordon, Laurie J., Holland, Vicky A., Powles, Jenifer, Riley, Graham J., Stean, Tania O., Trail, Brenda K., Upton, Neil, Austin, Nigel E., Ayrton, Andrew D., Coleman, Tanya, Cutler, Leanne

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Induction of the cytochrome P450 I and IV families and peroxisomal proliferation in the liver of rats treated with benoxaprofen: Possible implications in its hepatotoxicity von Ayrton, Andrew D., Ioannides, Costas, Parke, Dennis V.

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Induction of the cytochrome P450 I and IV families and peroxisomal proliferation in the liver of rats treated with benoxaprofen von Ayrton, Andrew D., Ioannides, Costas, Parke, Dennis V.

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Induction of the rat hepatic microsomal mixed-function oxidases by two aza-arenes: A comparison with their non-heterocyclic analogues von Ayrton, Andrew D., Trinick, Julia, Wood, Beverley P., Smith, Jonathan N., Ioannides, Costas

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Streptozotocin-induced diabetes modulates the metabolic activation of chemical carcinogens von Ioannides, Costas, Bass, Sarah L., Ayrton, Andrew D., Trinick, Julia, Walker, Ronald, Flatt, Peter R.

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Induction of the rat hepatic microsomal mixed-function oxidases by two aza-arenes von Ayrton, Andrew D., Trinick, Julia, Wood, Beverley P., Smith, Jonathan N., Ioannides, Costas

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Anthraflavic acid inhibits the mutagenicity of the food mutagen IQ: Mechanism of action von Ayrton, Andrew D., Ioannides, Costas, Walker, Ronald

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Preferential induction of the rat hepatic P450 I proteins by the food carcinogen 2-amino-3-methyl-imidazo[4,5-f]quinoline von Rodrigues, A.D. (University of Surrey, Guildford), Ayrton, A.D, Williams, E.J, Lewis, D.F.V, Walker, R, Ioannides, C

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Preferential induction of the rat hepatic P 450 I proteins by the food carcinogen 2‐amino‐3‐methyl‐imidazo[4,5‐ f ]quinoline von RODRIGUES, A. David, AYRTON, Andrew D., WILLIAMS, Elisabeth J., LEWIS, David F. V., WALKER, Ronald, IOANNIDES, Costas

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Feprazone: An inducer of the P450 II B family of proteins in the rat von Smith, Jonathan N., Ayrton, Andrew D., Chown, Janice, Lewis, David F. V., Ioannides, Costas

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Uncertainty in the Representation of Orography in Weather and Climate Models and Implications for Parameterized Drag von Elvidge, Andrew D., Sandu, Irina, Wedi, Nils, Vosper, Simon B., Zadra, Ayrton, Boussetta, Souhail, Bouyssel, François, Niekerk, Annelize, Tolstykh, Mikhail A., Ujiie, Masashi

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Using Targeted Transcriptome and Machine Learning of Pre- and Post-Transplant Bone Marrow Samples to Predict Acute Graft-versus-Host Disease and Overall Survival after Allogeneic S... von Rowley, Scott D, Gunning, Thomas S, Pelliccia, Michael, Della Pia, Alexandra, Lee, Albert, Behrmann, James, Bangolo, Ayrton, Jandir, Parul, Zhang, Hong, Kaur, Sukhdeep, Suh, Hyung C, Donato, Michele, Albitar, Maher, Ip, Andrew

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A peek behind the curtain: Peer review and editorial decision making at Stroke von Sposato, Luciano A., Ovbiagele, Bruce, Johnston, S. Claiborne, Fisher, Marc, Saposnik, Gustavo

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